Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Phenotype | Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Upregulated in class | FSHD2M |
| GeneSet | REACTOME_DNA_REPLICATION |
| Enrichment Score (ES) | -0.5735394 |
| Normalized Enrichment Score (NES) | -2.1716168 |
| Nominal p-value | 0.0 |
| FDR q-value | 2.049285E-4 |
| FWER p-Value | 0.002 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | PSMB9 | ENSG00000240065.8 | 653 | 2.409 | 0.0074 | No | ||
| 2 | PSMB8 | ENSG00000204264.11 | 1023 | 2.095 | 0.0185 | No | ||
| 3 | PSMB10 | ENSG00000205220.12 | 3086 | 1.313 | -0.0171 | No | ||
| 4 | CDC26 | ENSG00000176386.9 | 7372 | 0.703 | -0.1102 | No | ||
| 5 | ANAPC16 | ENSG00000166295.9 | 8822 | 0.582 | -0.1384 | No | ||
| 6 | PCNA | ENSG00000132646.11 | 8869 | 0.578 | -0.1340 | No | ||
| 7 | UBA52 | ENSG00000221983.8 | 9987 | 0.512 | -0.1552 | No | ||
| 8 | PRIM2 | ENSG00000146143.19 | 11511 | 0.413 | -0.1868 | No | ||
| 9 | POLD3 | ENSG00000077514.9 | 14781 | 0.293 | -0.2600 | No | ||
| 10 | DBF4 | ENSG00000006634.8 | 15252 | 0.287 | -0.2683 | No | ||
| 11 | PSMA2 | ENSG00000106588.11 | 16418 | 0.224 | -0.2933 | No | ||
| 12 | POLE | ENSG00000177084.17 | 16492 | 0.220 | -0.2929 | No | ||
| 13 | UBB | ENSG00000170315.14 | 17176 | 0.189 | -0.3070 | No | ||
| 14 | PSME1 | ENSG00000092010.15 | 17744 | 0.161 | -0.3187 | No | ||
| 15 | ANAPC4 | ENSG00000053900.10 | 19109 | 0.094 | -0.3495 | No | ||
| 16 | ANAPC5 | ENSG00000089053.13 | 19924 | 0.051 | -0.3680 | No | ||
| 17 | POLE4 | ENSG00000115350.12 | 20281 | 0.033 | -0.3760 | No | ||
| 18 | PSMF1 | ENSG00000125818.18 | 20560 | 0.019 | -0.3823 | No | ||
| 19 | MCM7 | ENSG00000166508.17 | 20623 | 0.016 | -0.3835 | No | ||
| 20 | SEM1 | ENSG00000127922.9 | 21274 | -0.020 | -0.3985 | No | ||
| 21 | ANAPC10 | ENSG00000164162.14 | 21601 | -0.037 | -0.4057 | No | ||
| 22 | UBC | ENSG00000150991.15 | 21944 | -0.054 | -0.4132 | No | ||
| 23 | CCNE2 | ENSG00000175305.17 | 21963 | -0.055 | -0.4131 | No | ||
| 24 | CDT1 | ENSG00000167513.9 | 22064 | -0.060 | -0.4148 | No | ||
| 25 | UBE2D1 | ENSG00000072401.15 | 22471 | -0.083 | -0.4235 | No | ||
| 26 | CDC16 | ENSG00000130177.16 | 23003 | -0.112 | -0.4348 | No | ||
| 27 | PSMD9 | ENSG00000110801.14 | 23060 | -0.115 | -0.4350 | No | ||
| 28 | RPA1 | ENSG00000132383.12 | 23094 | -0.118 | -0.4347 | No | ||
