Details for gene set KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS[GSEA]

Table: GSEA Results Summary

Dataset	preliminary.phenotype.cls#LG_versus_HG.phenotype.cls#LG_versus_HG_repos
Phenotype	phenotype.cls#LG_versus_HG_repos
Upregulated in class	HG
GeneSet	KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS
Enrichment Score (ES)	-0.3204281
Normalized Enrichment Score (NES)	-1.3184258
Nominal p-value	0.051671732
FDR q-value	0.36910596
FWER p-Value	0.998

Fig 1: Enrichment plot: KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	TRIM37	Trim37			1331	1.081	-0.0610	No
2	PRKN	Prkn			2001	0.835	-0.0849	No
3	UBE2QL1	Ube2ql1			2101	0.810	-0.0723	No
4	PIAS4	Pias4			3056	0.561	-0.1211	No
5	KLHL13	Klhl13			3124	0.548	-0.1126	No
6	PIAS3	Pias3			3172	0.540	-0.1029	No
7	RHOBTB2	Rhobtb2			3630	0.465	-0.1217	No
8	UBE2J1	Ube2j1			4234	0.404	-0.1514	No
9	UBE2U	Ube2u			4254	0.402	-0.1431	No
10	DDB2	Ddb2			4363	0.385	-0.1411	No
11	SMURF2	Smurf2			4576	0.347	-0.1467	No
12	WWP1	Wwp1			4673	0.331	-0.1452	No
13	UBE4A	Ube4a			4931	0.294	-0.1550	No
14	TRAF6	Traf6			4989	0.288	-0.1519	No
15	UBE3B	Ube3b			5115	0.272	-0.1537	No
16	UBE2H	Ube2h			5175	0.267	-0.1512	No
17	MID1	Mid1			5197	0.263	-0.1464	No
18	BTRC	Btrc			5255	0.254	-0.1442	No
19	UBE2Q1	Ube2q1			5424	0.231	-0.1496	No
20	UBE2A	Ube2a			5470	0.224	-0.1473	No
21	UBE2E1	Ube2e1			5476	0.223	-0.1424	No
22	RBX1	Rbx1			5635	0.202	-0.1479	No
23	MDM2	Mdm2			5688	0.197	-0.1466	No
24	FBXO4	Fbxo4			5690	0.197	-0.1421	No
25	UBA6	Uba6			5725	0.193	-0.1398	No
26	UBE2Q2	Ube2q2			5967	0.161	-0.1516	No
27	SMURF1	Smurf1			5977	0.159	-0.1485	No
28	UBE2M	Ube2m			6007	0.156	-0.1467	No
29	UBE2J2	Ube2j2			6093	0.146	-0.1488	No
30	UBE2E3	Ube2e3			6187	0.136	-0.1516	No
31	RNF7	Gm7075			6324	0.121	-0.1576	No
32	UBA7	Uba7			6475	0.103	-0.1649	No
33	UBE2D2	Ube2d2a			6521	0.098	-0.1656	No
34	UBE4B	Ube4b			6788	0.068	-0.1812	No
35	FBXW7	Fbxw7			6831	0.063	-0.1825	No
36	HERC4	Herc4			6881	0.058	-0.1843	No
37	ANAPC10	Anapc10			6956	0.051	-0.1879	No
38	STUB1	Stub1			7066	0.038	-0.1941	No
39	DDB1	Ddb1			7223	0.020	-0.2038	No
40	CUL2	Cul2			7267	0.018	-0.2061	No
41	UBE2D1	Ube2d1			7921	-0.001	-0.2485	No
42	UBE2I	Ube2i			8090	-0.017	-0.2590	No
43	UBE2Z	Ube2z			8173	-0.026	-0.2637	No
44	PPIL2	Ppil2			8345	-0.040	-0.2739	No
45	UBE2R2	Ube2r2			8412	-0.045	-0.2771	No
46	UBE2B	Ube2b			8521	-0.055	-0.2828	No
47	CUL7	Cul7			8529	-0.057	-0.2819	No
48	PIAS1	Pias1			8564	-0.061	-0.2827	No
49	UBE2L6	Ube2l6			8661	-0.070	-0.2873	No
50	FBXW8	Fbxw8			8789	-0.083	-0.2936	No
51	BRCA1	Brca1			8820	-0.085	-0.2936	No
52	FZR1	Fzr1			8822	-0.085	-0.2916	No
53	SAE1	Sae1			8894	-0.091	-0.2941	No
54	CUL4B	Cul4b			8910	-0.093	-0.2929	No
55	ANAPC13	Anapc13			8987	-0.102	-0.2954	No
56	ERCC8	Ercc8			9021	-0.107	-0.2951	No
57	UBE2D3	Ube2d3			9098	-0.115	-0.2973	No
58	SIAH1	Siah1a			9135	-0.118	-0.2969	No
59	MAP3K1	Map3k1			9194	-0.124	-0.2977	No
60	CBLC	Cblc			9219	-0.127	-0.2963	No
61	ELOC	Eloc			9322	-0.136	-0.2997	No
62	ANAPC5	Anapc5			9477	-0.151	-0.3062	No
63	ANAPC2	Anapc2			9592	-0.163	-0.3098	No
64	TRIM32	Trim32			9598	-0.164	-0.3062	No
65	UBA3	Uba3			9692	-0.174	-0.3082	No
66	ANAPC7	Anapc7			9705	-0.174	-0.3049	No
67	WWP2	Wwp2			9797	-0.183	-0.3065	No
68	UBE3C	Ube3c			9819	-0.185	-0.3035	No
69	UBE2G1	Ube2g1			9844	-0.188	-0.3007	No
70	RCHY1	Rchy1			9884	-0.191	-0.2987	No
71	ANAPC4	Anapc4			9900	-0.193	-0.2952	No
72	MGRN1	Mgrn1			9906	-0.194	-0.2909	No
73	ANAPC1	Anapc1			9975	-0.201	-0.2906	No
74	CDC23	Cdc23			10009	-0.204	-0.2880	No
75	CUL5	Cul5			10086	-0.213	-0.2879	No
76	PRPF19	Prpf19			10252	-0.229	-0.2933	No
77	SKP1	Skp1a			10594	-0.265	-0.3092	No
78	CUL4A	Cul4a			10743	-0.281	-0.3122	No
79	UBE2K	Ube2k			10867	-0.292	-0.3133	Yes
80	ITCH	Itch			10970	-0.304	-0.3128	Yes
81	CUL3	Cul3			11088	-0.318	-0.3130	Yes
82	UBA1	Uba1			11127	-0.322	-0.3079	Yes
83	FBXW11	Fbxw11			11134	-0.323	-0.3007	Yes
84	CDC26	Cdc26			11141	-0.324	-0.2935	Yes
85	CDC27	Cdc27			11269	-0.337	-0.2938	Yes
86	NHLRC1	Nhlrc1			11350	-0.347	-0.2908	Yes
87	PIAS2	Pias2			11351	-0.348	-0.2827	Yes
88	UBE2S	Ube2s			11365	-0.349	-0.2753	Yes
89	UBA2	Uba2			11510	-0.366	-0.2761	Yes
90	UBOX5	Ubox5			11590	-0.374	-0.2724	Yes
91	NEDD4L	Nedd4l			11605	-0.376	-0.2645	Yes
92	COP1	Cop1			11793	-0.401	-0.2673	Yes
93	UBE2O	Ube2o			11851	-0.409	-0.2614	Yes
94	UBE2G2	Ube2g2			11891	-0.414	-0.2542	Yes
95	CDC16	Cdc16			11919	-0.418	-0.2461	Yes
96	CUL1	Cul1			12150	-0.428	-0.2510	Yes
97	HERC2	Herc2			12359	-0.450	-0.2539	Yes
98	CBL	Cbl			12366	-0.451	-0.2437	Yes
99	KLHL9	Klhl9			12738	-0.506	-0.2559	Yes
100	SOCS1	Socs1			12954	-0.541	-0.2572	Yes
101	FANCL	Fancl			12963	-0.542	-0.2450	Yes
102	TRIP12	Trip12			12978	-0.547	-0.2331	Yes
103	SKP2	Skp2			13124	-0.579	-0.2289	Yes
104	HUWE1	Huwe1			13133	-0.581	-0.2158	Yes
105	XIAP	Xiap			13180	-0.594	-0.2048	Yes
106	UBR5	Ubr5			13360	-0.633	-0.2016	Yes
107	UBE3A	Ube3a			13385	-0.639	-0.1881	Yes
108	BIRC6	Birc6			13392	-0.641	-0.1735	Yes
109	HERC1	Herc1			13501	-0.668	-0.1648	Yes
110	PML	Pml			13619	-0.702	-0.1559	Yes
111	BIRC3	Birc3			13670	-0.718	-0.1423	Yes
112	CDC20	Cdc20			13683	-0.722	-0.1262	Yes
113	KEAP1	Keap1			13691	-0.724	-0.1096	Yes
114	UBE2C	Ube2c			13858	-0.773	-0.1022	Yes
115	SOCS3	Socs3			13904	-0.790	-0.0866	Yes
116	AIRE	Aire			13933	-0.796	-0.0697	Yes
117	CBLB	Cblb			13936	-0.797	-0.0511	Yes
118	NEDD4	Nedd4			13971	-0.808	-0.0344	Yes
119	BIRC2	Birc2			14162	-0.865	-0.0264	Yes
120	UBE2E2	Ube2e2			14451	-0.995	-0.0218	Yes
121	CDC34	Cdc34			14462	-1.002	0.0011	Yes
122	SYVN1	Syvn1			14852	-1.314	0.0067	Yes
123	FBXO2	Fbxo2			15050	-1.574	0.0308	Yes

Fig 2: KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS: Random ES distribution   
Gene set null distribution of ES for KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS