Details for gene set KEGG_FOCAL_ADHESION[GSEA]

Table: GSEA Results Summary

Dataset	preliminary.phenotype.cls#NGP_versus_HG.phenotype.cls#NGP_versus_HG_repos
Phenotype	phenotype.cls#NGP_versus_HG_repos
Upregulated in class	HG
GeneSet	KEGG_FOCAL_ADHESION
Enrichment Score (ES)	-0.3931931
Normalized Enrichment Score (NES)	-1.5387684
Nominal p-value	0.0
FDR q-value	0.14743951
FWER p-Value	0.557

Fig 1: Enrichment plot: KEGG_FOCAL_ADHESION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	VWF	Vwf			3	4.885	0.0208	No
2	KDR	Kdr			6	4.826	0.0415	No
3	COL11A2	Col11a2			135	3.829	0.0496	No
4	COL4A4	Col4a4			410	3.008	0.0446	No
5	PARVG	Parvg			443	2.954	0.0553	No
6	CHAD	Chad			566	2.774	0.0592	No
7	ITGB7	Itgb7			810	2.407	0.0538	No
8	ITGA9	Itga9			822	2.396	0.0633	No
9	RELN	Reln			1014	2.179	0.0603	No
10	FLT4	Flt4			1092	2.106	0.0643	No
11	LAMB3	Lamb3			1193	1.992	0.0664	No
12	LAMA1	Lama1			1210	1.976	0.0738	No
13	ITGB5	Itgb5			1310	1.874	0.0754	No
14	THBS3	Thbs3			1500	1.724	0.0705	No
15	VEGFB	Vegfb			1553	1.680	0.0743	No
16	PIK3CD	Pik3cd			1661	1.603	0.0743	No
17	TNXB	Tnxb			1735	1.558	0.0762	No
18	LAMB2	Lamb2			2107	1.356	0.0578	No
19	COMP	Comp			2116	1.353	0.0631	No
20	VEGFC	Vegfc			2190	1.316	0.0640	No
21	PRKCG	Prkcg			2224	1.299	0.0675	No
22	CTNNB1	Ctnnb1			2291	1.271	0.0686	No
23	PDGFB	Pdgfb			2294	1.269	0.0740	No
24	ITGB6	Itgb6			2499	1.178	0.0657	No
25	ELK1	Elk1			2849	1.035	0.0474	No
26	COL2A1	Col2a1			2933	1.004	0.0463	No
27	ERBB2	Erbb2			3125	0.943	0.0379	No
28	LAMA3	Lama3			3292	0.895	0.0310	No
29	BCAR1	Bcar1			3392	0.865	0.0282	No
30	GSK3B	Gsk3b			3418	0.860	0.0303	No
31	MYL12B	Myl12b			3439	0.856	0.0327	No
32	ITGA10	Gm42957			3450	0.853	0.0357	No
33	FLNA	Flna			3474	0.848	0.0378	No
34	PIK3CG	Pik3cg			3524	0.831	0.0382	No
35	SHC1	Shc1			3603	0.815	0.0366	No
36	FN1	Fn1			3678	0.794	0.0352	No
37	VEGFA	Vegfa			3726	0.782	0.0355	No
38	MAPK3	Mapk3			4012	0.720	0.0200	No
39	PARVB	Parvb			4025	0.717	0.0224	No
40	PAK5	Pak7			4180	0.678	0.0152	No
41	ARHGAP35	Arhgap35			4541	0.582	-0.0057	No
42	SOS2	Sos2			4544	0.582	-0.0034	No
43	MAPK8	Mapk8			4803	0.518	-0.0180	No
44	MAPK10	Mapk10			5168	0.449	-0.0398	No
45	FYN	Fyn			5264	0.436	-0.0441	No
46	ITGB8	Itgb8			5402	0.417	-0.0512	No
47	MYL10	Myl10			5411	0.415	-0.0500	No
48	DIAPH1	Diaph1			5425	0.412	-0.0491	No
49	BRAF	Braf			5445	0.408	-0.0485	No
50	LAMC3	Lamc3			5471	0.404	-0.0484	No
51	VTN	Vtn			5537	0.401	-0.0509	No
52	ITGA2B	Itga2b			5599	0.396	-0.0532	No
53	ITGA3	Itga3			5667	0.382	-0.0559	No
54	VAV1	Vav1			5811	0.356	-0.0637	No
55	IBSP	Ibsp			5837	0.356	-0.0638	No
56	IGF1R	Igf1r			6070	0.322	-0.0776	No
57	VAV2	Vav2			6085	0.320	-0.0771	No
58	LAMA5	Lama5			6321	0.271	-0.0913	No
59	LAMB1	Lamb1			6524	0.230	-0.1035	No
60	PTEN	Pten			6630	0.208	-0.1094	No
61	AKT2	Akt2			6853	0.164	-0.1232	No
