Details for gene set KEGG_PURINE_METABOLISM[GSEA]

Table: GSEA Results Summary

Dataset	preliminary.phenotype.cls#NGP_versus_HG.phenotype.cls#NGP_versus_HG_repos
Phenotype	phenotype.cls#NGP_versus_HG_repos
Upregulated in class	HG
GeneSet	KEGG_PURINE_METABOLISM
Enrichment Score (ES)	-0.39678466
Normalized Enrichment Score (NES)	-1.6479135
Nominal p-value	0.0
FDR q-value	0.085078955
FWER p-Value	0.211

Fig 1: Enrichment plot: KEGG_PURINE_METABOLISM   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	PDE6B	Pde6b			78	4.079	0.0189	No
2	PDE5A	Pde5a			141	3.802	0.0372	No
3	AMPD3	Ampd3			275	3.347	0.0482	No
4	ADCY1	Adcy1			388	3.055	0.0589	No
5	NPR1	Npr1			511	2.839	0.0676	No
6	PDE3A	Pde3a			557	2.787	0.0810	No
7	GUCY1A2	Gucy1a2			1024	2.169	0.0635	No
8	PAPSS2	Papss2			1055	2.136	0.0741	No
9	PDE8A	Pde8a			1099	2.096	0.0836	No
10	NPR2	Npr2			1368	1.829	0.0769	No
11	AMPD1	Ampd1			1379	1.818	0.0870	No
12	ADA	Ada			2253	1.288	0.0378	No
13	ADPRM	Adprm			2293	1.271	0.0427	No
14	POLR3A	Polr3a			2436	1.208	0.0406	No
15	PDE10A	Pde10a			2466	1.193	0.0457	No
16	ALLC	Allc			2480	1.187	0.0518	No
17	NME2	Nme2			2772	1.066	0.0392	No
18	PNP	Pnp			3071	0.961	0.0254	No
19	GUCY2C	Gucy2c			3154	0.935	0.0256	No
20	NME4	Nme4			3173	0.927	0.0299	No
21	POLR2A	Polr2a			3270	0.899	0.0289	No
22	ATIC	Atic			3327	0.884	0.0305	No
23	ADCY5	Adcy5			3459	0.852	0.0270	No
24	PRPS1L1	Prps1l1			3618	0.811	0.0214	No
25	XDH	Xdh			3810	0.758	0.0135	No
26	ENTPD3	Entpd3			3882	0.741	0.0132	No
27	NME5	Nme5			3927	0.740	0.0147	No
28	POLR3F	Polr3f			4075	0.706	0.0093	No
29	AK7	Ak7			4175	0.679	0.0068	No
30	ENTPD5	Entpd5			4183	0.678	0.0104	No
31	NME6	Nme6			4211	0.668	0.0125	No
32	POLR1C	Polr1c			4304	0.644	0.0103	No
33	NT5C	Nt5c			4348	0.634	0.0113	No
34	PRUNE1	Prune1			4448	0.606	0.0084	No
35	POLR3D	Polr3d			4533	0.585	0.0064	No
36	ADCY6	Adcy6			4574	0.576	0.0072	No
37	PDE9A	Pde9a			4604	0.569	0.0086	No
38	NUDT9	Nudt9			4659	0.551	0.0083	No
39	PRPS2	Prps2			4753	0.529	0.0054	No
40	RRM2B	Rrm2b			4757	0.528	0.0083	No
41	ENTPD2	Entpd2			5248	0.439	-0.0210	No
42	ENTPD8	Entpd8			5255	0.438	-0.0188	No
43	PDE2A	Gm45837			5538	0.401	-0.0348	No
44	POLR2K	Polr2k			5745	0.365	-0.0460	No
45	POLE4	Pole4			5924	0.353	-0.0555	No
46	CANT1	Cant1			5970	0.343	-0.0564	No
47	PDE6G	Pde6g			6065	0.324	-0.0606	No
48	ADCY3	Adcy3			6455	0.245	-0.0845	No
49	ADCY9	Adcy9			6506	0.234	-0.0863	No
50	FHIT	Fhit			6595	0.216	-0.0908	No
51	NME1	Nme1			6713	0.196	-0.0972	No
52	POLR3B	Polr3b			6746	0.188	-0.0982	No
53	POLR1D	Polr1d			6783	0.180	-0.0995	No
54	POLR3C	Polr3c			6841	0.167	-0.1022	No
55	AK1	Ak1			7178	0.103	-0.1235	No
56	ADCY2	Adcy2			7183	0.102	-0.1231	No
57	POLR2E	Polr2e			7241	0.091	-0.1263	No
58	AK5	Ak5			7393	0.062	-0.1357	No
59	AMPD2	Ampd2			7565	0.035	-0.1467	No
60	PDE11A	Pde11a			7685	0.010	-0.1543	No
61	PKLR	Pklr			7743	0.000	-0.1580	No
62	ENTPD4	Entpd4b			7766	0.000	-0.1595	No
63	GUK1	Guk1			8161	-0.029	-0.1849	No
64	PDE1C	Pde1c			8271	-0.051	-0.1917	No
65	POLR2F	Polr2f			8397	-0.073	-0.1994	No
66	POLR2G	Polr2g			8474	-0.089	-0.2038	No
67	IMPDH1	Impdh1			8586	-0.109	-0.2104	No
68	POLR2L	Polr2l			8655	-0.121	-0.2141	No
69	GUCY2F	Gucy2f			8849	-0.153	-0.2257	No
70	APRT	Aprt			8920	-0.165	-0.2293	No
71	PDE6A	Pde6a			8987	-0.175	-0.2326	No
72	PDE7A	Pde7a			9008	-0.179	-0.2328	No
73	ADCY10	Adcy10			9077	-0.192	-0.2361	No
74	NUDT2	Nudt2			9172	-0.209	-0.2410	No
75	AK4	Ak4			9261	-0.225	-0.2454	No
76	GUCY1B1	Gucy1b1			9272	-0.227	-0.2447	No
77	POLR2H	Polr2h			9286	-0.230	-0.2442	No
78	DGUOK	Dguok			9371	-0.247	-0.2482	No
79	PDE6D	Pde6d			9550	-0.279	-0.2582	No
80	PDE4A	Pde4a			9657	-0.299	-0.2633	No
81	POLR2I	Polr2i			9862	-0.341	-0.2746	No
82	PDE6H	Pde6h			10017	-0.372	-0.2824	No
83	NT5C2	Nt5c2			10183	-0.406	-0.2907	No
84	PKM	Pkm			10421	-0.430	-0.3036	No
85	POLR3K	Polr3k			10555	-0.447	-0.3096	No
86	PDE1B	Pde1b			10598	-0.456	-0.3097	No
87	GUCY2D	Gucy2e			10730	-0.485	-0.3154	No
88	NUDT5	Nudt5			10739	-0.487	-0.3130	No
89	PDE4B	Pde4b			10923	-0.517	-0.3219	No
90	PRPS1	Prps1			11558	-0.662	-0.3592	No
91	HPRT1	Hprt			11599	-0.673	-0.3578	No
92	POLR2B	Polr2b			11715	-0.703	-0.3612	No
93	NT5C3A	Nt5c3			11736	-0.708	-0.3583	No
94	NME7	Nme7			11837	-0.738	-0.3605	No
95	ZNRD1	Znrd1			11920	-0.760	-0.3614	No
96	ADCY4	Adcy4			12086	-0.808	-0.3673	No
97	POLR1E	Polr1e			12365	-0.888	-0.3802	No
98	POLR1A	Polr1a			12535	-0.950	-0.3856	No
99	PAICS	Paics			12639	-0.985	-0.3865	No
100	GUCY1A1	Gucy1a1			12798	-1.044	-0.3907	Yes
101	ENTPD6	Entpd6			12864	-1.069	-0.3886	Yes
102	POLR2C	Polr2c			12955	-1.103	-0.3880	Yes
103	ADSL	Adsl			12989	-1.117	-0.3836	Yes
104	GART	Gart			13085	-1.156	-0.3829	Yes
105	ENTPD1	Entpd1			13088	-1.158	-0.3763	Yes
106	PFAS	Pfas			13178	-1.195	-0.3750	Yes
107	PDE4D	Pde4d			13195	-1.205	-0.3690	Yes
108	NT5E	Nt5e			13397	-1.305	-0.3744	Yes
109	NT5M	Nt5m			13517	-1.366	-0.3741	Yes
110	PNPT1	Pnpt1			13581	-1.406	-0.3699	Yes
111	GMPS	Gmps			13639	-1.438	-0.3652	Yes
112	ADSS2	Adss			13778	-1.528	-0.3652	Yes
113	IMPDH2	Impdh2			13780	-1.528	-0.3563	Yes
114	POLD1	Pold1			13846	-1.575	-0.3513	Yes
115	POLR1B	Polr1b			13861	-1.583	-0.3429	Yes
116	ADK	Adk			13883	-1.600	-0.3348	Yes
117	GMPR2	Gmpr2			13974	-1.671	-0.3309	Yes
118	GMPR	Gmpr			13981	-1.678	-0.3214	Yes
119	POLE3	Pole3			14109	-1.780	-0.3192	Yes
120	POLR3H	Polr3h			14173	-1.839	-0.3125	Yes
121	POLR2D	Polr2d			14179	-1.845	-0.3020	Yes
122	ITPA	Itpa			14295	-1.974	-0.2979	Yes
123	POLD2	Pold2			14317	-1.999	-0.2875	Yes
124	PDE3B	Pde3b			14373	-2.067	-0.2789	Yes
125	ADSS1	Adssl1			14403	-2.096	-0.2685	Yes
126	POLE2	Pole2			14562	-2.309	-0.2652	Yes
127	PAPSS1	Papss1			14603	-2.365	-0.2539	Yes
128	AK2	Ak2			14719	-2.556	-0.2464	Yes
129	PPAT	Ppat			14726	-2.566	-0.2317	Yes
130	ADCY7	Adcy7			14846	-2.774	-0.2232	Yes
131	DCK	Dck			14956	-3.010	-0.2126	Yes
132	ADCY8	Adcy8			14970	-3.056	-0.1955	Yes
133	PRIM2	Prim2			15041	-3.242	-0.1810	Yes
134	PDE7B	Pde7b			15074	-3.359	-0.1633	Yes
135	RRM1	Rrm1			15152	-3.581	-0.1473	Yes
136	POLE	Pole			15214	-3.772	-0.1291	Yes
137	POLA1	Pola1			15219	-3.784	-0.1071	Yes
138	GDA	Gda			15220	-3.787	-0.0849	Yes
139	ENPP3	Enpp3			15367	-4.299	-0.0691	Yes
140	ENPP1	Enpp1			15399	-4.404	-0.0453	Yes
141	PDE1A	Pde1a			15430	-4.525	-0.0207	Yes
142	RRM2	Rrm2			15435	-4.557	0.0059	Yes

Fig 2: KEGG_PURINE_METABOLISM   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: KEGG_PURINE_METABOLISM: Random ES distribution   
Gene set null distribution of ES for KEGG_PURINE_METABOLISM