Details for gene set REACTOME_SIGNALING_BY_RHO_GTPASES[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Phenotype	Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Upregulated in class	ARH
GeneSet	REACTOME_SIGNALING_BY_RHO_GTPASES
Enrichment Score (ES)	-0.37870476
Normalized Enrichment Score (NES)	-2.239047
Nominal p-value	0.0
FDR q-value	4.1427696E-4
FWER p-Value	0.01

Fig 1: Enrichment plot: REACTOME_SIGNALING_BY_RHO_GTPASES   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	RHOU	ENSG00000116574.6			27	1.808	0.0109	No
2	ARHGAP8	ENSG00000241484.9			28	1.803	0.0224	No
3	ARHGEF4	ENSG00000136002.19			91	1.474	0.0303	No
4	RHOJ	ENSG00000126785.13			271	1.153	0.0332	No
5	PRKCZ	ENSG00000067606.17			345	1.095	0.0384	No
6	ARHGEF26	ENSG00000114790.13			531	1.002	0.0403	No
7	OBSCN	ENSG00000154358.21			663	0.954	0.0431	No
8	RHOF	ENSG00000139725.8			871	0.891	0.0437	No
9	ARHGAP6	ENSG00000047648.23			1010	0.857	0.0458	No
10	WAS	ENSG00000015285.10			1194	0.819	0.0466	No
11	ARHGDIB	ENSG00000111348.9			1205	0.817	0.0515	No
12	ARHGEF37	ENSG00000183111.12			1208	0.817	0.0567	No
13	PAK3	ENSG00000077264.15			1408	0.788	0.0568	No
14	KALRN	ENSG00000160145.15			1565	0.764	0.0579	No
15	RHOV	ENSG00000104140.7			1947	0.712	0.0531	No
16	HIST1H4D	ENSG00000277157.1			2603	0.643	0.0411	No
17	ARHGDIG	ENSG00000242173.10			3062	0.601	0.0337	No
18	ARHGEF10	ENSG00000104728.16			3173	0.593	0.0348	No
19	ABL1	ENSG00000097007.19			3251	0.588	0.0366	No
20	DLG4	ENSG00000132535.19			3287	0.584	0.0395	No
21	NOXA1	ENSG00000188747.8			3296	0.584	0.0430	No
22	TAGAP	ENSG00000164691.17			3391	0.576	0.0444	No
23	MCF2	ENSG00000101977.21			3514	0.566	0.0450	No
24	KIF5A	ENSG00000155980.12			3665	0.560	0.0449	No
25	VAV3	ENSG00000134215.16			4256	0.527	0.0338	No
26	CDKN1B	ENSG00000111276.11			4380	0.521	0.0341	No
27	ARHGAP20	ENSG00000137727.12			4799	0.504	0.0270	No
28	EVL	ENSG00000196405.13			5263	0.474	0.0187	No
29	FGD3	ENSG00000127084.19			5298	0.471	0.0208	No
30	HIST1H2BK	ENSG00000197903.7			5394	0.465	0.0215	No
31	ARHGAP36	ENSG00000147256.12			5441	0.463	0.0233	No
32	FAM13A	ENSG00000138640.15			5706	0.448	0.0197	No
33	A2M	ENSG00000175899.14			5880	0.440	0.0182	No
34	AR	ENSG00000169083.17			5886	0.439	0.0209	No
35	RHPN1	ENSG00000158106.14			5925	0.437	0.0228	No
36	ABR	ENSG00000159842.15			6000	0.433	0.0237	No
37	HIST1H4E	ENSG00000276966.2			6244	0.421	0.0204	No
38	ARPC1B	ENSG00000130429.15			6271	0.419	0.0225	No
39	HIST2H2AA3	ENSG00000203812.2			6372	0.414	0.0227	No
40	IQGAP2	ENSG00000145703.16			6469	0.409	0.0229	No
41	INPP5B	ENSG00000204084.13			6524	0.407	0.0242	No
42	KLC4	ENSG00000137171.15			6556	0.406	0.0260	No
43	HIST2H3D	ENSG00000183598.3			6567	0.405	0.0284	No
44	S100A8	ENSG00000143546.10			7056	0.387	0.0188	No
45	DYNC1I1	ENSG00000158560.14			7076	0.386	0.0208	No
46	CYBB	ENSG00000165168.7			7450	0.372	0.0141	No
47	KLK2	ENSG00000167751.13			7852	0.362	0.0065	No
48	TUBB1	ENSG00000101162.3			8127	0.356	0.0021	No
49	MEN1	ENSG00000133895.15			8178	0.354	0.0031	No
50	ARHGAP33	ENSG00000004777.18			8185	0.354	0.0052	No
51	HIST4H4	ENSG00000197837.3			8220	0.353	0.0066	No