| 29 | PSMD5 | ENSG00000095261.14 | 23841 | -0.161 | -0.4505 | No | ||
| 30 | CDC7 | ENSG00000097046.13 | 24231 | -0.184 | -0.4578 | No | ||
| 31 | RPS27A | ENSG00000143947.13 | 24249 | -0.185 | -0.4565 | No | ||
| 32 | ORC5 | ENSG00000164815.11 | 24869 | -0.222 | -0.4688 | No | ||
| 33 | PSMA8 | ENSG00000154611.14 | 26134 | -0.263 | -0.4957 | No | ||
| 34 | CUL1 | ENSG00000055130.17 | 26496 | -0.266 | -0.5016 | No | ||
| 35 | ORC6 | ENSG00000091651.9 | 27104 | -0.281 | -0.5131 | No | ||
| 36 | PSMB11 | ENSG00000222028.5 | 27828 | -0.302 | -0.5271 | No | ||
| 37 | RPA3 | ENSG00000106399.11 | 27907 | -0.302 | -0.5261 | No | ||
| 38 | ANAPC2 | ENSG00000176248.9 | 27964 | -0.306 | -0.5245 | No | ||
| 39 | RPA4 | ENSG00000204086.4 | 28017 | -0.310 | -0.5228 | No | ||
| 40 | ORC2 | ENSG00000115942.9 | 28093 | -0.316 | -0.5216 | No | ||
| 41 | MCM6 | ENSG00000076003.5 | 28225 | -0.325 | -0.5215 | No | ||
| 42 | LIG1 | ENSG00000105486.14 | 29118 | -0.354 | -0.5390 | No | ||
| 43 | PSMB3 | ENSG00000277791.5 | 29269 | -0.361 | -0.5391 | No | ||
| 44 | ORC3 | ENSG00000135336.14 | 29356 | -0.366 | -0.5376 | No | ||
| 45 | MCM3 | ENSG00000112118.20 | 29614 | -0.382 | -0.5400 | No | ||
| 46 | PSMA1 | ENSG00000129084.17 | 30662 | -0.448 | -0.5602 | No | ||
| 47 | PSME3 | ENSG00000131467.11 | 30737 | -0.449 | -0.5577 | No | ||
| 48 | PRIM1 | ENSG00000198056.15 | 30787 | -0.453 | -0.5545 | No | ||
| 49 | RFC3 | ENSG00000133119.13 | 31151 | -0.472 | -0.5586 | No | ||
| 50 | E2F3 | ENSG00000112242.15 | 31678 | -0.497 | -0.5661 | No | ||
| 51 | PSMA3 | ENSG00000100567.13 | 31911 | -0.509 | -0.5667 | No | ||
| 52 | E2F2 | ENSG00000007968.7 | 31923 | -0.510 | -0.5622 | No | ||
| 53 | FZR1 | ENSG00000105325.14 | 31978 | -0.512 | -0.5587 | No | ||
| 54 | GINS2 | ENSG00000131153.9 | 32126 | -0.521 | -0.5572 | No | ||
| 55 | CDC27 | ENSG00000004897.12 | 32830 | -0.571 | -0.5682 | Yes | ||
| 56 | MCM5 | ENSG00000100297.16 | 32907 | -0.577 | -0.5645 | Yes | ||
| 57 | PSMB1 | ENSG00000008018.9 | 33034 | -0.586 | -0.5620 | Yes | ||
| 58 | RBX1 | ENSG00000100387.9 | 33259 | -0.602 | -0.5615 | Yes | ||
| 59 | ORC4 | ENSG00000115947.13 | 33408 | -0.613 | -0.5592 | Yes | ||
| 60 | PSMD13 | ENSG00000185627.18 | 33437 | -0.616 | -0.5541 | Yes | ||
| 61 | RFC5 | ENSG00000111445.14 | 33522 | -0.623 | -0.5502 | Yes | ||
| 62 | PSMB4 | ENSG00000159377.11 | 33581 | -0.627 | -0.5456 | Yes | ||
