Details for gene set KEGG_P53_SIGNALING_PATHWAY[GSEA]

Table: GSEA Results Summary

Dataset	preliminary.phenotype.cls#NG_versus_LG.phenotype.cls#NG_versus_LG_repos
Phenotype	phenotype.cls#NG_versus_LG_repos
Upregulated in class	LG
GeneSet	KEGG_P53_SIGNALING_PATHWAY
Enrichment Score (ES)	-0.50739247
Normalized Enrichment Score (NES)	-1.7370912
Nominal p-value	0.0014556041
FDR q-value	0.016836757
FWER p-Value	0.225

Fig 1: Enrichment plot: KEGG_P53_SIGNALING_PATHWAY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	GADD45A	Gadd45a			138	2.445	0.0275	No
2	CCNG2	Ccng2			150	2.406	0.0626	No
3	CASP9	Casp9			587	1.576	0.0578	No
4	MDM2	Mdm2			1537	1.023	0.0117	No
5	STEAP3	Steap3			1584	1.006	0.0237	No
6	BAX	Bax			2064	0.856	0.0055	No
7	DDB2	Ddb2			2095	0.844	0.0161	No
8	RCHY1	Rchy1			2971	0.635	-0.0310	No
9	MDM4	Mdm4			3611	0.519	-0.0646	No
10	FAS	Fas			3663	0.510	-0.0603	No
11	COP1	Cop1			3843	0.494	-0.0646	No
12	SFN	Sfn			3965	0.473	-0.0653	No
13	ATM	Atm			3970	0.472	-0.0586	No
14	ADGRB1	Adgrb1			4384	0.423	-0.0790	No
15	TSC2	Tsc2			4639	0.384	-0.0897	No
16	CCNG1	Ccng1			5050	0.319	-0.1115	No
17	SESN3	Sesn3			5155	0.303	-0.1137	No
18	SHISA5	Shisa5			5179	0.299	-0.1107	No
19	SESN1	Sesn1			5274	0.286	-0.1125	No
20	EI24	Ei24			5428	0.265	-0.1185	No
21	PERP	Perp			5670	0.231	-0.1306	No
22	APAF1	Apaf1			6058	0.170	-0.1531	No
23	PTEN	Pten			6353	0.129	-0.1702	No
24	SERPINE1	Serpine1			6612	0.090	-0.1856	No
25	CDKN1A	Cdkn1a			7037	0.037	-0.2124	No
26	RRM2B	Rrm2b			7113	0.027	-0.2169	No
27	PMAIP1	Pmaip1			7125	0.026	-0.2172	No
28	CDK4	Cdk4			8434	-0.086	-0.3005	No
29	CCNB3	Ccnb3			8694	-0.120	-0.3155	No
30	CDK6	Cdk6			8988	-0.167	-0.3319	No
31	SESN2	Sesn2			9118	-0.184	-0.3375	No
32	CASP3	Casp3			9177	-0.192	-0.3384	No
33	GADD45B	Gadd45b			9269	-0.208	-0.3412	No
34	BID	Bid			9581	-0.255	-0.3575	No
35	ZMAT3	Zmat3			9796	-0.289	-0.3671	No
36	PPM1D	Ppm1d			11066	-0.454	-0.4424	No
37	CCND3	Ccnd3			11075	-0.456	-0.4361	No
38	TP53	Trp53			11444	-0.509	-0.4523	No
39	ATR	Atr			11688	-0.552	-0.4598	No
40	CYCS	Cycs			12387	-0.705	-0.4944	No
41	CD82	Cd82			12512	-0.733	-0.4915	No
42	CDK2	Cdk2			12758	-0.793	-0.4956	Yes
43	IGF1	Igf1			12887	-0.824	-0.4916	Yes
44	THBS1	Thbs1			13010	-0.847	-0.4869	Yes
45	TP73	Trp73			13089	-0.863	-0.4791	Yes
46	SERPINB5	Serpinb5			13099	-0.866	-0.4668	Yes
47	CASP8	Casp8			13491	-0.990	-0.4773	Yes
48	SIAH1	Siah1a			13546	-1.011	-0.4658	Yes
49	GADD45G	Gadd45g			14056	-1.231	-0.4803	Yes
50	CHEK2	Chek2			14135	-1.288	-0.4662	Yes
51	PIDD1	Pidd1			14140	-1.289	-0.4473	Yes
52	CCND1	Ccnd1			14737	-1.745	-0.4598	Yes
53	IGFBP3	Igfbp3			15038	-2.223	-0.4461	Yes
54	RPRM	Rprm			15087	-2.322	-0.4147	Yes
55	GTSE1	Gtse1			15334	-3.185	-0.3832	Yes
56	CDK1	Cdk1			15355	-3.325	-0.3350	Yes
57	CHEK1	Chek1			15360	-3.334	-0.2856	Yes
58	CCNE1	Ccne1			15413	-3.704	-0.2338	Yes
59	CCNE2	Ccne2			15435	-3.837	-0.1780	Yes
60	CCNB1	Ccnb1			15467	-3.995	-0.1206	Yes
61	CCNB2	Ccnb2			15480	-4.070	-0.0608	Yes
62	RRM2	Rrm2			15513	-4.272	0.0008	Yes

Fig 2: KEGG_P53_SIGNALING_PATHWAY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: KEGG_P53_SIGNALING_PATHWAY: Random ES distribution   
Gene set null distribution of ES for KEGG_P53_SIGNALING_PATHWAY