Details for gene set REACTOME_COMPLEMENT_CASCADE[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Phenotype	Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Upregulated in class	FSHD2
GeneSet	REACTOME_COMPLEMENT_CASCADE
Enrichment Score (ES)	0.4261623
Normalized Enrichment Score (NES)	1.6718168
Nominal p-value	0.011475409
FDR q-value	0.16877401
FWER p-Value	0.997

Fig 1: Enrichment plot: REACTOME_COMPLEMENT_CASCADE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	CFHR1	ENSG00000244414.6			457	1.033	0.0361	Yes
2	CFHR3	ENSG00000116785.13			920	0.878	0.0649	Yes
3	C1S	ENSG00000182326.15			1233	0.811	0.0944	Yes
4	CLU	ENSG00000120885.22			1659	0.752	0.1184	Yes
5	CFH	ENSG00000000971.15			2168	0.686	0.1374	Yes
6	ELANE	ENSG00000197561.7			2173	0.686	0.1687	Yes
7	C4A	ENSG00000244731.8			2677	0.636	0.1855	Yes
8	COLEC11	ENSG00000118004.17			2760	0.627	0.2122	Yes
9	C1R	ENSG00000159403.18			2987	0.607	0.2344	Yes
10	CR1	ENSG00000203710.11			3191	0.592	0.2565	Yes
11	CFP	ENSG00000126759.13			3748	0.554	0.2682	Yes
12	C7	ENSG00000112936.19			3802	0.550	0.2921	Yes
13	MASP2	ENSG00000009724.17			4725	0.509	0.2929	Yes
14	PROS1	ENSG00000184500.15			4767	0.507	0.3150	Yes
15	CFB	ENSG00000243649.8			4800	0.504	0.3373	Yes
16	C8G	ENSG00000176919.13			5255	0.474	0.3479	Yes
17	CFD	ENSG00000197766.8			6918	0.393	0.3254	Yes
18	FCN1	ENSG00000085265.11			7665	0.364	0.3239	Yes
19	IGLV1-51	ENSG00000211644.3			7791	0.363	0.3374	Yes
20	IGLV3-1	ENSG00000211673.2			7856	0.362	0.3524	Yes
21	COLEC10	ENSG00000184374.3			8219	0.353	0.3597	Yes
22	CFHR4	ENSG00000134365.13			8583	0.348	0.3668	Yes
23	GZMM	ENSG00000197540.8			9204	0.327	0.3666	Yes
24	MBL2	ENSG00000165471.6			9409	0.319	0.3763	Yes
25	CFHR5	ENSG00000134389.9			9439	0.319	0.3901	Yes
26	C4BPB	ENSG00000123843.13			10036	0.310	0.3898	Yes
27	C5AR2	ENSG00000134830.6			10132	0.306	0.4015	Yes
28	CRP	ENSG00000132693.12			10259	0.305	0.4124	Yes
29	C6	ENSG00000039537.13			10266	0.305	0.4262	Yes
30	C5AR1	ENSG00000197405.8			11756	0.280	0.4027	No
31	CD81	ENSG00000110651.11			12744	0.247	0.3900	No
32	F2	ENSG00000180210.14			12841	0.243	0.3987	No
33	C3	ENSG00000125730.17			13115	0.235	0.4028	No
34	VTN	ENSG00000109072.14			13279	0.229	0.4093	No
35	MASP1	ENSG00000127241.16			13988	0.206	0.4015	No
36	C2	ENSG00000166278.15			16704	0.125	0.3412	No
37	SERPING1	ENSG00000149131.15			17821	0.096	0.3184	No
38	C5	ENSG00000106804.7			18173	0.086	0.3138	No
39	CD46	ENSG00000117335.19			20971	0.013	0.2464	No
40	FCN3	ENSG00000142748.12			21773	-0.008	0.2273	No
41	CD55	ENSG00000196352.15			21778	-0.009	0.2276	No
42	IGLC2	ENSG00000211677.2			22079	-0.016	0.2210	No
43	CD59	ENSG00000085063.16			22198	-0.018	0.2189	No
44	CFHR2	ENSG00000080910.13			26270	-0.128	0.1257	No
45	CD19	ENSG00000177455.14			26551	-0.137	0.1252	No
46	C4BPA	ENSG00000123838.11			28435	-0.194	0.0882	No
47	C4B	ENSG00000224389.9			28524	-0.197	0.0951	No
48	C8B	ENSG00000021852.13			32651	-0.322	0.0095	No
49	C8A	ENSG00000157131.10			32976	-0.335	0.0169	No
50	C1QB	ENSG00000173369.16			33116	-0.336	0.0289	No
51	C3AR1	ENSG00000171860.5			34621	-0.353	0.0084	No
52	CFI	ENSG00000205403.13			35335	-0.380	0.0084	No
53	C1QA	ENSG00000173372.17			35837	-0.402	0.0146	No
54	CPB2	ENSG00000080618.16			36554	-0.430	0.0168	No
55	CPN2	ENSG00000178772.7			37083	-0.457	0.0249	No
56	CPN1	ENSG00000120054.12			38342	-0.555	0.0196	No
57	C9	ENSG00000113600.11			40949	-1.072	0.0052	No

Fig 2: REACTOME_COMPLEMENT_CASCADE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: REACTOME_COMPLEMENT_CASCADE: Random ES distribution   
Gene set null distribution of ES for REACTOME_COMPLEMENT_CASCADE