| 63 | PSME2 | ENSG00000100911.16 | 33632 | -0.632 | -0.5408 | Yes | ||
| 64 | PSMD10 | ENSG00000101843.19 | 33841 | -0.648 | -0.5396 | Yes | ||
| 65 | POLE2 | ENSG00000100479.13 | 34764 | -0.721 | -0.5543 | Yes | ||
| 66 | CCNA1 | ENSG00000133101.10 | 34815 | -0.726 | -0.5486 | Yes | ||
| 67 | UBE2C | ENSG00000175063.17 | 34985 | -0.740 | -0.5456 | Yes | ||
| 68 | E2F1 | ENSG00000101412.13 | 35122 | -0.753 | -0.5417 | Yes | ||
| 69 | POLD4 | ENSG00000175482.9 | 35331 | -0.771 | -0.5393 | Yes | ||
| 70 | CDC45 | ENSG00000093009.10 | 35359 | -0.774 | -0.5326 | Yes | ||
| 71 | CCNA2 | ENSG00000145386.10 | 35426 | -0.780 | -0.5268 | Yes | ||
| 72 | PSMC5 | ENSG00000087191.13 | 35455 | -0.783 | -0.5201 | Yes | ||
| 73 | ANAPC1 | ENSG00000153107.13 | 35605 | -0.799 | -0.5161 | Yes | ||
| 74 | PSMA7 | ENSG00000101182.15 | 35709 | -0.810 | -0.5109 | Yes | ||
| 75 | PSMB2 | ENSG00000126067.12 | 35837 | -0.822 | -0.5061 | Yes | ||
| 76 | MCM4 | ENSG00000104738.18 | 35969 | -0.840 | -0.5013 | Yes | ||
| 77 | RFC1 | ENSG00000035928.16 | 36076 | -0.852 | -0.4958 | Yes | ||
| 78 | PSMA5 | ENSG00000143106.13 | 36170 | -0.865 | -0.4898 | Yes | ||
| 79 | RFC2 | ENSG00000049541.11 | 36206 | -0.868 | -0.4825 | Yes | ||
| 80 | GINS1 | ENSG00000101003.10 | 36223 | -0.870 | -0.4747 | Yes | ||
| 81 | UBE2E1 | ENSG00000170142.12 | 36422 | -0.891 | -0.4709 | Yes | ||
| 82 | PSMC2 | ENSG00000161057.12 | 36487 | -0.899 | -0.4639 | Yes | ||
| 83 | ORC1 | ENSG00000085840.13 | 36693 | -0.928 | -0.4600 | Yes | ||
| 84 | PSMB7 | ENSG00000136930.13 | 36803 | -0.941 | -0.4537 | Yes | ||
| 85 | MCM10 | ENSG00000065328.16 | 36840 | -0.947 | -0.4456 | Yes | ||
| 86 | GINS3 | ENSG00000181938.13 | 36855 | -0.948 | -0.4370 | Yes | ||
| 87 | SKP1 | ENSG00000113558.18 | 36892 | -0.952 | -0.4289 | Yes | ||
| 88 | CDC23 | ENSG00000094880.11 | 36926 | -0.956 | -0.4207 | Yes | ||
| 89 | MCM2 | ENSG00000073111.14 | 36965 | -0.962 | -0.4126 | Yes | ||
| 90 | CDK2 | ENSG00000123374.11 | 37047 | -0.974 | -0.4053 | Yes | ||
| 91 | PSMB6 | ENSG00000142507.10 | 37064 | -0.976 | -0.3965 | Yes | ||
| 92 | GINS4 | ENSG00000147536.12 | 37217 | -0.994 | -0.3907 | Yes | ||
| 93 | MCM8 | ENSG00000125885.13 | 37350 | -1.014 | -0.3842 | Yes | ||
| 94 | RPA2 | ENSG00000117748.10 | 37640 | -1.058 | -0.3810 | Yes | ||
| 95 | RFC4 | ENSG00000163918.10 | 37809 | -1.085 | -0.3748 | Yes | ||
| 96 | PSMA4 | ENSG00000041357.16 | 38333 | -1.177 | -0.3759 | Yes | ||
| 97 | FEN1 | ENSG00000168496.4 | 38431 | -1.194 | -0.3669 | Yes | ||
| 98 | DNA2 | ENSG00000138346.15 | 38510 | -1.209 | -0.3574 | Yes | ||
| 99 | PSMB5 | ENSG00000100804.19 | 38565 | -1.217 | -0.3472 | Yes | ||
| 100 | PSMD7 | ENSG00000103035.11 | 38868 | -1.282 | -0.3422 | Yes | ||
| 101 | ANAPC7 | ENSG00000196510.12 | 38905 | -1.290 | -0.3309 | Yes | ||
| 102 | ANAPC11 | ENSG00000141552.17 | 39180 | -1.349 | -0.3246 | Yes | ||
| 103 | GMNN | ENSG00000112312.10 | 39191 | -1.351 | -0.3121 | Yes | ||
| 104 | PSMD6 | ENSG00000163636.10 | 39440 | -1.407 | -0.3047 | Yes | ||
| 105 | PSMA6 | ENSG00000100902.11 | 39610 | -1.444 | -0.2950 | Yes | ||
| 106 | POLE3 | ENSG00000148229.13 | 39649 | -1.454 | -0.2823 | Yes | ||
| 107 | PSMD3 | ENSG00000108344.15 | 39660 | -1.456 | -0.2688 | Yes | ||
| 108 | PSMD4 | ENSG00000159352.15 | 39708 | -1.468 | -0.2561 | Yes | ||
| 109 | POLD1 | ENSG00000062822.14 | 39718 | -1.471 | -0.2425 | Yes | ||
| 110 | ANAPC15 | ENSG00000110200.8 | 39750 | -1.479 | -0.2293 | Yes | ||
| 111 | PSMC1 | ENSG00000100764.14 | 39751 | -1.479 | -0.2154 | Yes | ||
| 112 | PSMD12 | ENSG00000197170.10 | 40160 | -1.590 | -0.2100 | Yes | ||
| 113 | POLD2 | ENSG00000106628.10 | 40288 | -1.623 | -0.1977 | Yes | ||
| 114 | PSMD8 | ENSG00000099341.11 | 40314 | -1.631 | -0.1830 | Yes | ||
| 115 | PSMC4 | ENSG00000013275.8 | 40405 | -1.659 | -0.1695 | Yes | ||
| 116 | PSMD11 | ENSG00000108671.11 | 40619 | -1.724 | -0.1582 | Yes | ||
| 117 | PSMD14 | ENSG00000115233.12 | 40751 | -1.767 | -0.1447 | Yes | ||
| 118 | PSMC6 | ENSG00000100519.12 | 40791 | -1.783 | -0.1288 | Yes | ||
| 119 | POLA2 | ENSG00000014138.9 | 41096 | -1.906 | -0.1180 | Yes | ||
| 120 | CCNE1 | ENSG00000105173.14 | 41239 | -1.974 | -0.1028 | Yes | ||
| 121 | PSMD1 | ENSG00000173692.13 | 41284 | -1.994 | -0.0851 | Yes | ||
| 122 | PSMC3 | ENSG00000165916.8 | 41467 | -2.112 | -0.0695 | Yes | ||
| 123 | CDC6 | ENSG00000094804.12 | 41614 | -2.200 | -0.0522 | Yes | ||
| 124 | SKP2 | ENSG00000145604.16 | 41748 | -2.288 | -0.0338 | Yes | ||
| 125 | POLA1 | ENSG00000101868.11 | 41785 | -2.314 | -0.0129 | Yes | ||
| 126 | PSME4 | ENSG00000068878.15 | 41799 | -2.328 | 0.0087 | Yes | ||
| 127 | PSMD2 | ENSG00000175166.17 | 41820 | -2.343 | 0.0302 | Yes |
