Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Phenotype | Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Upregulated in class | FSHD2M |
| GeneSet | REACTOME_DNA_REPLICATION_PRE_INITIATION |
| Enrichment Score (ES) | -0.5586614 |
| Normalized Enrichment Score (NES) | -2.0546162 |
| Nominal p-value | 0.0 |
| FDR q-value | 6.3930196E-4 |
| FWER p-Value | 0.016 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | PSMB9 | ENSG00000240065.8 | 653 | 2.409 | 0.0176 | No | ||
| 2 | PSMB8 | ENSG00000204264.11 | 1023 | 2.095 | 0.0375 | No | ||
| 3 | PSMB10 | ENSG00000205220.12 | 3086 | 1.313 | 0.0074 | No | ||
| 4 | UBA52 | ENSG00000221983.8 | 9987 | 0.512 | -0.1459 | No | ||
| 5 | PRIM2 | ENSG00000146143.19 | 11511 | 0.413 | -0.1757 | No | ||
| 6 | DBF4 | ENSG00000006634.8 | 15252 | 0.287 | -0.2587 | No | ||
| 7 | PSMA2 | ENSG00000106588.11 | 16418 | 0.224 | -0.2827 | No | ||
| 8 | POLE | ENSG00000177084.17 | 16492 | 0.220 | -0.2814 | No | ||
| 9 | UBB | ENSG00000170315.14 | 17176 | 0.189 | -0.2947 | No | ||
| 10 | PSME1 | ENSG00000092010.15 | 17744 | 0.161 | -0.3057 | No | ||
| 11 | POLE4 | ENSG00000115350.12 | 20281 | 0.033 | -0.3642 | No | ||
| 12 | PSMF1 | ENSG00000125818.18 | 20560 | 0.019 | -0.3704 | No | ||
| 13 | MCM7 | ENSG00000166508.17 | 20623 | 0.016 | -0.3716 | No | ||
| 14 | SEM1 | ENSG00000127922.9 | 21274 | -0.020 | -0.3865 | No | ||
| 15 | UBC | ENSG00000150991.15 | 21944 | -0.054 | -0.4013 | No | ||
| 16 | CDT1 | ENSG00000167513.9 | 22064 | -0.060 | -0.4032 | No | ||
| 17 | PSMD9 | ENSG00000110801.14 | 23060 | -0.115 | -0.4248 | No | ||
| 18 | RPA1 | ENSG00000132383.12 | 23094 | -0.118 | -0.4239 | No | ||
| 19 | PSMD5 | ENSG00000095261.14 | 23841 | -0.161 | -0.4391 | No | ||
| 20 | CDC7 | ENSG00000097046.13 | 24231 | -0.184 | -0.4456 | No | ||
| 21 | RPS27A | ENSG00000143947.13 | 24249 | -0.185 | -0.4435 | No | ||
| 22 | ORC5 | ENSG00000164815.11 | 24869 | -0.222 | -0.4549 | No | ||
| 23 | PSMA8 | ENSG00000154611.14 | 26134 | -0.263 | -0.4807 | No | ||
| 24 | ORC6 | ENSG00000091651.9 | 27104 | -0.281 | -0.4994 | No | ||
| 25 | PSMB11 | ENSG00000222028.5 | 27828 | -0.302 | -0.5121 | No | ||
| 26 | RPA3 | ENSG00000106399.11 | 27907 | -0.302 | -0.5098 | No | ||
| 27 | RPA4 | ENSG00000204086.4 | 28017 | -0.310 | -0.5081 | No | ||
| 28 | ORC2 | ENSG00000115942.9 | 28093 | -0.316 | -0.5055 | No | ||
| 29 | MCM6 | ENSG00000076003.5 | 28225 | -0.325 | -0.5041 | No | ||
| 30 | PSMB3 | ENSG00000277791.5 | 29269 | -0.361 | -0.5235 | No | ||
| 31 | ORC3 | ENSG00000135336.14 | 29356 | -0.366 | -0.5205 | No | ||
| 32 | MCM3 | ENSG00000112118.20 | 29614 | -0.382 | -0.5213 | No | ||
| 33 | PSMA1 | ENSG00000129084.17 | 30662 | -0.448 | -0.5395 | No | ||
| 34 | PSME3 | ENSG00000131467.11 | 30737 | -0.449 | -0.5351 | No | ||
| 35 | PRIM1 | ENSG00000198056.15 | 30787 | -0.453 | -0.5301 | No | ||
| 36 | E2F3 | ENSG00000112242.15 | 31678 | -0.497 | -0.5440 | No | ||
| 37 | PSMA3 | ENSG00000100567.13 | 31911 | -0.509 | -0.5425 | No | ||
| 38 | E2F2 | ENSG00000007968.7 | 31923 | -0.510 | -0.5358 | No | ||
| 39 | MCM5 | ENSG00000100297.16 | 32907 | -0.577 | -0.5508 | Yes | ||
| 40 | PSMB1 | ENSG00000008018.9 | 33034 | -0.586 | -0.5458 | Yes | ||
