Details for gene set KEGG_CHEMOKINE_SIGNALING_PATHWAY[GSEA]

Table: GSEA Results Summary

Dataset	preliminary.phenotype.cls#LG_versus_HG.phenotype.cls#LG_versus_HG_repos
Phenotype	phenotype.cls#LG_versus_HG_repos
Upregulated in class	HG
GeneSet	KEGG_CHEMOKINE_SIGNALING_PATHWAY
Enrichment Score (ES)	-0.36645043
Normalized Enrichment Score (NES)	-1.5362176
Nominal p-value	0.003236246
FDR q-value	0.19729522
FWER p-Value	0.704

Fig 1: Enrichment plot: KEGG_CHEMOKINE_SIGNALING_PATHWAY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	GNG4	Gng4			88	2.780	0.0218	No
2	ITK	Itk			172	2.428	0.0404	No
3	ADCY1	Adcy1			366	1.982	0.0475	No
4	RASGRP2	Rasgrp2			435	1.866	0.0616	No
5	CXCL12	Cxcl12			553	1.714	0.0709	No
6	LYN	Lyn			673	1.577	0.0788	No
7	ELMO1	Elmo1			709	1.541	0.0918	No
8	GNG3	Gng3			926	1.348	0.0911	No
9	GNG8	Gng8			1526	0.996	0.0620	No
10	PLCB4	Plcb4			1596	0.969	0.0671	No
11	PREX1	Prex1			1662	0.948	0.0722	No
12	GNAI1	Gnai1			1736	0.921	0.0766	No
13	GNG10	Gng10			1783	0.900	0.0825	No
14	GNG13	Gng13			1785	0.900	0.0914	No
15	PRKCD	Prkcd			1807	0.893	0.0988	No
16	STAT1	Stat1			1819	0.890	0.1069	No
17	CXCR4	Cxcr4			1862	0.875	0.1129	No
18	HRAS	Hras			2180	0.791	0.1001	No
19	CCR2	Ccr2			2197	0.789	0.1069	No
20	STAT2	Stat2			2285	0.762	0.1088	No
21	ADCY9	Adcy9			2390	0.729	0.1092	No
22	ADCY3	Adcy3			2687	0.646	0.0963	No
23	VAV2	Vav2			2775	0.625	0.0969	No
24	IKBKG	Ikbkg			2814	0.616	0.1005	No
25	SHC1	Shc1			2978	0.579	0.0956	No
26	PIK3CG	Pik3cg			3162	0.541	0.0891	No
27	STAT5B	Stat5b			3319	0.511	0.0840	No
28	NRAS	Nras			3680	0.455	0.0651	No
29	NFKBIB	Nfkbib			3766	0.441	0.0639	No
30	CCL27	Ccl27a			3997	0.421	0.0531	No
31	CCR6	Ccr6			4033	0.421	0.0550	No
32	CCR3	Ccr3			4034	0.421	0.0592	No
33	GRK5	Grk5			4072	0.415	0.0609	No
34	PIK3R5	Pik3r5			4080	0.414	0.0645	No
35	PARD3	Pard3			4305	0.394	0.0539	No
36	GNB5	Gnb5			4486	0.364	0.0458	No
37	CXCL16	Cxcl16			4492	0.362	0.0490	No
38	RAC2	Rac2			4827	0.309	0.0304	No
39	IKBKB	Ikbkb			5033	0.283	0.0198	No
40	PIK3CD	Pik3cd			5095	0.274	0.0186	No
41	KRAS	Kras			5181	0.266	0.0157	No
42	WASL	Wasl			5185	0.265	0.0181	No
43	PRKCZ	Prkcz			5239	0.256	0.0172	No
44	GRK4	Grk4			5252	0.255	0.0189	No
45	CCR7	Ccr7			5367	0.239	0.0139	No
