Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH |
| Phenotype | Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH |
| Upregulated in class | ARH |
| GeneSet | REACTOME_G2_M_CHECKPOINTS |
| Enrichment Score (ES) | -0.49725354 |
| Normalized Enrichment Score (NES) | -2.5681546 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | HIST1H4D | ENSG00000277157.1 | 2603 | 0.643 | -0.0498 | No | ||
| 2 | HIST1H2BK | ENSG00000197903.7 | 5394 | 0.465 | -0.1079 | No | ||
| 3 | HIST1H4E | ENSG00000276966.2 | 6244 | 0.421 | -0.1197 | No | ||
| 4 | HIST4H4 | ENSG00000197837.3 | 8220 | 0.353 | -0.1603 | No | ||
| 5 | HIST1H2BM | ENSG00000273703.1 | 10385 | 0.305 | -0.2066 | No | ||
| 6 | RAD9A | ENSG00000172613.8 | 12032 | 0.270 | -0.2410 | No | ||
| 7 | HIST1H2BH | ENSG00000275713.2 | 12502 | 0.254 | -0.2470 | No | ||
| 8 | HIST3H2BB | ENSG00000196890.4 | 13749 | 0.214 | -0.2729 | No | ||
| 9 | HIST3H3 | ENSG00000168148.3 | 13761 | 0.214 | -0.2686 | No | ||
| 10 | PSMB8 | ENSG00000204264.11 | 14058 | 0.204 | -0.2714 | No | ||
| 11 | CHEK2 | ENSG00000183765.22 | 14522 | 0.190 | -0.2787 | No | ||
| 12 | HIST1H4H | ENSG00000158406.4 | 14785 | 0.181 | -0.2812 | No | ||
| 13 | KAT5 | ENSG00000172977.13 | 15617 | 0.156 | -0.2982 | No | ||
| 14 | PIAS4 | ENSG00000105229.7 | 15657 | 0.155 | -0.2958 | No | ||
| 15 | HIST1H2BD | ENSG00000158373.8 | 15903 | 0.147 | -0.2987 | No | ||
| 16 | HIST1H2BJ | ENSG00000124635.8 | 16824 | 0.122 | -0.3185 | No | ||
| 17 | RFC5 | ENSG00000111445.14 | 16883 | 0.120 | -0.3174 | No | ||
| 18 | RPA2 | ENSG00000117748.10 | 16945 | 0.118 | -0.3163 | No | ||
| 19 | RAD1 | ENSG00000113456.19 | 17050 | 0.116 | -0.3164 | No | ||
| 20 | HERC2 | ENSG00000128731.17 | 17193 | 0.112 | -0.3175 | No | ||
| 21 | MCM7 | ENSG00000166508.17 | 17495 | 0.104 | -0.3226 | No | ||
| 22 | HIST1H4I | ENSG00000276180.1 | 17620 | 0.100 | -0.3235 | No | ||
| 23 | HIST1H2BG | ENSG00000273802.2 | 17796 | 0.096 | -0.3257 | No | ||
| 24 | TOP3A | ENSG00000177302.15 | 18116 | 0.088 | -0.3316 | No | ||
| 25 | MDC1 | ENSG00000137337.15 | 18206 | 0.085 | -0.3320 | No | ||
| 26 | ABRAXAS1 | ENSG00000163322.14 | 18710 | 0.073 | -0.3427 | No | ||
| 27 | PSME2 | ENSG00000100911.16 | 19274 | 0.057 | -0.3552 | No | ||
| 28 | PSMA3 | ENSG00000100567.13 | 19401 | 0.054 | -0.3571 | No | ||
| 29 | PSMA2 | ENSG00000106588.11 | 19562 | 0.050 | -0.3600 | No | ||
| 30 | ORC2 | ENSG00000115942.9 | 19607 | 0.048 | -0.3600 | No | ||
| 31 | MRE11 | ENSG00000020922.12 | 19896 | 0.041 | -0.3662 | No | ||
| 32 | PSMB10 | ENSG00000205220.12 | 19937 | 0.040 | -0.3663 | No | ||
| 33 | HIST1H2BE | ENSG00000274290.2 | 20074 | 0.038 | -0.3688 | No | ||
| 34 | HIST1H2BL | ENSG00000185130.5 | 20206 | 0.034 | -0.3713 | No | ||
| 35 | HIST1H4J | ENSG00000197238.4 | 20458 | 0.026 | -0.3768 | No | ||
| 36 | PSMC4 | ENSG00000013275.8 | 20810 | 0.018 | -0.3850 | No | ||
| 37 | HIST1H2BF | ENSG00000277224.2 | 20928 | 0.014 | -0.3876 | No | ||
| 38 | UBC | ENSG00000150991.15 | 20948 | 0.013 | -0.3878 | No | ||
| 39 | PSMA6 | ENSG00000100902.11 | 20976 | 0.013 | -0.3881 | No | ||
| 40 | PSMB4 | ENSG00000159377.11 | 21127 | 0.007 | -0.3916 | No | ||
| 41 | HIST1H2BO | ENSG00000274641.1 | 21190 | 0.007 | -0.3930 | No | ||
| 42 | SFN | ENSG00000175793.12 | 21306 | 0.004 | -0.3957 | No | ||
| 43 | NBN | ENSG00000104320.13 | 21733 | -0.007 | -0.4060 | No | ||
| 44 | UBB | ENSG00000170315.14 | 22145 | -0.016 | -0.4156 | No | ||
| 45 | RAD50 | ENSG00000113522.14 | 22224 | -0.019 | -0.4172 | No | ||
| 46 | UBA52 | ENSG00000221983.8 | 22256 | -0.020 | -0.4175 | No | ||
| 47 | HIST2H2BE | ENSG00000184678.10 | 22644 | -0.030 | -0.4263 | No | ||
| 48 | TOPBP1 | ENSG00000163781.14 | 22850 | -0.035 | -0.4306 | No | ||
| 49 | PSMD3 | ENSG00000108344.15 | 23004 | -0.040 | -0.4335 | No | ||
| 50 | PSME1 | ENSG00000092010.15 | 23061 | -0.041 | -0.4339 | No | ||
| 51 | HIST1H4L | ENSG00000275126.1 | 23088 | -0.042 | -0.4337 | No | ||
| 52 | PSMA1 | ENSG00000129084.17 | 23337 | -0.048 | -0.4387 | No | ||
| 53 | PSMB9 | ENSG00000240065.8 | 23347 | -0.048 | -0.4379 | No | ||
| 54 | HIST1H2BB | ENSG00000276410.3 | 23366 | -0.049 | -0.4373 | No | ||
| 55 | ORC5 | ENSG00000164815.11 | 23413 | -0.050 | -0.4374 | No | ||
| 56 | BABAM1 | ENSG00000105393.16 | 23442 | -0.051 | -0.4370 | No | ||
| 57 | BABAM2 | ENSG00000158019.20 | 23893 | -0.063 | -0.4466 | No | ||
| 58 | RNF8 | ENSG00000112130.17 | 24033 | -0.065 | -0.4486 | No | ||
| 59 | WRN | ENSG00000165392.10 | 24224 | -0.071 | -0.4517 | No | ||
| 60 | SEM1 | ENSG00000127922.9 | 24231 | -0.071 | -0.4504 | No | ||
| 61 | ATM | ENSG00000149311.18 | 24258 | -0.072 | -0.4495 | No | ||
| 62 | PSMB7 | ENSG00000136930.13 | 24754 | -0.084 | -0.4597 | No | ||
| 63 | RPS27A | ENSG00000143947.13 | 24801 | -0.086 | -0.4590 | No | ||
| 64 | PSMB1 | ENSG00000008018.9 | 25518 | -0.106 | -0.4742 | No | ||
| 65 | HIST1H2BN | ENSG00000233822.4 | 25715 | -0.111 | -0.4767 | No | ||
| 66 | PSMB6 | ENSG00000142507.10 | 25718 | -0.112 | -0.4743 | No | ||
| 67 | DNA2 | ENSG00000138346.15 | 25812 | -0.114 | -0.4742 | No | ||
| 68 | PSMD8 | ENSG00000099341.11 | 25815 | -0.114 | -0.4718 | No | ||
| 69 | HIST1H2BC | ENSG00000180596.7 | 25836 | -0.115 | -0.4698 | No | ||
| 70 | DBF4 | ENSG00000006634.8 | 25980 | -0.120 | -0.4708 | No | ||
| 71 | TP53BP1 | ENSG00000067369.13 | 26057 | -0.123 | -0.4700 | No | ||
| 72 | ATRIP | ENSG00000164053.21 | 26108 | -0.124 | -0.4686 | No | ||
| 73 | PSMB2 | ENSG00000126067.12 | 26219 | -0.126 | -0.4686 | No | ||
| 74 | HIST1H4K | ENSG00000273542.1 | 26308 | -0.129 | -0.4680 | No | ||
| 75 | PSMD2 | ENSG00000175166.17 | 26310 | -0.129 | -0.4653 | No | ||
| 76 | PSMD9 | ENSG00000110801.14 | 26323 | -0.129 | -0.4628 | No | ||
| 77 | PSMA7 | ENSG00000101182.15 | 26454 | -0.134 | -0.4631 | No | ||
| 78 | PSMC1 | ENSG00000100764.14 | 26467 | -0.134 | -0.4606 | No | ||
| 79 | H2AFX | ENSG00000188486.3 | 26590 | -0.138 | -0.4606 | No | ||
| 80 | RFC2 | ENSG00000049541.11 | 26606 | -0.138 | -0.4580 | No | ||
| 81 | PSMF1 | ENSG00000125818.18 | 26669 | -0.140 | -0.4566 | No | ||
| 82 | PSMD4 | ENSG00000159352.15 | 26816 | -0.144 | -0.4571 | No | ||
| 83 | TP53 | ENSG00000141510.17 | 27245 | -0.156 | -0.4642 | No | ||
| 84 | PSMD13 | ENSG00000185627.18 | 27620 | -0.168 | -0.4697 | No | ||
| 85 | PSMD11 | ENSG00000108671.11 | 27717 | -0.171 | -0.4684 | No | ||
| 86 | PSMC5 | ENSG00000087191.13 | 27761 | -0.172 | -0.4658 | No | ||
| 87 | PSMB3 | ENSG00000277791.5 | 27956 | -0.179 | -0.4667 | No | ||
| 88 | ORC4 | ENSG00000115947.13 | 28129 | -0.185 | -0.4670 | No | ||
| 89 | PSMD6 | ENSG00000163636.10 | 28425 | -0.194 | -0.4700 | No | ||
| 90 | PSMC6 | ENSG00000100519.12 | 28449 | -0.195 | -0.4664 | No | ||
| 91 | PSMC3 | ENSG00000165916.8 | 28625 | -0.200 | -0.4664 | No | ||
| 92 | MCM3 | ENSG00000112118.20 | 29007 | -0.212 | -0.4712 | No | ||
| 93 | RHNO1 | ENSG00000171792.11 | 29110 | -0.215 | -0.4691 | No | ||
| 94 | PSMD7 | ENSG00000103035.11 | 30001 | -0.244 | -0.4856 | No | ||
| 95 | PSMA4 | ENSG00000041357.16 | 30107 | -0.247 | -0.4829 | No | ||
| 96 | RFC4 | ENSG00000163918.10 | 30672 | -0.265 | -0.4910 | Yes | ||
| 97 | YWHAQ | ENSG00000134308.14 | 30852 | -0.271 | -0.4896 | Yes | ||
| 98 | MCM8 | ENSG00000125885.13 | 31052 | -0.279 | -0.4885 | Yes | ||
| 99 | RPA1 | ENSG00000132383.12 | 31119 | -0.282 | -0.4841 | Yes | ||
| 100 | HIST1H4F | ENSG00000274618.1 | 31237 | -0.285 | -0.4809 | Yes | ||
| 101 | PSMA8 | ENSG00000154611.14 | 31324 | -0.285 | -0.4769 | Yes | ||
| 102 | BRCC3 | ENSG00000185515.14 | 32158 | -0.302 | -0.4908 | Yes | ||
| 103 | CDK2 | ENSG00000123374.11 | 32246 | -0.307 | -0.4864 | Yes | ||
| 104 | YWHAG | ENSG00000170027.7 | 32308 | -0.310 | -0.4813 | Yes | ||
| 105 | MCM2 | ENSG00000073111.14 | 32546 | -0.318 | -0.4803 | Yes | ||
| 106 | RAD17 | ENSG00000152942.19 | 32645 | -0.322 | -0.4758 | Yes | ||
| 107 | RNF168 | ENSG00000163961.4 | 32669 | -0.323 | -0.4695 | Yes | ||
| 108 | PSMD10 | ENSG00000101843.19 | 32694 | -0.324 | -0.4632 | Yes | ||
| 109 | PSMD12 | ENSG00000197170.10 | 32756 | -0.326 | -0.4577 | Yes | ||
| 110 | UIMC1 | ENSG00000087206.17 | 32823 | -0.329 | -0.4523 | Yes | ||
| 111 | RBBP8 | ENSG00000101773.19 | 32876 | -0.331 | -0.4466 | Yes | ||
| 112 | RMI2 | ENSG00000175643.10 | 33556 | -0.338 | -0.4559 | Yes | ||
| 113 | HUS1 | ENSG00000136273.13 | 34665 | -0.355 | -0.4754 | Yes | ||
| 114 | MCM6 | ENSG00000076003.5 | 34728 | -0.357 | -0.4693 | Yes | ||
| 115 | PSMB5 | ENSG00000100804.19 | 35039 | -0.367 | -0.4690 | Yes | ||
| 116 | UBE2V2 | ENSG00000169139.12 | 35086 | -0.368 | -0.4623 | Yes | ||
| 117 | PSMD5 | ENSG00000095261.14 | 35294 | -0.378 | -0.4593 | Yes | ||
| 118 | SUMO1 | ENSG00000116030.16 | 35376 | -0.382 | -0.4531 | Yes | ||
| 119 | PSME3 | ENSG00000131467.11 | 35430 | -0.385 | -0.4462 | Yes | ||
| 120 | YWHAB | ENSG00000166913.13 | 35457 | -0.386 | -0.4386 | Yes | ||
| 121 | PSMA5 | ENSG00000143106.13 | 35640 | -0.395 | -0.4346 | Yes | ||
| 122 | YWHAZ | ENSG00000164924.18 | 35696 | -0.397 | -0.4275 | Yes | ||
| 123 | HIST1H2BI | ENSG00000278588.1 | 35748 | -0.400 | -0.4202 | Yes | ||
| 124 | BLM | ENSG00000197299.12 | 35803 | -0.402 | -0.4130 | Yes | ||
| 125 | MCM5 | ENSG00000100297.16 | 35805 | -0.402 | -0.4044 | Yes | ||
| 126 | PSMC2 | ENSG00000161057.12 | 35948 | -0.403 | -0.3993 | Yes | ||
| 127 | CDC25C | ENSG00000158402.20 | 35954 | -0.403 | -0.3908 | Yes | ||
| 128 | HIST1H4C | ENSG00000197061.4 | 36084 | -0.408 | -0.3853 | Yes | ||
| 129 | UBE2N | ENSG00000177889.10 | 36090 | -0.408 | -0.3767 | Yes | ||
| 130 | ORC3 | ENSG00000135336.14 | 36389 | -0.421 | -0.3750 | Yes | ||
| 131 | PSMD14 | ENSG00000115233.12 | 36419 | -0.422 | -0.3667 | Yes | ||
| 132 | YWHAE | ENSG00000108953.17 | 36492 | -0.426 | -0.3594 | Yes | ||
| 133 | CCNB2 | ENSG00000157456.8 | 36613 | -0.432 | -0.3531 | Yes | ||
| 134 | RPA3 | ENSG00000106399.11 | 36661 | -0.434 | -0.3450 | Yes | ||
| 135 | ATR | ENSG00000175054.16 | 36761 | -0.438 | -0.3381 | Yes | ||
| 136 | HIST2H4A | ENSG00000270882.2 | 37017 | -0.453 | -0.3347 | Yes | ||
| 137 | ORC1 | ENSG00000085840.13 | 37179 | -0.462 | -0.3288 | Yes | ||
| 138 | PKMYT1 | ENSG00000127564.17 | 37418 | -0.479 | -0.3244 | Yes | ||
| 139 | RFC3 | ENSG00000133119.13 | 37532 | -0.487 | -0.3168 | Yes | ||
| 140 | PSMD1 | ENSG00000173692.13 | 37725 | -0.504 | -0.3107 | Yes | ||
| 141 | BRIP1 | ENSG00000136492.8 | 37949 | -0.524 | -0.3050 | Yes | ||
| 142 | CDC7 | ENSG00000097046.13 | 38052 | -0.531 | -0.2961 | Yes | ||
| 143 | PSME4 | ENSG00000068878.15 | 38072 | -0.532 | -0.2852 | Yes | ||
| 144 | CCNB1 | ENSG00000134057.15 | 38169 | -0.540 | -0.2761 | Yes | ||
| 145 | NSD2 | ENSG00000109685.18 | 38242 | -0.546 | -0.2662 | Yes | ||
| 146 | CHEK1 | ENSG00000149554.13 | 38279 | -0.549 | -0.2554 | Yes | ||
| 147 | GTSE1 | ENSG00000075218.19 | 38414 | -0.557 | -0.2468 | Yes | ||
| 148 | CDC45 | ENSG00000093009.10 | 38822 | -0.583 | -0.2443 | Yes | ||
| 149 | ORC6 | ENSG00000091651.9 | 38888 | -0.589 | -0.2333 | Yes | ||
| 150 | RAD9B | ENSG00000151164.18 | 39057 | -0.607 | -0.2245 | Yes | ||
| 151 | EXO1 | ENSG00000174371.17 | 39163 | -0.615 | -0.2140 | Yes | ||
| 152 | CDK1 | ENSG00000170312.16 | 39453 | -0.632 | -0.2076 | Yes | ||
| 153 | CLSPN | ENSG00000092853.14 | 39505 | -0.635 | -0.1953 | Yes | ||
| 154 | BARD1 | ENSG00000138376.11 | 39685 | -0.660 | -0.1856 | Yes | ||
| 155 | BRCA1 | ENSG00000012048.22 | 39857 | -0.687 | -0.1751 | Yes | ||
| 156 | WEE1 | ENSG00000166483.11 | 40002 | -0.714 | -0.1634 | Yes | ||
| 157 | CDC6 | ENSG00000094804.12 | 40060 | -0.723 | -0.1494 | Yes | ||
| 158 | CDC25A | ENSG00000164045.12 | 40263 | -0.768 | -0.1380 | Yes | ||
| 159 | YWHAH | ENSG00000128245.15 | 40295 | -0.774 | -0.1222 | Yes | ||
| 160 | MCM4 | ENSG00000104738.18 | 40591 | -0.872 | -0.1108 | Yes | ||
| 161 | RMI1 | ENSG00000178966.16 | 40663 | -0.903 | -0.0933 | Yes | ||
| 162 | MCM10 | ENSG00000065328.16 | 40670 | -0.907 | -0.0741 | Yes | ||
| 163 | HIST1H4B | ENSG00000278705.1 | 40718 | -0.927 | -0.0555 | Yes | ||
| 164 | PSMB11 | ENSG00000222028.5 | 40874 | -1.018 | -0.0376 | Yes | ||
| 165 | HIST1H4A | ENSG00000278637.1 | 41148 | -2.093 | 0.0003 | Yes |
