Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH |
| Phenotype | Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH |
| Upregulated in class | ARH |
| GeneSet | REACTOME_DNA_REPLICATION |
| Enrichment Score (ES) | -0.53621894 |
| Normalized Enrichment Score (NES) | -2.708154 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | ANAPC2 | ENSG00000176248.9 | 6153 | 0.426 | -0.1378 | No | ||
| 2 | ANAPC5 | ENSG00000089053.13 | 6368 | 0.414 | -0.1312 | No | ||
| 3 | PSMB8 | ENSG00000204264.11 | 14058 | 0.204 | -0.3128 | No | ||
| 4 | POLE4 | ENSG00000115350.12 | 15368 | 0.163 | -0.3400 | No | ||
| 5 | CDC26 | ENSG00000176386.9 | 15890 | 0.148 | -0.3485 | No | ||
| 6 | RFC5 | ENSG00000111445.14 | 16883 | 0.120 | -0.3693 | No | ||
| 7 | RPA2 | ENSG00000117748.10 | 16945 | 0.118 | -0.3674 | No | ||
| 8 | MCM7 | ENSG00000166508.17 | 17495 | 0.104 | -0.3778 | No | ||
| 9 | CCNA1 | ENSG00000133101.10 | 17734 | 0.098 | -0.3808 | No | ||
| 10 | PSME2 | ENSG00000100911.16 | 19274 | 0.057 | -0.4167 | No | ||
| 11 | PSMA3 | ENSG00000100567.13 | 19401 | 0.054 | -0.4182 | No | ||
| 12 | POLE | ENSG00000177084.17 | 19403 | 0.054 | -0.4167 | No | ||
| 13 | PSMA2 | ENSG00000106588.11 | 19562 | 0.050 | -0.4192 | No | ||
| 14 | ORC2 | ENSG00000115942.9 | 19607 | 0.048 | -0.4189 | No | ||
| 15 | PSMB10 | ENSG00000205220.12 | 19937 | 0.040 | -0.4257 | No | ||
| 16 | PSMC4 | ENSG00000013275.8 | 20810 | 0.018 | -0.4465 | No | ||
| 17 | UBC | ENSG00000150991.15 | 20948 | 0.013 | -0.4494 | No | ||
| 18 | PSMA6 | ENSG00000100902.11 | 20976 | 0.013 | -0.4497 | No | ||
| 19 | PSMB4 | ENSG00000159377.11 | 21127 | 0.007 | -0.4532 | No | ||
| 20 | UBB | ENSG00000170315.14 | 22145 | -0.016 | -0.4775 | No | ||
| 21 | POLD4 | ENSG00000175482.9 | 22165 | -0.017 | -0.4775 | No | ||
| 22 | UBA52 | ENSG00000221983.8 | 22256 | -0.020 | -0.4791 | No | ||
| 23 | PSMD3 | ENSG00000108344.15 | 23004 | -0.040 | -0.4962 | No | ||
| 24 | PSME1 | ENSG00000092010.15 | 23061 | -0.041 | -0.4964 | No | ||
| 25 | PSMA1 | ENSG00000129084.17 | 23337 | -0.048 | -0.5017 | No | ||
| 26 | PSMB9 | ENSG00000240065.8 | 23347 | -0.048 | -0.5006 | No | ||
| 27 | ORC5 | ENSG00000164815.11 | 23413 | -0.050 | -0.5007 | No | ||
| 28 | POLE3 | ENSG00000148229.13 | 23456 | -0.051 | -0.5003 | No | ||
| 29 | ANAPC1 | ENSG00000153107.13 | 24092 | -0.067 | -0.5139 | No | ||