46	GNB2	Gnb2			5542	0.215	0.0047	No
47	STAT3	Stat3			5568	0.212	0.0052	No
48	ADCY6	Adcy6			5613	0.207	0.0044	No
49	TIAM1	Tiam1			5659	0.199	0.0034	No
50	CCR10	Ccr10			5709	0.194	0.0021	No
51	GNG11	Gng11			5798	0.181	-0.0018	No
52	GSK3B	Gsk3b			5879	0.171	-0.0053	No
53	GNB1	Gnb1			5973	0.160	-0.0098	No
54	GNG7	Gng7			5994	0.157	-0.0095	No
55	CCR4	Ccr4			6059	0.149	-0.0122	No
56	CSK	Csk			6066	0.149	-0.0111	No
57	GNG12	Gng12			6124	0.143	-0.0134	No
58	PLCB2	Plcb2			6348	0.118	-0.0267	No
59	ARRB2	Arrb2			6766	0.070	-0.0532	No
60	ADCY2	Adcy2			6832	0.063	-0.0568	No
61	ADCY4	Adcy4			6834	0.063	-0.0562	No
62	RHOA	Rhoa			6904	0.056	-0.0601	No
63	CRK	Crk			6925	0.054	-0.0609	No
64	PIK3CB	Pik3cb			7007	0.045	-0.0657	No
65	GNAI3	Gnai3			7030	0.042	-0.0667	No
66	AKT2	Akt2			7049	0.039	-0.0675	No
67	RAP1B	Rap1b			7080	0.036	-0.0691	No
68	MAPK3	Mapk3			7199	0.024	-0.0766	No
69	RELA	Rela			7327	0.011	-0.0847	No
70	GNG5	Gm4356			7417	0.002	-0.0905	No
71	BCAR1	Bcar1			7425	0.001	-0.0909	No
72	VAV1	Vav1			7515	0.000	-0.0967	No
73	GRK6	Grk6			7931	-0.003	-0.1237	No
74	ADCY5	Adcy5			8247	-0.030	-0.1439	No
75	AKT1	Akt1			8293	-0.035	-0.1464	No
76	MAPK1	Mapk1			8316	-0.037	-0.1475	No
77	GRB2	Grb2			8518	-0.055	-0.1600	No
78	RAF1	Raf1			8539	-0.058	-0.1608	No
79	GNAI2	Gnai2			8727	-0.077	-0.1722	No
80	PPBP	Ppbp			8737	-0.078	-0.1720	No
81	JAK2	Jak2			8984	-0.102	-0.1870	No
82	SOS2	Sos2			9170	-0.122	-0.1978	No
83	BRAF	Braf			9178	-0.123	-0.1970	No
84	CDC42	Cdc42			9384	-0.142	-0.2090	No
85	SOS1	Sos1			9428	-0.146	-0.2103	No
86	GNB4	Gnb4			9471	-0.150	-0.2116	No
87	GSK3A	Gsk3a			9523	-0.156	-0.2133	No
88	PLCB3	Plcb3			9618	-0.166	-0.2178	No
89	NFKBIA	Nfkbia			9707	-0.174	-0.2218	No
90	ROCK1	Rock1			9810	-0.184	-0.2266	No
91	CCL20	Ccl20			9827	-0.186	-0.2258	No
92	GRK2	Grk2			9845	-0.188	-0.2250	No
93	JAK3	Jak3			9873	-0.191	-0.2249	No
94	CRKL	Crkl			10150	-0.218	-0.2407	No
95	PRKACB	Prkacb			10431	-0.249	-0.2565	No
96	RAP1A	Rap1a			10620	-0.267	-0.2660	No
97	CHUK	Chuk			10845	-0.290	-0.2777	No
98	GRK1	Grk1			11094	-0.319	-0.2907	No
99	ROCK2	Rock2			11123	-0.321	-0.2894	No
100	RAC1	Rac1			11450	-0.360	-0.3070	No
101	CX3CR1	Cx3cr1			11578	-0.373	-0.3116	No
102	PXN	Pxn			11609	-0.377	-0.3098	No
103	GNGT2	Gngt2			11936	-0.418	-0.3268	No
