Details for gene set REACTOME_METABOLISM_OF_STEROIDS[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Phenotype	Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Upregulated in class	FSHD2
GeneSet	REACTOME_METABOLISM_OF_STEROIDS
Enrichment Score (ES)	0.52237636
Normalized Enrichment Score (NES)	2.263524
Nominal p-value	0.0
FDR q-value	0.0
FWER p-Value	0.0

Fig 1: Enrichment plot: REACTOME_METABOLISM_OF_STEROIDS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	DHCR24	ENSG00000116133.13			91	3.768	0.0225	Yes
2	OSBPL1A	ENSG00000141447.18			144	3.507	0.0443	Yes
3	HSD17B14	ENSG00000087076.9			272	3.059	0.0613	Yes
4	STARD5	ENSG00000172345.14			297	2.997	0.0804	Yes
5	ACOX2	ENSG00000168306.13			370	2.812	0.0971	Yes
6	CYP27A1	ENSG00000135929.9			400	2.753	0.1144	Yes
7	HELZ2	ENSG00000130589.16			462	2.659	0.1304	Yes
8	LSS	ENSG00000160285.15			553	2.538	0.1449	Yes
9	SQLE	ENSG00000104549.12			823	2.241	0.1533	Yes
10	CYP51A1	ENSG00000001630.17			829	2.232	0.1678	Yes
11	ACAT2	ENSG00000120437.9			847	2.219	0.1819	Yes
12	CYP11A1	ENSG00000140459.18			920	2.156	0.1943	Yes
13	CYP7B1	ENSG00000172817.4			995	2.108	0.2064	Yes
14	CUBN	ENSG00000107611.15			1068	2.070	0.2182	Yes
15	INSIG1	ENSG00000186480.13			1265	1.957	0.2265	Yes
16	SCD	ENSG00000099194.6			1288	1.946	0.2387	Yes
17	RXRA	ENSG00000186350.12			1332	1.918	0.2502	Yes
18	STAR	ENSG00000147465.12			1357	1.903	0.2621	Yes
19	HMGCR	ENSG00000113161.16			1456	1.862	0.2720	Yes
20	MBTPS1	ENSG00000140943.17			1603	1.798	0.2804	Yes
21	MSMO1	ENSG00000052802.13			1692	1.758	0.2898	Yes
22	MVK	ENSG00000110921.14			1775	1.727	0.2992	Yes
23	SLC27A5	ENSG00000083807.10			1786	1.722	0.3103	Yes
24	FDXR	ENSG00000161513.12			1927	1.658	0.3178	Yes
25	HSD17B7	ENSG00000132196.14			1994	1.633	0.3270	Yes
26	PLPP6	ENSG00000205808.6			2085	1.603	0.3354	Yes
27	PTGIS	ENSG00000124212.6			2119	1.592	0.3450	Yes
28	HSD17B11	ENSG00000198189.11			2389	1.508	0.3486	Yes
29	TSPO	ENSG00000100300.18			2475	1.481	0.3563	Yes
30	UBE2I	ENSG00000103275.20			2589	1.445	0.3631	Yes
31	HMGCS1	ENSG00000112972.15			2715	1.404	0.3694	Yes
32	AKR1C1	ENSG00000187134.14			2865	1.362	0.3749	Yes
33	CARM1	ENSG00000142453.11			2879	1.361	0.3835	Yes
34	SREBF2	ENSG00000198911.12			3043	1.323	0.3883	Yes
35	FASN	ENSG00000169710.9			3072	1.316	0.3963	Yes
36	AKR1C3	ENSG00000196139.14			3123	1.306	0.4037	Yes
37	SREBF1	ENSG00000072310.17			3181	1.292	0.4108	Yes
38	MVD	ENSG00000167508.12			3276	1.273	0.4169	Yes
39	CH25H	ENSG00000138135.7			3303	1.268	0.4246	Yes
40	FDPS	ENSG00000160752.14			3502	1.225	0.4280	Yes
41	STARD4	ENSG00000164211.13			3550	1.216	0.4349	Yes
42	HSD3B2	ENSG00000203859.10			3594	1.207	0.4418	Yes
43	OSBPL3	ENSG00000070882.13			3598	1.207	0.4496	Yes
44	CYP7A1	ENSG00000167910.4			3605	1.205	0.4573	Yes
