Details for gene set KEGG_CALCIUM_SIGNALING_PATHWAY[GSEA]

Table: GSEA Results Summary

Dataset	preliminary.phenotype.cls#LG_versus_HG.phenotype.cls#LG_versus_HG_repos
Phenotype	phenotype.cls#LG_versus_HG_repos
Upregulated in class	HG
GeneSet	KEGG_CALCIUM_SIGNALING_PATHWAY
Enrichment Score (ES)	-0.31841573
Normalized Enrichment Score (NES)	-1.3453138
Nominal p-value	0.021943573
FDR q-value	0.3336386
FWER p-Value	0.993

Fig 1: Enrichment plot: KEGG_CALCIUM_SIGNALING_PATHWAY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	RYR3	Ryr3			38	3.221	0.0251	No
2	GRIN1	Grin1			102	2.719	0.0443	No
3	SLC8A1	Slc8a1			302	2.078	0.0492	No
4	ADCY1	Adcy1			366	1.982	0.0621	No
5	ADRB2	Adrb2			399	1.934	0.0766	No
6	P2RX3	P2rx3			480	1.802	0.0868	No
7	PLCG2	Plcg2			551	1.717	0.0970	No
8	SLC8A2	Slc8a2			608	1.650	0.1075	No
9	SPHK1	Sphk1			621	1.628	0.1207	No
10	ADRB1	Adrb1			647	1.600	0.1328	No
11	PLCD1	Plcd1			710	1.541	0.1419	No
12	TACR3	Tacr3			817	1.442	0.1474	No
13	PLCE1	Plce1			837	1.426	0.1584	No
14	ATP2A3	Atp2a3			923	1.350	0.1644	No
15	PRKCG	Prkcg			996	1.303	0.1709	No
16	ITPKB	Itpkb			1264	1.115	0.1631	No
17	P2RX4	P2rx4			1329	1.083	0.1682	No
18	ATP2A1	Atp2a1			1354	1.073	0.1759	No
19	MYLK2	Mylk2			1459	1.027	0.1779	No
20	ITPR2	Itpr2			1579	0.974	0.1785	No
21	PLCB4	Plcb4			1596	0.969	0.1858	No
22	PTGER1	Ptger1			1695	0.934	0.1874	No
23	GNAL	Gnal			1772	0.905	0.1902	No
24	PLCD4	Plcd4			1840	0.882	0.1934	No
25	TNNC1	Tnnc1			2252	0.773	0.1733	No
26	CACNA1B	Cacna1b			2361	0.738	0.1726	No
27	PDE1C	Pde1c			2365	0.735	0.1787	No
28	ADCY9	Adcy9			2390	0.729	0.1834	No
29	CHRM1	Chrm1			2456	0.707	0.1852	No
30	ERBB2	Erbb2			2475	0.702	0.1900	No
31	HRH1	Hrh1			2606	0.667	0.1873	No
32	ADORA2B	Adora2b			2645	0.656	0.1905	No
33	P2RX2	P2rx2			2676	0.649	0.1941	No
34	ADCY3	Adcy3			2687	0.646	0.1990	No
35	GRIN2D	Grin2d			2733	0.635	0.2015	No
36	ERBB3	Erbb3			3192	0.536	0.1763	No
37	ADRA1A	Adra1a			3415	0.494	0.1660	No
38	HTR5A	Htr5a			3816	0.432	0.1437	No
39	CACNA1H	Cacna1h			3896	0.430	0.1422	No
40	PTAFR	Ptafr			3900	0.429	0.1457	No
41	GRIN2C	Grin2c			4219	0.407	0.1285	No
42	RYR2	Ryr2			4307	0.394	0.1262	No
43	CALM1	Calm1			4354	0.386	0.1265	No
44	ITPR3	Itpr3			4419	0.376	0.1256	No
45	TACR2	Tacr2			4472	0.366	0.1254	No
46	MYLK3	Mylk3			4545	0.354	0.1237	No
47	PHKG1	Phkg1			4588	0.345	0.1239	No
48	PHKA1	Phka1			4590	0.345	0.1268	No
49	GRM5	Grm5			4660	0.333	0.1252	No
