Details for gene set REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Phenotype	Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Upregulated in class	FSHD2
GeneSet	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES
Enrichment Score (ES)	0.37891006
Normalized Enrichment Score (NES)	1.6264288
Nominal p-value	0.0031496063
FDR q-value	0.16778718
FWER p-Value	1.0

Fig 1: Enrichment plot: REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	SLITRK2	ENSG00000185985.10			52	1.628	0.0434	Yes
2	SLITRK5	ENSG00000165300.7			105	1.414	0.0809	Yes
3	SLITRK4	ENSG00000179542.16			259	1.164	0.1091	Yes
4	GRM5	ENSG00000168959.14			374	1.077	0.1358	Yes
5	EPB41	ENSG00000159023.21			916	0.879	0.1467	Yes
6	SYT7	ENSG00000011347.9			1114	0.834	0.1648	Yes
7	SHANK1	ENSG00000161681.15			1204	0.817	0.1851	Yes
8	BEGAIN	ENSG00000183092.16			1379	0.791	0.2025	Yes
9	LRRTM4	ENSG00000176204.13			1622	0.756	0.2173	Yes
10	PPFIA2	ENSG00000139220.16			1802	0.733	0.2331	Yes
11	PPFIBP2	ENSG00000166387.13			2053	0.698	0.2461	Yes
12	NLGN4Y	ENSG00000165246.14			2146	0.688	0.2628	Yes
13	LRRC4B	ENSG00000131409.13			2177	0.686	0.2809	Yes
14	GRIN1	ENSG00000176884.15			2182	0.686	0.2995	Yes
15	GRIN2C	ENSG00000161509.14			3016	0.605	0.2958	Yes
16	GRIN2D	ENSG00000105464.3			3138	0.596	0.3092	Yes
17	DLG4	ENSG00000132535.19			3287	0.584	0.3217	Yes
18	AC005954.1	ENSG00000267138.1			3787	0.551	0.3246	Yes
19	LRFN2	ENSG00000156564.9			3853	0.547	0.3380	Yes
20	NLGN3	ENSG00000196338.12			3869	0.547	0.3526	Yes
21	SYT9	ENSG00000170743.17			3970	0.542	0.3651	Yes
22	SHANK2	ENSG00000162105.19			4607	0.513	0.3636	Yes
23	SYT10	ENSG00000110975.8			4643	0.512	0.3768	Yes
24	DLGAP3	ENSG00000116544.12			5257	0.474	0.3749	Yes
25	SLITRK1	ENSG00000178235.7			5801	0.443	0.3738	Yes
26	GRIN2B	ENSG00000273079.5			6565	0.405	0.3664	Yes
27	SLITRK6	ENSG00000184564.11			6857	0.394	0.3701	Yes
28	LRRTM2	ENSG00000146006.8			6937	0.392	0.3789	Yes
29	SYT12	ENSG00000173227.14			7802	0.362	0.3678	No
30	PPFIA3	ENSG00000177380.14			9332	0.322	0.3394	No
31	NLGN4X	ENSG00000146938.16			10948	0.293	0.3081	No
32	DLG3	ENSG00000082458.12			11151	0.285	0.3110	No
33	NLGN2	ENSG00000169992.10			11877	0.275	0.3009	No
34	PTPRS	ENSG00000105426.16			12480	0.255	0.2933	No
35	LRFN1	ENSG00000128011.4			12899	0.241	0.2897	No
36	PPFIA4	ENSG00000143847.15			13557	0.220	0.2797	No
37	GRIA1	ENSG00000155511.18			13800	0.213	0.2797	No
38	APBA2	ENSG00000034053.14			14052	0.204	0.2792	No
39	SYT2	ENSG00000143858.12			14514	0.190	0.2732	No
40	HOMER3	ENSG00000051128.19			14643	0.186	0.2751	No
41	PTPRD	ENSG00000153707.17			15413	0.161	0.2608	No
42	GRIA3	ENSG00000125675.18			15568	0.157	0.2614	No
43	NTRK3	ENSG00000140538.16			15638	0.155	0.2640	No
44	LRFN3	ENSG00000126243.8			16530	0.130	0.2459	No
45	IL1RAPL2	ENSG00000189108.13			17767	0.097	0.2184	No
46	IL1RAP	ENSG00000196083.10			19912	0.041	0.1674	No
47	LIN7B	ENSG00000104863.12			20102	0.037	0.1638	No
48	DLG2	ENSG00000150672.17			20501	0.024	0.1547	No
49	EPB41L3	ENSG00000082397.17			20603	0.022	0.1529	No
50	SHARPIN	ENSG00000179526.17			20639	0.021	0.1526	No
51	STX1A	ENSG00000106089.12			21247	0.005	0.1380	No
52	IL1RAPL1	ENSG00000169306.10			23578	-0.055	0.0828	No
53	PPFIA1	ENSG00000131626.18			24477	-0.077	0.0630	No
54	DLGAP4	ENSG00000080845.17			24771	-0.085	0.0582	No
55	DBNL	ENSG00000136279.20			25322	-0.100	0.0475	No
56	NLGN1	ENSG00000169760.17			25527	-0.106	0.0455	No
57	CASK	ENSG00000147044.21			26307	-0.129	0.0300	No
58	LIN7A	ENSG00000111052.7			26675	-0.140	0.0249	No
59	HOMER1	ENSG00000152413.15			28384	-0.192	-0.0114	No
60	FLOT2	ENSG00000132589.16			28570	-0.198	-0.0105	No
61	SHANK3	ENSG00000251322.8			29602	-0.230	-0.0292	No
62	LRFN4	ENSG00000173621.9			29933	-0.242	-0.0306	No
63	SLITRK3	ENSG00000121871.4			30133	-0.248	-0.0287	No
64	RTN3	ENSG00000133318.14			30339	-0.255	-0.0267	No
65	GRM1	ENSG00000152822.14			30417	-0.257	-0.0215	No
66	LRRTM3	ENSG00000198739.11			30506	-0.260	-0.0165	No
67	APBA1	ENSG00000107282.8			30789	-0.269	-0.0160	No
68	SIPA1L1	ENSG00000197555.9			31158	-0.283	-0.0172	No
69	STXBP1	ENSG00000136854.21			31972	-0.295	-0.0289	No
70	NRXN2	ENSG00000110076.18			32739	-0.325	-0.0386	No
71	PPFIBP1	ENSG00000110841.14			32972	-0.335	-0.0351	No
72	SYT1	ENSG00000067715.14			33600	-0.340	-0.0410	No
73	NRXN1	ENSG00000179915.23			34602	-0.352	-0.0558	No
74	DLGAP2	ENSG00000198010.12			34606	-0.352	-0.0462	No
75	FLOT1	ENSG00000137312.15			34673	-0.355	-0.0381	No
76	DLG1	ENSG00000075711.21			35280	-0.377	-0.0425	No
77	GRIA4	ENSG00000152578.13			35362	-0.382	-0.0340	No
78	LIN7C	ENSG00000148943.12			35551	-0.391	-0.0278	No
79	DLGAP1	ENSG00000170579.17			36379	-0.420	-0.0365	No
80	EPB41L5	ENSG00000115109.14			36945	-0.449	-0.0379	No
81	NRXN3	ENSG00000021645.18			37213	-0.464	-0.0317	No
82	HOMER2	ENSG00000103942.13			37764	-0.508	-0.0311	No
83	PTPRF	ENSG00000142949.17			38859	-0.586	-0.0417	No
84	LRRTM1	ENSG00000162951.11			39016	-0.602	-0.0290	No
85	EPB41L1	ENSG00000088367.23			39064	-0.608	-0.0135	No
86	PDLIM5	ENSG00000163110.15			40169	-0.746	-0.0199	No
87	EPB41L2	ENSG00000079819.19			40303	-0.778	-0.0018	No
88	GRIN2A	ENSG00000183454.17			40459	-0.827	0.0171	No

Fig 2: REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES: Random ES distribution   
Gene set null distribution of ES for REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES