Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH |
| Phenotype | Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH |
| Upregulated in class | ARH |
| GeneSet | REACTOME_DNA_REPLICATION_PRE_INITIATION |
| Enrichment Score (ES) | -0.5490854 |
| Normalized Enrichment Score (NES) | -2.5686603 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | PSMB8 | ENSG00000204264.11 | 14058 | 0.204 | -0.3330 | No | ||
| 2 | POLE4 | ENSG00000115350.12 | 15368 | 0.163 | -0.3575 | No | ||
| 3 | RPA2 | ENSG00000117748.10 | 16945 | 0.118 | -0.3906 | No | ||
| 4 | MCM7 | ENSG00000166508.17 | 17495 | 0.104 | -0.3992 | No | ||
| 5 | PSME2 | ENSG00000100911.16 | 19274 | 0.057 | -0.4399 | No | ||
| 6 | PSMA3 | ENSG00000100567.13 | 19401 | 0.054 | -0.4406 | No | ||
| 7 | POLE | ENSG00000177084.17 | 19403 | 0.054 | -0.4382 | No | ||
| 8 | PSMA2 | ENSG00000106588.11 | 19562 | 0.050 | -0.4398 | No | ||
| 9 | ORC2 | ENSG00000115942.9 | 19607 | 0.048 | -0.4387 | No | ||
| 10 | PSMB10 | ENSG00000205220.12 | 19937 | 0.040 | -0.4449 | No | ||
| 11 | PSMC4 | ENSG00000013275.8 | 20810 | 0.018 | -0.4653 | No | ||
| 12 | UBC | ENSG00000150991.15 | 20948 | 0.013 | -0.4681 | No | ||
| 13 | PSMA6 | ENSG00000100902.11 | 20976 | 0.013 | -0.4681 | No | ||
| 14 | PSMB4 | ENSG00000159377.11 | 21127 | 0.007 | -0.4715 | No | ||
| 15 | UBB | ENSG00000170315.14 | 22145 | -0.016 | -0.4955 | No | ||
| 16 | UBA52 | ENSG00000221983.8 | 22256 | -0.020 | -0.4973 | No | ||
| 17 | PSMD3 | ENSG00000108344.15 | 23004 | -0.040 | -0.5137 | No | ||
| 18 | PSME1 | ENSG00000092010.15 | 23061 | -0.041 | -0.5132 | No | ||
| 19 | PSMA1 | ENSG00000129084.17 | 23337 | -0.048 | -0.5177 | No | ||
| 20 | PSMB9 | ENSG00000240065.8 | 23347 | -0.048 | -0.5157 | No | ||
| 21 | ORC5 | ENSG00000164815.11 | 23413 | -0.050 | -0.5150 | No | ||
| 22 | POLE3 | ENSG00000148229.13 | 23456 | -0.051 | -0.5138 | No | ||
| 23 | SEM1 | ENSG00000127922.9 | 24231 | -0.071 | -0.5294 | No | ||
| 24 | PSMB7 | ENSG00000136930.13 | 24754 | -0.084 | -0.5383 | No | ||
| 25 | RPS27A | ENSG00000143947.13 | 24801 | -0.086 | -0.5356 | No | ||
| 26 | POLA2 | ENSG00000014138.9 | 24862 | -0.087 | -0.5331 | No | ||
| 27 | PSMB1 | ENSG00000008018.9 | 25518 | -0.106 | -0.5442 | Yes | ||
| 28 | PSMB6 | ENSG00000142507.10 | 25718 | -0.112 | -0.5440 | Yes | ||
| 29 | PSMD8 | ENSG00000099341.11 | 25815 | -0.114 | -0.5412 | Yes | ||
| 30 | DBF4 | ENSG00000006634.8 | 25980 | -0.120 | -0.5398 | Yes | ||
| 31 | PSMB2 | ENSG00000126067.12 | 26219 | -0.126 | -0.5399 | Yes | ||
| 32 | PSMD2 | ENSG00000175166.17 | 26310 | -0.129 | -0.5363 | Yes | ||
| 33 | PSMD9 | ENSG00000110801.14 | 26323 | -0.129 | -0.5307 | Yes | ||
| 34 | PSMA7 | ENSG00000101182.15 | 26454 | -0.134 | -0.5278 | Yes | ||
| 35 | PSMC1 | ENSG00000100764.14 | 26467 | -0.134 | -0.5221 | Yes | ||
| 36 | POLA1 | ENSG00000101868.11 | 26537 | -0.136 | -0.5176 | Yes | ||
| 37 | PSMF1 | ENSG00000125818.18 | 26669 | -0.140 | -0.5145 | Yes | ||
| 38 | PSMD4 | ENSG00000159352.15 | 26816 | -0.144 | -0.5115 | Yes | ||
| 39 | PSMD13 | ENSG00000185627.18 | 27620 | -0.168 | -0.5235 | Yes | ||
| 40 | PSMD11 | ENSG00000108671.11 | 27717 | -0.171 | -0.5181 | Yes | ||
| 41 | GMNN | ENSG00000112312.10 | 27728 | -0.171 | -0.5106 | Yes | ||
| 42 | PSMC5 | ENSG00000087191.13 | 27761 | -0.172 | -0.5036 | Yes | ||
| 43 | PSMB3 | ENSG00000277791.5 | 27956 | -0.179 | -0.5002 | Yes | ||
| 44 | RPA4 | ENSG00000204086.4 | 28029 | -0.182 | -0.4938 | Yes | ||
| 45 | ORC4 | ENSG00000115947.13 | 28129 | -0.185 | -0.4878 | Yes | ||
| 46 | PSMD6 | ENSG00000163636.10 | 28425 | -0.194 | -0.4863 | Yes | ||
| 47 | PSMC6 | ENSG00000100519.12 | 28449 | -0.195 | -0.4780 | Yes | ||
| 48 | PSMC3 | ENSG00000165916.8 | 28625 | -0.200 | -0.4733 | Yes | ||
| 49 | MCM3 | ENSG00000112118.20 | 29007 | -0.212 | -0.4730 | Yes | ||
| 50 | PSMD7 | ENSG00000103035.11 | 30001 | -0.244 | -0.4861 | Yes | ||
| 51 | PSMA4 | ENSG00000041357.16 | 30107 | -0.247 | -0.4775 | Yes | ||
| 52 | E2F2 | ENSG00000007968.7 | 30138 | -0.249 | -0.4670 | Yes | ||
| 53 | MCM8 | ENSG00000125885.13 | 31052 | -0.279 | -0.4766 | Yes | ||
| 54 | RPA1 | ENSG00000132383.12 | 31119 | -0.282 | -0.4655 | Yes | ||
| 55 | PSMA8 | ENSG00000154611.14 | 31324 | -0.285 | -0.4576 | Yes | ||
| 56 | CDK2 | ENSG00000123374.11 | 32246 | -0.307 | -0.4661 | Yes | ||
| 57 | MCM2 | ENSG00000073111.14 | 32546 | -0.318 | -0.4590 | Yes | ||
| 58 | PSMD10 | ENSG00000101843.19 | 32694 | -0.324 | -0.4480 | Yes | ||
| 59 | PSMD12 | ENSG00000197170.10 | 32756 | -0.326 | -0.4347 | Yes | ||
| 60 | MCM6 | ENSG00000076003.5 | 34728 | -0.357 | -0.4666 | Yes | ||
| 61 | PSMB5 | ENSG00000100804.19 | 35039 | -0.367 | -0.4576 | Yes | ||
| 62 | PSMD5 | ENSG00000095261.14 | 35294 | -0.378 | -0.4467 | Yes | ||
| 63 | PSME3 | ENSG00000131467.11 | 35430 | -0.385 | -0.4325 | Yes | ||
| 64 | PSMA5 | ENSG00000143106.13 | 35640 | -0.395 | -0.4198 | Yes | ||
| 65 | CDT1 | ENSG00000167513.9 | 35789 | -0.401 | -0.4053 | Yes | ||
| 66 | MCM5 | ENSG00000100297.16 | 35805 | -0.402 | -0.3874 | Yes | ||
| 67 | PSMC2 | ENSG00000161057.12 | 35948 | -0.403 | -0.3727 | Yes | ||
| 68 | ORC3 | ENSG00000135336.14 | 36389 | -0.421 | -0.3644 | Yes | ||
| 69 | PSMD14 | ENSG00000115233.12 | 36419 | -0.422 | -0.3461 | Yes | ||
| 70 | RPA3 | ENSG00000106399.11 | 36661 | -0.434 | -0.3323 | Yes | ||
| 71 | ORC1 | ENSG00000085840.13 | 37179 | -0.462 | -0.3240 | Yes | ||
| 72 | POLE2 | ENSG00000100479.13 | 37582 | -0.492 | -0.3116 | Yes | ||
| 73 | PSMD1 | ENSG00000173692.13 | 37725 | -0.504 | -0.2923 | Yes | ||
| 74 | CDC7 | ENSG00000097046.13 | 38052 | -0.531 | -0.2762 | Yes | ||
| 75 | PSME4 | ENSG00000068878.15 | 38072 | -0.532 | -0.2526 | Yes | ||
| 76 | E2F1 | ENSG00000101412.13 | 38085 | -0.533 | -0.2288 | Yes | ||
| 77 | PRIM1 | ENSG00000198056.15 | 38325 | -0.554 | -0.2096 | Yes | ||
| 78 | CDC45 | ENSG00000093009.10 | 38822 | -0.583 | -0.1953 | Yes | ||
| 79 | ORC6 | ENSG00000091651.9 | 38888 | -0.589 | -0.1703 | Yes | ||
| 80 | PRIM2 | ENSG00000146143.19 | 39937 | -0.702 | -0.1641 | Yes | ||
| 81 | CDC6 | ENSG00000094804.12 | 40060 | -0.723 | -0.1344 | Yes | ||
| 82 | E2F3 | ENSG00000112242.15 | 40268 | -0.769 | -0.1047 | Yes | ||
| 83 | MCM4 | ENSG00000104738.18 | 40591 | -0.872 | -0.0731 | Yes | ||
| 84 | MCM10 | ENSG00000065328.16 | 40670 | -0.907 | -0.0340 | Yes | ||
| 85 | PSMB11 | ENSG00000222028.5 | 40874 | -1.018 | 0.0070 | Yes |