50	TBXA2R	Tbxa2r			4892	0.299	0.1127	No
51	P2RX6	P2rx6			4979	0.289	0.1096	No
52	GNAS	Gnas			5004	0.286	0.1105	No
53	PTGER3	Ptger3			5145	0.270	0.1037	No
54	CHP1	Chp1			5427	0.231	0.0874	No
55	BDKRB2	Bdkrb2			5530	0.216	0.0826	No
56	F2R	F2r			5581	0.211	0.0811	No
57	PLCD3	Plcd3			5646	0.201	0.0787	No
58	SLC25A4	Slc25a4			5658	0.199	0.0797	No
59	HTR4	Htr4			5770	0.184	0.0741	No
60	PHKG2	Phkg2			5842	0.176	0.0709	No
61	HTR2A	Htr2a			6033	0.152	0.0599	No
62	VDAC3	Vdac3			6062	0.149	0.0593	No
63	ITPKA	Itpka			6253	0.130	0.0481	No
64	PLCB2	Plcb2			6348	0.118	0.0430	No
65	PPP3CC	Ppp3cc			6542	0.096	0.0312	No
66	CACNA1S	Cacna1s			6583	0.091	0.0294	No
67	PHKB	Phkb			6754	0.071	0.0190	No
68	CAMK4	Camk4			6790	0.068	0.0173	No
69	ADCY2	Adcy2			6832	0.063	0.0151	No
70	ADCY4	Adcy4			6834	0.063	0.0156	No
71	CALML3	Calml3			7106	0.034	-0.0017	No
72	ATP2B3	Atp2b3			7139	0.032	-0.0035	No
73	LTB4R2	Ltb4r2			7161	0.028	-0.0047	No
74	EDNRB	Ednrb			7287	0.015	-0.0127	No
75	AVPR1B	Avpr1b			7492	0.000	-0.0260	No
76	AVPR1A	Avpr1a			7493	0.000	-0.0260	No
77	CHRM5	Chrm5			7538	0.000	-0.0288	No
78	NTSR1	Ntsr1			7543	0.000	-0.0291	No
79	ERBB4	Erbb4			7547	0.000	-0.0293	No
80	ATP2B2	Atp2b2			7591	0.000	-0.0321	No
81	PLN	Pln			7638	0.000	-0.0351	No
82	PPP3R2	Ppp3r2			7663	0.000	-0.0366	No
83	CACNA1F	Cacna1f			7745	0.000	-0.0419	No
84	TNNC2	Tnnc2			7782	0.000	-0.0442	No
85	HRH2	Hrh2			7875	0.000	-0.0502	No
86	DRD1	Drd1			8002	-0.009	-0.0583	No
87	ADORA2A	Adora2a			8092	-0.018	-0.0640	No
88	SPHK2	Sphk2			8222	-0.028	-0.0721	No
89	RYR1	Ryr1			8411	-0.045	-0.0840	No
90	ATP2A2	Atp2a2			8693	-0.074	-0.1016	No
91	VDAC2	Vdac2			8746	-0.079	-0.1043	No
92	ADRA1D	Adra1d			8756	-0.080	-0.1042	No
93	NOS1	Nos1			8757	-0.080	-0.1036	No
94	GNA11	Gna11			9020	-0.106	-0.1197	No
95	CYSLTR1	Cysltr1			9042	-0.109	-0.1201	No
96	CCKAR	Cckar			9103	-0.116	-0.1230	No
97	P2RX1	P2rx1			9227	-0.127	-0.1300	No
98	HTR2B	Htr2b			9391	-0.143	-0.1393	No
99	PLCB3	Plcb3			9618	-0.166	-0.1526	No
100	PLCG1	Plcg1			9622	-0.167	-0.1514	No
101	CALM3	Calm3			9742	-0.178	-0.1576	No
102	PPID	Ppid			9929	-0.196	-0.1680	No
103	PPP3CA	Ppp3ca			10018	-0.206	-0.1720	No
104	CALM2	Calm2			10048	-0.209	-0.1721	No
105	CAMK2G	Camk2g			10068	-0.211	-0.1715	No
106	VDAC1	Vdac1			10290	-0.233	-0.1839	No
107	PRKACB	Prkacb			10431	-0.249	-0.1909	No
108	GNA14	Gna14			10481	-0.252	-0.1919	No
109	SLC25A5	Slc25a5			10636	-0.269	-0.1996	No
110	BST1	Bst1			10910	-0.296	-0.2149	No
111	CAMK2A	Camk2a			11400	-0.353	-0.2437	No
112	ADRA1B	Adra1b			11495	-0.365	-0.2467	No
113	PPP3CB	Ppp3cb			11662	-0.384	-0.2542	No
114	ATP2B1	Atp2b1			11724	-0.392	-0.2548	No
115	AGTR1	Agtr1a			11925	-0.418	-0.2642	No
116	SLC25A31	Slc25a31			11959	-0.418	-0.2628	No
117	TACR1	Tacr1			11982	-0.418	-0.2606	No
118	PRKACA	Prkaca			12054	-0.424	-0.2616	No
119	HTR6	Htr6			12406	-0.458	-0.2805	No
120	CACNA1E	Cacna1e			12413	-0.459	-0.2770	No
121	MYLK	Mylk			12500	-0.474	-0.2785	No
122	PHKA2	Phka2			12527	-0.479	-0.2761	No
123	PTK2B	Ptk2b			12544	-0.483	-0.2730	No
124	CHP2	Chp2			12674	-0.499	-0.2771	No
125	HTR7	Htr7			12756	-0.508	-0.2780	No
126	GRIN2A	Grin2a			12999	-0.553	-0.2890	No
127	EDNRA	Ednra			13143	-0.585	-0.2933	No
128	OXTR	Oxtr			13326	-0.625	-0.2998	No
129	ITPR1	Itpr1			13613	-0.701	-0.3124	Yes
130	PDE1B	Pde1b			13655	-0.712	-0.3090	Yes
131	CHRM3	Chrm3			13776	-0.750	-0.3103	Yes
132	CACNA1D	Cacna1d			13877	-0.781	-0.3102	Yes
133	GRM1	Grm1			13914	-0.793	-0.3057	Yes
134	CACNA1A	Cacna1a			14005	-0.819	-0.3045	Yes
135	TRHR	Trhr			14079	-0.842	-0.3021	Yes
136	NOS2	Nos2			14138	-0.860	-0.2985	Yes
137	EGFR	Egfr			14176	-0.870	-0.2934	Yes
138	TRPC1	Trpc1			14289	-0.920	-0.2928	Yes
139	SLC8A3	Slc8a3			14459	-1.001	-0.2952	Yes
140	GNA15	Gna15			14497	-1.023	-0.2889	Yes
141	ADCY7	Adcy7			14683	-1.147	-0.2911	Yes
142	CD38	Cd38			14688	-1.151	-0.2815	Yes
143	PRKCA	Prkca			14737	-1.199	-0.2743	Yes
144	GRPR	Grpr			14779	-1.235	-0.2664	Yes
145	PDGFRB	Pdgfrb			14829	-1.288	-0.2585	Yes
146	PLCB1	Plcb1			15032	-1.546	-0.2584	Yes
147	CACNA1C	Cacna1c			15057	-1.590	-0.2464	Yes
148	CACNA1G	Cacna1g			15111	-1.688	-0.2353	Yes
149	PDGFRA	Pdgfra			15163	-1.787	-0.2233	Yes
150	NOS3	Nos3			15187	-1.828	-0.2092	Yes
151	PTGFR	Ptgfr			15226	-1.922	-0.1952	Yes
152	ATP2B4	Atp2b4			15310	-2.170	-0.1820	Yes
153	CAMK2B	Camk2b			15320	-2.213	-0.1636	Yes
154	ADCY8	Adcy8			15381	-2.433	-0.1466	Yes
155	P2RX7	P2rx7			15418	-2.691	-0.1259	Yes
156	BDKRB1	Bdkrb1			15429	-2.734	-0.1031	Yes
157	PRKCB	Prkcb			15461	-2.954	-0.0798	Yes
158	CCKBR	Cckbr			15465	-3.027	-0.0540	Yes
159	CACNA1I	Cacna1i			15487	-3.296	-0.0272	Yes
160	PDE1A	Pde1a			15499	-3.449	0.0017	Yes

Fig 2: KEGG_CALCIUM_SIGNALING_PATHWAY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: KEGG_CALCIUM_SIGNALING_PATHWAY: Random ES distribution   
Gene set null distribution of ES for KEGG_CALCIUM_SIGNALING_PATHWAY