Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Phenotype | Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Upregulated in class | FSHD2M |
| GeneSet | REACTOME_CARDIAC_CONDUCTION |
| Enrichment Score (ES) | -0.547382 |
| Normalized Enrichment Score (NES) | -2.1140876 |
| Nominal p-value | 0.0 |
| FDR q-value | 3.7056694E-4 |
| FWER p-Value | 0.006 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CLIC2 | ENSG00000155962.13 | 4 | 4.773 | 0.0208 | No | ||
| 2 | KCNIP3 | ENSG00000115041.13 | 68 | 3.944 | 0.0366 | No | ||
| 3 | CACNA2D4 | ENSG00000151062.15 | 124 | 3.591 | 0.0511 | No | ||
| 4 | TBX5 | ENSG00000089225.19 | 139 | 3.525 | 0.0662 | No | ||
| 5 | CACNA1C | ENSG00000151067.22 | 193 | 3.311 | 0.0794 | No | ||
| 6 | ASPH | ENSG00000198363.18 | 590 | 2.483 | 0.0811 | No | ||
| 7 | ATP2B4 | ENSG00000058668.14 | 627 | 2.432 | 0.0909 | No | ||
| 8 | KCNK2 | ENSG00000082482.13 | 754 | 2.305 | 0.0981 | No | ||
| 9 | KCND1 | ENSG00000102057.10 | 763 | 2.298 | 0.1080 | No | ||
| 10 | CACNB3 | ENSG00000167535.8 | 947 | 2.135 | 0.1131 | No | ||
| 11 | KCND3 | ENSG00000171385.9 | 1341 | 1.914 | 0.1123 | No | ||
| 12 | NPR2 | ENSG00000159899.14 | 1451 | 1.865 | 0.1179 | No | ||
| 13 | KCNK15 | ENSG00000124249.7 | 1548 | 1.821 | 0.1237 | No | ||
| 14 | ORAI2 | ENSG00000160991.16 | 1886 | 1.673 | 0.1232 | No | ||
| 15 | SCN1A | ENSG00000144285.21 | 1902 | 1.668 | 0.1301 | No | ||
| 16 | KCNIP4 | ENSG00000185774.16 | 2362 | 1.517 | 0.1261 | No | ||
| 17 | CACNA1D | ENSG00000157388.19 | 2414 | 1.501 | 0.1315 | No | ||
| 18 | SCN4B | ENSG00000177098.8 | 2566 | 1.451 | 0.1343 | No | ||
| 19 | KCNK12 | ENSG00000184261.4 | 2821 | 1.373 | 0.1344 | No | ||
| 20 | KCNE3 | ENSG00000175538.10 | 3493 | 1.226 | 0.1242 | No | ||
| 21 | CACNA2D2 | ENSG00000007402.11 | 3855 | 1.154 | 0.1208 | No | ||
| 22 | SCN2A | ENSG00000136531.16 | 3989 | 1.130 | 0.1227 | No | ||
| 23 | NPR1 | ENSG00000169418.10 | 4423 | 1.058 | 0.1172 | No | ||
| 24 | CACNA2D3 | ENSG00000157445.15 | 4802 | 0.997 | 0.1128 | No | ||
| 25 | FGF12 | ENSG00000114279.13 | 4831 | 0.993 | 0.1165 | No | ||
| 26 | FGF14 | ENSG00000102466.15 | 4922 | 0.980 | 0.1187 | No | ||
| 27 | CACNG7 | ENSG00000105605.7 | 5004 | 0.967 | 0.1211 | No | ||
| 28 | SCN7A | ENSG00000136546.16 | 5073 | 0.957 | 0.1237 | No | ||
| 29 | KCND2 | ENSG00000184408.10 | 5100 | 0.954 | 0.1272 | No | ||
| 30 | CACNB2 | ENSG00000165995.20 | 5260 | 0.933 | 0.1276 | No | ||
| 31 | TRPC1 | ENSG00000144935.15 | 5774 | 0.867 | 0.1195 | No | ||