62	AKT1	Akt1			7042	0.129	-0.1349	No
63	ROCK1	Rock1			7085	0.119	-0.1371	No
64	PDPK1	Pdpk1			7121	0.114	-0.1389	No
65	CRK	Crk			7127	0.113	-0.1387	No
66	CAPN2	Capn2			7213	0.097	-0.1439	No
67	PXN	Pxn			7416	0.059	-0.1568	No
68	CCND3	Ccnd3			7483	0.049	-0.1609	No
69	PIP5K1C	Pip5k1c			7567	0.035	-0.1661	No
70	PIK3CA	Pik3ca			7585	0.030	-0.1671	No
71	LAMA2	Lama2			7738	0.001	-0.1770	No
72	MYLK3	Mylk3			8106	-0.017	-0.2009	No
73	SOS1	Sos1			8166	-0.030	-0.2046	No
74	XIAP	Xiap			8244	-0.044	-0.2094	No
75	CAV3	Cav3			8261	-0.048	-0.2103	No
76	MYLK2	Mylk2			8447	-0.083	-0.2220	No
77	VAV3	Vav3			8467	-0.087	-0.2229	No
78	MYL2	Myl2			8535	-0.099	-0.2268	No
79	SHC3	Shc3			8552	-0.102	-0.2274	No
80	PAK6	Pak6			8612	-0.113	-0.2308	No
81	ITGA5	Itga5			8800	-0.145	-0.2423	No
82	BAD	Bad			8802	-0.146	-0.2418	No
83	FLNC	Flnc			8860	-0.154	-0.2448	No
84	COL5A2	Col5a2			8874	-0.155	-0.2450	No
85	SRC	Src			8880	-0.156	-0.2447	No
86	VASP	Vasp			8892	-0.158	-0.2447	No
87	PIK3R5	Pik3r5			8900	-0.160	-0.2445	No
88	RAC3	Rac3			9015	-0.180	-0.2511	No
89	PDGFA	Pdgfa			9111	-0.196	-0.2565	No
90	ACTN2	Actn2			9209	-0.215	-0.2619	No
91	RHOA	Rhoa			9229	-0.220	-0.2622	No
92	FLNB	Flnb			9256	-0.224	-0.2629	No
93	RAC2	Rac2			9271	-0.227	-0.2628	No
94	HRAS	Hras			9287	-0.231	-0.2628	No
95	MAP2K1	Map2k1			9298	-0.232	-0.2625	No
96	RAPGEF1	Rapgef1			9338	-0.241	-0.2640	No
97	RAP1B	Rap1b			9457	-0.264	-0.2705	No
98	ACTN1	Actn1			9458	-0.264	-0.2694	No
99	PAK4	Pak4			9515	-0.272	-0.2719	No
100	CRKL	Crkl			9708	-0.310	-0.2831	No
101	THBS1	Thbs1			9747	-0.318	-0.2842	No
102	PPP1R12A	Ppp1r12a			9753	-0.318	-0.2831	No
103	PDGFC	Pdgfc			9842	-0.336	-0.2874	No
104	PAK3	Pak3			9856	-0.340	-0.2868	No
105	COL6A6	Col6a6			10063	-0.382	-0.2986	No
106	ACTB	Actb			10078	-0.384	-0.2979	No
107	ITGB1	Itgb1			10224	-0.414	-0.3056	No
108	ACTG1	Actg1			10326	-0.421	-0.3103	No
109	ITGA11	Itga11			10396	-0.426	-0.3130	No
110	PPP1CB	Ppp1cb			10446	-0.435	-0.3143	No
111	BIRC2	Birc2			10458	-0.437	-0.3132	No
112	ROCK2	Rock2			10537	-0.442	-0.3163	No
113	MAPK9	Mapk9			10579	-0.451	-0.3171	No
114	PAK2	Pak2			10634	-0.463	-0.3186	No
115	MAPK1	Mapk1			10768	-0.489	-0.3252	No
116	MYLPF	Mylpf			10790	-0.494	-0.3244	No
117	CDC42	Cdc42			11074	-0.550	-0.3405	No
118	VCL	Vcl			11113	-0.558	-0.3406	No
119	GRB2	Grb2			11322	-0.609	-0.3515	No
120	TLN1	Tln1			11397	-0.628	-0.3537	No
121	PTK2	Ptk2			11527	-0.655	-0.3592	No
122	RAF1	Raf1			11555	-0.662	-0.3582	No
123	BCL2	Bcl2			11593	-0.671	-0.3577	No
124	MYL12A	Myl12a			11642	-0.682	-0.3579	No
125	ITGA7	Itga7			11843	-0.740	-0.3677	No
126	THBS4	Thbs4			11879	-0.752	-0.3668	No
127	RAP1A	Rap1a			11967	-0.775	-0.3691	No
128	AKT3	Akt3			11977	-0.777	-0.3664	No
129	ITGAV	Itgav			12032	-0.796	-0.3665	No
130	LAMC2	Lamc2			12244	-0.851	-0.3766	No
131	PPP1CA	Ppp1ca			12259	-0.857	-0.3738	No
