Details for gene set KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION[GSEA]

Table: GSEA Results Summary

Dataset	preliminary.phenotype.cls#NGP_versus_NG.phenotype.cls#NGP_versus_NG_repos
Phenotype	phenotype.cls#NGP_versus_NG_repos
Upregulated in class	NGP
GeneSet	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION
Enrichment Score (ES)	0.3627522
Normalized Enrichment Score (NES)	1.5343941
Nominal p-value	0.0
FDR q-value	0.3589833
FWER p-Value	0.847

Fig 1: Enrichment plot: KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	HTR1F	Htr1f			16	2.890	0.0252	Yes
2	OPRL1	Oprl1			19	2.825	0.0507	Yes
3	PRL	Prl			100	1.955	0.0632	Yes
4	GPR50	Gpr50			174	1.724	0.0740	Yes
5	P2RX7	P2rx7			198	1.627	0.0873	Yes
6	CHRNA10	Chrna10			204	1.613	0.1016	Yes
7	S1PR4	S1pr4			337	1.348	0.1052	Yes
8	DRD4	Drd4			359	1.314	0.1158	Yes
9	P2RY10	P2ry10			410	1.242	0.1238	Yes
10	CHRND	Chrnd			430	1.228	0.1337	Yes
11	GRID1	Grid1			431	1.226	0.1448	Yes
12	CHRNB2	Chrnb2			454	1.188	0.1541	Yes
13	HTR6	Htr6			460	1.185	0.1646	Yes
14	GABRB2	Gabrb2			462	1.183	0.1752	Yes
15	VIPR2	Vipr2			548	1.088	0.1795	Yes
16	CHRNA5	Chrna5			552	1.081	0.1891	Yes
17	F2RL3	F2rl3			587	1.052	0.1965	Yes
18	RXFP2	Rxfp2			619	1.029	0.2038	Yes
19	GNRHR	Gnrhr			651	1.008	0.2109	Yes
20	FPR1	Fpr1			721	0.961	0.2151	Yes
21	PTGER2	Ptger2			800	0.912	0.2183	Yes
22	SSTR5	Sstr5			811	0.907	0.2259	Yes
23	GRIN2B	Grin2b			828	0.898	0.2330	Yes
24	CHRNB4	Chrnb4			909	0.866	0.2356	Yes
25	GABRA6	Gabra6			930	0.859	0.2421	Yes
26	GRIK3	Grik3			933	0.859	0.2497	Yes
27	GABRQ	Gabrq			976	0.839	0.2546	Yes
28	GALR3	Galr3			978	0.839	0.2622	Yes
29	ADRA2B	Adra2b			1005	0.825	0.2679	Yes
30	NPFFR1	Npffr1			1022	0.820	0.2743	Yes
31	GPR156	Gpr156			1032	0.820	0.2812	Yes
32	GRM2	Grm2			1034	0.819	0.2885	Yes
33	FPR2	Fpr2			1087	0.802	0.2924	Yes
34	ADORA1	Adora1			1090	0.801	0.2996	Yes
35	S1PR5	S1pr5			1141	0.784	0.3034	Yes
36	P2RX1	P2rx1			1189	0.770	0.3073	Yes
37	GCGR	Gcgr			1229	0.751	0.3116	Yes
38	GPR83	Gpr83			1263	0.741	0.3162	Yes
39	OXTR	Oxtr			1472	0.683	0.3088	Yes
40	LPAR4	Lpar4			1483	0.680	0.3143	Yes
41	GRM5	Grm5			1553	0.661	0.3158	Yes
42	GRIN3A	Grin3a			1563	0.658	0.3212	Yes
43	TRPV1	Trpv1			1623	0.641	0.3231	Yes
44	GRIN3B	Grin3b			1701	0.620	0.3237	Yes
45	APLNR	Aplnr			1819	0.582	0.3213	Yes
46	ADCYAP1R1	Adcyap1r1			1991	0.539	0.3151	Yes
