Details for gene set KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Phenotype	Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Upregulated in class	FSHD2
GeneSet	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION
Enrichment Score (ES)	0.31094286
Normalized Enrichment Score (NES)	1.5568869
Nominal p-value	0.0
FDR q-value	0.22079466
FWER p-Value	1.0

Fig 1: Enrichment plot: KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	P2RX7	ENSG00000089041.17			265	1.162	0.0054	Yes
2	PRSS3	ENSG00000010438.16			372	1.078	0.0138	Yes
3	GRM5	ENSG00000168959.14			374	1.077	0.0248	Yes
4	GRIK4	ENSG00000149403.12			451	1.036	0.0335	Yes
5	CHRM4	ENSG00000180720.7			496	1.017	0.0428	Yes
6	GABRE	ENSG00000102287.19			522	1.007	0.0524	Yes
7	GABBR1	ENSG00000204681.11			700	0.941	0.0577	Yes
8	MCHR1	ENSG00000128285.4			786	0.916	0.0650	Yes
9	GRID1	ENSG00000182771.19			795	0.913	0.0741	Yes
10	LTB4R	ENSG00000213903.9			876	0.890	0.0812	Yes
11	GABRR2	ENSG00000111886.11			1016	0.855	0.0866	Yes
12	GLRA3	ENSG00000145451.13			1026	0.853	0.0950	Yes
13	HRH3	ENSG00000101180.16			1043	0.850	0.1033	Yes
14	EDNRB	ENSG00000136160.17			1086	0.840	0.1109	Yes
15	CHRM3	ENSG00000133019.11			1132	0.830	0.1183	Yes
16	GRM4	ENSG00000124493.13			1190	0.820	0.1252	Yes
17	GALR1	ENSG00000166573.5			1221	0.813	0.1328	Yes
18	GRIN3A	ENSG00000198785.6			1228	0.811	0.1409	Yes
19	EDNRA	ENSG00000151617.17			1243	0.810	0.1488	Yes
20	GALR3	ENSG00000128310.3			1427	0.784	0.1524	Yes
21	DRD2	ENSG00000149295.14			1652	0.753	0.1546	Yes
22	LPAR1	ENSG00000198121.13			1657	0.752	0.1622	Yes
23	S1PR1	ENSG00000170989.9			1724	0.744	0.1681	Yes
24	GABRA5	ENSG00000186297.12			1739	0.740	0.1754	Yes
25	DRD1	ENSG00000184845.4			2029	0.701	0.1754	Yes
26	TACR1	ENSG00000115353.11			2141	0.689	0.1798	Yes
27	GRIN1	ENSG00000176884.15			2182	0.686	0.1858	Yes
28	GRM6	ENSG00000113262.16			2295	0.673	0.1899	Yes
29	HRH4	ENSG00000134489.7			2336	0.669	0.1958	Yes
30	CHRM1	ENSG00000168539.4			2370	0.665	0.2017	Yes
31	RXFP1	ENSG00000171509.16			2374	0.665	0.2084	Yes
32	PTH1R	ENSG00000160801.14			2572	0.646	0.2102	Yes
33	ADCYAP1R1	ENSG00000078549.14			2720	0.631	0.2131	Yes
34	P2RX3	ENSG00000109991.9			2740	0.629	0.2190	Yes
35	GABRB2	ENSG00000145864.12			2852	0.618	0.2226	Yes
36	PTGER4	ENSG00000171522.6			2872	0.616	0.2284	Yes
37	GRIN2C	ENSG00000161509.14			3016	0.605	0.2311	Yes
38	P2RY1	ENSG00000169860.7			3067	0.601	0.2360	Yes
39	GRIN2D	ENSG00000105464.3			3138	0.596	0.2404	Yes
40	LTB4R2	ENSG00000213906.10			3197	0.591	0.2450	Yes
41	CNR2	ENSG00000188822.8			3218	0.590	0.2505	Yes
42	ADORA2A	ENSG00000128271.22			3375	0.578	0.2526	Yes
43	GLP1R	ENSG00000112164.6			3548	0.564	0.2542	Yes
44	CHRM2	ENSG00000181072.11			3635	0.563	0.2578	Yes
45	CCKBR	ENSG00000110148.10			3724	0.555	0.2613	Yes
46	PLG	ENSG00000122194.18			3746	0.554	0.2665	Yes
47	GABRA1	ENSG00000022355.18			3780	0.551	0.2713	Yes
48	BRS3	ENSG00000102239.5			3905	0.545	0.2738	Yes
49	GLRA2	ENSG00000101958.14			4150	0.534	0.2733	Yes
50	LHCGR	ENSG00000138039.15			4207	0.530	0.2773	Yes
51	CHRNA7	ENSG00000175344.18			4215	0.529	0.2826	Yes
52	HTR5A	ENSG00000157219.5			4461	0.518	0.2819	Yes
53	GABRB3	ENSG00000166206.15			4603	0.513	0.2837	Yes
54	GRM2	ENSG00000164082.15			4737	0.508	0.2856	Yes
55	VIPR1	ENSG00000114812.13			4835	0.501	0.2883	Yes
56	ADRA2A	ENSG00000150594.7			4855	0.501	0.2930	Yes
57	GRIK5	ENSG00000105737.9			5006	0.491	0.2943	Yes
58	GRM7	ENSG00000196277.16			5442	0.463	0.2884	Yes
59	GLP2R	ENSG00000065325.13			5444	0.462	0.2931	Yes
60	ADORA3	ENSG00000282608.1			5574	0.455	0.2946	Yes
61	F2RL2	ENSG00000164220.7			5734	0.446	0.2953	Yes
62	HCRTR1	ENSG00000121764.11			5792	0.444	0.2984	Yes
63	TRPV1	ENSG00000196689.12			5833	0.442	0.3019	Yes
64	GHRHR	ENSG00000106128.19			5891	0.439	0.3050	Yes
65	F2RL1	ENSG00000164251.5			6217	0.422	0.3014	Yes
66	GRIN2B	ENSG00000273079.5			6565	0.405	0.2970	Yes
67	GABRA6	ENSG00000145863.11			6837	0.394	0.2944	Yes
68	NPY1R	ENSG00000164128.7			6929	0.393	0.2962	Yes
69	PTGER2	ENSG00000125384.7			6983	0.390	0.2989	Yes
70	CHRM5	ENSG00000184984.9			6992	0.390	0.3027	Yes
71	TRHR	ENSG00000174417.2			7297	0.376	0.2991	Yes
72	GABRG2	ENSG00000113327.16			7403	0.372	0.3003	Yes
73	CHRNA10	ENSG00000129749.3			7511	0.370	0.3015	Yes
74	GABRR1	ENSG00000146276.11			7680	0.364	0.3011	Yes
75	GPR35	ENSG00000178623.12			8056	0.359	0.2956	Yes
76	P2RY2	ENSG00000175591.11			8099	0.358	0.2982	Yes
77	VIPR2	ENSG00000106018.14			8210	0.353	0.2991	Yes
78	PTH2R	ENSG00000144407.9			8371	0.352	0.2988	Yes
79	GHR	ENSG00000112964.14			8521	0.350	0.2988	Yes
80	P2RY13	ENSG00000181631.7			8620	0.348	0.2999	Yes
81	TSHB	ENSG00000134200.3			8624	0.348	0.3034	Yes
82	CALCR	ENSG00000004948.15			8664	0.348	0.3060	Yes
83	CCKAR	ENSG00000163394.6			8778	0.345	0.3068	Yes
84	CHRNB2	ENSG00000160716.6			8851	0.342	0.3085	Yes
85	ADORA1	ENSG00000163485.17			8893	0.340	0.3109	Yes
86	PRSS2	ENSG00000275896.5			9771	0.319	0.2928	No
87	HTR1B	ENSG00000135312.6			9893	0.316	0.2930	No
88	TACR3	ENSG00000169836.5			9919	0.315	0.2956	No
89	F2R	ENSG00000181104.7			10089	0.309	0.2947	No
90	NPFFR2	ENSG00000056291.17			10245	0.305	0.2940	No
91	TAAR6	ENSG00000146383.7			10382	0.305	0.2938	No
92	OPRM1	ENSG00000112038.18			10578	0.305	0.2921	No
93	HRH2	ENSG00000113749.7			10712	0.302	0.2920	No
94	NMBR	ENSG00000135577.4			10811	0.298	0.2926	No
95	MC1R	ENSG00000258839.3			10863	0.297	0.2944	No
96	GABRA3	ENSG00000011677.13			10870	0.296	0.2973	No
97	P2RX1	ENSG00000108405.4			10911	0.294	0.2993	No
98	PRL	ENSG00000172179.12			11008	0.290	0.2999	No
99	GRIK3	ENSG00000163873.10			11137	0.286	0.2997	No
100	GIPR	ENSG00000010310.9			11655	0.284	0.2900	No
101	C5AR1	ENSG00000197405.8			11756	0.280	0.2904	No
102	MC5R	ENSG00000176136.6			11838	0.277	0.2912	No
103	LPAR6	ENSG00000139679.15			12262	0.262	0.2835	No
104	GHSR	ENSG00000121853.4			12383	0.258	0.2832	No
105	NPBWR1	ENSG00000183729.3			12397	0.257	0.2856	No
106	P2RY11	ENSG00000244165.2			12440	0.256	0.2871	No
107	GABRD	ENSG00000187730.9			12675	0.249	0.2840	No
108	GPR50	ENSG00000102195.10			12703	0.248	0.2858	No
109	APLNR	ENSG00000134817.10			12714	0.247	0.2881	No
110	F2	ENSG00000180210.14			12841	0.243	0.2875	No
111	P2RX4	ENSG00000135124.14			13164	0.233	0.2820	No
112	CHRNA6	ENSG00000147434.8			13522	0.221	0.2755	No
113	PTGDR	ENSG00000168229.4			13554	0.221	0.2770	No
114	ADRB2	ENSG00000169252.5			13629	0.218	0.2775	No
115	KISS1R	ENSG00000116014.10			13685	0.216	0.2783	No
116	CNR1	ENSG00000118432.12			13795	0.213	0.2778	No
117	NPY4R	ENSG00000204174.8			13796	0.213	0.2800	No
118	GRIA1	ENSG00000155511.18			13800	0.213	0.2821	No
119	S1PR2	ENSG00000267534.4			13832	0.212	0.2835	No
120	GABRG1	ENSG00000163285.8			13875	0.210	0.2846	No
121	NTSR1	ENSG00000101188.5			13961	0.207	0.2847	No
122	PTGER3	ENSG00000050628.20			14098	0.203	0.2834	No
123	PRSS1	ENSG00000204983.14			14179	0.200	0.2835	No
124	HTR4	ENSG00000164270.17			14226	0.199	0.2844	No
125	GRM3	ENSG00000198822.10			14489	0.191	0.2799	No
126	P2RY6	ENSG00000171631.14			14567	0.188	0.2800	No
127	AVPR1B	ENSG00000198049.7			14592	0.187	0.2813	No
128	MCHR2	ENSG00000152034.10			14600	0.187	0.2830	No
129	OPRK1	ENSG00000082556.12			14604	0.187	0.2849	No
130	ADRA1A	ENSG00000120907.18			14898	0.177	0.2795	No
131	GRIA2	ENSG00000120251.20			14914	0.176	0.2810	No
132	S1PR3	ENSG00000213694.5			15224	0.167	0.2751	No
133	THRA	ENSG00000126351.12			15269	0.166	0.2757	No
134	HTR1D	ENSG00000179546.4			15284	0.165	0.2771	No
135	GRIA3	ENSG00000125675.18			15568	0.157	0.2718	No
136	FPR2	ENSG00000171049.9			15612	0.156	0.2723	No
137	CRHR2	ENSG00000106113.19			16030	0.144	0.2636	No
138	SSTR1	ENSG00000139874.6			16048	0.144	0.2646	No
139	GRM8	ENSG00000179603.17			16235	0.139	0.2615	No
140	LPAR2	ENSG00000064547.14			16718	0.125	0.2510	No
141	GRIK1	ENSG00000171189.17			17092	0.115	0.2431	No
142	PTGER1	ENSG00000160951.4			17244	0.111	0.2405	No
143	SSTR3	ENSG00000278195.2			17503	0.104	0.2352	No
144	DRD4	ENSG00000069696.7			17787	0.097	0.2293	No
145	PTGFR	ENSG00000122420.10			18031	0.090	0.2243	No
146	OPRL1	ENSG00000125510.17			18265	0.085	0.2195	No
147	BDKRB2	ENSG00000168398.6			19500	0.051	0.1898	No
148	P2RX6	ENSG00000099957.16			19616	0.048	0.1875	No
149	HTR6	ENSG00000158748.4			19796	0.043	0.1836	No
150	P2RX2	ENSG00000187848.15			19991	0.039	0.1792	No
151	HTR7	ENSG00000148680.16			20138	0.036	0.1760	No
152	SSTR2	ENSG00000180616.9			20360	0.029	0.1709	No
153	CHRNA5	ENSG00000169684.13			20402	0.028	0.1702	No
154	HTR2C	ENSG00000147246.10			20403	0.028	0.1705	No
155	CHRNB1	ENSG00000170175.11			20569	0.023	0.1667	No
156	HTR1F	ENSG00000179097.5			20615	0.022	0.1658	No
157	PTAFR	ENSG00000169403.12			20842	0.016	0.1605	No
158	P2RX5	ENSG00000083454.22			21195	0.007	0.1519	No
159	OPRD1	ENSG00000116329.11			21215	0.006	0.1515	No
160	F2RL3	ENSG00000127533.4			21269	0.005	0.1503	No
161	ADRA1B	ENSG00000170214.5			21501	-0.001	0.1447	No
162	CALCRL	ENSG00000064989.13			21590	-0.004	0.1425	No
163	P2RY4	ENSG00000186912.6			22362	-0.022	0.1239	No
164	P2RY14	ENSG00000174944.9			22378	-0.023	0.1238	No
165	MLNR	ENSG00000102539.5			22447	-0.025	0.1224	No
166	AVPR2	ENSG00000126895.15			22484	-0.026	0.1218	No
167	CHRND	ENSG00000135902.10			22684	-0.030	0.1172	No
168	CHRNA3	ENSG00000080644.16			23023	-0.040	0.1094	No
169	GLRB	ENSG00000109738.11			23315	-0.047	0.1027	No
170	LPAR4	ENSG00000147145.12			23512	-0.052	0.0985	No
171	ADRB1	ENSG00000043591.6			23550	-0.054	0.0981	No
172	GRID2	ENSG00000152208.13			23651	-0.057	0.0963	No
173	CHRNG	ENSG00000196811.13			23760	-0.059	0.0942	No
174	LPAR3	ENSG00000171517.6			24108	-0.067	0.0864	No
175	FPR3	ENSG00000187474.5			24763	-0.084	0.0713	No
176	TSPO	ENSG00000100300.18			24994	-0.091	0.0666	No
177	GRIK2	ENSG00000164418.20			25508	-0.105	0.0552	No
178	TACR2	ENSG00000075073.15			25513	-0.106	0.0561	No
179	GPR83	ENSG00000123901.9			25578	-0.107	0.0557	No
180	AVPR1A	ENSG00000166148.3			25596	-0.108	0.0564	No
181	UTS2R	ENSG00000181408.3			29139	-0.216	-0.0280	No
182	SCTR	ENSG00000080293.9			29298	-0.221	-0.0296	No
183	GNRHR	ENSG00000109163.6			29617	-0.231	-0.0350	No
184	CYSLTR1	ENSG00000173198.6			29657	-0.233	-0.0336	No
185	HTR2A	ENSG00000102468.10			29695	-0.234	-0.0321	No
186	NPY2R	ENSG00000185149.6			29775	-0.237	-0.0316	No
187	GALR2	ENSG00000182687.4			29884	-0.241	-0.0318	No
188	SSTR5	ENSG00000162009.8			29945	-0.242	-0.0308	No
189	GRM1	ENSG00000152822.14			30417	-0.257	-0.0397	No
190	CHRNE	ENSG00000108556.10			30952	-0.275	-0.0499	No
191	PARD3	ENSG00000148498.16			30979	-0.276	-0.0477	No
192	ADRA1D	ENSG00000171873.8			31003	-0.277	-0.0455	No
193	CHRNA1	ENSG00000138435.16			31043	-0.279	-0.0436	No
194	GCGR	ENSG00000215644.10			31354	-0.285	-0.0482	No
195	PRLHR	ENSG00000119973.6			31596	-0.285	-0.0512	No
196	MTNR1B	ENSG00000134640.2			33023	-0.336	-0.0826	No
197	TAAR5	ENSG00000135569.4			33160	-0.336	-0.0825	No
198	TAAR1	ENSG00000146399.1			33161	-0.336	-0.0791	No
199	GABRG3	ENSG00000182256.13			33546	-0.337	-0.0850	No
200	HRH1	ENSG00000196639.6			33562	-0.338	-0.0820	No
201	BDKRB1	ENSG00000100739.11			33570	-0.339	-0.0787	No
202	CHRNA2	ENSG00000120903.13			33924	-0.342	-0.0838	No
203	CHRNA4	ENSG00000101204.17			33925	-0.342	-0.0803	No
204	C3AR1	ENSG00000171860.5			34621	-0.353	-0.0937	No
205	GABRA4	ENSG00000109158.11			34874	-0.363	-0.0962	No
206	NPFFR1	ENSG00000148734.8			35166	-0.372	-0.0995	No
207	NMUR1	ENSG00000171596.7			35208	-0.374	-0.0967	No
208	GRIA4	ENSG00000152578.13			35362	-0.382	-0.0965	No
209	FPR1	ENSG00000171051.8			36312	-0.416	-0.1154	No
210	TSHR	ENSG00000165409.17			36318	-0.417	-0.1113	No
211	TBXA2R	ENSG00000006638.11			36470	-0.425	-0.1107	No
212	AGTR1	ENSG00000144891.17			36522	-0.428	-0.1075	No
213	FSHR	ENSG00000170820.11			36568	-0.430	-0.1042	No
214	ADRA2B	ENSG00000274286.2			36632	-0.433	-0.1014	No
215	GABRA2	ENSG00000151834.15			36692	-0.435	-0.0984	No
216	HCRTR2	ENSG00000137252.9			37119	-0.458	-0.1041	No
217	GPR156	ENSG00000175697.10			37121	-0.459	-0.0994	No
218	HTR1A	ENSG00000178394.4			37182	-0.463	-0.0962	No
219	PTGIR	ENSG00000160013.9			37306	-0.471	-0.0944	No
220	ADRA2C	ENSG00000184160.8			37339	-0.474	-0.0903	No
221	MTNR1A	ENSG00000168412.6			37417	-0.479	-0.0873	No
222	OXTR	ENSG00000180914.10			37721	-0.504	-0.0896	No
223	GRIN3B	ENSG00000116032.5			37905	-0.521	-0.0888	No
224	S1PR5	ENSG00000180739.14			38075	-0.533	-0.0874	No
225	RXFP2	ENSG00000133105.8			38396	-0.556	-0.0896	No
226	TAAR8	ENSG00000146385.1			38554	-0.561	-0.0877	No
227	CHRNA9	ENSG00000174343.6			38792	-0.580	-0.0876	No
228	S1PR4	ENSG00000125910.6			38905	-0.590	-0.0843	No
229	HTR2B	ENSG00000135914.6			39026	-0.604	-0.0811	No
230	CYSLTR2	ENSG00000152207.7			39117	-0.614	-0.0770	No
231	LEP	ENSG00000174697.5			39396	-0.626	-0.0774	No
232	LHB	ENSG00000104826.14			39576	-0.644	-0.0752	No
233	LEPR	ENSG00000116678.19			39644	-0.653	-0.0702	No
234	GABRQ	ENSG00000268089.3			39813	-0.677	-0.0674	No
235	ADORA2B	ENSG00000170425.3			39882	-0.692	-0.0620	No
236	THRB	ENSG00000151090.19			40393	-0.803	-0.0662	No
237	GRIN2A	ENSG00000183454.17			40459	-0.827	-0.0594	No
238	NR3C1	ENSG00000113580.15			40550	-0.857	-0.0529	No
239	MC4R	ENSG00000166603.5			40630	-0.889	-0.0457	No
240	PRLR	ENSG00000113494.17			40839	-0.987	-0.0407	No
241	GABBR2	ENSG00000136928.7			40863	-1.008	-0.0310	No
242	GLRA1	ENSG00000145888.10			40927	-1.046	-0.0219	No
243	MAS1	ENSG00000130368.5			40956	-1.077	-0.0116	No
244	GRPR	ENSG00000126010.6			41123	-1.622	0.0009	No

Fig 2: KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION: Random ES distribution   
Gene set null distribution of ES for KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION