Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH |
| Phenotype | Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH |
| Upregulated in class | ARH |
| GeneSet | REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX |
| Enrichment Score (ES) | -0.55281997 |
| Normalized Enrichment Score (NES) | -2.399308 |
| Nominal p-value | 0.0 |
| FDR q-value | 8.174219E-5 |
| FWER p-Value | 0.001 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | PSMB8 | ENSG00000204264.11 | 14058 | 0.204 | -0.3297 | No | ||
| 2 | MCM7 | ENSG00000166508.17 | 17495 | 0.104 | -0.4070 | No | ||
| 3 | PSME2 | ENSG00000100911.16 | 19274 | 0.057 | -0.4468 | No | ||
| 4 | PSMA3 | ENSG00000100567.13 | 19401 | 0.054 | -0.4466 | No | ||
| 5 | PSMA2 | ENSG00000106588.11 | 19562 | 0.050 | -0.4474 | No | ||
| 6 | ORC2 | ENSG00000115942.9 | 19607 | 0.048 | -0.4456 | No | ||
| 7 | PSMB10 | ENSG00000205220.12 | 19937 | 0.040 | -0.4511 | No | ||
| 8 | PSMC4 | ENSG00000013275.8 | 20810 | 0.018 | -0.4713 | No | ||
| 9 | UBC | ENSG00000150991.15 | 20948 | 0.013 | -0.4738 | No | ||
| 10 | PSMA6 | ENSG00000100902.11 | 20976 | 0.013 | -0.4737 | No | ||
| 11 | PSMB4 | ENSG00000159377.11 | 21127 | 0.007 | -0.4769 | No | ||
| 12 | UBB | ENSG00000170315.14 | 22145 | -0.016 | -0.5007 | No | ||
| 13 | UBA52 | ENSG00000221983.8 | 22256 | -0.020 | -0.5021 | No | ||
| 14 | PSMD3 | ENSG00000108344.15 | 23004 | -0.040 | -0.5179 | No | ||
| 15 | PSME1 | ENSG00000092010.15 | 23061 | -0.041 | -0.5168 | No | ||
| 16 | PSMA1 | ENSG00000129084.17 | 23337 | -0.048 | -0.5205 | No | ||
| 17 | PSMB9 | ENSG00000240065.8 | 23347 | -0.048 | -0.5178 | No | ||
| 18 | ORC5 | ENSG00000164815.11 | 23413 | -0.050 | -0.5163 | No | ||
| 19 | SEM1 | ENSG00000127922.9 | 24231 | -0.071 | -0.5319 | No | ||
| 20 | PSMB7 | ENSG00000136930.13 | 24754 | -0.084 | -0.5395 | No | ||
| 21 | RPS27A | ENSG00000143947.13 | 24801 | -0.086 | -0.5354 | No | ||
| 22 | PSMB1 | ENSG00000008018.9 | 25518 | -0.106 | -0.5464 | Yes | ||
| 23 | PSMB6 | ENSG00000142507.10 | 25718 | -0.112 | -0.5444 | Yes | ||
| 24 | PSMD8 | ENSG00000099341.11 | 25815 | -0.114 | -0.5398 | Yes | ||
| 25 | PSMB2 | ENSG00000126067.12 | 26219 | -0.126 | -0.5419 | Yes | ||
| 26 | PSMD2 | ENSG00000175166.17 | 26310 | -0.129 | -0.5363 | Yes | ||
| 27 | PSMD9 | ENSG00000110801.14 | 26323 | -0.129 | -0.5287 | Yes | ||
| 28 | PSMA7 | ENSG00000101182.15 | 26454 | -0.134 | -0.5237 | Yes | ||
| 29 | PSMC1 | ENSG00000100764.14 | 26467 | -0.134 | -0.5159 | Yes | ||
| 30 | PSMF1 | ENSG00000125818.18 | 26669 | -0.140 | -0.5123 | Yes | ||
| 31 | PSMD4 | ENSG00000159352.15 | 26816 | -0.144 | -0.5070 | Yes | ||
| 32 | PSMD13 | ENSG00000185627.18 | 27620 | -0.168 | -0.5163 | Yes | ||
| 33 | PSMD11 | ENSG00000108671.11 | 27717 | -0.171 | -0.5083 | Yes | ||
| 34 | GMNN | ENSG00000112312.10 | 27728 | -0.171 | -0.4981 | Yes | ||
| 35 | PSMC5 | ENSG00000087191.13 | 27761 | -0.172 | -0.4884 | Yes | ||
| 36 | PSMB3 | ENSG00000277791.5 | 27956 | -0.179 | -0.4822 | Yes | ||
| 37 | ORC4 | ENSG00000115947.13 | 28129 | -0.185 | -0.4752 | Yes | ||
| 38 | PSMD6 | ENSG00000163636.10 | 28425 | -0.194 | -0.4706 | Yes | ||
| 39 | PSMC6 | ENSG00000100519.12 | 28449 | -0.195 | -0.4593 | Yes | ||
| 40 | PSMC3 | ENSG00000165916.8 | 28625 | -0.200 | -0.4514 | Yes | ||
| 41 | MCM3 | ENSG00000112118.20 | 29007 | -0.212 | -0.4477 | Yes | ||
| 42 | PSMD7 | ENSG00000103035.11 | 30001 | -0.244 | -0.4571 | Yes | ||
| 43 | PSMA4 | ENSG00000041357.16 | 30107 | -0.247 | -0.4446 | Yes | ||
| 44 | E2F2 | ENSG00000007968.7 | 30138 | -0.249 | -0.4302 | Yes | ||
| 45 | MCM8 | ENSG00000125885.13 | 31052 | -0.279 | -0.4354 | Yes | ||
| 46 | PSMA8 | ENSG00000154611.14 | 31324 | -0.285 | -0.4246 | Yes | ||
| 47 | MCM2 | ENSG00000073111.14 | 32546 | -0.318 | -0.4350 | Yes | ||
| 48 | PSMD10 | ENSG00000101843.19 | 32694 | -0.324 | -0.4188 | Yes | ||
| 49 | PSMD12 | ENSG00000197170.10 | 32756 | -0.326 | -0.4005 | Yes | ||
| 50 | MCM6 | ENSG00000076003.5 | 34728 | -0.357 | -0.4267 | Yes | ||
| 51 | PSMB5 | ENSG00000100804.19 | 35039 | -0.367 | -0.4119 | Yes | ||
| 52 | PSMD5 | ENSG00000095261.14 | 35294 | -0.378 | -0.3951 | Yes | ||
| 53 | PSME3 | ENSG00000131467.11 | 35430 | -0.385 | -0.3750 | Yes | ||
| 54 | PSMA5 | ENSG00000143106.13 | 35640 | -0.395 | -0.3560 | Yes | ||
| 55 | CDT1 | ENSG00000167513.9 | 35789 | -0.401 | -0.3352 | Yes | ||
| 56 | MCM5 | ENSG00000100297.16 | 35805 | -0.402 | -0.3111 | Yes | ||
| 57 | PSMC2 | ENSG00000161057.12 | 35948 | -0.403 | -0.2900 | Yes | ||
| 58 | ORC3 | ENSG00000135336.14 | 36389 | -0.421 | -0.2751 | Yes | ||
| 59 | PSMD14 | ENSG00000115233.12 | 36419 | -0.422 | -0.2501 | Yes | ||
| 60 | ORC1 | ENSG00000085840.13 | 37179 | -0.462 | -0.2405 | Yes | ||
| 61 | PSMD1 | ENSG00000173692.13 | 37725 | -0.504 | -0.2230 | Yes | ||
| 62 | PSME4 | ENSG00000068878.15 | 38072 | -0.532 | -0.1991 | Yes | ||
| 63 | E2F1 | ENSG00000101412.13 | 38085 | -0.533 | -0.1669 | Yes | ||
| 64 | ORC6 | ENSG00000091651.9 | 38888 | -0.589 | -0.1506 | Yes | ||
| 65 | CDC6 | ENSG00000094804.12 | 40060 | -0.723 | -0.1350 | Yes | ||
| 66 | E2F3 | ENSG00000112242.15 | 40268 | -0.769 | -0.0933 | Yes | ||
| 67 | MCM4 | ENSG00000104738.18 | 40591 | -0.872 | -0.0481 | Yes | ||
| 68 | PSMB11 | ENSG00000222028.5 | 40874 | -1.018 | 0.0070 | Yes |