52	PREX1	ENSG00000124126.14			8560	0.349	0.0005	No
53	MCF2L	ENSG00000126217.21			9062	0.333	-0.0096	No
54	RCC2	ENSG00000179051.14			9112	0.331	-0.0087	No
55	ARHGEF15	ENSG00000198844.12			9150	0.329	-0.0076	No
56	RHOH	ENSG00000168421.13			9330	0.322	-0.0099	No
57	RHOT2	ENSG00000140983.14			9334	0.322	-0.0079	No
58	RASGRF2	ENSG00000113319.13			9355	0.321	-0.0064	No
59	ARHGEF1	ENSG00000076928.17			9391	0.319	-0.0052	No
60	ARHGEF19	ENSG00000142632.17			9844	0.317	-0.0143	No
61	HIST1H2BM	ENSG00000273703.1			10385	0.305	-0.0256	No
62	TUBA3D	ENSG00000075886.11			10693	0.303	-0.0312	No
63	RTKN	ENSG00000114993.17			10789	0.299	-0.0316	No
64	ARHGAP44	ENSG00000006740.17			10817	0.298	-0.0304	No
65	CENPP	ENSG00000188312.14			10894	0.295	-0.0303	No
66	H2AFB1	ENSG00000274183.1			10917	0.294	-0.0290	No
67	NCKAP1L	ENSG00000123338.13			11030	0.289	-0.0299	No
68	HIST1H3A	ENSG00000275714.1			11153	0.285	-0.0311	No
69	HIST1H2AB	ENSG00000278463.1			11645	0.285	-0.0413	No
70	FGD4	ENSG00000139132.14			11874	0.275	-0.0452	No
71	HIST1H3E	ENSG00000274750.2			11945	0.273	-0.0451	No
72	BCR	ENSG00000186716.21			12013	0.270	-0.0451	No
73	NOXO1	ENSG00000196408.11			12048	0.269	-0.0442	No
74	BTK	ENSG00000010671.15			12211	0.264	-0.0465	No
75	HIST1H3I	ENSG00000275379.1			12235	0.263	-0.0454	No
76	ARHGAP15	ENSG00000075884.14			12247	0.263	-0.0440	No
77	MYH10	ENSG00000133026.12			12352	0.259	-0.0449	No
78	ARHGAP28	ENSG00000088756.12			12493	0.255	-0.0467	No
79	HIST1H2BH	ENSG00000275713.2			12502	0.254	-0.0452	No
80	H3F3B	ENSG00000132475.10			12860	0.243	-0.0525	No
81	DVL2	ENSG00000004975.12			13260	0.230	-0.0608	No
82	CHN2	ENSG00000106069.22			13503	0.221	-0.0653	No
83	ARHGEF11	ENSG00000132694.18			13549	0.221	-0.0650	No
84	ITGB3BP	ENSG00000142856.16			13741	0.215	-0.0683	No
85	HIST3H2BB	ENSG00000196890.4			13749	0.214	-0.0671	No
86	ARAP3	ENSG00000120318.16			13943	0.208	-0.0706	No
87	RHOD	ENSG00000173156.7			13948	0.208	-0.0693	No
88	B9D2	ENSG00000123810.8			14121	0.202	-0.0723	No
89	HIST1H4H	ENSG00000158406.4			14785	0.181	-0.0874	No
90	KLC1	ENSG00000126214.21			14819	0.180	-0.0870	No
91	CYFIP2	ENSG00000055163.20			14875	0.178	-0.0873	No
92	PIK3R2	ENSG00000105647.18			15272	0.165	-0.0959	No
93	TUBB3	ENSG00000258947.7			15608	0.156	-0.1032	No
94	RPS27	ENSG00000177954.14			15622	0.156	-0.1025	No
95	RANGAP1	ENSG00000100401.19			15733	0.152	-0.1042	No
96	CENPC	ENSG00000145241.11			15881	0.148	-0.1069	No
97	HIST1H2BD	ENSG00000158373.8			15903	0.147	-0.1065	No
98	HIST1H3H	ENSG00000278828.1			16040	0.144	-0.1089	No
99	RHOB	ENSG00000143878.10			16535	0.130	-0.1202	No
100	HIST1H2BJ	ENSG00000124635.8			16824	0.122	-0.1265	No
101	PPP2R5A	ENSG00000066027.12			16937	0.118	-0.1285	No
102	FMNL1	ENSG00000184922.14			17281	0.110	-0.1362	No
103	ARHGEF35	ENSG00000213214.4			17366	0.108	-0.1376	No
104	AKAP13	ENSG00000170776.21			17381	0.108	-0.1372	No
105	GOPC	ENSG00000047932.14			17583	0.101	-0.1415	No
106	HIST1H4I	ENSG00000276180.1			17620	0.100	-0.1418	No
107	HIST1H2BG	ENSG00000273802.2			17796	0.096	-0.1454	No
108	PMF1	ENSG00000160783.19			17911	0.093	-0.1476	No
109	PLEKHG2	ENSG00000090924.15			17977	0.091	-0.1487	No
110	ARAP1	ENSG00000186635.14			18374	0.082	-0.1579	No
111	ARHGAP26	ENSG00000145819.18			18424	0.081	-0.1585	No
112	ARAP2	ENSG00000047365.12			18482	0.080	-0.1594	No
113	ARHGEF5	ENSG00000050327.15			18743	0.072	-0.1654	No
114	NUP160	ENSG00000030066.13			18845	0.069	-0.1674	No
115	HIST1H2AC	ENSG00000180573.9			18977	0.066	-0.1702	No
116	TUBA4B	ENSG00000243910.8			19289	0.057	-0.1775	No
117	ARHGAP29	ENSG00000137962.13			19325	0.056	-0.1780	No
118	MAPK11	ENSG00000185386.15			19782	0.044	-0.1889	No
119	ARHGAP4	ENSG00000089820.15			19943	0.040	-0.1926	No
120	DVL1	ENSG00000107404.20			19947	0.040	-0.1924	No
121	NUP43	ENSG00000120253.14			20047	0.038	-0.1946	No
122	HIST1H2BE	ENSG00000274290.2			20074	0.038	-0.1950	No
123	CENPT	ENSG00000102901.13			20096	0.037	-0.1952	No
124	LIN7B	ENSG00000104863.12			20102	0.037	-0.1951	No
125	HIST1H3J	ENSG00000197153.4			20172	0.035	-0.1966	No
126	HIST1H2BL	ENSG00000185130.5			20206	0.034	-0.1972	No
127	HIST1H4J	ENSG00000197238.4			20458	0.026	-0.2032	No
128	TIAM1	ENSG00000156299.13			20475	0.025	-0.2034	No
129	ARHGEF39	ENSG00000137135.18			20505	0.024	-0.2040	No
130	PIK3R4	ENSG00000196455.8			20595	0.022	-0.2060	No
131	TIAM2	ENSG00000146426.18			20666	0.021	-0.2076	No
132	HIST1H2BF	ENSG00000277224.2			20928	0.014	-0.2139	No
133	HIST1H2BO	ENSG00000274641.1			21190	0.007	-0.2203	No
134	TUBA4A	ENSG00000127824.14			21284	0.004	-0.2225	No
135	SFN	ENSG00000175793.12			21306	0.004	-0.2230	No
136	ARHGEF18	ENSG00000104880.18			21465	0.000	-0.2269	No
137	HIST2H2AC	ENSG00000184260.5			21544	-0.002	-0.2288	No
138	CYBA	ENSG00000051523.11			21714	-0.007	-0.2329	No
139	ARHGEF7	ENSG00000102606.18			21717	-0.007	-0.2329	No
140	ARHGEF2	ENSG00000116584.19			21758	-0.008	-0.2339	No
141	PPP1R14A	ENSG00000167641.11			22008	-0.015	-0.2399	No
142	ARHGEF33	ENSG00000214694.11			22024	-0.015	-0.2402	No
143	KLC2	ENSG00000174996.11			22207	-0.018	-0.2445	No
144	PRKCA	ENSG00000154229.12			22219	-0.019	-0.2447	No
145	KDM1A	ENSG00000004487.16			22359	-0.022	-0.2479	No
146	SEC13	ENSG00000157020.18			22468	-0.026	-0.2504	No
147	HIST2H2BE	ENSG00000184678.10			22644	-0.030	-0.2545	No
148	SOS1	ENSG00000115904.12			22667	-0.030	-0.2549	No
149	WASF2	ENSG00000158195.11			22827	-0.034	-0.2586	No
150	SYDE2	ENSG00000097096.9			22857	-0.035	-0.2591	No
151	NDEL1	ENSG00000166579.15			22882	-0.036	-0.2594	No
152	DAAM1	ENSG00000100592.15			22886	-0.036	-0.2593	No
153	PLEKHG5	ENSG00000171680.22			22912	-0.037	-0.2596	No
154	GDI1	ENSG00000203879.12			23060	-0.041	-0.2630	No
155	HIST1H4L	ENSG00000275126.1			23088	-0.042	-0.2634	No
156	ARHGAP39	ENSG00000147799.11			23224	-0.045	-0.2664	No
157	CIT	ENSG00000122966.16			23230	-0.045	-0.2662	No
158	DYNLL2	ENSG00000264364.3			23336	-0.048	-0.2685	No
159	HIST1H2BB	ENSG00000276410.3			23366	-0.049	-0.2689	No
160	ARHGAP32	ENSG00000134909.18			23390	-0.050	-0.2692	No
161	MAPK3	ENSG00000102882.12			23490	-0.052	-0.2713	No
162	NUDC	ENSG00000090273.14			23568	-0.054	-0.2728	No
163	GMIP	ENSG00000089639.11			23695	-0.058	-0.2755	No
164	ARHGAP25	ENSG00000163219.12			23727	-0.058	-0.2759	No