| 32 | KCNK4 | ENSG00000182450.13 | 6171 | 0.820 | 0.1139 | No | ||
| 33 | RANGRF | ENSG00000108961.14 | 6214 | 0.815 | 0.1165 | No | ||
| 34 | SRI | ENSG00000075142.13 | 6706 | 0.767 | 0.1084 | No | ||
| 35 | CACNG2 | ENSG00000166862.6 | 6896 | 0.747 | 0.1073 | No | ||
| 36 | CACNA1F | ENSG00000102001.12 | 7370 | 0.703 | 0.0994 | No | ||
| 37 | CACNB4 | ENSG00000182389.19 | 8084 | 0.640 | 0.0856 | No | ||
| 38 | FXYD7 | ENSG00000221946.7 | 8301 | 0.620 | 0.0833 | No | ||
| 39 | SCN2B | ENSG00000149575.6 | 8311 | 0.619 | 0.0858 | No | ||
| 40 | KCNK6 | ENSG00000099337.5 | 9639 | 0.527 | 0.0572 | No | ||
| 41 | KCNE2 | ENSG00000159197.3 | 10168 | 0.499 | 0.0471 | No | ||
| 42 | KCNK1 | ENSG00000135750.15 | 10219 | 0.496 | 0.0481 | No | ||
| 43 | KCNIP1 | ENSG00000182132.13 | 10791 | 0.460 | 0.0368 | No | ||
| 44 | KAT2B | ENSG00000114166.8 | 11450 | 0.417 | 0.0233 | No | ||
| 45 | KCNK9 | ENSG00000169427.8 | 11595 | 0.408 | 0.0218 | No | ||
| 46 | SCN1B | ENSG00000105711.12 | 12081 | 0.383 | 0.0122 | No | ||
| 47 | AHCYL1 | ENSG00000168710.18 | 12224 | 0.376 | 0.0105 | No | ||
| 48 | ORAI1 | ENSG00000276045.3 | 15880 | 0.255 | -0.0734 | No | ||
| 49 | ATP1B2 | ENSG00000129244.9 | 16230 | 0.234 | -0.0805 | No | ||
| 50 | ABCC9 | ENSG00000069431.11 | 17517 | 0.171 | -0.1097 | No | ||
| 51 | SCN11A | ENSG00000168356.12 | 17688 | 0.164 | -0.1129 | No | ||
| 52 | ITPR3 | ENSG00000096433.11 | 18641 | 0.116 | -0.1345 | No | ||
| 53 | SCN8A | ENSG00000196876.17 | 19100 | 0.095 | -0.1448 | No | ||
| 54 | KCNE4 | ENSG00000152049.6 | 19402 | 0.077 | -0.1514 | No | ||
| 55 | KCNK13 | ENSG00000152315.5 | 20537 | 0.020 | -0.1777 | No | ||
| 56 | KCNJ14 | ENSG00000182324.6 | 20632 | 0.015 | -0.1799 | No | ||
| 57 | ATP1A3 | ENSG00000105409.19 | 20648 | 0.014 | -0.1801 | No | ||
| 58 | CORIN | ENSG00000145244.12 | 21624 | -0.038 | -0.2027 | No | ||
| 59 | CACNG8 | ENSG00000142408.4 | 21638 | -0.039 | -0.2028 | No | ||
| 60 | ATP2A3 | ENSG00000074370.18 | 22034 | -0.059 | -0.2117 | No | ||
| 61 | FKBP1B | ENSG00000119782.14 | 22563 | -0.088 | -0.2236 | No | ||
| 62 | GATA4 | ENSG00000136574.17 | 22602 | -0.091 | -0.2241 | No | ||
| 63 | KCNK10 | ENSG00000100433.15 | 24682 | -0.210 | -0.2716 | No | ||
| 64 | CACNG3 | ENSG00000006116.3 | 26144 | -0.263 | -0.3044 | No | ||
| 65 | KCNK16 | ENSG00000095981.10 | 26337 | -0.263 | -0.3077 | No | ||
| 66 | RYR2 | ENSG00000198626.17 | 28784 | -0.351 | -0.3631 | No | ||
| 67 | NPPC | ENSG00000163273.4 | 29301 | -0.362 | -0.3735 | No | ||
