Details for gene set KEGG_PURINE_METABOLISM[GSEA]

Table: GSEA Results Summary

Dataset	preliminary.phenotype.cls#NGP_versus_LG.phenotype.cls#NGP_versus_LG_repos
Phenotype	phenotype.cls#NGP_versus_LG_repos
Upregulated in class	LG
GeneSet	KEGG_PURINE_METABOLISM
Enrichment Score (ES)	-0.424942
Normalized Enrichment Score (NES)	-1.7113243
Nominal p-value	0.0
FDR q-value	0.026973516
FWER p-Value	0.298

Fig 1: Enrichment plot: KEGG_PURINE_METABOLISM   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	PDE3A	Pde3a			335	2.266	-0.0043	No
2	PDE8A	Pde8a			413	2.143	0.0072	No
3	PDE6B	Pde6b			458	2.079	0.0204	No
4	AMPD3	Ampd3			823	1.637	0.0093	No
5	PDE5A	Pde5a			930	1.540	0.0143	No
6	GUCY1A2	Gucy1a2			1049	1.461	0.0179	No
7	ADCY1	Adcy1			1119	1.417	0.0243	No
8	NPR1	Npr1			1186	1.375	0.0306	No
9	POLR2A	Polr2a			1279	1.322	0.0349	No
10	PDE9A	Pde9a			1439	1.241	0.0341	No
11	ALLC	Allc			1569	1.187	0.0348	No
12	POLR3A	Polr3a			2144	0.970	0.0050	No
13	ADPRM	Adprm			2164	0.962	0.0112	No
14	POLR1C	Polr1c			2676	0.827	-0.0156	No
15	NPR2	Npr2			2682	0.825	-0.0096	No
16	ENTPD3	Entpd3			3060	0.741	-0.0284	No
17	NUDT9	Nudt9			3542	0.638	-0.0548	No
18	ATIC	Atic			3582	0.630	-0.0524	No
19	AK4	Ak4			3711	0.602	-0.0561	No
20	ADCY5	Adcy5			3753	0.589	-0.0542	No
21	PRUNE1	Prune1			3831	0.571	-0.0548	No
22	PRPS1L1	Prps1l1			4216	0.500	-0.0759	No
23	GUCY2C	Gucy2c			4352	0.480	-0.0810	No
24	ENTPD8	Entpd8			4359	0.479	-0.0777	No
25	POLR3F	Polr3f			4510	0.458	-0.0839	No
26	NME5	Nme5			4530	0.454	-0.0817	No
27	PDE4A	Pde4a			4699	0.434	-0.0893	No
28	NT5C	Nt5c			4717	0.430	-0.0870	No
29	DGUOK	Dguok			5078	0.390	-0.1074	No
30	CANT1	Cant1			5083	0.390	-0.1047	No
31	PDE10A	Pde10a			5131	0.382	-0.1048	No
32	ADCY6	Adcy6			5199	0.371	-0.1063	No
33	PDE6G	Pde6g			5266	0.359	-0.1078	No
34	NME4	Nme4			5785	0.293	-0.1392	No
35	AK1	Ak1			5798	0.291	-0.1378	No
36	PKM	Pkm			5973	0.264	-0.1471	No
37	AMPD2	Ampd2			6107	0.241	-0.1538	No
38	PDE11A	Pde11a			6290	0.209	-0.1641	No
39	POLR3C	Polr3c			6439	0.187	-0.1722	No
40	POLR2K	Polr2k			6533	0.170	-0.1770	No
41	POLR3B	Polr3b			6660	0.148	-0.1840	No
42	AK7	Ak7			6689	0.146	-0.1847	No
43	ADA	Ada			6808	0.124	-0.1914	No
44	ADCY2	Adcy2			7198	0.064	-0.2162	No
45	POLR1D	Polr1d			7211	0.062	-0.2165	No
46	PDE1B	Pde1b			7408	0.032	-0.2290	No
47	RRM2B	Rrm2b			7528	0.015	-0.2366	No
48	PKLR	Pklr			7619	0.000	-0.2425	No
49	POLR2E	Polr2e			7885	-0.000	-0.2597	No
50	PRPS2	Prps2			8063	-0.030	-0.2710	No
51	PDE2A	Gm45837			8203	-0.048	-0.2797	No
52	GUCY1A1	Gucy1a1			8261	-0.059	-0.2829	No
53	NUDT5	Nudt5			8390	-0.077	-0.2906	No
54	PDE7A	Pde7a			8460	-0.088	-0.2944	No
55	PAICS	Paics			8586	-0.106	-0.3018	No
56	POLR2B	Polr2b			8603	-0.111	-0.3019	No
57	AMPD1	Ampd1			8630	-0.112	-0.3028	No
58	POLE4	Pole4			8754	-0.132	-0.3097	No
59	POLR3D	Polr3d			8818	-0.144	-0.3127	No
60	GUCY2F	Gucy2f			9036	-0.171	-0.3255	No
61	PRPS1	Prps1			9072	-0.175	-0.3264	No
62	ENTPD5	Entpd5			9114	-0.181	-0.3277	No
63	PDE6D	Pde6d			9462	-0.236	-0.3484	No
64	ADCY10	Adcy10			9477	-0.238	-0.3475	No
65	GUCY1B1	Gucy1b1			9490	-0.241	-0.3464	No
66	NME7	Nme7			9923	-0.312	-0.3721	No
67	PDE6A	Pde6a			10035	-0.328	-0.3768	No
68	POLR2H	Polr2h			10136	-0.349	-0.3806	No
69	ADCY3	Adcy3			10447	-0.403	-0.3977	No
70	GUCY2D	Gucy2e			10641	-0.421	-0.4070	No
71	ENTPD4	Entpd4b			10733	-0.432	-0.4096	No
72	POLR1A	Polr1a			10830	-0.440	-0.4124	No
73	ENTPD2	Entpd2			10852	-0.443	-0.4103	No
74	POLR2G	Polr2g			10854	-0.443	-0.4070	No
75	NUDT2	Nudt2			10960	-0.463	-0.4102	No
76	ZNRD1	Znrd1			11035	-0.476	-0.4114	No
77	POLR2I	Polr2i			11145	-0.489	-0.4147	No
78	ADCY9	Adcy9			11200	-0.498	-0.4144	No
79	NT5C2	Nt5c2			11291	-0.515	-0.4163	No
80	NT5C3A	Nt5c3			11318	-0.519	-0.4139	No
81	APRT	Aprt			11453	-0.546	-0.4184	No
82	ADCY4	Adcy4			11554	-0.569	-0.4206	Yes
83	POLR3K	Polr3k			11577	-0.573	-0.4176	Yes
84	POLR1E	Polr1e			11668	-0.593	-0.4189	Yes
85	POLR2F	Polr2f			11750	-0.606	-0.4194	Yes
86	NME1	Nme1			11779	-0.614	-0.4165	Yes
87	POLR2C	Polr2c			11845	-0.629	-0.4159	Yes
88	IMPDH1	Impdh1			11858	-0.632	-0.4118	Yes
89	PNP	Pnp			11964	-0.658	-0.4136	Yes
90	PDE6H	Pde6h			11966	-0.658	-0.4086	Yes
91	AK5	Ak5			12046	-0.677	-0.4085	Yes
92	PDE7B	Pde7b			12049	-0.678	-0.4034	Yes
93	NME6	Nme6			12074	-0.684	-0.3997	Yes
94	ADCY8	Adcy8			12101	-0.691	-0.3960	Yes
95	FHIT	Fhit			12121	-0.698	-0.3919	Yes
96	IMPDH2	Impdh2			12196	-0.712	-0.3912	Yes
97	POLR2L	Polr2l			12313	-0.742	-0.3930	Yes
98	PAPSS2	Papss2			12374	-0.756	-0.3911	Yes
99	NME2	Nme2			12378	-0.757	-0.3855	Yes
100	ENTPD6	Entpd6			12567	-0.804	-0.3915	Yes
101	PFAS	Pfas			12802	-0.861	-0.4001	Yes
102	GUK1	Guk1			12886	-0.885	-0.3986	Yes
103	PDE3B	Pde3b			13101	-0.955	-0.4052	Yes
104	HPRT1	Hprt			13196	-0.988	-0.4037	Yes
105	NT5M	Nt5m			13236	-1.007	-0.3985	Yes
106	ADSS2	Adss			13280	-1.029	-0.3933	Yes
107	GMPR2	Gmpr2			13287	-1.031	-0.3858	Yes
108	PDE1C	Pde1c			13335	-1.053	-0.3807	Yes
109	XDH	Xdh			13354	-1.058	-0.3737	Yes
110	GART	Gart			13450	-1.091	-0.3715	Yes
111	POLR2D	Polr2d			13573	-1.136	-0.3707	Yes
112	ADSL	Adsl			13574	-1.137	-0.3619	Yes
113	GMPS	Gmps			13642	-1.161	-0.3573	Yes
114	ENTPD1	Entpd1			13706	-1.190	-0.3522	Yes
115	POLR1B	Polr1b			13708	-1.191	-0.3431	Yes
116	ADK	Adk			13719	-1.200	-0.3345	Yes
117	PNPT1	Pnpt1			13876	-1.270	-0.3349	Yes
118	ADSS1	Adssl1			13980	-1.325	-0.3314	Yes
119	PDE4D	Pde4d			14071	-1.378	-0.3266	Yes
120	GMPR	Gmpr			14157	-1.433	-0.3211	Yes
121	POLD1	Pold1			14287	-1.514	-0.3178	Yes
122	GDA	Gda			14343	-1.556	-0.3094	Yes
123	POLR3H	Polr3h			14483	-1.689	-0.3054	Yes
124	POLE3	Pole3			14552	-1.771	-0.2961	Yes
125	ENPP1	Enpp1			14600	-1.813	-0.2852	Yes
126	PAPSS1	Papss1			14623	-1.838	-0.2725	Yes
127	PDE1A	Pde1a			14637	-1.847	-0.2591	Yes
128	ADCY7	Adcy7			14656	-1.864	-0.2459	Yes
129	ITPA	Itpa			14791	-2.005	-0.2391	Yes
130	POLD2	Pold2			14805	-2.019	-0.2244	Yes
131	AK2	Ak2			14878	-2.105	-0.2129	Yes
132	POLE2	Pole2			14892	-2.125	-0.1973	Yes
133	NT5E	Nt5e			14899	-2.139	-0.1813	Yes
134	PPAT	Ppat			14915	-2.162	-0.1656	Yes
135	PDE4B	Pde4b			14963	-2.263	-0.1512	Yes
136	PRIM2	Prim2			15147	-2.715	-0.1421	Yes
137	DCK	Dck			15218	-2.933	-0.1241	Yes
138	RRM1	Rrm1			15294	-3.282	-0.1037	Yes
139	POLA1	Pola1			15332	-3.491	-0.0792	Yes
140	POLE	Pole			15345	-3.558	-0.0525	Yes
141	ENPP3	Enpp3			15369	-3.703	-0.0255	Yes
142	RRM2	Rrm2			15500	-4.610	0.0016	Yes

Fig 2: KEGG_PURINE_METABOLISM   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: KEGG_PURINE_METABOLISM: Random ES distribution   
Gene set null distribution of ES for KEGG_PURINE_METABOLISM