47	PRLR	Prlr			2014	0.536	0.3185	Yes
48	HRH1	Hrh1			2025	0.533	0.3227	Yes
49	LEPR	Lepr			2041	0.531	0.3265	Yes
50	C3AR1	C3ar1			2066	0.525	0.3297	Yes
51	NTSR1	Ntsr1			2117	0.517	0.3311	Yes
52	LPAR2	Lpar2			2327	0.486	0.3219	Yes
53	MTNR1A	Mtnr1a			2367	0.478	0.3237	Yes
54	F2	F2			2369	0.478	0.3280	Yes
55	PRLHR	Prlhr			2380	0.478	0.3317	Yes
56	CHRNB3	Chrnb3			2430	0.473	0.3327	Yes
57	CNR1	Cnr1			2455	0.470	0.3354	Yes
58	HTR2B	Htr2b			2490	0.463	0.3374	Yes
59	PTH1R	Pth1r			2515	0.459	0.3400	Yes
60	AGTR1	Agtr1a			2633	0.440	0.3364	Yes
61	MC1R	Mc1r			2637	0.440	0.3402	Yes
62	GRM8	Grm8			2638	0.440	0.3442	Yes
63	ADRA1A	Adra1a			2644	0.440	0.3478	Yes
64	GLP2R	Glp2r			2671	0.440	0.3501	Yes
65	TACR1	Tacr1			2674	0.440	0.3540	Yes
66	ADORA2A	Adora2a			2688	0.440	0.3571	Yes
67	CHRNA3	Chrna3			2781	0.428	0.3550	Yes
68	GRIK4	Grik4			2837	0.424	0.3553	Yes
69	ADRA2C	Adra2c			2902	0.415	0.3548	Yes
70	CHRNE	Chrne			2912	0.414	0.3580	Yes
71	GABRD	Gabrd			3004	0.401	0.3557	Yes
72	GALR1	Galr1			3034	0.401	0.3574	Yes
73	OPRK1	Oprk1			3061	0.401	0.3594	Yes
74	F2RL2	F2rl2			3066	0.401	0.3628	Yes
75	MC4R	Mc4r			3381	0.356	0.3455	No
76	MC3R	Mc3r			3382	0.356	0.3487	No
77	AVPR1B	Avpr1b			3396	0.356	0.3511	No
78	NPY2R	Npy2r			3487	0.356	0.3484	No
79	GHRHR	Ghrhr			3515	0.356	0.3499	No
80	GABRA1	Gabra1			3541	0.353	0.3515	No
81	GABRR2	Gabrr2			3652	0.339	0.3474	No
82	ADRA2A	Adra2a			3688	0.334	0.3481	No
83	NMUR1	Nmur1			3700	0.332	0.3504	No
84	GABRE	Gabre			3763	0.324	0.3493	No
85	GABBR2	Gabbr2			3918	0.303	0.3420	No
86	GIPR	Gipr			3953	0.300	0.3425	No
87	HRH3	Hrh3			3972	0.297	0.3440	No
88	KISS1R	Kiss1r			4051	0.287	0.3415	No
89	TSHR	Tshr			4075	0.284	0.3426	No
90	GRIN2D	Grin2d			4098	0.282	0.3437	No
91	P2RX2	P2rx2			4195	0.271	0.3399	No
92	LTB4R2	Ltb4r2			4269	0.263	0.3375	No
93	GLRA1	Glra1			4314	0.257	0.3370	No
94	GRIA3	Gria3			4381	0.251	0.3349	No
95	THRB	Thrb			4495	0.237	0.3297	No
96	GRPR	Grpr			4594	0.228	0.3254	No
97	P2RY1	P2ry1			4611	0.226	0.3264	No
98	EDNRA	Ednra			4774	0.210	0.3177	No
99	TRHR	Trhr			5126	0.179	0.2964	No
100	HCRTR1	Hcrtr1			5153	0.177	0.2963	No
101	GABRA3	Gabra3			5435	0.153	0.2793	No
102	OPRD1	Oprd1			5672	0.132	0.2651	No
103	CHRM1	Chrm1			5755	0.125	0.2609	No
104	PLG	Plg			5776	0.123	0.2607	No
105	VIPR1	Vipr1			5831	0.119	0.2583	No
106	GLP1R	Glp1r			6034	0.105	0.2460	No
107	HTR7	Htr7			6183	0.091	0.2372	No
108	CHRM3	Chrm3			6292	0.084	0.2309	No
109	GRIN2A	Grin2a			6303	0.084	0.2310	No
110	SSTR3	Sstr3			6377	0.079	0.2270	No
111	AVPR2	Avpr2			6395	0.078	0.2266	No
112	CNR2	Cnr2			6536	0.068	0.2180	No
113	PARD3	Pard3			6561	0.066	0.2171	No
114	PTGIR	Ptgir			6807	0.048	0.2015	No
115	HTR1B	Htr1b			7140	0.024	0.1800	No
116	EDNRB	Ednrb			7141	0.024	0.1802	No
117	PTGER4	Ptger4			7147	0.023	0.1801	No
118	GALR2	Galr2			7283	0.013	0.1714	No
119	HTR5A	Htr5a			7459	0.000	0.1600	No
120	GRM1	Grm1			7468	0.000	0.1595	No
121	GRM3	Grm3			7469	0.000	0.1595	No
122	GRM6	Grm6			7470	0.000	0.1595	No
123	MCHR1	Mchr1			7543	0.000	0.1548	No
124	GABRG2	Gabrg2			7609	0.000	0.1505	No
125	GABRG1	Gabrg1			7610	0.000	0.1505	No
126	CHRNA9	Chrna9			7622	0.000	0.1498	No
127	CTSG	Ctsg			7631	0.000	0.1493	No
128	CCKBR	Cckbr			7648	0.000	0.1482	No
129	C5AR1	C5ar1			7651	0.000	0.1481	No
130	P2RY4	P2ry4			7725	0.000	0.1433	No
131	CALCR	Calcr			7746	0.000	0.1420	No
132	GHSR	Ghsr			7756	0.000	0.1414	No
133	HCRTR2	Hcrtr2			7764	0.000	0.1410	No
134	P2RY13	P2ry13			7782	0.000	0.1399	No
135	GRIK5	Grik5			7882	-0.002	0.1334	No
136	CHRNA2	Chrna2			7892	-0.003	0.1329	No
137	GRM4	Grm4			7931	-0.005	0.1304	No
138	BDKRB2	Bdkrb2			8193	-0.024	0.1136	No
139	GRIA2	Gria2			8328	-0.034	0.1051	No
140	DRD1	Drd1			8497	-0.044	0.0946	No
141	GPR35	Gpr35			8583	-0.050	0.0895	No
142	ADORA2B	Adora2b			8584	-0.050	0.0899	No
143	PTAFR	Ptafr			8596	-0.051	0.0897	No
144	GRIN2C	Grin2c			8617	-0.052	0.0888	No
145	TSHB	Tshb			8629	-0.053	0.0886	No
146	SSTR4	Sstr4			8753	-0.062	0.0811	No
147	CHRNA4	Chrna4			8772	-0.063	0.0805	No
148	P2RX4	P2rx4			8863	-0.069	0.0753	No
149	GABRA4	Gabra4			9105	-0.087	0.0603	No
150	LPAR3	Lpar3			9276	-0.098	0.0501	No
151	MAS1	Mas1			9376	-0.105	0.0446	No
152	SSTR1	Sstr1			9433	-0.110	0.0419	No
153	HRH4	Hrh4			9588	-0.122	0.0330	No
154	BDKRB1	Bdkrb1			9865	-0.145	0.0163	No
155	GRIA1	Gria1			10005	-0.154	0.0086	No
156	S1PR2	S1pr2			10078	-0.159	0.0053	No
157	GABRB3	Gabrb3			10267	-0.174	-0.0054	No
158	CHRM5	Chrm5			10841	-0.218	-0.0408	No
159	LPAR1	Lpar1			11074	-0.240	-0.0538	No
160	LPAR6	Lpar6			11378	-0.270	-0.0711	No
161	GABRR1	Gabrr1			11417	-0.273	-0.0711	No
162	TBXA2R	Tbxa2r			11426	-0.274	-0.0692	No
163	NPY5R	Npy5r			11597	-0.290	-0.0777	No
164	AGTR2	Agtr2			11603	-0.291	-0.0753	No
165	F2R	F2r			11677	-0.299	-0.0774	No
