Details for gene set KEGG_PURINE_METABOLISM[GSEA]

Table: GSEA Results Summary

Dataset	preliminary.phenotype.cls#NG_versus_LG.phenotype.cls#NG_versus_LG_repos
Phenotype	phenotype.cls#NG_versus_LG_repos
Upregulated in class	LG
GeneSet	KEGG_PURINE_METABOLISM
Enrichment Score (ES)	-0.46225506
Normalized Enrichment Score (NES)	-1.8190451
Nominal p-value	0.0
FDR q-value	0.007308117
FWER p-Value	0.084

Fig 1: Enrichment plot: KEGG_PURINE_METABOLISM   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	PDE8A	Pde8a			146	2.422	0.0114	No
2	PDE3A	Pde3a			306	1.983	0.0181	No
3	GUCY1A2	Gucy1a2			368	1.853	0.0301	No
4	ADCY1	Adcy1			609	1.555	0.0279	No
5	NPR1	Npr1			1074	1.223	0.0082	No
6	PDE5A	Pde5a			1098	1.216	0.0172	No
7	AK4	Ak4			1238	1.144	0.0180	No
8	AMPD3	Ampd3			1853	0.915	-0.0140	No
9	NPR2	Npr2			1927	0.891	-0.0111	No
10	ADPRM	Adprm			2283	0.790	-0.0273	No
11	POLR2A	Polr2a			2558	0.722	-0.0389	No
12	POLR3A	Polr3a			2932	0.643	-0.0576	No
13	PDE6B	Pde6b			2952	0.638	-0.0534	No
14	ADCY2	Adcy2			3321	0.565	-0.0724	No
15	PRUNE1	Prune1			3326	0.565	-0.0678	No
16	PKLR	Pklr			3742	0.499	-0.0905	No
17	POLR1C	Polr1c			3833	0.496	-0.0921	No
18	CANT1	Cant1			3923	0.482	-0.0937	No
19	NT5C	Nt5c			4070	0.453	-0.0993	No
20	PRPS1L1	Prps1l1			4579	0.393	-0.1290	No
21	POLR3F	Polr3f			4591	0.391	-0.1263	No
22	PDE10A	Pde10a			4674	0.379	-0.1284	No
23	ENTPD5	Entpd5			4785	0.360	-0.1324	No
24	GUCY2F	Gucy2f			5008	0.324	-0.1441	No
25	ENTPD2	Entpd2			5020	0.323	-0.1420	No
26	PNP	Pnp			5076	0.316	-0.1429	No
27	PKM	Pkm			5082	0.315	-0.1405	No
28	ADCY6	Adcy6			5258	0.288	-0.1494	No
29	PDE7A	Pde7a			5287	0.283	-0.1487	No
30	ENTPD8	Entpd8			5440	0.262	-0.1564	No
31	GUCY2D	Gucy2e			5634	0.234	-0.1669	No
32	ADCY10	Adcy10			5767	0.216	-0.1736	No
33	PDE9A	Pde9a			5857	0.201	-0.1777	No
34	PDE4A	Pde4a			5909	0.192	-0.1793	No
35	ADCY9	Adcy9			6051	0.171	-0.1870	No
36	NUDT9	Nudt9			6061	0.170	-0.1861	No
37	NME5	Nme5			6101	0.163	-0.1873	No
38	AK1	Ak1			6153	0.156	-0.1893	No
39	ADCY5	Adcy5			6247	0.143	-0.1941	No
40	POLR3B	Polr3b			6288	0.138	-0.1955	No
41	NT5C2	Nt5c2			6328	0.133	-0.1969	No
42	AMPD2	Ampd2			6515	0.103	-0.2081	No
43	POLR3C	Polr3c			6792	0.070	-0.2254	No
44	PDE6G	Pde6g			6883	0.057	-0.2308	No
45	NUDT2	Nudt2			6905	0.054	-0.2317	No
46	NME2	Nme2			6947	0.049	-0.2339	No
47	PRPS1	Prps1			6969	0.046	-0.2349	No
48	RRM2B	Rrm2b			7113	0.027	-0.2439	No
49	ATIC	Atic			7249	0.009	-0.2526	No
50	GUCY1B1	Gucy1b1			7290	0.003	-0.2552	No
51	POLR2E	Polr2e			7297	0.002	-0.2556	No
52	ENTPD3	Entpd3			7359	0.000	-0.2596	No
53	ALLC	Allc			7533	0.000	-0.2708	No
54	POLR2K	Polr2k			8341	-0.073	-0.3226	No
55	DGUOK	Dguok			8707	-0.121	-0.3453	No
56	POLR1D	Polr1d			8713	-0.122	-0.3446	No
57	GUCY2C	Gucy2c			8854	-0.144	-0.3525	No
58	PRPS2	Prps2			9021	-0.172	-0.3618	No
59	POLR2B	Polr2b			9053	-0.176	-0.3623	No
60	POLR3D	Polr3d			9214	-0.198	-0.3710	No
61	POLR2H	Polr2h			9411	-0.228	-0.3817	No
62	POLR2L	Polr2l			9643	-0.264	-0.3945	No
63	NME7	Nme7			9731	-0.278	-0.3977	No
64	PAPSS2	Papss2			9771	-0.285	-0.3978	No
65	NT5C3A	Nt5c3			9916	-0.313	-0.4045	No
66	ADCY3	Adcy3			9917	-0.313	-0.4018	No
67	PDE1B	Pde1b			10031	-0.330	-0.4063	No
68	POLE4	Pole4			10260	-0.365	-0.4180	No
69	POLR2F	Polr2f			10293	-0.371	-0.4169	No
70	ADA	Ada			10334	-0.376	-0.4162	No
71	POLR2G	Polr2g			10418	-0.392	-0.4182	No
72	NUDT5	Nudt5			10496	-0.405	-0.4198	No
73	PDE11A	Pde11a			10699	-0.421	-0.4293	No
74	PDE2A	Gm45837			10753	-0.421	-0.4291	No
75	ENTPD4	Entpd4b			10870	-0.432	-0.4329	No
76	NT5E	Nt5e			10983	-0.438	-0.4364	No
77	PDE1C	Pde1c			11035	-0.448	-0.4359	No
78	PAICS	Paics			11123	-0.465	-0.4375	No
79	HPRT1	Hprt			11174	-0.476	-0.4367	No
80	PDE6D	Pde6d			11248	-0.486	-0.4372	No
81	GUCY1A1	Gucy1a1			11359	-0.494	-0.4401	No
82	ZNRD1	Znrd1			11369	-0.495	-0.4365	No
83	POLR3K	Polr3k			11415	-0.506	-0.4350	No
84	NME4	Nme4			11811	-0.575	-0.4558	No
85	AK5	Ak5			11912	-0.593	-0.4571	Yes
86	PDE6A	Pde6a			11918	-0.594	-0.4524	Yes
87	AK7	Ak7			11936	-0.598	-0.4483	Yes
88	GDA	Gda			11953	-0.601	-0.4442	Yes
89	POLR1A	Polr1a			11974	-0.606	-0.4403	Yes
90	POLR2C	Polr2c			12004	-0.615	-0.4368	Yes
91	GUK1	Guk1			12166	-0.652	-0.4417	Yes
92	POLR2I	Polr2i			12246	-0.671	-0.4411	Yes
93	NME1	Nme1			12325	-0.688	-0.4402	Yes
94	POLR1E	Polr1e			12338	-0.692	-0.4350	Yes
95	APRT	Aprt			12566	-0.745	-0.4434	Yes
96	PDE3B	Pde3b			12600	-0.753	-0.4390	Yes
97	POLR2D	Polr2d			12724	-0.786	-0.4403	Yes
98	PDE7B	Pde7b			12755	-0.791	-0.4354	Yes
99	ENTPD1	Entpd1			12851	-0.814	-0.4346	Yes
100	ADK	Adk			12964	-0.835	-0.4346	Yes
101	NME6	Nme6			13129	-0.878	-0.4378	Yes
102	NT5M	Nt5m			13162	-0.888	-0.4322	Yes
103	PFAS	Pfas			13218	-0.901	-0.4280	Yes
104	ENTPD6	Entpd6			13266	-0.917	-0.4232	Yes
105	IMPDH1	Impdh1			13293	-0.924	-0.4169	Yes
106	GMPR2	Gmpr2			13414	-0.964	-0.4164	Yes
107	ADSS2	Adss			13455	-0.980	-0.4105	Yes
108	PNPT1	Pnpt1			13503	-0.996	-0.4050	Yes
109	ADCY4	Adcy4			13520	-1.004	-0.3974	Yes
110	PDE6H	Pde6h			13652	-1.049	-0.3969	Yes
111	ADCY8	Adcy8			13717	-1.075	-0.3918	Yes
112	PAPSS1	Papss1			13895	-1.146	-0.3935	Yes
113	GMPR	Gmpr			13964	-1.183	-0.3877	Yes
114	XDH	Xdh			14099	-1.261	-0.3855	Yes
115	PDE1A	Pde1a			14154	-1.294	-0.3779	Yes
116	POLD2	Pold2			14224	-1.334	-0.3709	Yes
117	FHIT	Fhit			14257	-1.350	-0.3614	Yes
118	GMPS	Gmps			14266	-1.357	-0.3502	Yes
119	POLR1B	Polr1b			14279	-1.367	-0.3392	Yes
120	ADSL	Adsl			14418	-1.466	-0.3356	Yes
121	GART	Gart			14439	-1.477	-0.3241	Yes
122	IMPDH2	Impdh2			14447	-1.483	-0.3118	Yes
123	AK2	Ak2			14618	-1.628	-0.3089	Yes
124	POLE2	Pole2			14634	-1.637	-0.2957	Yes
125	POLR3H	Polr3h			14639	-1.640	-0.2819	Yes
126	POLD1	Pold1			14686	-1.694	-0.2703	Yes
127	ADCY7	Adcy7			14692	-1.702	-0.2560	Yes
128	POLE3	Pole3			14735	-1.741	-0.2437	Yes
129	ENPP1	Enpp1			14795	-1.830	-0.2318	Yes
130	PDE4D	Pde4d			14808	-1.840	-0.2167	Yes
131	ITPA	Itpa			14823	-1.854	-0.2017	Yes
132	ADSS1	Adssl1			14825	-1.855	-0.1857	Yes
133	AMPD1	Ampd1			14835	-1.869	-0.1702	Yes
134	PDE4B	Pde4b			14952	-2.054	-0.1601	Yes
135	PPAT	Ppat			15033	-2.208	-0.1463	Yes
136	PRIM2	Prim2			15067	-2.285	-0.1288	Yes
137	ENPP3	Enpp3			15119	-2.389	-0.1115	Yes
138	DCK	Dck			15213	-2.656	-0.0947	Yes
139	POLA1	Pola1			15271	-2.864	-0.0737	Yes
140	RRM1	Rrm1			15319	-3.083	-0.0502	Yes
141	POLE	Pole			15321	-3.101	-0.0236	Yes
142	RRM2	Rrm2			15513	-4.272	0.0008	Yes

Fig 2: KEGG_PURINE_METABOLISM   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: KEGG_PURINE_METABOLISM: Random ES distribution   
Gene set null distribution of ES for KEGG_PURINE_METABOLISM