Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH |
| Phenotype | Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH |
| Upregulated in class | ARH |
| GeneSet | REACTOME_ORC1_REMOVAL_FROM_CHROMATIN |
| Enrichment Score (ES) | -0.54618627 |
| Normalized Enrichment Score (NES) | -2.4326074 |
| Nominal p-value | 0.0 |
| FDR q-value | 9.4003524E-5 |
| FWER p-Value | 0.001 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | PSMB8 | ENSG00000204264.11 | 14058 | 0.204 | -0.3304 | No | ||
| 2 | MCM7 | ENSG00000166508.17 | 17495 | 0.104 | -0.4080 | No | ||
| 3 | CCNA1 | ENSG00000133101.10 | 17734 | 0.098 | -0.4081 | No | ||
| 4 | PSME2 | ENSG00000100911.16 | 19274 | 0.057 | -0.4423 | No | ||
| 5 | PSMA3 | ENSG00000100567.13 | 19401 | 0.054 | -0.4423 | No | ||
| 6 | PSMA2 | ENSG00000106588.11 | 19562 | 0.050 | -0.4433 | No | ||
| 7 | ORC2 | ENSG00000115942.9 | 19607 | 0.048 | -0.4416 | No | ||
| 8 | PSMB10 | ENSG00000205220.12 | 19937 | 0.040 | -0.4473 | No | ||
| 9 | PSMC4 | ENSG00000013275.8 | 20810 | 0.018 | -0.4675 | No | ||
| 10 | UBC | ENSG00000150991.15 | 20948 | 0.013 | -0.4700 | No | ||
| 11 | PSMA6 | ENSG00000100902.11 | 20976 | 0.013 | -0.4700 | No | ||
| 12 | PSMB4 | ENSG00000159377.11 | 21127 | 0.007 | -0.4732 | No | ||
| 13 | UBB | ENSG00000170315.14 | 22145 | -0.016 | -0.4970 | No | ||
| 14 | UBA52 | ENSG00000221983.8 | 22256 | -0.020 | -0.4986 | No | ||
| 15 | PSMD3 | ENSG00000108344.15 | 23004 | -0.040 | -0.5144 | No | ||
| 16 | PSME1 | ENSG00000092010.15 | 23061 | -0.041 | -0.5134 | No | ||
| 17 | PSMA1 | ENSG00000129084.17 | 23337 | -0.048 | -0.5174 | No | ||
| 18 | PSMB9 | ENSG00000240065.8 | 23347 | -0.048 | -0.5148 | No | ||
| 19 | ORC5 | ENSG00000164815.11 | 23413 | -0.050 | -0.5135 | No | ||
| 20 | SEM1 | ENSG00000127922.9 | 24231 | -0.071 | -0.5293 | No | ||
| 21 | CUL1 | ENSG00000055130.17 | 24550 | -0.079 | -0.5325 | No | ||
| 22 | PSMB7 | ENSG00000136930.13 | 24754 | -0.084 | -0.5326 | No | ||
| 23 | RPS27A | ENSG00000143947.13 | 24801 | -0.086 | -0.5288 | No | ||
| 24 | PSMB1 | ENSG00000008018.9 | 25518 | -0.106 | -0.5401 | Yes | ||
| 25 | PSMB6 | ENSG00000142507.10 | 25718 | -0.112 | -0.5385 | Yes | ||
| 26 | PSMD8 | ENSG00000099341.11 | 25815 | -0.114 | -0.5343 | Yes | ||
| 27 | PSMB2 | ENSG00000126067.12 | 26219 | -0.126 | -0.5368 | Yes | ||
| 28 | PSMD2 | ENSG00000175166.17 | 26310 | -0.129 | -0.5315 | Yes | ||
| 29 | PSMD9 | ENSG00000110801.14 | 26323 | -0.129 | -0.5244 | Yes | ||
| 30 | PSMA7 | ENSG00000101182.15 | 26454 | -0.134 | -0.5198 | Yes | ||
| 31 | PSMC1 | ENSG00000100764.14 | 26467 | -0.134 | -0.5124 | Yes | ||
| 32 | PSMF1 | ENSG00000125818.18 | 26669 | -0.140 | -0.5092 | Yes | ||
| 33 | PSMD4 | ENSG00000159352.15 | 26816 | -0.144 | -0.5045 | Yes | ||
| 34 | PSMD13 | ENSG00000185627.18 | 27620 | -0.168 | -0.5143 | Yes | ||
| 35 | PSMD11 | ENSG00000108671.11 | 27717 | -0.171 | -0.5068 | Yes | ||
| 36 | PSMC5 | ENSG00000087191.13 | 27761 | -0.172 | -0.4979 | Yes | ||
| 37 | PSMB3 | ENSG00000277791.5 | 27956 | -0.179 | -0.4923 | Yes | ||
| 38 | ORC4 | ENSG00000115947.13 | 28129 | -0.185 | -0.4859 | Yes | ||
| 39 | PSMD6 | ENSG00000163636.10 | 28425 | -0.194 | -0.4819 | Yes | ||
| 40 | PSMC6 | ENSG00000100519.12 | 28449 | -0.195 | -0.4712 | Yes | ||
| 41 | PSMC3 | ENSG00000165916.8 | 28625 | -0.200 | -0.4639 | Yes | ||
| 42 | SKP1 | ENSG00000113558.18 | 28827 | -0.206 | -0.4569 | Yes | ||
| 43 | MCM3 | ENSG00000112118.20 | 29007 | -0.212 | -0.4491 | Yes | ||
| 44 | PSMD7 | ENSG00000103035.11 | 30001 | -0.244 | -0.4592 | Yes | ||
| 45 | PSMA4 | ENSG00000041357.16 | 30107 | -0.247 | -0.4475 | Yes | ||
| 46 | MCM8 | ENSG00000125885.13 | 31052 | -0.279 | -0.4544 | Yes | ||
| 47 | PSMA8 | ENSG00000154611.14 | 31324 | -0.285 | -0.4445 | Yes | ||
| 48 | CDK2 | ENSG00000123374.11 | 32246 | -0.307 | -0.4492 | Yes | ||
| 49 | RBX1 | ENSG00000100387.9 | 32483 | -0.316 | -0.4367 | Yes | ||
| 50 | MCM2 | ENSG00000073111.14 | 32546 | -0.318 | -0.4199 | Yes | ||
| 51 | PSMD10 | ENSG00000101843.19 | 32694 | -0.324 | -0.4048 | Yes | ||
| 52 | PSMD12 | ENSG00000197170.10 | 32756 | -0.326 | -0.3875 | Yes | ||
| 53 | MCM6 | ENSG00000076003.5 | 34728 | -0.357 | -0.4149 | Yes | ||
| 54 | PSMB5 | ENSG00000100804.19 | 35039 | -0.367 | -0.4013 | Yes | ||
| 55 | PSMD5 | ENSG00000095261.14 | 35294 | -0.378 | -0.3857 | Yes | ||
| 56 | PSME3 | ENSG00000131467.11 | 35430 | -0.385 | -0.3667 | Yes | ||
| 57 | PSMA5 | ENSG00000143106.13 | 35640 | -0.395 | -0.3490 | Yes | ||
| 58 | CDT1 | ENSG00000167513.9 | 35789 | -0.401 | -0.3295 | Yes | ||
| 59 | MCM5 | ENSG00000100297.16 | 35805 | -0.402 | -0.3067 | Yes | ||
| 60 | PSMC2 | ENSG00000161057.12 | 35948 | -0.403 | -0.2869 | Yes | ||
| 61 | ORC3 | ENSG00000135336.14 | 36389 | -0.421 | -0.2734 | Yes | ||
| 62 | PSMD14 | ENSG00000115233.12 | 36419 | -0.422 | -0.2498 | Yes | ||
| 63 | ORC1 | ENSG00000085840.13 | 37179 | -0.462 | -0.2416 | Yes | ||
| 64 | PSMD1 | ENSG00000173692.13 | 37725 | -0.504 | -0.2258 | Yes | ||
| 65 | PSME4 | ENSG00000068878.15 | 38072 | -0.532 | -0.2035 | Yes | ||
| 66 | ORC6 | ENSG00000091651.9 | 38888 | -0.589 | -0.1894 | Yes | ||
| 67 | CDC6 | ENSG00000094804.12 | 40060 | -0.723 | -0.1762 | Yes | ||
| 68 | SKP2 | ENSG00000145604.16 | 40211 | -0.755 | -0.1363 | Yes | ||
| 69 | MCM4 | ENSG00000104738.18 | 40591 | -0.872 | -0.0952 | Yes | ||
| 70 | CCNA2 | ENSG00000145386.10 | 40598 | -0.874 | -0.0450 | Yes | ||
| 71 | PSMB11 | ENSG00000222028.5 | 40874 | -1.018 | 0.0070 | Yes |
