Details for gene set KEGG_PURINE_METABOLISM[GSEA]

Table: GSEA Results Summary

Dataset	preliminary.phenotype.cls#NG_versus_HG.phenotype.cls#NG_versus_HG_repos
Phenotype	phenotype.cls#NG_versus_HG_repos
Upregulated in class	HG
GeneSet	KEGG_PURINE_METABOLISM
Enrichment Score (ES)	-0.43025044
Normalized Enrichment Score (NES)	-1.6934788
Nominal p-value	0.0
FDR q-value	0.027025063
FWER p-Value	0.278

Fig 1: Enrichment plot: KEGG_PURINE_METABOLISM   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	PDE5A	Pde5a			127	3.643	0.0142	No
2	PDE6B	Pde6b			141	3.596	0.0354	No
3	ADCY1	Adcy1			256	3.148	0.0474	No
4	AMPD3	Ampd3			360	2.875	0.0584	No
5	GUCY1A2	Gucy1a2			377	2.838	0.0748	No
6	NPR1	Npr1			444	2.703	0.0871	No
7	PAPSS2	Papss2			492	2.616	0.1002	No
8	PDE3A	Pde3a			531	2.539	0.1133	No
9	PDE8A	Pde8a			665	2.329	0.1190	No
10	NPR2	Npr2			1060	1.887	0.1050	No
11	NME2	Nme2			1154	1.809	0.1101	No
12	ENTPD2	Entpd2			1406	1.612	0.1037	No
13	PNP	Pnp			1435	1.591	0.1117	No
14	ENTPD5	Entpd5			2132	1.201	0.0738	No
15	PDE10A	Pde10a			2156	1.190	0.0796	No
16	ADPRM	Adprm			2366	1.104	0.0728	No
17	ADCY9	Adcy9			2906	0.895	0.0433	No
18	POLR3A	Polr3a			2931	0.886	0.0472	No
19	ADA	Ada			3217	0.809	0.0337	No
20	NT5C	Nt5c			3776	0.657	0.0014	No
21	PRPS1L1	Prps1l1			3792	0.654	0.0045	No
22	POLR3F	Polr3f			3837	0.640	0.0056	No
23	PRUNE1	Prune1			3998	0.600	-0.0012	No
24	NT5E	Nt5e			4002	0.598	0.0023	No
25	XDH	Xdh			4208	0.547	-0.0076	No
26	RRM2B	Rrm2b			4242	0.540	-0.0065	No
27	ADCY2	Adcy2			4283	0.534	-0.0058	No
28	POLR3D	Polr3d			4297	0.532	-0.0033	No
29	PKLR	Pklr			4465	0.499	-0.0111	No
30	ADCY6	Adcy6			4579	0.494	-0.0154	No
31	GUCY2C	Gucy2c			4654	0.478	-0.0173	No
32	NME6	Nme6			4688	0.472	-0.0165	No
33	NME5	Nme5			4772	0.451	-0.0192	No
34	CANT1	Cant1			4993	0.436	-0.0308	No
35	PRPS2	Prps2			5219	0.388	-0.0430	No
36	POLR2L	Polr2l			5359	0.362	-0.0498	No
37	GUCY2F	Gucy2f			5413	0.353	-0.0511	No
38	ADCY3	Adcy3			5512	0.336	-0.0554	No
39	AK4	Ak4			5527	0.334	-0.0543	No
40	POLR1C	Polr1c			5644	0.311	-0.0599	No
41	NUDT2	Nudt2			5656	0.308	-0.0587	No
42	ADCY10	Adcy10			5755	0.290	-0.0633	No
43	POLR2A	Polr2a			5816	0.281	-0.0655	No
44	ATIC	Atic			5877	0.269	-0.0677	No
45	PDE1C	Pde1c			5948	0.253	-0.0707	No
46	NT5C2	Nt5c2			6005	0.243	-0.0729	No
47	ENTPD8	Entpd8			6103	0.227	-0.0778	No
48	GUK1	Guk1			6203	0.210	-0.0829	No
49	PDE7A	Pde7a			6276	0.193	-0.0864	No
50	POLR3B	Polr3b			6371	0.177	-0.0914	No
51	ADCY5	Adcy5			6439	0.164	-0.0948	No
52	POLR2F	Polr2f			6440	0.164	-0.0938	No
53	AK5	Ak5			6524	0.148	-0.0982	No
54	PDE6G	Pde6g			6558	0.141	-0.0995	No
55	POLR2K	Polr2k			6668	0.122	-0.1059	No
56	NME1	Nme1			6678	0.121	-0.1057	No
57	POLE4	Pole4			6682	0.120	-0.1052	No
58	POLR2E	Polr2e			6822	0.093	-0.1136	No
59	NUDT9	Nudt9			6887	0.081	-0.1173	No
60	AK7	Ak7			6924	0.075	-0.1192	No
61	NME4	Nme4			6990	0.068	-0.1230	No
62	GUCY2D	Gucy2e			7082	0.054	-0.1285	No
63	POLR3C	Polr3c			7145	0.050	-0.1323	No
64	ENTPD3	Entpd3			7511	0.000	-0.1560	No
65	ENTPD4	Entpd4b			7512	0.000	-0.1560	No
66	ALLC	Allc			7680	0.000	-0.1668	No
67	PDE2A	Gm45837			7817	0.000	-0.1757	No
68	POLR1D	Polr1d			8047	-0.003	-0.1906	No
69	AK1	Ak1			8198	-0.033	-0.2001	No
70	POLR2G	Polr2g			8221	-0.037	-0.2013	No
71	GUCY1B1	Gucy1b1			8467	-0.083	-0.2167	No
72	AMPD2	Ampd2			8577	-0.103	-0.2232	No
73	POLR2H	Polr2h			8604	-0.108	-0.2242	No
74	HPRT1	Hprt			8854	-0.153	-0.2394	No
75	PDE4B	Pde4b			9464	-0.262	-0.2774	No
76	FHIT	Fhit			9955	-0.365	-0.3070	No
77	APRT	Aprt			9959	-0.366	-0.3050	No
78	PKM	Pkm			10041	-0.378	-0.3079	No
79	POLR3K	Polr3k			10048	-0.380	-0.3060	No
80	PDE6A	Pde6a			10101	-0.390	-0.3069	No
81	IMPDH1	Impdh1			10167	-0.407	-0.3087	No
82	PRPS1	Prps1			10627	-0.444	-0.3358	No
83	PDE9A	Pde9a			10820	-0.484	-0.3453	No
84	PDE11A	Pde11a			10866	-0.489	-0.3452	No
85	NT5C3A	Nt5c3			10970	-0.503	-0.3488	No
86	POLR2I	Polr2i			11098	-0.525	-0.3538	No
87	PDE6D	Pde6d			11119	-0.529	-0.3519	No
88	PDE4A	Pde4a			11180	-0.541	-0.3524	No
89	ENTPD1	Entpd1			11300	-0.569	-0.3567	No
90	PDE6H	Pde6h			11597	-0.642	-0.3720	No
91	NME7	Nme7			11816	-0.705	-0.3818	No
92	DGUOK	Dguok			11981	-0.753	-0.3878	No
93	POLR2B	Polr2b			12029	-0.766	-0.3862	No
94	ZNRD1	Znrd1			12079	-0.779	-0.3846	No
95	NUDT5	Nudt5			12207	-0.810	-0.3878	No
96	PDE1B	Pde1b			12285	-0.834	-0.3877	No
97	POLR1E	Polr1e			12837	-0.986	-0.4174	No
98	AMPD1	Ampd1			13035	-1.060	-0.4237	Yes
99	POLR2C	Polr2c			13094	-1.090	-0.4208	Yes
100	POLR1A	Polr1a			13147	-1.110	-0.4173	Yes
101	PNPT1	Pnpt1			13209	-1.135	-0.4143	Yes
102	ENTPD6	Entpd6			13296	-1.179	-0.4127	Yes
103	PFAS	Pfas			13405	-1.234	-0.4121	Yes
104	ADK	Adk			13447	-1.251	-0.4071	Yes
105	NT5M	Nt5m			13450	-1.252	-0.3995	Yes
106	POLD2	Pold2			13544	-1.311	-0.3975	Yes
107	PAICS	Paics			13569	-1.325	-0.3909	Yes
108	GMPR	Gmpr			13770	-1.436	-0.3950	Yes
109	ADSL	Adsl			13792	-1.447	-0.3875	Yes
110	ADSS2	Adss			13842	-1.482	-0.3816	Yes
111	POLR2D	Polr2d			13903	-1.524	-0.3761	Yes
112	GART	Gart			13917	-1.540	-0.3675	Yes
113	GMPR2	Gmpr2			14015	-1.608	-0.3639	Yes
114	GMPS	Gmps			14039	-1.627	-0.3554	Yes
115	ADCY4	Adcy4			14043	-1.629	-0.3455	Yes
116	GUCY1A1	Gucy1a1			14085	-1.664	-0.3379	Yes
117	PDE4D	Pde4d			14100	-1.677	-0.3285	Yes
118	PAPSS1	Papss1			14168	-1.733	-0.3222	Yes
119	POLE3	Pole3			14191	-1.751	-0.3129	Yes
120	POLR1B	Polr1b			14194	-1.751	-0.3023	Yes
121	POLD1	Pold1			14198	-1.754	-0.2917	Yes
122	POLR3H	Polr3h			14239	-1.790	-0.2832	Yes
123	ITPA	Itpa			14268	-1.822	-0.2738	Yes
124	POLE2	Pole2			14290	-1.839	-0.2639	Yes
125	PDE3B	Pde3b			14337	-1.891	-0.2553	Yes
126	AK2	Ak2			14513	-2.122	-0.2536	Yes
127	IMPDH2	Impdh2			14580	-2.224	-0.2442	Yes
128	ADSS1	Adssl1			14796	-2.558	-0.2424	Yes
129	PPAT	Ppat			14814	-2.607	-0.2275	Yes
130	ADCY7	Adcy7			14838	-2.643	-0.2127	Yes
131	DCK	Dck			14890	-2.741	-0.1992	Yes
132	PRIM2	Prim2			14956	-2.884	-0.1857	Yes
133	GDA	Gda			15035	-3.050	-0.1720	Yes
134	POLA1	Pola1			15115	-3.254	-0.1571	Yes
135	ADCY8	Adcy8			15131	-3.320	-0.1376	Yes
136	POLE	Pole			15155	-3.370	-0.1184	Yes
137	RRM1	Rrm1			15164	-3.410	-0.0979	Yes
138	ENPP3	Enpp3			15180	-3.458	-0.0776	Yes
139	PDE7B	Pde7b			15198	-3.513	-0.0571	Yes
140	PDE1A	Pde1a			15393	-4.119	-0.0444	Yes
141	RRM2	Rrm2			15407	-4.177	-0.0195	Yes
142	ENPP1	Enpp1			15473	-4.411	0.0034	Yes

Fig 2: KEGG_PURINE_METABOLISM   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: KEGG_PURINE_METABOLISM: Random ES distribution   
Gene set null distribution of ES for KEGG_PURINE_METABOLISM