166	HTR4	Htr4			11702	-0.301	-0.0762	No
167	PTGFR	Ptgfr			11709	-0.302	-0.0739	No
168	CHRNA1	Chrna1			11738	-0.305	-0.0730	No
169	NMBR	Nmbr			11775	-0.308	-0.0725	No
170	SCTR	Sctr			11852	-0.318	-0.0746	No
171	CCKAR	Cckar			12028	-0.339	-0.0829	No
172	HTR2A	Htr2a			12327	-0.370	-0.0991	No
173	P2RX3	P2rx3			12424	-0.382	-0.1019	No
174	CHRM4	Chrm4			12488	-0.389	-0.1024	No
175	GABBR1	Gabbr1			12524	-0.394	-0.1012	No
176	S1PR1	S1pr1			12551	-0.397	-0.0993	No
177	GRIA4	Gria4			12601	-0.402	-0.0988	No
178	CHRNB1	Chrnb1			12717	-0.418	-0.1025	No
179	RXFP1	Rxfp1			12726	-0.420	-0.0992	No
180	AVPR1A	Avpr1a			12863	-0.438	-0.1042	No
181	SSTR2	Sstr2			12910	-0.438	-0.1032	No
182	GLRA3	Glra3			12950	-0.443	-0.1017	No
183	PTH2R	Pth2r			12986	-0.446	-0.1000	No
184	NTSR2	Ntsr2			13379	-0.501	-0.1210	No
185	NPY1R	Npy1r			13430	-0.507	-0.1197	No
186	TACR2	Tacr2			13539	-0.525	-0.1220	No
187	NR3C1	Nr3c1			13565	-0.527	-0.1188	No
188	ADRB1	Adrb1			13566	-0.528	-0.1140	No
189	GLRB	Glrb			13621	-0.536	-0.1127	No
190	GHR	Ghr			13688	-0.550	-0.1120	No
191	PTGER1	Ptger1			13825	-0.578	-0.1157	No
192	GRM7	Grm7			14096	-0.636	-0.1275	No
193	THRA	Thra			14170	-0.654	-0.1264	No
194	TACR3	Tacr3			14338	-0.704	-0.1309	No
195	ADRA1D	Adra1d			14341	-0.705	-0.1246	No
196	P2RY6	P2ry6			14431	-0.737	-0.1238	No
197	TSPO	Tspo			14451	-0.745	-0.1182	No
198	ADRB2	Adrb2			14481	-0.754	-0.1133	No
199	S1PR3	S1pr3			14482	-0.755	-0.1064	No
200	GRID2	Grid2			14557	-0.780	-0.1042	No
201	MC5R	Mc5r			14715	-0.853	-0.1067	No
202	P2RX6	P2rx6			14748	-0.865	-0.1010	No
203	PTGER3	Ptger3			14852	-0.919	-0.0994	No
204	HRH2	Hrh2			14939	-0.969	-0.0962	No
205	P2RY2	P2ry2			14979	-0.994	-0.0897	No
206	GRIN1	Grin1			14989	-0.997	-0.0813	No
207	CALCRL	Calcrl			14996	-1.002	-0.0726	No
208	CYSLTR1	Cysltr1			15059	-1.058	-0.0670	No
209	CHRNG	Chrng			15182	-1.191	-0.0642	No
210	GRIK1	Grik1			15203	-1.217	-0.0544	No
211	ADRA1B	Adra1b			15210	-1.225	-0.0437	No
212	GABRB1	Gabrb1			15227	-1.245	-0.0335	No
213	GRIK2	Grik2			15282	-1.346	-0.0248	No
214	GABRA2	Gabra2			15292	-1.364	-0.0130	No
215	P2RY14	P2ry14			15374	-1.538	-0.0043	No
216	F2RL1	F2rl1			15379	-1.559	0.0095	No

Fig 2: KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION: Random ES distribution   
Gene set null distribution of ES for KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION