Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH |
| Phenotype | Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH |
| Upregulated in class | ARH |
| GeneSet | REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS |
| Enrichment Score (ES) | -0.6300732 |
| Normalized Enrichment Score (NES) | -2.4475863 |
| Nominal p-value | 0.0 |
| FDR q-value | 9.895107E-5 |
| FWER p-Value | 0.001 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | RAD9A | ENSG00000172613.8 | 12032 | 0.270 | -0.2732 | No | ||
| 2 | RFC5 | ENSG00000111445.14 | 16883 | 0.120 | -0.3825 | No | ||
| 3 | RPA2 | ENSG00000117748.10 | 16945 | 0.118 | -0.3754 | No | ||
| 4 | RAD1 | ENSG00000113456.19 | 17050 | 0.116 | -0.3696 | No | ||
| 5 | MCM7 | ENSG00000166508.17 | 17495 | 0.104 | -0.3729 | No | ||
| 6 | ORC2 | ENSG00000115942.9 | 19607 | 0.048 | -0.4208 | No | ||
| 7 | ORC5 | ENSG00000164815.11 | 23413 | -0.050 | -0.5097 | No | ||
| 8 | DBF4 | ENSG00000006634.8 | 25980 | -0.120 | -0.5635 | No | ||
| 9 | ATRIP | ENSG00000164053.21 | 26108 | -0.124 | -0.5577 | No | ||
| 10 | RFC2 | ENSG00000049541.11 | 26606 | -0.138 | -0.5598 | No | ||
| 11 | ORC4 | ENSG00000115947.13 | 28129 | -0.185 | -0.5835 | No | ||
| 12 | MCM3 | ENSG00000112118.20 | 29007 | -0.212 | -0.5896 | No | ||
| 13 | RFC4 | ENSG00000163918.10 | 30672 | -0.265 | -0.6110 | Yes | ||
| 14 | MCM8 | ENSG00000125885.13 | 31052 | -0.279 | -0.6002 | Yes | ||
| 15 | RPA1 | ENSG00000132383.12 | 31119 | -0.282 | -0.5815 | Yes | ||
| 16 | CDK2 | ENSG00000123374.11 | 32246 | -0.307 | -0.5868 | Yes | ||
| 17 | MCM2 | ENSG00000073111.14 | 32546 | -0.318 | -0.5712 | Yes | ||
| 18 | RAD17 | ENSG00000152942.19 | 32645 | -0.322 | -0.5505 | Yes | ||
| 19 | HUS1 | ENSG00000136273.13 | 34665 | -0.355 | -0.5740 | Yes | ||
| 20 | MCM6 | ENSG00000076003.5 | 34728 | -0.357 | -0.5498 | Yes | ||
| 21 | MCM5 | ENSG00000100297.16 | 35805 | -0.402 | -0.5471 | Yes | ||
| 22 | CDC25C | ENSG00000158402.20 | 35954 | -0.403 | -0.5217 | Yes | ||
| 23 | ORC3 | ENSG00000135336.14 | 36389 | -0.421 | -0.5020 | Yes | ||
| 24 | RPA3 | ENSG00000106399.11 | 36661 | -0.434 | -0.4773 | Yes | ||
| 25 | ATR | ENSG00000175054.16 | 36761 | -0.438 | -0.4482 | Yes | ||
| 26 | ORC1 | ENSG00000085840.13 | 37179 | -0.462 | -0.4251 | Yes | ||
| 27 | RFC3 | ENSG00000133119.13 | 37532 | -0.487 | -0.3986 | Yes | ||
| 28 | CDC7 | ENSG00000097046.13 | 38052 | -0.531 | -0.3730 | Yes | ||
| 29 | CHEK1 | ENSG00000149554.13 | 38279 | -0.549 | -0.3390 | Yes | ||
| 30 | CDC45 | ENSG00000093009.10 | 38822 | -0.583 | -0.3103 | Yes | ||
| 31 | ORC6 | ENSG00000091651.9 | 38888 | -0.589 | -0.2695 | Yes | ||
| 32 | RAD9B | ENSG00000151164.18 | 39057 | -0.607 | -0.2299 | Yes | ||
| 33 | CLSPN | ENSG00000092853.14 | 39505 | -0.635 | -0.1951 | Yes | ||
| 34 | CDC6 | ENSG00000094804.12 | 40060 | -0.723 | -0.1565 | Yes | ||
| 35 | CDC25A | ENSG00000164045.12 | 40263 | -0.768 | -0.1062 | Yes | ||
| 36 | MCM4 | ENSG00000104738.18 | 40591 | -0.872 | -0.0514 | Yes | ||
| 37 | MCM10 | ENSG00000065328.16 | 40670 | -0.907 | 0.0119 | Yes |