165	SEH1L	ENSG00000085415.16			23768	-0.059	-0.2765	No
166	PTK2	ENSG00000169398.19			23810	-0.061	-0.2771	No
167	FGD1	ENSG00000102302.8			23908	-0.064	-0.2791	No
168	NDE1	ENSG00000072864.15			23985	-0.064	-0.2806	No
169	PIK3C3	ENSG00000078142.13			24036	-0.065	-0.2814	No
170	CTNNB1	ENSG00000168036.18			24288	-0.073	-0.2871	No
171	ABI2	ENSG00000138443.16			24458	-0.076	-0.2908	No
172	ARHGEF40	ENSG00000165801.10			24545	-0.078	-0.2924	No
173	RHOBTB2	ENSG00000008853.16			24729	-0.083	-0.2963	No
174	NUP133	ENSG00000069248.12			24802	-0.086	-0.2976	No
175	RHPN2	ENSG00000131941.8			24829	-0.086	-0.2976	No
176	DVL3	ENSG00000161202.20			24922	-0.089	-0.2993	No
177	PPP2R5D	ENSG00000112640.15			24932	-0.090	-0.2990	No
178	MIS12	ENSG00000167842.15			25231	-0.097	-0.3057	No
179	NSL1	ENSG00000117697.15			25239	-0.097	-0.3052	No
180	DYNC1LI2	ENSG00000135720.13			25352	-0.101	-0.3073	No
181	ITSN1	ENSG00000205726.15			25392	-0.102	-0.3076	No
182	RAC3	ENSG00000169750.9			25542	-0.106	-0.3106	No
183	PRKCB	ENSG00000166501.14			25710	-0.111	-0.3140	No
184	HIST1H2BN	ENSG00000233822.4			25715	-0.111	-0.3134	No
185	HIST1H2BC	ENSG00000180596.7			25836	-0.115	-0.3156	No
186	STARD13	ENSG00000133121.21			25957	-0.119	-0.3178	No
187	H3F3A	ENSG00000163041.11			26218	-0.126	-0.3234	No
188	ARHGAP1	ENSG00000175220.12			26230	-0.127	-0.3228	No
189	HIST1H4K	ENSG00000273542.1			26308	-0.129	-0.3239	No
190	ARHGEF3	ENSG00000163947.11			26368	-0.131	-0.3245	No
191	MAPK14	ENSG00000112062.10			26416	-0.133	-0.3248	No
192	BAIAP2	ENSG00000175866.15			26425	-0.133	-0.3242	No
193	VAV2	ENSG00000160293.17			26522	-0.136	-0.3257	No
194	TUBA8	ENSG00000183785.15			26534	-0.136	-0.3251	No
195	H2AFX	ENSG00000188486.3			26590	-0.138	-0.3255	No
196	VAV1	ENSG00000141968.8			26770	-0.143	-0.3290	No
197	NUP107	ENSG00000111581.10			26867	-0.145	-0.3304	No
198	RHOG	ENSG00000177105.10			26871	-0.145	-0.3296	No
199	MYH14	ENSG00000105357.17			26877	-0.146	-0.3288	No
200	BRK1	ENSG00000254999.4			26937	-0.147	-0.3293	No
201	LIMK1	ENSG00000106683.15			27117	-0.153	-0.3327	No
202	ARHGAP10	ENSG00000071205.12			27122	-0.153	-0.3318	No
203	PPP2R5E	ENSG00000154001.14			27182	-0.155	-0.3323	No
204	NCKIPSD	ENSG00000213672.8			27356	-0.160	-0.3355	No
205	PPP1R12B	ENSG00000077157.22			27498	-0.164	-0.3379	No
206	SYDE1	ENSG00000105137.13			27536	-0.166	-0.3378	No
207	CFTR	ENSG00000001626.15			27772	-0.173	-0.3425	No
208	NUP85	ENSG00000125450.11			27774	-0.173	-0.3414	No
209	SCAI	ENSG00000173611.17			27825	-0.175	-0.3415	No
210	TUBA3C	ENSG00000198033.12			27829	-0.175	-0.3405	No
211	MYO9B	ENSG00000099331.13			27847	-0.175	-0.3398	No
212	WASL	ENSG00000106299.8			27968	-0.179	-0.3416	No
213	CLASP1	ENSG00000074054.18			28043	-0.182	-0.3422	No
214	FMNL3	ENSG00000161791.14			28065	-0.183	-0.3416	No
215	PKN2	ENSG00000065243.20			28119	-0.184	-0.3417	No
216	NUP98	ENSG00000110713.17			28185	-0.186	-0.3421	No
217	ARPC4	ENSG00000241553.12			28206	-0.186	-0.3414	No
218	CLASP2	ENSG00000163539.17			28270	-0.189	-0.3417	No
219	PPP1CC	ENSG00000186298.12			28475	-0.195	-0.3455	No
220	ARHGAP35	ENSG00000160007.19			28479	-0.196	-0.3443	No
