Details for gene set KEGG_P53_SIGNALING_PATHWAY[GSEA]

Table: GSEA Results Summary

Dataset	preliminary.phenotype.cls#NGP_versus_HG.phenotype.cls#NGP_versus_HG_repos
Phenotype	phenotype.cls#NGP_versus_HG_repos
Upregulated in class	HG
GeneSet	KEGG_P53_SIGNALING_PATHWAY
Enrichment Score (ES)	-0.3623384
Normalized Enrichment Score (NES)	-1.752646
Nominal p-value	0.0
FDR q-value	0.058000036
FWER p-Value	0.058

Fig 1: Enrichment plot: KEGG_P53_SIGNALING_PATHWAY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	ADGRB1	Adgrb1			26	4.445	0.0446	No
2	PERP	Perp			337	3.201	0.0579	No
3	GADD45A	Gadd45a			525	2.819	0.0752	No
4	SFN	Sfn			902	2.312	0.0749	No
5	CASP9	Casp9			1077	2.120	0.0858	No
6	BAX	Bax			1205	1.979	0.0982	No
7	STEAP3	Steap3			1222	1.969	0.1176	No
8	MDM2	Mdm2			1417	1.780	0.1236	No
9	FAS	Fas			1454	1.752	0.1396	No
10	CCNG2	Ccng2			1731	1.561	0.1380	No
11	PMAIP1	Pmaip1			1884	1.476	0.1435	No
12	DDB2	Ddb2			2089	1.365	0.1445	No
13	SERPINB5	Serpinb5			2657	1.110	0.1194	No
14	CCNG1	Ccng1			2811	1.048	0.1205	No
15	BID	Bid			2885	1.022	0.1264	No
16	PIDD1	Pidd1			3151	0.935	0.1190	No
17	EI24	Ei24			3291	0.895	0.1193	No
18	CDK4	Cdk4			4004	0.722	0.0808	No
19	TSC2	Tsc2			4174	0.679	0.0769	No
20	TP73	Trp73			4320	0.640	0.0742	No
21	SHISA5	Shisa5			4350	0.633	0.0789	No
22	SESN2	Sesn2			4480	0.596	0.0768	No
23	CDKN1A	Cdkn1a			4516	0.587	0.0807	No
24	RRM2B	Rrm2b			4757	0.528	0.0706	No
25	ZMAT3	Zmat3			4899	0.499	0.0667	No
26	APAF1	Apaf1			5108	0.461	0.0581	No
27	RCHY1	Rchy1			5399	0.418	0.0437	No
28	ATM	Atm			6278	0.282	-0.0102	No
29	PTEN	Pten			6630	0.208	-0.0307	No
30	COP1	Cop1			6636	0.208	-0.0289	No
31	CCNB3	Ccnb3			7166	0.106	-0.0620	No
32	GADD45B	Gadd45b			7336	0.072	-0.0721	No
33	CCND3	Ccnd3			7483	0.049	-0.0811	No
34	MDM4	Mdm4			9017	-0.180	-0.1783	No
35	THBS1	Thbs1			9747	-0.318	-0.2222	No
36	SERPINE1	Serpine1			10784	-0.493	-0.2840	No
37	TP53	Trp53			10894	-0.512	-0.2857	No
38	ATR	Atr			11319	-0.608	-0.3068	No
39	CDK2	Cdk2			11744	-0.710	-0.3268	No
40	PPM1D	Ppm1d			12163	-0.832	-0.3452	No
41	RPRM	Rprm			12265	-0.858	-0.3428	No
42	CDK6	Cdk6			12347	-0.884	-0.3388	No
43	SESN1	Sesn1			12546	-0.953	-0.3417	No
44	CYCS	Cycs			12866	-1.070	-0.3512	Yes
45	GADD45G	Gadd45g			12910	-1.085	-0.3427	Yes
46	CASP3	Casp3			12911	-1.085	-0.3314	Yes
47	SIAH1	Siah1a			13081	-1.155	-0.3303	Yes
48	CASP8	Casp8			13325	-1.265	-0.3328	Yes
49	CD82	Cd82			13595	-1.413	-0.3355	Yes
50	CHEK2	Chek2			13683	-1.463	-0.3259	Yes
51	SESN3	Sesn3			13801	-1.546	-0.3173	Yes
52	GTSE1	Gtse1			14494	-2.215	-0.3390	Yes
53	CCND1	Ccnd1			14834	-2.752	-0.3323	Yes
54	IGF1	Igf1			15091	-3.421	-0.3132	Yes
55	IGFBP3	Igfbp3			15148	-3.569	-0.2796	Yes
56	CCNE1	Ccne1			15174	-3.647	-0.2433	Yes
57	CHEK1	Chek1			15207	-3.730	-0.2065	Yes
58	CDK1	Cdk1			15246	-3.862	-0.1687	Yes
59	CCNE2	Ccne2			15271	-3.945	-0.1292	Yes
60	RRM2	Rrm2			15435	-4.557	-0.0923	Yes
61	CCNB1	Ccnb1			15478	-4.669	-0.0464	Yes
62	CCNB2	Ccnb2			15493	-4.736	0.0021	Yes

Fig 2: KEGG_P53_SIGNALING_PATHWAY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: KEGG_P53_SIGNALING_PATHWAY: Random ES distribution   
Gene set null distribution of ES for KEGG_P53_SIGNALING_PATHWAY