Details for gene set KEGG_FOCAL_ADHESION[GSEA]

Table: GSEA Results Summary

Dataset	preliminary.phenotype.cls#LG_versus_HG.phenotype.cls#LG_versus_HG_repos
Phenotype	phenotype.cls#LG_versus_HG_repos
Upregulated in class	HG
GeneSet	KEGG_FOCAL_ADHESION
Enrichment Score (ES)	-0.3368867
Normalized Enrichment Score (NES)	-1.4577802
Nominal p-value	0.0034965035
FDR q-value	0.25269252
FWER p-Value	0.897

Fig 1: Enrichment plot: KEGG_FOCAL_ADHESION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	VWF	Vwf			11	3.767	0.0267	No
2	KDR	Kdr			32	3.271	0.0492	No
3	FLT4	Flt4			243	2.244	0.0518	No
4	CHAD	Chad			378	1.964	0.0574	No
5	COL11A2	Col11a2			415	1.909	0.0690	No
6	COL4A4	Col4a4			612	1.644	0.0681	No
7	ITGA9	Itga9			614	1.642	0.0800	No
8	PARVG	Parvg			686	1.562	0.0868	No
9	ITGB5	Itgb5			810	1.446	0.0893	No
10	LAMA1	Lama1			860	1.405	0.0963	No
11	LAMA3	Lama3			971	1.318	0.0987	No
12	PRKCG	Prkcg			996	1.303	0.1066	No
13	VEGFB	Vegfb			1101	1.223	0.1088	No
14	VEGFC	Vegfc			1115	1.215	0.1168	No
15	PAK6	Pak6			1283	1.107	0.1139	No
16	LAMB3	Lamb3			1294	1.102	0.1213	No
17	ITGB7	Itgb7			1393	1.056	0.1226	No
18	MYLK2	Mylk2			1459	1.027	0.1258	No
19	MYL10	Myl10			1563	0.980	0.1262	No
20	FYN	Fyn			1575	0.976	0.1326	No
21	PAK3	Pak3			1844	0.880	0.1216	No
22	RELN	Reln			1891	0.866	0.1249	No
23	ITGA10	Gm42957			2099	0.810	0.1173	No
24	PDGFB	Pdgfb			2135	0.802	0.1208	No
25	HRAS	Hras			2180	0.791	0.1237	No
26	ITGB6	Itgb6			2216	0.782	0.1271	No
27	RAC3	Rac3			2306	0.753	0.1268	No
28	THBS3	Thbs3			2347	0.742	0.1296	No
29	MYL9	Myl9			2425	0.716	0.1298	No
30	ERBB2	Erbb2			2475	0.702	0.1317	No
31	BCL2	Bcl2			2537	0.682	0.1327	No
32	VAV2	Vav2			2775	0.625	0.1218	No
33	CCND3	Ccnd3			2789	0.623	0.1255	No
34	MYL12B	Myl12b			2916	0.593	0.1216	No
35	SHC1	Shc1			2978	0.579	0.1218	No
36	ELK1	Elk1			3014	0.569	0.1237	No
37	PDGFA	Pdgfa			3028	0.566	0.1269	No
38	PIK3CG	Pik3cg			3162	0.541	0.1222	No
39	BAD	Bad			3217	0.532	0.1225	No
40	VTN	Vtn			3346	0.506	0.1179	No
41	LAMC3	Lamc3			3901	0.428	0.0849	No
42	PIK3R5	Pik3r5			4080	0.414	0.0763	No
43	COL2A1	Col2a1			4394	0.380	0.0586	No
44	COL5A2	Col5a2			4478	0.365	0.0559	No
45	PTEN	Pten			4496	0.362	0.0574	No
46	MYLK3	Mylk3			4545	0.354	0.0568	No
47	ITGB4	Itgb4			4802	0.312	0.0424	No
48	RAC2	Rac2			4827	0.309	0.0431	No
49	COL5A3	Col5a3			5063	0.278	0.0298	No
50	PIK3CD	Pik3cd			5095	0.274	0.0298	No
51	CAPN2	Capn2			5378	0.237	0.0131	No
52	LAMB2	Lamb2			5389	0.236	0.0142	No
53	MAPK9	Mapk9			5489	0.221	0.0093	No
54	GSK3B	Gsk3b			5879	0.171	-0.0148	No
55	FLNC	Flnc			5890	0.169	-0.0142	No
56	PARVB	Parvb			6123	0.143	-0.0283	No
57	COL4A6	Col4a6			6263	0.129	-0.0364	No
58	FN1	Fn1			6272	0.127	-0.0360	No
59	TNXB	Tnxb			6509	0.099	-0.0507	No
60	CTNNB1	Ctnnb1			6545	0.096	-0.0523	No
61	MYL12A	Myl12a			6708	0.077	-0.0623	No
62	ITGA11	Itga11			6767	0.070	-0.0656	No
63	VASP	Vasp			6798	0.066	-0.0670	No
64	RHOA	Rhoa			6904	0.056	-0.0735	No
65	CRK	Crk			6925	0.054	-0.0744	No
66	PIK3CB	Pik3cb			7007	0.045	-0.0793	No
67	AKT2	Akt2			7049	0.039	-0.0817	No
68	RAP1B	Rap1b			7080	0.036	-0.0834	No
69	MAPK3	Mapk3			7199	0.024	-0.0909	No
70	DIAPH1	Diaph1			7233	0.020	-0.0930	No
71	FLNA	Flna			7289	0.015	-0.0964	No
72	BCAR1	Bcar1			7425	0.001	-0.1052	No
73	VAV1	Vav1			7515	0.000	-0.1110	No
74	IBSP	Ibsp			7609	0.000	-0.1171	No
75	PAK5	Pak7			7772	0.000	-0.1277	No
76	ITGB8	Itgb8			7970	-0.006	-0.1405	No
77	MAPK10	Mapk10			8030	-0.011	-0.1442	No
78	AKT1	Akt1			8293	-0.035	-0.1611	No
79	MAPK1	Mapk1			8316	-0.037	-0.1622	No
80	ITGA8	Itga8			8483	-0.052	-0.1727	No
81	GRB2	Grb2			8518	-0.055	-0.1745	No
82	RAF1	Raf1			8539	-0.058	-0.1754	No
83	PIP5K1C	Pip5k1c			8624	-0.067	-0.1804	No
84	PDPK1	Pdpk1			8649	-0.070	-0.1814	No
85	ACTN1	Actn1			8908	-0.092	-0.1976	No
86	ITGA7	Itga7			9113	-0.117	-0.2100	No
87	ITGA2B	Itga2b			9122	-0.117	-0.2097	No
88	SOS2	Sos2			9170	-0.122	-0.2119	No
89	BRAF	Braf			9178	-0.123	-0.2114	No
90	CDC42	Cdc42			9384	-0.142	-0.2238	No
91	SOS1	Sos1			9428	-0.146	-0.2255	No
92	MAPK8	Mapk8			9552	-0.159	-0.2324	No
93	ARHGAP35	Arhgap35			9635	-0.167	-0.2365	No
94	THBS1	Thbs1			9661	-0.170	-0.2369	No
95	PAK2	Pak2			9749	-0.178	-0.2413	No
96	ROCK1	Rock1			9810	-0.184	-0.2438	No
97	PPP1CA	Ppp1ca			9846	-0.188	-0.2448	No
98	PAK4	Pak4			9936	-0.197	-0.2491	No
99	CAV2	Cav2			10143	-0.218	-0.2610	No
100	CRKL	Crkl			10150	-0.218	-0.2598	No
101	LAMA2	Lama2			10249	-0.228	-0.2645	No
102	LAMC2	Lamc2			10283	-0.232	-0.2650	No
103	TLN2	Tln2			10355	-0.240	-0.2679	No
104	VCL	Vcl			10545	-0.259	-0.2783	No
105	ITGA5	Itga5			10612	-0.266	-0.2807	No
106	RAP1A	Rap1a			10620	-0.267	-0.2792	No
107	ACTG1	Actg1			10670	-0.272	-0.2804	No
108	PPP1CB	Ppp1cb			10731	-0.279	-0.2823	No
109	ITGA3	Itga3			10773	-0.284	-0.2829	No
110	ACTN2	Actn2			10874	-0.293	-0.2873	No
111	CCND1	Ccnd1			10950	-0.301	-0.2900	No
112	ITGAV	Itgav			10977	-0.305	-0.2894	No
113	ROCK2	Rock2			11123	-0.321	-0.2966	No
114	VEGFD	Vegfd			11156	-0.326	-0.2963	No
115	CAV1	Cav1			11181	-0.328	-0.2955	No
116	PDGFC	Pdgfc			11255	-0.336	-0.2978	No
117	ITGB1	Itgb1			11361	-0.348	-0.3021	No
118	RAC1	Rac1			11450	-0.360	-0.3052	No
119	PXN	Pxn			11609	-0.377	-0.3128	No
120	ACTB	Actb			11649	-0.382	-0.3125	No
121	RAPGEF1	Rapgef1			11670	-0.385	-0.3110	No
122	FLNB	Flnb			11676	-0.386	-0.3085	No
123	PPP1R12A	Ppp1r12a			11682	-0.388	-0.3060	No
124	ACTN4	Actn4			11761	-0.397	-0.3082	No
125	IGF1R	Igf1r			11788	-0.400	-0.3070	No
126	PPP1CC	Ppp1cc			12176	-0.431	-0.3291	No
127	PTK2	Ptk2			12178	-0.432	-0.3260	No
128	THBS4	Thbs4			12181	-0.432	-0.3230	No
129	PDGFD	Pdgfd			12217	-0.437	-0.3221	No
130	MYL2	Myl2			12280	-0.440	-0.3230	No
131	TLN1	Tln1			12307	-0.442	-0.3214	No
132	LAMB1	Lamb1			12329	-0.446	-0.3196	No
133	SRC	Src			12330	-0.446	-0.3163	No
134	MYLK	Mylk			12500	-0.474	-0.3239	No
135	COL6A6	Col6a6			12543	-0.483	-0.3231	No
136	AKT3	Akt3			12618	-0.490	-0.3244	No
137	COL4A1	Col4a1			12625	-0.491	-0.3212	No
138	PIK3R1	Pik3r1			12760	-0.509	-0.3262	No
139	COL1A2	Col1a2			12914	-0.534	-0.3323	Yes
140	ITGA2	Itga2			12923	-0.536	-0.3289	Yes
141	VEGFA	Vegfa			12953	-0.540	-0.3269	Yes
142	COL11A1	Col11a1			12986	-0.548	-0.3250	Yes
143	COL4A2	Col4a2			13046	-0.562	-0.3247	Yes
144	MAP2K1	Map2k1			13134	-0.581	-0.3262	Yes
145	XIAP	Xiap			13180	-0.594	-0.3248	Yes
146	PAK1	Pak1			13205	-0.599	-0.3220	Yes
147	LAMC1	Lamc1			13207	-0.600	-0.3177	Yes
148	PIK3CA	Pik3ca			13327	-0.625	-0.3209	Yes
149	JUN	Jun			13518	-0.673	-0.3284	Yes
150	ITGA4	Itga4			13649	-0.711	-0.3317	Yes
151	BIRC3	Birc3			13670	-0.718	-0.3278	Yes
152	COL1A1	Col1a1			13688	-0.723	-0.3236	Yes
153	DOCK1	Dock1			13707	-0.729	-0.3195	Yes
154	PGF	Pgf			13830	-0.765	-0.3219	Yes
155	ARHGAP5	Arhgap5			13836	-0.767	-0.3166	Yes
156	MET	Met			13861	-0.774	-0.3126	Yes
157	PARVA	Parva			13906	-0.791	-0.3097	Yes
158	MYL7	Myl7			13922	-0.793	-0.3049	Yes
159	ITGA6	Itga6			13973	-0.809	-0.3023	Yes
160	LAMA5	Lama5			14003	-0.818	-0.2982	Yes
161	SHC3	Shc3			14013	-0.825	-0.2928	Yes
162	FLT1	Flt1			14053	-0.837	-0.2892	Yes
163	MYLPF	Mylpf			14058	-0.839	-0.2834	Yes
164	BIRC2	Birc2			14162	-0.865	-0.2838	Yes
165	EGFR	Egfr			14176	-0.870	-0.2783	Yes
166	COMP	Comp			14208	-0.884	-0.2739	Yes
167	COL5A1	Col5a1			14238	-0.898	-0.2693	Yes
168	ILK	Ilk			14252	-0.902	-0.2635	Yes
169	ZYX	Zyx			14445	-0.991	-0.2688	Yes
170	ITGA1	Itga1			14526	-1.039	-0.2665	Yes
171	SHC4	Shc4			14695	-1.160	-0.2690	Yes
172	PRKCA	Prkca			14737	-1.199	-0.2630	Yes
173	PDGFRB	Pdgfrb			14829	-1.288	-0.2595	Yes
174	VAV3	Vav3			14888	-1.356	-0.2534	Yes
175	EGF	Egf			14924	-1.396	-0.2455	Yes
176	CAV3	Cav3			15102	-1.666	-0.2450	Yes
177	LAMA4	Lama4			15118	-1.696	-0.2336	Yes
178	ACTN3	Actn3			15126	-1.708	-0.2216	Yes
179	SPP1	Spp1			15131	-1.718	-0.2094	Yes
180	COL6A3	Col6a3			15151	-1.768	-0.1978	Yes
181	PDGFRA	Pdgfra			15163	-1.787	-0.1855	Yes
182	COL6A1	Col6a1			15185	-1.824	-0.1735	Yes
183	COL6A2	Col6a2			15240	-1.962	-0.1628	Yes
184	TNR	Tnr			15265	-2.028	-0.1496	Yes
185	COL3A1	Col3a1			15313	-2.188	-0.1367	Yes
186	THBS2	Thbs2			15404	-2.585	-0.1238	Yes
187	IGF1	Igf1			15412	-2.616	-0.1052	Yes
188	RASGRF1	Rasgrf1			15442	-2.844	-0.0864	Yes
189	TNC	Tnc			15451	-2.893	-0.0658	Yes
190	PRKCB	Prkcb			15461	-2.954	-0.0449	Yes
191	HGF	Hgf			15472	-3.068	-0.0233	Yes
192	TNN	Tnn			15508	-3.660	0.0011	Yes

Fig 2: KEGG_FOCAL_ADHESION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: KEGG_FOCAL_ADHESION: Random ES distribution   
Gene set null distribution of ES for KEGG_FOCAL_ADHESION