Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH |
| Phenotype | Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH |
| Upregulated in class | ARH |
| GeneSet | REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION |
| Enrichment Score (ES) | -0.47857887 |
| Normalized Enrichment Score (NES) | -2.392078 |
| Nominal p-value | 0.0 |
| FDR q-value | 7.833627E-5 |
| FWER p-Value | 0.001 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CTSB | ENSG00000164733.21 | 706 | 0.938 | 0.0044 | No | ||
| 2 | CTSF | ENSG00000174080.11 | 2136 | 0.689 | -0.0146 | No | ||
| 3 | SPTBN2 | ENSG00000173898.13 | 2627 | 0.640 | -0.0118 | No | ||
| 4 | KIF5A | ENSG00000155980.12 | 3665 | 0.560 | -0.0242 | No | ||
| 5 | SH3GL2 | ENSG00000107295.10 | 5359 | 0.468 | -0.0547 | No | ||
| 6 | KIF26A | ENSG00000066735.14 | 5366 | 0.467 | -0.0441 | No | ||
| 7 | KLC4 | ENSG00000137171.15 | 6556 | 0.406 | -0.0637 | No | ||
| 8 | CTSL | ENSG00000135047.15 | 6908 | 0.393 | -0.0632 | No | ||
| 9 | DYNC1I1 | ENSG00000158560.14 | 7076 | 0.386 | -0.0584 | No | ||
| 10 | TUBB1 | ENSG00000101162.3 | 8127 | 0.356 | -0.0758 | No | ||
| 11 | CTSH | ENSG00000103811.16 | 9963 | 0.313 | -0.1133 | No | ||
| 12 | CD74 | ENSG00000019582.15 | 9998 | 0.311 | -0.1069 | No | ||
| 13 | HLA-DQB2 | ENSG00000232629.9 | 10325 | 0.305 | -0.1078 | No | ||
| 14 | TUBA3D | ENSG00000075886.11 | 10693 | 0.303 | -0.1098 | No | ||
| 15 | RILP | ENSG00000167705.12 | 11028 | 0.289 | -0.1113 | No | ||
| 16 | HLA-DQA2 | ENSG00000237541.4 | 11220 | 0.285 | -0.1094 | No | ||
| 17 | CTSS | ENSG00000163131.11 | 12694 | 0.248 | -0.1396 | No | ||
| 18 | DNM1 | ENSG00000106976.20 | 14252 | 0.198 | -0.1730 | No | ||
| 19 | KLC1 | ENSG00000126214.21 | 14819 | 0.180 | -0.1826 | No | ||
| 20 | AC027237.1 | ENSG00000259191.2 | 15280 | 0.165 | -0.1900 | No | ||
| 21 | TUBB3 | ENSG00000258947.7 | 15608 | 0.156 | -0.1944 | No | ||
| 22 | HLA-DRA | ENSG00000204287.14 | 16028 | 0.144 | -0.2013 | No | ||
| 23 | CTSC | ENSG00000109861.16 | 16154 | 0.141 | -0.2011 | No | ||
| 24 | HLA-DRB5 | ENSG00000198502.6 | 19223 | 0.059 | -0.2745 | No | ||
| 25 | TUBA4B | ENSG00000243910.8 | 19289 | 0.057 | -0.2748 | No | ||
| 26 | TUBA4A | ENSG00000127824.14 | 21284 | 0.004 | -0.3232 | No | ||
| 27 | KLC2 | ENSG00000174996.11 | 22207 | -0.018 | -0.3453 | No | ||
| 28 | LGMN | ENSG00000100600.15 | 22291 | -0.020 | -0.3468 | No | ||
| 29 | SEC13 | ENSG00000157020.18 | 22468 | -0.026 | -0.3505 | No | ||
| 30 | DCTN3 | ENSG00000137100.16 | 22796 | -0.033 | -0.3577 | No | ||
| 31 | CTSV | ENSG00000136943.11 | 22972 | -0.039 | -0.3611 | No | ||
| 32 | ARF1 | ENSG00000143761.16 | 23029 | -0.040 | -0.3615 | No | ||
| 33 | AP2S1 | ENSG00000042753.11 | 23077 | -0.042 | -0.3617 | No | ||
| 34 | DNM2 | ENSG00000079805.16 | 23080 | -0.042 | -0.3608 | No | ||
| 35 | DYNLL2 | ENSG00000264364.3 | 23336 | -0.048 | -0.3659 | No | ||
| 36 | HLA-DPB1 | ENSG00000223865.11 | 24027 | -0.065 | -0.3812 | No | ||