132	LAMC1	Lamc1			12320	-0.874	-0.3740	No
133	RAC1	Rac1			12614	-0.976	-0.3889	Yes
134	FLT1	Flt1			12627	-0.980	-0.3854	Yes
135	TLN2	Tln2			12685	-1.001	-0.3848	Yes
136	PPP1CC	Ppp1cc			12721	-1.015	-0.3828	Yes
137	MYL9	Myl9			12847	-1.060	-0.3863	Yes
138	ZYX	Zyx			12930	-1.092	-0.3870	Yes
139	DOCK1	Dock1			13026	-1.132	-0.3883	Yes
140	ARHGAP5	Arhgap5			13074	-1.152	-0.3864	Yes
141	PGF	Pgf			13145	-1.179	-0.3859	Yes
142	PAK1	Pak1			13152	-1.182	-0.3812	Yes
143	EGF	Egf			13161	-1.188	-0.3766	Yes
144	BIRC3	Birc3			13233	-1.225	-0.3760	Yes
145	MYL7	Myl7			13295	-1.248	-0.3746	Yes
146	ACTN4	Actn4			13388	-1.302	-0.3750	Yes
147	COL4A6	Col4a6			13425	-1.324	-0.3717	Yes
148	ITGA8	Itga8			13437	-1.329	-0.3667	Yes
149	COL4A1	Col4a1			13442	-1.331	-0.3612	Yes
150	COL4A2	Col4a2			13510	-1.361	-0.3597	Yes
151	MET	Met			13710	-1.474	-0.3664	Yes
152	PIK3CB	Pik3cb			13719	-1.479	-0.3605	Yes
153	PIK3R1	Pik3r1			13721	-1.480	-0.3542	Yes
154	PRKCA	Prkca			13942	-1.648	-0.3615	Yes
155	COL1A2	Col1a2			14054	-1.731	-0.3613	Yes
156	ITGB4	Itgb4			14125	-1.795	-0.3581	Yes
157	ITGA6	Itga6			14158	-1.823	-0.3523	Yes
158	COL5A3	Col5a3			14168	-1.835	-0.3450	Yes
159	PARVA	Parva			14233	-1.907	-0.3410	Yes
160	CAV2	Cav2			14255	-1.925	-0.3341	Yes
161	ILK	Ilk			14293	-1.971	-0.3280	Yes
162	SHC4	Shc4			14330	-2.013	-0.3217	Yes
163	COL11A1	Col11a1			14344	-2.028	-0.3138	Yes
164	ITGA4	Itga4			14396	-2.091	-0.3082	Yes
165	PDGFRA	Pdgfra			14432	-2.130	-0.3013	Yes
166	PDGFD	Pdgfd			14454	-2.166	-0.2933	Yes
167	PDGFRB	Pdgfrb			14505	-2.226	-0.2870	Yes
168	EGFR	Egfr			14536	-2.270	-0.2792	Yes
169	VEGFD	Vegfd			14548	-2.290	-0.2701	Yes
170	ITGA1	Itga1			14614	-2.383	-0.2641	Yes
171	ITGA2	Itga2			14691	-2.524	-0.2581	Yes
172	JUN	Jun			14704	-2.538	-0.2480	Yes
173	ACTN3	Actn3			14766	-2.627	-0.2407	Yes
174	LAMA4	Lama4			14786	-2.655	-0.2305	Yes
175	MYLK	Mylk			14799	-2.685	-0.2197	Yes
176	CCND1	Ccnd1			14834	-2.752	-0.2101	Yes
177	COL6A3	Col6a3			14860	-2.803	-0.1997	Yes
178	COL5A1	Col5a1			14890	-2.862	-0.1893	Yes
179	CAV1	Cav1			14966	-3.049	-0.1810	Yes
180	COL6A1	Col6a1			15022	-3.185	-0.1709	Yes
181	SPP1	Spp1			15038	-3.234	-0.1580	Yes
182	IGF1	Igf1			15091	-3.421	-0.1466	Yes
183	TNR	Tnr			15117	-3.492	-0.1333	Yes
184	COL6A2	Col6a2			15186	-3.673	-0.1219	Yes
185	COL1A1	Col1a1			15187	-3.673	-0.1061	Yes
186	RASGRF1	Rasgrf1			15189	-3.674	-0.0903	Yes
187	HGF	Hgf			15293	-4.036	-0.0797	Yes
188	TNN	Tnn			15295	-4.041	-0.0624	Yes
189	COL3A1	Col3a1			15359	-4.249	-0.0482	Yes
190	THBS2	Thbs2			15382	-4.337	-0.0310	Yes
191	TNC	Tnc			15423	-4.499	-0.0142	Yes
192	PRKCB	Prkcb			15515	-4.838	0.0007	Yes

Fig 2: KEGG_FOCAL_ADHESION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: KEGG_FOCAL_ADHESION: Random ES distribution   
Gene set null distribution of ES for KEGG_FOCAL_ADHESION