| 41 | ORC4 | ENSG00000115947.13 | 33408 | -0.613 | -0.5461 | Yes | ||
| 42 | PSMD13 | ENSG00000185627.18 | 33437 | -0.616 | -0.5384 | Yes | ||
| 43 | PSMB4 | ENSG00000159377.11 | 33581 | -0.627 | -0.5332 | Yes | ||
| 44 | PSME2 | ENSG00000100911.16 | 33632 | -0.632 | -0.5257 | Yes | ||
| 45 | PSMD10 | ENSG00000101843.19 | 33841 | -0.648 | -0.5218 | Yes | ||
| 46 | POLE2 | ENSG00000100479.13 | 34764 | -0.721 | -0.5334 | Yes | ||
| 47 | E2F1 | ENSG00000101412.13 | 35122 | -0.753 | -0.5314 | Yes | ||
| 48 | CDC45 | ENSG00000093009.10 | 35359 | -0.774 | -0.5264 | Yes | ||
| 49 | PSMC5 | ENSG00000087191.13 | 35455 | -0.783 | -0.5180 | Yes | ||
| 50 | PSMA7 | ENSG00000101182.15 | 35709 | -0.810 | -0.5128 | Yes | ||
| 51 | PSMB2 | ENSG00000126067.12 | 35837 | -0.822 | -0.5046 | Yes | ||
| 52 | MCM4 | ENSG00000104738.18 | 35969 | -0.840 | -0.4962 | Yes | ||
| 53 | PSMA5 | ENSG00000143106.13 | 36170 | -0.865 | -0.4891 | Yes | ||
| 54 | PSMC2 | ENSG00000161057.12 | 36487 | -0.899 | -0.4842 | Yes | ||
| 55 | ORC1 | ENSG00000085840.13 | 36693 | -0.928 | -0.4764 | Yes | ||
| 56 | PSMB7 | ENSG00000136930.13 | 36803 | -0.941 | -0.4661 | Yes | ||
| 57 | MCM10 | ENSG00000065328.16 | 36840 | -0.947 | -0.4541 | Yes | ||
| 58 | MCM2 | ENSG00000073111.14 | 36965 | -0.962 | -0.4439 | Yes | ||
| 59 | CDK2 | ENSG00000123374.11 | 37047 | -0.974 | -0.4325 | Yes | ||
| 60 | PSMB6 | ENSG00000142507.10 | 37064 | -0.976 | -0.4196 | Yes | ||
| 61 | MCM8 | ENSG00000125885.13 | 37350 | -1.014 | -0.4124 | Yes | ||
| 62 | RPA2 | ENSG00000117748.10 | 37640 | -1.058 | -0.4048 | Yes | ||
| 63 | PSMA4 | ENSG00000041357.16 | 38333 | -1.177 | -0.4048 | Yes | ||
| 64 | PSMB5 | ENSG00000100804.19 | 38565 | -1.217 | -0.3937 | Yes | ||
| 65 | PSMD7 | ENSG00000103035.11 | 38868 | -1.282 | -0.3832 | Yes | ||
| 66 | GMNN | ENSG00000112312.10 | 39191 | -1.351 | -0.3723 | Yes | ||
| 67 | PSMD6 | ENSG00000163636.10 | 39440 | -1.407 | -0.3590 | Yes | ||
| 68 | PSMA6 | ENSG00000100902.11 | 39610 | -1.444 | -0.3433 | Yes | ||
| 69 | POLE3 | ENSG00000148229.13 | 39649 | -1.454 | -0.3244 | Yes | ||
| 70 | PSMD3 | ENSG00000108344.15 | 39660 | -1.456 | -0.3048 | Yes | ||
| 71 | PSMD4 | ENSG00000159352.15 | 39708 | -1.468 | -0.2859 | Yes | ||
| 72 | PSMC1 | ENSG00000100764.14 | 39751 | -1.479 | -0.2668 | Yes | ||
| 73 | PSMD12 | ENSG00000197170.10 | 40160 | -1.590 | -0.2547 | Yes | ||
| 74 | PSMD8 | ENSG00000099341.11 | 40314 | -1.631 | -0.2360 | Yes | ||
| 75 | PSMC4 | ENSG00000013275.8 | 40405 | -1.659 | -0.2156 | Yes | ||
| 76 | PSMD11 | ENSG00000108671.11 | 40619 | -1.724 | -0.1971 | Yes | ||
| 77 | PSMD14 | ENSG00000115233.12 | 40751 | -1.767 | -0.1761 | Yes | ||
| 78 | PSMC6 | ENSG00000100519.12 | 40791 | -1.783 | -0.1527 | Yes | ||
| 79 | POLA2 | ENSG00000014138.9 | 41096 | -1.906 | -0.1339 | Yes | ||
| 80 | PSMD1 | ENSG00000173692.13 | 41284 | -1.994 | -0.1111 | Yes | ||
| 81 | PSMC3 | ENSG00000165916.8 | 41467 | -2.112 | -0.0866 | Yes | ||
| 82 | CDC6 | ENSG00000094804.12 | 41614 | -2.200 | -0.0601 | Yes | ||
| 83 | POLA1 | ENSG00000101868.11 | 41785 | -2.314 | -0.0326 | Yes | ||
| 84 | PSME4 | ENSG00000068878.15 | 41799 | -2.328 | -0.0012 | Yes | ||
| 85 | PSMD2 | ENSG00000175166.17 | 41820 | -2.343 | 0.0302 | Yes |