| 37 | CANX | ENSG00000127022.15 | 24334 | -0.074 | -0.3870 | No | ||
| 38 | CTSO | ENSG00000256043.3 | 24619 | -0.080 | -0.3921 | No | ||
| 39 | DYNC1LI2 | ENSG00000135720.13 | 25352 | -0.101 | -0.4076 | No | ||
| 40 | LAG3 | ENSG00000089692.9 | 25399 | -0.102 | -0.4064 | No | ||
| 41 | CTSD | ENSG00000117984.14 | 25979 | -0.120 | -0.4177 | No | ||
| 42 | TUBA8 | ENSG00000183785.15 | 26534 | -0.136 | -0.4281 | No | ||
| 43 | AP2M1 | ENSG00000161203.13 | 26819 | -0.144 | -0.4317 | No | ||
| 44 | HLA-DOB | ENSG00000241106.8 | 26961 | -0.148 | -0.4317 | No | ||
| 45 | OSBPL1A | ENSG00000141447.18 | 27014 | -0.150 | -0.4295 | No | ||
| 46 | SEC24C | ENSG00000176986.16 | 27265 | -0.157 | -0.4320 | No | ||
| 47 | AP2A1 | ENSG00000196961.12 | 27276 | -0.157 | -0.4286 | No | ||
| 48 | AP2A2 | ENSG00000183020.13 | 27410 | -0.161 | -0.4282 | No | ||
| 49 | KIFAP3 | ENSG00000075945.13 | 27710 | -0.171 | -0.4315 | No | ||
| 50 | ACTR1B | ENSG00000115073.8 | 27745 | -0.172 | -0.4284 | No | ||
| 51 | SEC24D | ENSG00000150961.15 | 27788 | -0.173 | -0.4254 | No | ||
| 52 | TUBA3C | ENSG00000198033.12 | 27829 | -0.175 | -0.4224 | No | ||
| 53 | SAR1B | ENSG00000152700.14 | 28046 | -0.182 | -0.4235 | No | ||
| 54 | DCTN4 | ENSG00000132912.12 | 28497 | -0.197 | -0.4299 | No | ||
| 55 | HLA-DRB1 | ENSG00000196126.11 | 28911 | -0.209 | -0.4352 | No | ||
| 56 | SEC24B | ENSG00000138802.11 | 29309 | -0.222 | -0.4397 | No | ||
| 57 | TUBA3E | ENSG00000152086.9 | 29330 | -0.222 | -0.4351 | No | ||
| 58 | AP1G1 | ENSG00000166747.12 | 30442 | -0.258 | -0.4562 | No | ||
| 59 | TUBB8 | ENSG00000261456.5 | 30717 | -0.267 | -0.4568 | No | ||
| 60 | CTSK | ENSG00000143387.13 | 30865 | -0.272 | -0.4541 | No | ||
| 61 | KIF22 | ENSG00000079616.12 | 30925 | -0.274 | -0.4492 | No | ||
| 62 | DCTN5 | ENSG00000166847.10 | 31044 | -0.279 | -0.4457 | No | ||
| 63 | KIF3C | ENSG00000084731.15 | 31061 | -0.279 | -0.4397 | No | ||
| 64 | TUBB4A | ENSG00000104833.12 | 31106 | -0.281 | -0.4343 | No | ||
| 65 | SEC31A | ENSG00000138674.17 | 31154 | -0.283 | -0.4289 | No | ||
| 66 | DYNC1H1 | ENSG00000197102.12 | 31822 | -0.290 | -0.4385 | No | ||
| 67 | CTSA | ENSG00000064601.18 | 32764 | -0.326 | -0.4539 | No | ||
| 68 | DCTN2 | ENSG00000175203.15 | 32923 | -0.333 | -0.4501 | No | ||
| 69 | HLA-DOA | ENSG00000204252.14 | 32977 | -0.335 | -0.4437 | No | ||
| 70 | TUBAL3 | ENSG00000178462.12 | 33185 | -0.336 | -0.4410 | No | ||
| 71 | AP1B1 | ENSG00000100280.16 | 34073 | -0.344 | -0.4547 | No | ||
| 72 | HLA-DPA1 | ENSG00000231389.7 | 35055 | -0.368 | -0.4701 | Yes | ||
| 73 | KIF3A | ENSG00000131437.15 | 35070 | -0.368 | -0.4620 | Yes | ||
| 74 | CLTA | ENSG00000122705.17 | 35217 | -0.375 | -0.4569 | Yes | ||
| 75 | CAPZB | ENSG00000077549.18 | 35414 | -0.384 | -0.4529 | Yes | ||
| 76 | DCTN1 | ENSG00000204843.12 | 35697 | -0.397 | -0.4506 | Yes | ||
| 77 | KIF20A | ENSG00000112984.12 | 35970 | -0.404 | -0.4479 | Yes | ||
| 78 | AP2B1 | ENSG00000006125.18 | 35998 | -0.406 | -0.4393 | Yes | ||
| 79 | DYNC1I2 | ENSG00000077380.15 | 36153 | -0.411 | -0.4335 | Yes | ||
| 80 | DCTN6 | ENSG00000104671.8 | 36330 | -0.417 | -0.4282 | Yes | ||
| 81 | AP1S1 | ENSG00000106367.15 | 36495 | -0.426 | -0.4224 | Yes | ||
| 82 | SEC24A | ENSG00000113615.13 | 36665 | -0.434 | -0.4165 | Yes | ||
| 83 | KIF2C | ENSG00000142945.13 | 36852 | -0.443 | -0.4109 | Yes | ||
| 84 | RAB7A | ENSG00000075785.12 | 36901 | -0.446 | -0.4018 | Yes | ||
| 85 | ACTR1A | ENSG00000138107.13 | 36970 | -0.450 | -0.3931 | Yes | ||
| 86 | KIF2A | ENSG00000068796.16 | 36994 | -0.452 | -0.3832 | Yes | ||
| 87 | HLA-DMA | ENSG00000204257.15 | 37225 | -0.465 | -0.3782 | Yes | ||
| 88 | TUBA1B | ENSG00000123416.15 | 37411 | -0.478 | -0.3717 | Yes | ||
| 89 | AP1S3 | ENSG00000152056.17 | 37559 | -0.489 | -0.3640 | Yes | ||
| 90 | KIF4A | ENSG00000090889.12 | 37615 | -0.495 | -0.3539 | Yes | ||
| 91 | HLA-DMB | ENSG00000242574.9 | 37679 | -0.501 | -0.3440 | Yes | ||
| 92 | KIF3B | ENSG00000101350.8 | 37801 | -0.512 | -0.3351 | Yes | ||
| 93 | SEC23A | ENSG00000100934.15 | 37819 | -0.514 | -0.3237 | Yes | ||
| 94 | CLTC | ENSG00000141367.12 | 37942 | -0.523 | -0.3146 | Yes | ||
| 95 | CAPZA2 | ENSG00000198898.14 | 38185 | -0.541 | -0.3081 | Yes | ||
| 96 | KIF15 | ENSG00000163808.17 | 38204 | -0.543 | -0.2960 | Yes | ||
| 97 | DYNC1LI1 | ENSG00000144635.9 | 38271 | -0.548 | -0.2850 | Yes | ||
| 98 | DYNLL1 | ENSG00000088986.11 | 38317 | -0.554 | -0.2734 | Yes | ||
| 99 | TUBA1A | ENSG00000167552.14 | 38598 | -0.561 | -0.2673 | Yes | ||
| 100 | AP1M1 | ENSG00000072958.8 | 38869 | -0.587 | -0.2604 | Yes | ||
| 101 | DNM3 | ENSG00000197959.14 | 38960 | -0.596 | -0.2489 | Yes | ||
| 102 | AP1S2 | ENSG00000182287.15 | 39189 | -0.618 | -0.2402 | Yes | ||
| 103 | IFI30 | ENSG00000216490.4 | 39276 | -0.621 | -0.2280 | Yes | ||
| 104 | CAPZA1 | ENSG00000116489.13 | 39314 | -0.624 | -0.2145 | Yes | ||
| 105 | ACTR10 | ENSG00000131966.14 | 39413 | -0.627 | -0.2025 | Yes | ||
| 106 | RACGAP1 | ENSG00000161800.13 | 39469 | -0.633 | -0.1893 | Yes | ||
| 107 | KIF4B | ENSG00000226650.6 | 39776 | -0.670 | -0.1813 | Yes | ||
| 108 | TUBB4B | ENSG00000188229.6 | 40106 | -0.733 | -0.1725 | Yes | ||
| 109 | TUBB2B | ENSG00000137285.10 | 40109 | -0.733 | -0.1557 | Yes | ||
| 110 | CENPE | ENSG00000138778.12 | 40145 | -0.740 | -0.1395 | Yes | ||
| 111 | TUBB2A | ENSG00000137267.6 | 40266 | -0.768 | -0.1247 | Yes | ||
| 112 | TUBA1C | ENSG00000167553.15 | 40512 | -0.843 | -0.1113 | Yes | ||
| 113 | KIF11 | ENSG00000138160.6 | 40519 | -0.845 | -0.0920 | Yes | ||
| 114 | AP1M2 | ENSG00000129354.11 | 40522 | -0.847 | -0.0726 | Yes | ||
| 115 | KLC3 | ENSG00000104892.17 | 40542 | -0.855 | -0.0533 | Yes | ||
| 116 | KIF5B | ENSG00000170759.11 | 40785 | -0.954 | -0.0373 | Yes | ||
| 117 | TUBB6 | ENSG00000176014.13 | 40817 | -0.979 | -0.0155 | Yes | ||
| 118 | KIF18A | ENSG00000121621.7 | 40921 | -1.038 | 0.0058 | Yes |