| 30 | SEM1 | ENSG00000127922.9 | 24231 | -0.071 | -0.5152 | No | ||
| 31 | CUL1 | ENSG00000055130.17 | 24550 | -0.079 | -0.5207 | No | ||
| 32 | PSMB7 | ENSG00000136930.13 | 24754 | -0.084 | -0.5233 | No | ||
| 33 | RPS27A | ENSG00000143947.13 | 24801 | -0.086 | -0.5219 | No | ||
| 34 | FZR1 | ENSG00000105325.14 | 24842 | -0.087 | -0.5205 | No | ||
| 35 | POLA2 | ENSG00000014138.9 | 24862 | -0.087 | -0.5184 | No | ||
| 36 | PSMB1 | ENSG00000008018.9 | 25518 | -0.106 | -0.5314 | No | ||
| 37 | PSMB6 | ENSG00000142507.10 | 25718 | -0.112 | -0.5330 | Yes | ||
| 38 | DNA2 | ENSG00000138346.15 | 25812 | -0.114 | -0.5321 | Yes | ||
| 39 | PSMD8 | ENSG00000099341.11 | 25815 | -0.114 | -0.5289 | Yes | ||
| 40 | POLD1 | ENSG00000062822.14 | 25827 | -0.115 | -0.5259 | Yes | ||
| 41 | DBF4 | ENSG00000006634.8 | 25980 | -0.120 | -0.5262 | Yes | ||
| 42 | ANAPC10 | ENSG00000164162.14 | 26104 | -0.124 | -0.5256 | Yes | ||
| 43 | RFC1 | ENSG00000035928.16 | 26169 | -0.125 | -0.5236 | Yes | ||
| 44 | PSMB2 | ENSG00000126067.12 | 26219 | -0.126 | -0.5212 | Yes | ||
| 45 | POLD3 | ENSG00000077514.9 | 26261 | -0.128 | -0.5186 | Yes | ||
| 46 | ANAPC7 | ENSG00000196510.12 | 26263 | -0.128 | -0.5150 | Yes | ||
| 47 | PSMD2 | ENSG00000175166.17 | 26310 | -0.129 | -0.5124 | Yes | ||
| 48 | PSMD9 | ENSG00000110801.14 | 26323 | -0.129 | -0.5090 | Yes | ||
| 49 | PSMA7 | ENSG00000101182.15 | 26454 | -0.134 | -0.5084 | Yes | ||
| 50 | PSMC1 | ENSG00000100764.14 | 26467 | -0.134 | -0.5048 | Yes | ||
| 51 | POLA1 | ENSG00000101868.11 | 26537 | -0.136 | -0.5026 | Yes | ||
| 52 | ANAPC11 | ENSG00000141552.17 | 26543 | -0.136 | -0.4989 | Yes | ||
| 53 | RFC2 | ENSG00000049541.11 | 26606 | -0.138 | -0.4965 | Yes | ||
| 54 | PSMF1 | ENSG00000125818.18 | 26669 | -0.140 | -0.4940 | Yes | ||
| 55 | ANAPC4 | ENSG00000053900.10 | 26737 | -0.142 | -0.4916 | Yes | ||
| 56 | PSMD4 | ENSG00000159352.15 | 26816 | -0.144 | -0.4894 | Yes | ||
| 57 | PSMD13 | ENSG00000185627.18 | 27620 | -0.168 | -0.5041 | Yes | ||
| 58 | PSMD11 | ENSG00000108671.11 | 27717 | -0.171 | -0.5016 | Yes | ||
| 59 | GMNN | ENSG00000112312.10 | 27728 | -0.171 | -0.4970 | Yes | ||
| 60 | PSMC5 | ENSG00000087191.13 | 27761 | -0.172 | -0.4928 | Yes | ||
| 61 | PSMB3 | ENSG00000277791.5 | 27956 | -0.179 | -0.4925 | Yes | ||
| 62 | RPA4 | ENSG00000204086.4 | 28029 | -0.182 | -0.4890 | Yes | ||
| 63 | ORC4 | ENSG00000115947.13 | 28129 | -0.185 | -0.4862 | Yes | ||
| 64 | LIG1 | ENSG00000105486.14 | 28401 | -0.193 | -0.4873 | Yes | ||
| 65 | PSMD6 | ENSG00000163636.10 | 28425 | -0.194 | -0.4823 | Yes | ||
| 66 | PSMC6 | ENSG00000100519.12 | 28449 | -0.195 | -0.4774 | Yes | ||
| 67 | PSMC3 | ENSG00000165916.8 | 28625 | -0.200 | -0.4759 | Yes | ||
| 68 | SKP1 | ENSG00000113558.18 | 28827 | -0.206 | -0.4749 | Yes | ||
| 69 | ANAPC16 | ENSG00000166295.9 | 29001 | -0.212 | -0.4731 | Yes | ||
| 70 | MCM3 | ENSG00000112118.20 | 29007 | -0.212 | -0.4672 | Yes | ||
| 71 | CDC27 | ENSG00000004897.12 | 29738 | -0.236 | -0.4783 | Yes | ||
| 72 | POLD2 | ENSG00000106628.10 | 29968 | -0.243 | -0.4769 | Yes | ||
| 73 | PSMD7 | ENSG00000103035.11 | 30001 | -0.244 | -0.4708 | Yes | ||
| 74 | PSMA4 | ENSG00000041357.16 | 30107 | -0.247 | -0.4663 | Yes | ||
| 75 | E2F2 | ENSG00000007968.7 | 30138 | -0.249 | -0.4599 | Yes | ||
| 76 | CDC23 | ENSG00000094880.11 | 30249 | -0.252 | -0.4554 | Yes | ||
| 77 | RFC4 | ENSG00000163918.10 | 30672 | -0.265 | -0.4582 | Yes | ||
| 78 | UBE2D1 | ENSG00000072401.15 | 30679 | -0.265 | -0.4508 | Yes | ||
| 79 | MCM8 | ENSG00000125885.13 | 31052 | -0.279 | -0.4519 | Yes | ||
| 80 | RPA1 | ENSG00000132383.12 | 31119 | -0.282 | -0.4455 | Yes | ||
| 81 | PSMA8 | ENSG00000154611.14 | 31324 | -0.285 | -0.4423 | Yes | ||
| 82 | CCNE1 | ENSG00000105173.14 | 32197 | -0.305 | -0.4549 | Yes | ||
| 83 | CDK2 | ENSG00000123374.11 | 32246 | -0.307 | -0.4473 | Yes | ||
| 84 | RBX1 | ENSG00000100387.9 | 32483 | -0.316 | -0.4440 | Yes | ||
| 85 | MCM2 | ENSG00000073111.14 | 32546 | -0.318 | -0.4365 | Yes | ||
| 86 | PSMD10 | ENSG00000101843.19 | 32694 | -0.324 | -0.4308 | Yes | ||
| 87 | PSMD12 | ENSG00000197170.10 | 32756 | -0.326 | -0.4230 | Yes | ||
| 88 | MCM6 | ENSG00000076003.5 | 34728 | -0.357 | -0.4609 | Yes | ||
| 89 | PSMB5 | ENSG00000100804.19 | 35039 | -0.367 | -0.4580 | Yes | ||
| 90 | PSMD5 | ENSG00000095261.14 | 35294 | -0.378 | -0.4534 | Yes | ||
| 91 | PSME3 | ENSG00000131467.11 | 35430 | -0.385 | -0.4457 | Yes | ||
| 92 | PSMA5 | ENSG00000143106.13 | 35640 | -0.395 | -0.4395 | Yes | ||
| 93 | CDT1 | ENSG00000167513.9 | 35789 | -0.401 | -0.4317 | Yes | ||
| 94 | CDC16 | ENSG00000130177.16 | 35800 | -0.402 | -0.4205 | Yes | ||
| 95 | MCM5 | ENSG00000100297.16 | 35805 | -0.402 | -0.4091 | Yes | ||
| 96 | PSMC2 | ENSG00000161057.12 | 35948 | -0.403 | -0.4011 | Yes | ||
| 97 | ORC3 | ENSG00000135336.14 | 36389 | -0.421 | -0.3998 | Yes | ||
| 98 | PSMD14 | ENSG00000115233.12 | 36419 | -0.422 | -0.3885 | Yes | ||
| 99 | RPA3 | ENSG00000106399.11 | 36661 | -0.434 | -0.3820 | Yes | ||
| 100 | GINS3 | ENSG00000181938.13 | 36693 | -0.435 | -0.3704 | Yes | ||
| 101 | ANAPC15 | ENSG00000110200.8 | 36886 | -0.445 | -0.3624 | Yes | ||
| 102 | PCNA | ENSG00000132646.11 | 37166 | -0.461 | -0.3560 | Yes | ||
| 103 | ORC1 | ENSG00000085840.13 | 37179 | -0.462 | -0.3431 | Yes | ||
| 104 | CCNE2 | ENSG00000175305.17 | 37360 | -0.475 | -0.3340 | Yes | ||
| 105 | UBE2E1 | ENSG00000170142.12 | 37384 | -0.477 | -0.3209 | Yes | ||
| 106 | RFC3 | ENSG00000133119.13 | 37532 | -0.487 | -0.3106 | Yes | ||
| 107 | POLE2 | ENSG00000100479.13 | 37582 | -0.492 | -0.2978 | Yes | ||
| 108 | PSMD1 | ENSG00000173692.13 | 37725 | -0.504 | -0.2869 | Yes | ||
| 109 | GINS2 | ENSG00000131153.9 | 37954 | -0.524 | -0.2775 | Yes | ||
| 110 | CDC7 | ENSG00000097046.13 | 38052 | -0.531 | -0.2647 | Yes | ||
| 111 | PSME4 | ENSG00000068878.15 | 38072 | -0.532 | -0.2500 | Yes | ||
| 112 | E2F1 | ENSG00000101412.13 | 38085 | -0.533 | -0.2351 | Yes | ||
| 113 | UBE2C | ENSG00000175063.17 | 38091 | -0.534 | -0.2200 | Yes | ||
| 114 | PRIM1 | ENSG00000198056.15 | 38325 | -0.554 | -0.2099 | Yes | ||
| 115 | FEN1 | ENSG00000168496.4 | 38636 | -0.565 | -0.2013 | Yes | ||
| 116 | CDC45 | ENSG00000093009.10 | 38822 | -0.583 | -0.1892 | Yes | ||
| 117 | ORC6 | ENSG00000091651.9 | 38888 | -0.589 | -0.1740 | Yes | ||
| 118 | GINS4 | ENSG00000147536.12 | 39830 | -0.681 | -0.1776 | Yes | ||
| 119 | PRIM2 | ENSG00000146143.19 | 39937 | -0.702 | -0.1601 | Yes | ||
| 120 | CDC6 | ENSG00000094804.12 | 40060 | -0.723 | -0.1425 | Yes | ||
| 121 | GINS1 | ENSG00000101003.10 | 40151 | -0.741 | -0.1236 | Yes | ||
| 122 | SKP2 | ENSG00000145604.16 | 40211 | -0.755 | -0.1035 | Yes | ||
| 123 | E2F3 | ENSG00000112242.15 | 40268 | -0.769 | -0.0829 | Yes | ||
| 124 | MCM4 | ENSG00000104738.18 | 40591 | -0.872 | -0.0659 | Yes | ||
| 125 | CCNA2 | ENSG00000145386.10 | 40598 | -0.874 | -0.0412 | Yes | ||
| 126 | MCM10 | ENSG00000065328.16 | 40670 | -0.907 | -0.0171 | Yes | ||
| 127 | PSMB11 | ENSG00000222028.5 | 40874 | -1.018 | 0.0070 | Yes |