45	DHCR7	ENSG00000172893.15			3663	1.193	0.4638	Yes
46	NCOA2	ENSG00000140396.13			3691	1.187	0.4709	Yes
47	FDFT1	ENSG00000079459.13			3715	1.180	0.4781	Yes
48	SUMO2	ENSG00000188612.12			3876	1.150	0.4819	Yes
49	AKR1C4	ENSG00000198610.11			3885	1.148	0.4892	Yes
50	ACACA	ENSG00000278540.5			4007	1.126	0.4938	Yes
51	PPARA	ENSG00000186951.16			4083	1.114	0.4993	Yes
52	AKR1C2	ENSG00000151632.17			4394	1.062	0.4991	Yes
53	HSD3B7	ENSG00000099377.14			4474	1.048	0.5041	Yes
54	SCP2	ENSG00000116171.18			4794	0.999	0.5032	Yes
55	CYP19A1	ENSG00000137869.15			4946	0.977	0.5061	Yes
56	SEC24D	ENSG00000150961.15			5090	0.956	0.5090	Yes
57	CYP24A1	ENSG00000019186.10			5219	0.937	0.5121	Yes
58	HSD11B1	ENSG00000117594.10			5743	0.870	0.5057	Yes
59	FDX1	ENSG00000137714.3			5937	0.849	0.5067	Yes
60	STARD6	ENSG00000174448.8			6112	0.828	0.5081	Yes
61	SRD5A3	ENSG00000128039.11			6114	0.828	0.5135	Yes
62	TSPOAP1	ENSG00000005379.17			6121	0.827	0.5188	Yes
63	TM7SF2	ENSG00000149809.15			6196	0.817	0.5224	Yes
64	SRD5A1	ENSG00000145545.12			7045	0.733	0.5074	No
65	HSD17B1	ENSG00000108786.10			7364	0.704	0.5046	No
66	NSDHL	ENSG00000147383.11			7604	0.679	0.5035	No
67	CREBBP	ENSG00000005339.14			7714	0.671	0.5054	No
68	TBL1X	ENSG00000101849.17			8055	0.642	0.5017	No
69	LBR	ENSG00000143815.15			8417	0.611	0.4973	No
70	SEC24A	ENSG00000113615.13			8884	0.577	0.4902	No
71	ALB	ENSG00000163631.17			9377	0.545	0.4823	No
72	HSD11B2	ENSG00000176387.7			9508	0.537	0.4828	No
73	EBP	ENSG00000147155.11			9521	0.536	0.4860	No
74	SP1	ENSG00000185591.10			9660	0.525	0.4863	No
75	FDX2	ENSG00000267673.6			10225	0.495	0.4764	No
76	GGPS1	ENSG00000152904.11			10416	0.484	0.4751	No
77	INSIG2	ENSG00000125629.15			10915	0.450	0.4665	No
78	NCOA6	ENSG00000198646.14			10986	0.446	0.4678	No
79	HSD17B12	ENSG00000149084.13			11318	0.426	0.4628	No
80	ACOT8	ENSG00000101473.17			11383	0.422	0.4641	No
81	CYP39A1	ENSG00000146233.8			12375	0.371	0.4435	No
82	OSBPL2	ENSG00000130703.16			12992	0.355	0.4315	No
83	CYP21A2	ENSG00000231852.9			13927	0.321	0.4118	No
84	AKR1B1	ENSG00000085662.14			14091	0.312	0.4101	No
85	VDR	ENSG00000111424.11			15378	0.281	0.3820	No
86	ACACB	ENSG00000076555.15			16077	0.244	0.3674	No
87	HSD17B2	ENSG00000086696.11			17842	0.155	0.3273	No
88	STARD3	ENSG00000131748.16			17944	0.149	0.3259	No
89	LGMN	ENSG00000100600.15			17960	0.148	0.3266	No
90	POMC	ENSG00000115138.11			18442	0.128	0.3162	No
91	SEC24B	ENSG00000138802.11			18776	0.108	0.3092	No
92	ABCC3	ENSG00000108846.16			19322	0.082	0.2970	No
93	ABCB11	ENSG00000073734.10			19500	0.072	0.2934	No
94	IDI1	ENSG00000067064.11			20014	0.048	0.2818	No
95	CYP17A1	ENSG00000148795.7			20505	0.022	0.2705	No
96	TGS1	ENSG00000137574.11			20524	0.021	0.2702	No
97	OSBP	ENSG00000110048.12			20544	0.019	0.2699	No
98	SLC10A2	ENSG00000125255.7			20650	0.014	0.2675	No
99	SEC23A	ENSG00000100934.15			21852	-0.049	0.2399	No
100	SLC10A1	ENSG00000100652.5			22006	-0.057	0.2367	No
101	CYP2R1	ENSG00000186104.10			22814	-0.103	0.2186	No
102	MTF1	ENSG00000188786.10			23796	-0.157	0.1968	No
103	HSD17B4	ENSG00000133835.16			24029	-0.173	0.1926	No
104	NR1H4	ENSG00000012504.15			24416	-0.194	0.1849	No
105	SCAP	ENSG00000114650.20			25720	-0.241	0.1561	No
106	OSBPL9	ENSG00000117859.19			27087	-0.279	0.1262	No
107	PIAS4	ENSG00000105229.7			27321	-0.296	0.1227	No
108	NFYA	ENSG00000001167.14			28408	-0.331	0.0996	No
109	MBTPS2	ENSG00000012174.12			29161	-0.357	0.0844	No
110	SLCO1A2	ENSG00000084453.16			29259	-0.360	0.0845	No
111	SLC27A2	ENSG00000140284.11			30591	-0.441	0.0564	No
112	TBL1XR1	ENSG00000177565.16			30634	-0.446	0.0584	No
113	AMACR	ENSG00000242110.8			31155	-0.472	0.0493	No
114	IDI2	ENSG00000148377.6			31693	-0.497	0.0401	No
115	NFYB	ENSG00000120837.8			32930	-0.578	0.0151	No
116	ARV1	ENSG00000173409.14			33238	-0.601	0.0119	No
117	FABP6	ENSG00000170231.15			33830	-0.647	0.0024	No
118	KPNB1	ENSG00000108424.10			33836	-0.648	0.0065	No
119	SC5D	ENSG00000109929.10			34365	-0.689	-0.0013	No
120	MED1	ENSG00000125686.12			34391	-0.691	0.0027	No
121	CHD9	ENSG00000177200.17			34510	-0.703	0.0045	No
122	CYP8B1	ENSG00000180432.6			34531	-0.704	0.0087	No
123	CGA	ENSG00000135346.8			35164	-0.757	-0.0011	No
124	AKR1D1	ENSG00000122787.15			35205	-0.760	0.0030	No
125	AKR1B15	ENSG00000227471.9			35436	-0.782	0.0027	No
126	PMVK	ENSG00000163344.6			36154	-0.862	-0.0083	No
127	SEC24C	ENSG00000176986.16			36491	-0.899	-0.0103	No
128	CYP27B1	ENSG00000111012.10			36871	-0.950	-0.0129	No
129	SRD5A2	ENSG00000277893.2			37000	-0.965	-0.0095	No
130	NFYC	ENSG00000066136.20			37025	-0.969	-0.0038	No
131	LHB	ENSG00000104826.14			37320	-1.009	-0.0040	No
132	STARD3NL	ENSG00000010270.13			38109	-1.136	-0.0149	No
133	ELOVL6	ENSG00000170522.9			38394	-1.186	-0.0137	No
134	SAR1B	ENSG00000152700.14			39095	-1.330	-0.0213	No
135	LRP2	ENSG00000081479.15			39141	-1.340	-0.0136	No
136	NCOA1	ENSG00000084676.15			39735	-1.475	-0.0178	No
137	RAN	ENSG00000132341.12			39982	-1.544	-0.0134	No
138	GPAM	ENSG00000119927.14			40785	-1.781	-0.0204	No
139	SMARCD3	ENSG00000082014.16			41524	-2.144	-0.0236	No
140	OSBPL6	ENSG00000079156.17			42066	-2.542	-0.0195	No
141	BAAT	ENSG00000136881.11			42499	-3.123	-0.0091	No
142	CYP46A1	ENSG00000036530.9			42702	-3.599	0.0097	No

Fig 2: REACTOME_METABOLISM_OF_STEROIDS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: REACTOME_METABOLISM_OF_STEROIDS: Random ES distribution   
Gene set null distribution of ES for REACTOME_METABOLISM_OF_STEROIDS