221	SRC	ENSG00000197122.11			28621	-0.200	-0.3465	No
222	CTTN	ENSG00000085733.16			28654	-0.201	-0.3460	No
223	TRIP10	ENSG00000125733.18			28717	-0.203	-0.3463	No
224	ARHGAP24	ENSG00000138639.18			28741	-0.203	-0.3455	No
225	WIPF1	ENSG00000115935.17			28844	-0.207	-0.3467	No
226	ARHGEF17	ENSG00000110237.5			28938	-0.210	-0.3477	No
227	ARHGEF38	ENSG00000236699.9			29045	-0.213	-0.3489	No
228	PKN3	ENSG00000160447.7			29201	-0.218	-0.3513	No
229	PIN1	ENSG00000127445.13			29228	-0.218	-0.3506	No
230	SRGAP3	ENSG00000196220.16			29273	-0.220	-0.3502	No
231	TUBA3E	ENSG00000152086.9			29330	-0.222	-0.3502	No
232	ARHGEF9	ENSG00000131089.16			29371	-0.224	-0.3497	No
233	WIPF3	ENSG00000122574.10			29782	-0.237	-0.3583	No
234	ARHGAP18	ENSG00000146376.11			29866	-0.240	-0.3588	No
235	DIAPH1	ENSG00000131504.17			29982	-0.243	-0.3601	No
236	NCOA2	ENSG00000140396.13			30070	-0.246	-0.3606	No
237	ARHGAP21	ENSG00000107863.18			30204	-0.250	-0.3623	No
238	NOX1	ENSG00000007952.18			30308	-0.254	-0.3632	No
239	PDPK1	ENSG00000140992.19			30393	-0.256	-0.3636	No
240	CTNNA1	ENSG00000044115.21			30649	-0.264	-0.3682	No
241	PPP2R5C	ENSG00000078304.19			30677	-0.265	-0.3672	No
242	TUBB8	ENSG00000261456.5			30717	-0.267	-0.3665	No
243	ARHGEF6	ENSG00000129675.16			30786	-0.269	-0.3664	No
244	ARHGAP30	ENSG00000186517.14			30794	-0.269	-0.3649	No
245	YWHAQ	ENSG00000134308.14			30852	-0.271	-0.3645	No
246	ZW10	ENSG00000086827.9			30856	-0.271	-0.3629	No
247	OCRL	ENSG00000122126.17			30912	-0.274	-0.3625	No
248	PPP2R1B	ENSG00000137713.16			30954	-0.276	-0.3617	No
249	ARHGEF10L	ENSG00000074964.17			30977	-0.276	-0.3605	No
250	PPP2R5B	ENSG00000068971.14			31101	-0.281	-0.3617	No
251	TUBB4A	ENSG00000104833.12			31106	-0.281	-0.3600	No
252	HIST1H4F	ENSG00000274618.1			31237	-0.285	-0.3614	No
253	ARHGEF16	ENSG00000130762.15			31719	-0.286	-0.3714	No
254	LIMK2	ENSG00000182541.18			31738	-0.287	-0.3700	No
255	CYFIP1	ENSG00000273749.5			31788	-0.289	-0.3694	No
256	RHOC	ENSG00000155366.16			31789	-0.289	-0.3675	No
257	DYNC1H1	ENSG00000197102.12			31822	-0.290	-0.3664	No
258	ARHGAP17	ENSG00000140750.17			31837	-0.291	-0.3649	No
259	ARHGEF12	ENSG00000196914.9			31905	-0.293	-0.3647	No
260	ARHGAP23	ENSG00000275832.5			31919	-0.294	-0.3631	No
261	KTN1	ENSG00000126777.18			32063	-0.299	-0.3648	No
262	BUB3	ENSG00000154473.18			32087	-0.300	-0.3634	No
263	SRGAP1	ENSG00000196935.9			32109	-0.301	-0.3620	No
264	INCENP	ENSG00000149503.13			32126	-0.301	-0.3605	No
265	CENPQ	ENSG00000031691.7			32142	-0.302	-0.3589	No
266	ARHGAP27	ENSG00000159314.11			32245	-0.307	-0.3595	No
267	YWHAG	ENSG00000170027.7			32308	-0.310	-0.3590	No
268	MRTFA	ENSG00000196588.17			32346	-0.311	-0.3579	No
269	CENPO	ENSG00000138092.11			32352	-0.312	-0.3561	No
270	CENPU	ENSG00000151725.12			32395	-0.313	-0.3551	No
271	PPP2CA	ENSG00000113575.10			32408	-0.314	-0.3534	No
272	NUF2	ENSG00000143228.13			32503	-0.317	-0.3537	No
273	RANBP2	ENSG00000153201.16			32550	-0.318	-0.3528	No
274	SOS2	ENSG00000100485.12			32631	-0.321	-0.3527	No
275	ARHGAP9	ENSG00000123329.19			32744	-0.326	-0.3534	No
276	AHCTF1	ENSG00000153207.15			32851	-0.330	-0.3539	No
277	TUBAL3	ENSG00000178462.12			33185	-0.336	-0.3599	No
278	ROPN1	ENSG00000065371.17			33345	-0.336	-0.3616	No
279	PKN1	ENSG00000123143.12			33580	-0.339	-0.3652	No
280	DSN1	ENSG00000149636.15			34130	-0.346	-0.3765	Yes
281	H2AFJ	ENSG00000246705.4			34136	-0.347	-0.3744	Yes
282	GDI2	ENSG00000057608.17			34142	-0.347	-0.3723	Yes
283	ARPC3	ENSG00000111229.16			34158	-0.348	-0.3705	Yes
284	CDC20	ENSG00000117399.14			34187	-0.349	-0.3689	Yes
285	PFN2	ENSG00000070087.14			34203	-0.350	-0.3671	Yes
286	DEPDC7	ENSG00000121690.11			34623	-0.353	-0.3751	Yes
287	HIST1H2AE	ENSG00000277075.2			34697	-0.356	-0.3746	Yes
288	PRKCD	ENSG00000163932.15			34711	-0.356	-0.3727	Yes
289	H2AFV	ENSG00000105968.18			34723	-0.357	-0.3707	Yes
290	PPP2R1A	ENSG00000105568.18			34725	-0.357	-0.3684	Yes
291	TAOK1	ENSG00000160551.11			34732	-0.358	-0.3663	Yes
292	SGO1	ENSG00000129810.15			34782	-0.360	-0.3652	Yes
293	WASF3	ENSG00000132970.14			34998	-0.365	-0.3681	Yes
294	FMNL2	ENSG00000157827.20			35058	-0.368	-0.3672	Yes
295	MYLK	ENSG00000065534.18			35071	-0.368	-0.3652	Yes
296	H2AFZ	ENSG00000164032.12			35129	-0.370	-0.3642	Yes
297	IQGAP3	ENSG00000183856.11			35185	-0.373	-0.3632	Yes
298	CENPH	ENSG00000153044.10			35190	-0.373	-0.3609	Yes
299	GRB2	ENSG00000177885.15			35242	-0.375	-0.3598	Yes
300	MYO9A	ENSG00000066933.16			35301	-0.379	-0.3588	Yes
301	RAC2	ENSG00000128340.15			35304	-0.379	-0.3564	Yes
302	GNA13	ENSG00000120063.10			35417	-0.384	-0.3567	Yes
303	YWHAB	ENSG00000166913.13			35457	-0.386	-0.3552	Yes
304	KDM4C	ENSG00000107077.18			35535	-0.390	-0.3546	Yes
305	CENPS	ENSG00000175279.22			35550	-0.391	-0.3524	Yes
306	RHOT1	ENSG00000126858.18			35588	-0.393	-0.3508	Yes
307	CFL1	ENSG00000172757.13			35593	-0.393	-0.3484	Yes
308	NCF1	ENSG00000158517.15			35600	-0.393	-0.3461	Yes
309	NUP37	ENSG00000075188.9			35611	-0.394	-0.3438	Yes
310	STARD8	ENSG00000130052.13			35636	-0.395	-0.3419	Yes
311	SRGAP2	ENSG00000266028.7			35672	-0.396	-0.3402	Yes
312	DLC1	ENSG00000164741.15			35687	-0.397	-0.3380	Yes
313	YWHAZ	ENSG00000164924.18			35696	-0.397	-0.3357	Yes
314	WASF1	ENSG00000112290.13			35700	-0.397	-0.3332	Yes
315	RALBP1	ENSG00000017797.13			35709	-0.398	-0.3309	Yes
316	HIST1H2BI	ENSG00000278588.1			35748	-0.400	-0.3292	Yes
317	NCK1	ENSG00000158092.7			35806	-0.402	-0.3281	Yes
318	CDC25C	ENSG00000158402.20			35954	-0.403	-0.3291	Yes
319	ARPC1A	ENSG00000241685.10			35966	-0.404	-0.3268	Yes
320	PAFAH1B1	ENSG00000007168.13			36076	-0.408	-0.3269	Yes
321	HIST1H4C	ENSG00000197061.4			36084	-0.408	-0.3244	Yes
322	CENPK	ENSG00000123219.13			36086	-0.408	-0.3219	Yes
323	DYNC1I2	ENSG00000077380.15			36153	-0.411	-0.3209	Yes
324	TAX1BP3	ENSG00000213977.8			36266	-0.414	-0.3210	Yes
325	ARHGAP22	ENSG00000128805.14			36278	-0.415	-0.3186	Yes
326	BIRC5	ENSG00000089685.15			36279	-0.415	-0.3159	Yes
327	ACTG1	ENSG00000184009.12			36290	-0.416	-0.3135	Yes
328	ARPC2	ENSG00000163466.16			36320	-0.417	-0.3116	Yes
329	PPP1CB	ENSG00000213639.10			36325	-0.417	-0.3090	Yes
330	RHOA	ENSG00000067560.12			36363	-0.419	-0.3073	Yes
331	ABI1	ENSG00000136754.17			36378	-0.420	-0.3049	Yes
332	OPHN1	ENSG00000079482.13			36417	-0.422	-0.3032	Yes
333	CHN1	ENSG00000128656.14			36448	-0.424	-0.3012	Yes
334	YWHAE	ENSG00000108953.17			36492	-0.426	-0.2995	Yes
335	PAK1	ENSG00000149269.9			36549	-0.430	-0.2982	Yes
336	WIPF2	ENSG00000171475.14			36617	-0.432	-0.2971	Yes
337	SPC24	ENSG00000161888.11			36669	-0.434	-0.2955	Yes
338	PLK1	ENSG00000166851.15			36707	-0.436	-0.2937	Yes
339	KIF2C	ENSG00000142945.13			36852	-0.443	-0.2944	Yes
340	TRIO	ENSG00000038382.20			36905	-0.446	-0.2928	Yes
341	CENPN	ENSG00000166451.13			36906	-0.447	-0.2899	Yes
342	HIST1H2AJ	ENSG00000276368.1			36931	-0.448	-0.2877	Yes
343	SRF	ENSG00000112658.8			36941	-0.449	-0.2850	Yes
344	PAK2	ENSG00000180370.10			36983	-0.451	-0.2832	Yes
345	KIF2A	ENSG00000068796.16			36994	-0.452	-0.2805	Yes
346	HIST2H4A	ENSG00000270882.2			37017	-0.453	-0.2782	Yes
347	NGEF	ENSG00000066248.15			37021	-0.453	-0.2754	Yes
348	SPC25	ENSG00000152253.9			37054	-0.455	-0.2732	Yes
349	ARHGAP42	ENSG00000165895.19			37066	-0.456	-0.2706	Yes
350	ARHGDIA	ENSG00000141522.12			37082	-0.457	-0.2680	Yes
351	MAPRE1	ENSG00000101367.9			37101	-0.458	-0.2656	Yes
352	HIST1H3F	ENSG00000277775.1			37151	-0.460	-0.2638	Yes
353	ACTR3	ENSG00000115091.12			37178	-0.462	-0.2615	Yes
354	XPO1	ENSG00000082898.17			37227	-0.465	-0.2597	Yes
355	DIAPH2	ENSG00000147202.18			37240	-0.467	-0.2571	Yes
356	MAD1L1	ENSG00000002822.15			37265	-0.468	-0.2547	Yes
357	RAC1	ENSG00000136238.18			37298	-0.471	-0.2524	Yes
358	SPDL1	ENSG00000040275.17			37361	-0.475	-0.2509	Yes
359	MYH11	ENSG00000133392.18			37382	-0.477	-0.2484	Yes
360	TUBA1B	ENSG00000123416.15			37411	-0.478	-0.2460	Yes
361	AURKB	ENSG00000178999.13			37485	-0.484	-0.2447	Yes
362	ARHGAP19	ENSG00000213390.11			37488	-0.484	-0.2417	Yes
363	SKA1	ENSG00000154839.10			37525	-0.487	-0.2395	Yes
364	FAM13B	ENSG00000031003.10			37674	-0.500	-0.2399	Yes
365	ITGB1	ENSG00000150093.19			37687	-0.501	-0.2370	Yes
366	BUB1	ENSG00000169679.15			37763	-0.508	-0.2356	Yes
367	CKAP5	ENSG00000175216.15			37814	-0.514	-0.2335	Yes
368	FLNA	ENSG00000196924.17			37839	-0.515	-0.2308	Yes
369	MAD2L1	ENSG00000164109.14			37893	-0.520	-0.2288	Yes
370	NDC80	ENSG00000080986.13			37927	-0.522	-0.2263	Yes
371	ARHGAP31	ENSG00000031081.11			37934	-0.523	-0.2231	Yes
372	CENPA	ENSG00000115163.15			37993	-0.527	-0.2212	Yes
373	NF2	ENSG00000186575.18			37996	-0.527	-0.2179	Yes
374	ARPC5	ENSG00000162704.16			38000	-0.527	-0.2146	Yes
375	MAPK1	ENSG00000100030.14			38116	-0.536	-0.2140	Yes
376	BUB1B	ENSG00000156970.12			38129	-0.537	-0.2108	Yes
377	NCKAP1	ENSG00000061676.15			38149	-0.538	-0.2079	Yes
378	ACTR2	ENSG00000138071.13			38158	-0.539	-0.2046	Yes
379	ARHGAP11A	ENSG00000198826.11			38179	-0.541	-0.2017	Yes
380	CDC42	ENSG00000070831.17			38194	-0.542	-0.1986	Yes
381	DYNC1LI1	ENSG00000144635.9			38271	-0.548	-0.1969	Yes
382	RHOQ	ENSG00000119729.12			38298	-0.551	-0.1940	Yes
383	CENPL	ENSG00000120334.15			38315	-0.553	-0.1909	Yes
384	DYNLL1	ENSG00000088986.11			38317	-0.554	-0.1874	Yes
385	CALM1	ENSG00000198668.12			38464	-0.558	-0.1874	Yes
386	TUBA1A	ENSG00000167552.14			38598	-0.561	-0.1871	Yes
387	PFN1	ENSG00000108518.7			38610	-0.563	-0.1838	Yes
388	KIF14	ENSG00000118193.12			38614	-0.563	-0.1803	Yes
389	IQGAP1	ENSG00000140575.13			38621	-0.564	-0.1768	Yes
390	CDCA8	ENSG00000134690.11			38629	-0.564	-0.1734	Yes
391	DEPDC1B	ENSG00000035499.13			38687	-0.569	-0.1712	Yes
392	PPP2CB	ENSG00000104695.13			38708	-0.572	-0.1680	Yes
393	CENPM	ENSG00000100162.15			38711	-0.572	-0.1644	Yes
394	SKA2	ENSG00000182628.13			38739	-0.574	-0.1614	Yes
395	SGO2	ENSG00000163535.18			38980	-0.599	-0.1635	Yes
396	ROCK1	ENSG00000067900.8			39050	-0.606	-0.1613	Yes
397	ZWINT	ENSG00000122952.17			39173	-0.616	-0.1604	Yes
398	CLIP1	ENSG00000130779.20			39284	-0.622	-0.1591	Yes
399	NOX3	ENSG00000074771.4			39344	-0.624	-0.1565	Yes
400	ARHGAP5	ENSG00000100852.13			39363	-0.626	-0.1530	Yes
401	NCF2	ENSG00000116701.14			39400	-0.627	-0.1499	Yes
402	CENPF	ENSG00000117724.13			39444	-0.631	-0.1469	Yes
403	RACGAP1	ENSG00000161800.13			39469	-0.633	-0.1435	Yes
404	MYH9	ENSG00000100345.21			39531	-0.641	-0.1409	Yes
405	ARHGAP12	ENSG00000165322.18			39577	-0.644	-0.1379	Yes
406	PRC1	ENSG00000198901.14			39769	-0.668	-0.1383	Yes
407	KNTC1	ENSG00000184445.12			39875	-0.690	-0.1365	Yes
408	FGD2	ENSG00000146192.15			39883	-0.692	-0.1322	Yes
409	ERCC6L	ENSG00000186871.7			39947	-0.704	-0.1293	Yes
410	CDH1	ENSG00000039068.19			40053	-0.722	-0.1273	Yes
411	TUBB4B	ENSG00000188229.6			40106	-0.733	-0.1239	Yes
412	TUBB2B	ENSG00000137285.10			40109	-0.733	-0.1192	Yes
413	ZWILCH	ENSG00000174442.12			40134	-0.739	-0.1151	Yes
414	KNL1	ENSG00000137812.19			40136	-0.739	-0.1104	Yes
415	CENPE	ENSG00000138778.12			40145	-0.740	-0.1059	Yes
416	MYL6	ENSG00000092841.18			40195	-0.751	-0.1023	Yes
417	MYL12B	ENSG00000118680.13			40197	-0.752	-0.0975	Yes
418	ROCK2	ENSG00000134318.14			40245	-0.764	-0.0938	Yes
419	PPP1R12A	ENSG00000058272.19			40248	-0.765	-0.0890	Yes
420	TUBB2A	ENSG00000137267.6			40266	-0.768	-0.0845	Yes
421	YWHAH	ENSG00000128245.15			40295	-0.774	-0.0802	Yes
422	ACTB	ENSG00000075624.16			40426	-0.816	-0.0782	Yes
423	TUBA1C	ENSG00000167553.15			40512	-0.843	-0.0749	Yes
424	KLC3	ENSG00000104892.17			40542	-0.855	-0.0702	Yes
425	MYL9	ENSG00000101335.10			40576	-0.868	-0.0654	Yes
426	HIST1H3G	ENSG00000273983.1			40669	-0.906	-0.0619	Yes
427	HIST1H4B	ENSG00000278705.1			40718	-0.927	-0.0572	Yes
428	ECT2	ENSG00000114346.13			40756	-0.937	-0.0521	Yes
429	KIF5B	ENSG00000170759.11			40785	-0.954	-0.0467	Yes
430	NET1	ENSG00000173848.19			40812	-0.977	-0.0411	Yes
431	TUBB6	ENSG00000176014.13			40817	-0.979	-0.0350	Yes
432	KIF18A	ENSG00000121621.7			40921	-1.038	-0.0309	Yes
433	DIAPH3	ENSG00000139734.19			40924	-1.041	-0.0243	Yes
434	RHOBTB1	ENSG00000072422.17			41025	-1.186	-0.0192	Yes
435	CENPI	ENSG00000102384.13			41099	-1.425	-0.0119	Yes
436	HIST1H4A	ENSG00000278637.1			41148	-2.093	0.0003	Yes

Fig 2: REACTOME_SIGNALING_BY_RHO_GTPASES   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: REACTOME_SIGNALING_BY_RHO_GTPASES: Random ES distribution   
Gene set null distribution of ES for REACTOME_SIGNALING_BY_RHO_GTPASES