| 68 | CAMK2D | ENSG00000145349.17 | 30036 | -0.410 | -0.3888 | No | ||
| 69 | SCN9A | ENSG00000169432.16 | 30394 | -0.431 | -0.3952 | No | ||
| 70 | FXYD2 | ENSG00000137731.14 | 30992 | -0.458 | -0.4071 | No | ||
| 71 | FGF13 | ENSG00000129682.16 | 31976 | -0.511 | -0.4277 | No | ||
| 72 | KCNJ2 | ENSG00000123700.4 | 32768 | -0.566 | -0.4436 | No | ||
| 73 | SLC8A2 | ENSG00000118160.14 | 33723 | -0.639 | -0.4630 | No | ||
| 74 | CAMK2G | ENSG00000148660.20 | 34193 | -0.675 | -0.4710 | No | ||
| 75 | KCNK5 | ENSG00000164626.9 | 34538 | -0.705 | -0.4759 | No | ||
| 76 | STIM1 | ENSG00000167323.11 | 34747 | -0.720 | -0.4776 | No | ||
| 77 | FXYD3 | ENSG00000089356.18 | 34904 | -0.733 | -0.4780 | No | ||
| 78 | NOS1 | ENSG00000089250.19 | 35284 | -0.766 | -0.4835 | No | ||
| 79 | KCNK17 | ENSG00000124780.14 | 35928 | -0.835 | -0.4948 | No | ||
| 80 | KCNK3 | ENSG00000171303.7 | 35941 | -0.836 | -0.4914 | No | ||
| 81 | KCNIP2 | ENSG00000120049.19 | 36062 | -0.851 | -0.4904 | No | ||
| 82 | ATP1B3 | ENSG00000069849.11 | 37044 | -0.973 | -0.5090 | No | ||
| 83 | KCNQ1 | ENSG00000053918.17 | 37057 | -0.975 | -0.5050 | No | ||
| 84 | PRKACA | ENSG00000072062.14 | 37389 | -1.018 | -0.5083 | No | ||
| 85 | ATP2B3 | ENSG00000067842.17 | 38460 | -1.199 | -0.5279 | No | ||
| 86 | TRDN | ENSG00000186439.14 | 39054 | -1.322 | -0.5359 | No | ||
| 87 | HIPK1 | ENSG00000163349.22 | 39433 | -1.406 | -0.5385 | No | ||
| 88 | FXYD4 | ENSG00000150201.15 | 39814 | -1.497 | -0.5408 | Yes | ||
| 89 | NKX2-5 | ENSG00000183072.10 | 39974 | -1.542 | -0.5378 | Yes | ||
| 90 | KCNJ4 | ENSG00000168135.4 | 40091 | -1.569 | -0.5336 | Yes | ||
| 91 | CAMK2B | ENSG00000058404.20 | 40117 | -1.578 | -0.5273 | Yes | ||
| 92 | FXYD1 | ENSG00000266964.5 | 40154 | -1.588 | -0.5211 | Yes | ||
| 93 | ATP2B2 | ENSG00000157087.20 | 40162 | -1.590 | -0.5143 | Yes | ||
| 94 | ATP2B1 | ENSG00000070961.15 | 40174 | -1.593 | -0.5076 | Yes | ||
| 95 | CACNG4 | ENSG00000075461.6 | 40209 | -1.603 | -0.5014 | Yes | ||
| 96 | KCNE5 | ENSG00000176076.7 | 40321 | -1.633 | -0.4968 | Yes | ||
| 97 | SCN3A | ENSG00000153253.18 | 40335 | -1.638 | -0.4900 | Yes | ||
| 98 | WWTR1 | ENSG00000018408.14 | 40806 | -1.787 | -0.4931 | Yes | ||
| 99 | KCNE1 | ENSG00000180509.12 | 40863 | -1.808 | -0.4865 | Yes | ||
| 100 | PLN | ENSG00000198523.6 | 40873 | -1.812 | -0.4787 | Yes | ||
| 101 | ITPR1 | ENSG00000150995.19 | 41025 | -1.877 | -0.4740 | Yes | ||
| 102 | SCN10A | ENSG00000185313.8 | 41147 | -1.932 | -0.4684 | Yes | ||
| 103 | TNNI3 | ENSG00000129991.13 | 41255 | -1.980 | -0.4622 | Yes | ||
| 104 | ATP1A1 | ENSG00000163399.16 | 41345 | -2.032 | -0.4554 | Yes | ||
| 105 | SCN3B | ENSG00000166257.9 | 41392 | -2.060 | -0.4474 | Yes | ||
| 106 | FXYD6 | ENSG00000137726.17 | 41634 | -2.212 | -0.4433 | Yes | ||
| 107 | ATP2A1 | ENSG00000196296.13 | 41742 | -2.285 | -0.4358 | Yes | ||
| 108 | AKAP9 | ENSG00000127914.16 | 41818 | -2.342 | -0.4273 | Yes | ||
| 109 | ITPR2 | ENSG00000123104.12 | 41853 | -2.368 | -0.4177 | Yes | ||
| 110 | CACNG6 | ENSG00000130433.7 | 41917 | -2.421 | -0.4086 | Yes | ||
| 111 | SLC8A1 | ENSG00000183023.18 | 41918 | -2.421 | -0.3980 | Yes | ||
| 112 | CACNA2D1 | ENSG00000153956.16 | 41945 | -2.451 | -0.3879 | Yes | ||
| 113 | KCNH2 | ENSG00000055118.15 | 41985 | -2.477 | -0.3779 | Yes | ||
| 114 | RYR3 | ENSG00000198838.13 | 41998 | -2.488 | -0.3673 | Yes | ||
| 115 | CASQ1 | ENSG00000143318.13 | 42074 | -2.550 | -0.3579 | Yes | ||
| 116 | KCNJ12 | ENSG00000184185.10 | 42159 | -2.647 | -0.3482 | Yes | ||
| 117 | ATP2A2 | ENSG00000174437.17 | 42170 | -2.663 | -0.3368 | Yes | ||
| 118 | NPPA | ENSG00000175206.10 | 42186 | -2.680 | -0.3254 | Yes | ||
| 119 | CALM1 | ENSG00000198668.12 | 42323 | -2.877 | -0.3160 | Yes | ||
| 120 | ATP1A4 | ENSG00000132681.16 | 42353 | -2.919 | -0.3039 | Yes | ||
| 121 | HIPK2 | ENSG00000064393.16 | 42572 | -3.249 | -0.2947 | Yes | ||
| 122 | ATP1B1 | ENSG00000143153.13 | 42642 | -3.447 | -0.2812 | Yes | ||
| 123 | KCNK7 | ENSG00000173338.12 | 42693 | -3.578 | -0.2667 | Yes | ||
| 124 | CAMK2A | ENSG00000070808.16 | 42777 | -3.811 | -0.2519 | Yes | ||
| 125 | DMPK | ENSG00000104936.17 | 42797 | -3.886 | -0.2354 | Yes | ||
| 126 | CACNB1 | ENSG00000067191.16 | 42803 | -3.923 | -0.2183 | Yes | ||
| 127 | CASQ2 | ENSG00000118729.11 | 42823 | -4.006 | -0.2012 | Yes | ||
| 128 | SLN | ENSG00000170290.4 | 42839 | -4.058 | -0.1838 | Yes | ||
| 129 | FGF11 | ENSG00000161958.11 | 42850 | -4.106 | -0.1660 | Yes | ||
| 130 | SLC8A3 | ENSG00000100678.18 | 43023 | -4.807 | -0.1490 | Yes | ||
| 131 | KCNJ11 | ENSG00000187486.5 | 43027 | -4.829 | -0.1279 | Yes | ||
| 132 | SCN5A | ENSG00000183873.15 | 43064 | -4.912 | -0.1072 | Yes | ||
| 133 | ATP1A2 | ENSG00000018625.15 | 43067 | -4.924 | -0.0857 | Yes | ||
| 134 | RYR1 | ENSG00000196218.12 | 43074 | -4.942 | -0.0642 | Yes | ||
| 135 | CACNG1 | ENSG00000108878.5 | 43077 | -4.944 | -0.0426 | Yes | ||
| 136 | SCN4A | ENSG00000007314.12 | 43094 | -4.963 | -0.0212 | Yes | ||
| 137 | CACNA1S | ENSG00000081248.11 | 43107 | -4.973 | 0.0003 | Yes |
