Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH |
| Phenotype | Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH |
| Upregulated in class | ARH |
| GeneSet | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES |
| Enrichment Score (ES) | -0.59760064 |
| Normalized Enrichment Score (NES) | -2.3008811 |
| Nominal p-value | 0.0 |
| FDR q-value | 3.5035532E-4 |
| FWER p-Value | 0.006 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | PAK3 | ENSG00000077264.15 | 1408 | 0.788 | 0.0167 | No | ||
| 2 | ANGPTL2 | ENSG00000136859.10 | 2134 | 0.689 | 0.0436 | No | ||
| 3 | PAK5 | ENSG00000101349.16 | 3573 | 0.564 | 0.0450 | No | ||
| 4 | FSCN3 | ENSG00000106328.10 | 12944 | 0.239 | -0.1674 | No | ||
| 5 | FSCN1 | ENSG00000075618.18 | 13471 | 0.223 | -0.1658 | No | ||
| 6 | PAK6 | ENSG00000137843.12 | 15121 | 0.170 | -0.1949 | No | ||
| 7 | RHO | ENSG00000163914.5 | 16492 | 0.131 | -0.2197 | No | ||
| 8 | AKT1 | ENSG00000142208.16 | 21695 | -0.006 | -0.3458 | No | ||
| 9 | GDI1 | ENSG00000203879.12 | 23060 | -0.041 | -0.3763 | No | ||
| 10 | LIMK1 | ENSG00000106683.15 | 27117 | -0.153 | -0.4651 | No | ||
| 11 | MYH2 | ENSG00000125414.19 | 27417 | -0.161 | -0.4619 | No | ||
| 12 | WASL | ENSG00000106299.8 | 27968 | -0.179 | -0.4637 | No | ||
| 13 | PAK4 | ENSG00000130669.17 | 30208 | -0.250 | -0.5020 | No | ||
| 14 | GDI2 | ENSG00000057608.17 | 34142 | -0.347 | -0.5752 | Yes | ||
| 15 | PFN2 | ENSG00000070087.14 | 34203 | -0.350 | -0.5540 | Yes | ||
| 16 | MYLK | ENSG00000065534.18 | 35071 | -0.368 | -0.5514 | Yes | ||
| 17 | MYLK2 | ENSG00000101306.10 | 35330 | -0.380 | -0.5331 | Yes | ||
| 18 | CFL1 | ENSG00000172757.13 | 35593 | -0.393 | -0.5141 | Yes | ||
| 19 | WASF1 | ENSG00000112290.13 | 35700 | -0.397 | -0.4910 | Yes | ||
| 20 | ACTG1 | ENSG00000184009.12 | 36290 | -0.416 | -0.4784 | Yes | ||
| 21 | PAK1 | ENSG00000149269.9 | 36549 | -0.430 | -0.4570 | Yes | ||
| 22 | PAK2 | ENSG00000180370.10 | 36983 | -0.451 | -0.4383 | Yes | ||
| 23 | ACTR3 | ENSG00000115091.12 | 37178 | -0.462 | -0.4132 | Yes | ||
| 24 | VASP | ENSG00000125753.14 | 37239 | -0.466 | -0.3845 | Yes | ||
| 25 | FLNA | ENSG00000196924.17 | 37839 | -0.515 | -0.3658 | Yes | ||
| 26 | ACTR2 | ENSG00000138071.13 | 38158 | -0.539 | -0.3387 | Yes | ||
| 27 | CDC42 | ENSG00000070831.17 | 38194 | -0.542 | -0.3045 | Yes | ||
| 28 | PFN1 | ENSG00000108518.7 | 38610 | -0.563 | -0.2783 | Yes | ||
| 29 | RPS4X | ENSG00000198034.11 | 38823 | -0.583 | -0.2458 | Yes | ||
| 30 | FLNC | ENSG00000128591.15 | 38901 | -0.590 | -0.2095 | Yes | ||
| 31 | ROCK1 | ENSG00000067900.8 | 39050 | -0.606 | -0.1739 | Yes | ||
| 32 | FSCN2 | ENSG00000186765.11 | 39069 | -0.608 | -0.1351 | Yes | ||
| 33 | ACTG2 | ENSG00000163017.14 | 39698 | -0.662 | -0.1076 | Yes | ||
| 34 | ROCK2 | ENSG00000134318.14 | 40245 | -0.764 | -0.0716 | Yes | ||
| 35 | CFL2 | ENSG00000165410.15 | 41108 | -1.452 | 0.0013 | Yes |