104	PRKACA	Prkaca			12054	-0.424	-0.3302	No
105	GRK3	Grk3			12058	-0.424	-0.3262	No
106	CXCR5	Cxcr5			12091	-0.424	-0.3241	No
107	PTK2	Ptk2			12178	-0.432	-0.3254	No
108	CXCL9	Cxcl9			12254	-0.440	-0.3260	No
109	GNB3	Gnb3			12381	-0.453	-0.3297	No
110	GNG2	Gng2			12418	-0.460	-0.3275	No
111	FGR	Fgr			12518	-0.479	-0.3292	No
112	CCL22	Ccl22			12519	-0.479	-0.3244	No
113	PTK2B	Ptk2b			12544	-0.483	-0.3212	No
114	AKT3	Akt3			12618	-0.490	-0.3211	No
115	PIK3R1	Pik3r1			12760	-0.509	-0.3252	No
116	TIAM2	Tiam2			12968	-0.543	-0.3333	No
117	CCR9	Ccr9			13066	-0.568	-0.3340	No
118	MAP2K1	Map2k1			13134	-0.581	-0.3326	No
119	PAK1	Pak1			13205	-0.599	-0.3312	No
120	FOXO3	Foxo3			13292	-0.619	-0.3307	No
121	PIK3CA	Pik3ca			13327	-0.625	-0.3267	No
122	NCF1	Ncf1			13939	-0.799	-0.3585	Yes
123	CXCL6	Cxcl5			13940	-0.800	-0.3506	Yes
124	SHC3	Shc3			14013	-0.825	-0.3471	Yes
125	DOCK2	Dock2			14227	-0.892	-0.3522	Yes
126	WAS	Was			14396	-0.970	-0.3535	Yes
127	CXCR2	Cxcr2			14460	-1.001	-0.3477	Yes
128	CXCR6	Cxcr6			14519	-1.034	-0.3412	Yes
129	CCL28	Ccl28			14534	-1.046	-0.3318	Yes
130	XCR1	Xcr1			14584	-1.073	-0.3243	Yes
131	NFKB1	Nfkb1			14677	-1.142	-0.3190	Yes
132	ADCY7	Adcy7			14683	-1.147	-0.3080	Yes
133	SHC4	Shc4			14695	-1.160	-0.2972	Yes
134	CX3CL1	Cx3cl1			14878	-1.343	-0.2957	Yes
135	VAV3	Vav3			14888	-1.356	-0.2829	Yes
136	CXCL11	Cxcl11			14938	-1.408	-0.2721	Yes
137	ARRB1	Arrb1			14990	-1.490	-0.2607	Yes
138	PLCB1	Plcb1			15032	-1.546	-0.2481	Yes
139	CCR1	Ccr1			15042	-1.555	-0.2333	Yes
140	CCL7	Ccl7			15132	-1.719	-0.2220	Yes
141	HCK	Hck			15262	-2.026	-0.2103	Yes
142	CCL2	Ccl2			15268	-2.037	-0.1905	Yes
143	CCL5	Ccl5			15278	-2.073	-0.1706	Yes
144	CCL8	Ccl12			15326	-2.242	-0.1514	Yes
145	CCL17	Ccl17			15346	-2.308	-0.1298	Yes
146	ADCY8	Adcy8			15381	-2.433	-0.1079	Yes
147	CXCL10	Cxcl10			15390	-2.511	-0.0836	Yes
148	CCL11	Ccl11			15445	-2.856	-0.0588	Yes
149	PRKCB	Prkcb			15461	-2.954	-0.0306	Yes
150	CXCL14	Cxcl14			15502	-3.500	0.0015	Yes

Fig 2: KEGG_CHEMOKINE_SIGNALING_PATHWAY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: KEGG_CHEMOKINE_SIGNALING_PATHWAY: Random ES distribution   
Gene set null distribution of ES for KEGG_CHEMOKINE_SIGNALING_PATHWAY