Details for gene set KEGG_P53_SIGNALING_PATHWAY[GSEA]

Table: GSEA Results Summary

Dataset	preliminary.phenotype.cls#NGP_versus_LG.phenotype.cls#NGP_versus_LG_repos
Phenotype	phenotype.cls#NGP_versus_LG_repos
Upregulated in class	LG
GeneSet	KEGG_P53_SIGNALING_PATHWAY
Enrichment Score (ES)	-0.5181166
Normalized Enrichment Score (NES)	-1.8115513
Nominal p-value	0.0
FDR q-value	0.009750378
FWER p-Value	0.092

Fig 1: Enrichment plot: KEGG_P53_SIGNALING_PATHWAY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	ADGRB1	Adgrb1			58	3.326	0.0393	No
2	CCNG2	Ccng2			284	2.369	0.0554	No
3	GADD45A	Gadd45a			287	2.360	0.0858	No
4	MDM2	Mdm2			859	1.605	0.0697	No
5	CASP9	Casp9			1138	1.403	0.0699	No
6	STEAP3	Steap3			1557	1.192	0.0583	No
7	BAX	Bax			1579	1.182	0.0722	No
8	DDB2	Ddb2			2034	1.001	0.0558	No
9	SERPINE1	Serpine1			2820	0.790	0.0153	No
10	SFN	Sfn			3543	0.638	-0.0231	No
11	ATM	Atm			3647	0.615	-0.0218	No
12	RCHY1	Rchy1			3681	0.607	-0.0161	No
13	COP1	Cop1			3682	0.607	-0.0082	No
14	MDM4	Mdm4			4500	0.459	-0.0551	No
15	SESN2	Sesn2			4687	0.435	-0.0615	No
16	CDK4	Cdk4			4881	0.408	-0.0687	No
17	TSC2	Tsc2			4901	0.402	-0.0647	No
18	CDKN1A	Cdkn1a			5155	0.378	-0.0762	No
19	EI24	Ei24			5414	0.355	-0.0883	No
20	CCNG1	Ccng1			5648	0.314	-0.0993	No
21	PERP	Perp			5671	0.311	-0.0967	No
22	APAF1	Apaf1			5922	0.272	-0.1093	No
23	ZMAT3	Zmat3			6430	0.188	-0.1397	No
24	CCNB3	Ccnb3			6667	0.148	-0.1531	No
25	FAS	Fas			7110	0.077	-0.1806	No
26	SHISA5	Shisa5			7197	0.064	-0.1854	No
27	RRM2B	Rrm2b			7528	0.015	-0.2065	No
28	CASP3	Casp3			8435	-0.085	-0.2640	No
29	TP73	Trp73			8594	-0.108	-0.2728	No
30	THBS1	Thbs1			8857	-0.147	-0.2879	No
31	GADD45B	Gadd45b			8870	-0.149	-0.2867	No
32	PTEN	Pten			8901	-0.154	-0.2867	No
33	SESN1	Sesn1			9415	-0.229	-0.3169	No
34	PIDD1	Pidd1			9428	-0.230	-0.3147	No
35	ATR	Atr			9758	-0.283	-0.3323	No
36	TP53	Trp53			9922	-0.312	-0.3388	No
37	PPM1D	Ppm1d			10002	-0.323	-0.3397	No
38	SESN3	Sesn3			11008	-0.471	-0.3986	No
39	PMAIP1	Pmaip1			11161	-0.493	-0.4020	No
40	CCND3	Ccnd3			11584	-0.575	-0.4219	No
41	BID	Bid			12362	-0.754	-0.4624	No
42	CYCS	Cycs			13225	-1.002	-0.5051	Yes
43	IGF1	Igf1			13244	-1.013	-0.4932	Yes
44	SIAH1	Siah1a			13316	-1.042	-0.4843	Yes
45	CDK6	Cdk6			13323	-1.045	-0.4711	Yes
46	CDK2	Cdk2			13919	-1.295	-0.4929	Yes
47	CASP8	Casp8			14068	-1.374	-0.4846	Yes
48	SERPINB5	Serpinb5			14192	-1.456	-0.4737	Yes
49	CD82	Cd82			14221	-1.472	-0.4565	Yes
50	CHEK2	Chek2			14458	-1.668	-0.4502	Yes
51	GADD45G	Gadd45g			14592	-1.803	-0.4354	Yes
52	IGFBP3	Igfbp3			14771	-1.987	-0.4212	Yes
53	GTSE1	Gtse1			14830	-2.039	-0.3986	Yes
54	CCND1	Ccnd1			15096	-2.535	-0.3829	Yes
55	RPRM	Rprm			15104	-2.555	-0.3503	Yes
56	CHEK1	Chek1			15361	-3.652	-0.3196	Yes
57	CDK1	Cdk1			15367	-3.695	-0.2721	Yes
58	CCNE1	Ccne1			15394	-3.949	-0.2226	Yes
59	CCNE2	Ccne2			15410	-4.096	-0.1706	Yes
60	CCNB2	Ccnb2			15491	-4.557	-0.1167	Yes
61	CCNB1	Ccnb1			15492	-4.568	-0.0576	Yes
62	RRM2	Rrm2			15500	-4.610	0.0016	Yes

Fig 2: KEGG_P53_SIGNALING_PATHWAY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: KEGG_P53_SIGNALING_PATHWAY: Random ES distribution   
Gene set null distribution of ES for KEGG_P53_SIGNALING_PATHWAY