Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Phenotype | Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Upregulated in class | FSHD2M |
| GeneSet | REACTOME_MITOTIC_METAPHASE_AND_ANAPHASE |
| Enrichment Score (ES) | -0.52111167 |
| Normalized Enrichment Score (NES) | -2.0730588 |
| Nominal p-value | 0.0 |
| FDR q-value | 4.177965E-4 |
| FWER p-Value | 0.01 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | PSMB9 | ENSG00000240065.8 | 653 | 2.409 | -0.0005 | No | ||
| 2 | PSMB8 | ENSG00000204264.11 | 1023 | 2.095 | 0.0037 | No | ||
| 3 | RPS27 | ENSG00000177954.14 | 2643 | 1.428 | -0.0253 | No | ||
| 4 | NDE1 | ENSG00000072864.15 | 3021 | 1.329 | -0.0259 | No | ||
| 5 | PSMB10 | ENSG00000205220.12 | 3086 | 1.313 | -0.0194 | No | ||
| 6 | CENPS | ENSG00000175279.22 | 3140 | 1.303 | -0.0126 | No | ||
| 7 | VRK2 | ENSG00000028116.17 | 3237 | 1.279 | -0.0071 | No | ||
| 8 | STAG1 | ENSG00000118007.13 | 3483 | 1.228 | -0.0053 | No | ||
| 9 | PPP2R5A | ENSG00000066027.12 | 3610 | 1.204 | -0.0008 | No | ||
| 10 | TUBA3D | ENSG00000075886.11 | 4260 | 1.082 | -0.0093 | No | ||
| 11 | DSN1 | ENSG00000149636.15 | 5002 | 0.968 | -0.0207 | No | ||
| 12 | PPP2R5C | ENSG00000078304.19 | 5802 | 0.864 | -0.0340 | No | ||
| 13 | PPP1CC | ENSG00000186298.12 | 5936 | 0.849 | -0.0319 | No | ||
| 14 | B9D2 | ENSG00000123810.8 | 6448 | 0.792 | -0.0390 | No | ||
| 15 | CDC26 | ENSG00000176386.9 | 7372 | 0.703 | -0.0562 | No | ||
| 16 | NDEL1 | ENSG00000166579.15 | 7623 | 0.678 | -0.0579 | No | ||
| 17 | ANAPC16 | ENSG00000166295.9 | 8822 | 0.582 | -0.0822 | No | ||
| 18 | SPDL1 | ENSG00000040275.17 | 9088 | 0.565 | -0.0850 | No | ||
| 19 | UBA52 | ENSG00000221983.8 | 9987 | 0.512 | -0.1027 | No | ||
| 20 | CENPC | ENSG00000145241.11 | 10230 | 0.495 | -0.1054 | No | ||
| 21 | ITGB3BP | ENSG00000142856.16 | 10820 | 0.457 | -0.1163 | No | ||
| 22 | LEMD2 | ENSG00000161904.12 | 13966 | 0.319 | -0.1876 | No | ||
| 23 | PDS5B | ENSG00000083642.19 | 14594 | 0.304 | -0.2004 | No | ||
| 24 | LMNA | ENSG00000160789.20 | 15491 | 0.275 | -0.2195 | No | ||
| 25 | PSMA2 | ENSG00000106588.11 | 16418 | 0.224 | -0.2398 | No | ||
| 26 | UBB | ENSG00000170315.14 | 17176 | 0.189 | -0.2562 | No | ||
| 27 | PDS5A | ENSG00000121892.15 | 17329 | 0.182 | -0.2587 | No | ||
| 28 | PSME1 | ENSG00000092010.15 | 17744 | 0.161 | -0.2673 | No | ||
| 29 | EMD | ENSG00000102119.10 | 18485 | 0.125 | -0.2838 | No | ||
| 30 | STAG2 | ENSG00000101972.18 | 18529 | 0.122 | -0.2841 | No | ||
| 31 | ANAPC4 | ENSG00000053900.10 | 19109 | 0.094 | -0.2970 | No | ||
| 32 | TUBA3E | ENSG00000152086.9 | 19116 | 0.094 | -0.2965 | No | ||
| 33 | ANAPC5 | ENSG00000089053.13 | 19924 | 0.051 | -0.3150 | No | ||
| 34 | MAD1L1 | ENSG00000002822.15 | 20371 | 0.028 | -0.3253 | No | ||
| 35 | TUBA4B | ENSG00000243910.8 | 20489 | 0.024 | -0.3278 | No | ||
| 36 | PSMF1 | ENSG00000125818.18 | 20560 | 0.019 | -0.3294 | No | ||
| 37 | TUBB1 | ENSG00000101162.3 | 20635 | 0.015 | -0.3310 | No | ||
| 38 | PMF1 | ENSG00000160783.19 | 20847 | 0.005 | -0.3359 | No | ||
| 39 | PPP2R5E | ENSG00000154001.14 | 21137 | -0.013 | -0.3425 | No | ||
| 40 | SEM1 | ENSG00000127922.9 | 21274 | -0.020 | -0.3456 | No | ||
| 41 | SEC13 | ENSG00000157020.18 | 21577 | -0.036 | -0.3524 | No | ||
| 42 | ANAPC10 | ENSG00000164162.14 | 21601 | -0.037 | -0.3527 | No | ||
| 43 | CENPL | ENSG00000120334.15 | 21669 | -0.041 | -0.3540 | No | ||
| 44 | CENPO | ENSG00000138092.11 | 21874 | -0.050 | -0.3585 | No | ||
| 45 | UBC | ENSG00000150991.15 | 21944 | -0.054 | -0.3597 | No | ||
| 46 | UBE2D1 | ENSG00000072401.15 | 22471 | -0.083 | -0.3715 | No | ||
| 47 | FBXO5 | ENSG00000112029.10 | 22909 | -0.108 | -0.3810 | No | ||
| 48 | CDC16 | ENSG00000130177.16 | 23003 | -0.112 | -0.3825 | No | ||
| 49 | PSMD9 | ENSG00000110801.14 | 23060 | -0.115 | -0.3831 | No | ||
| 50 | LEMD3 | ENSG00000174106.3 | 23273 | -0.128 | -0.3872 | No | ||
| 51 | CENPM | ENSG00000100162.15 | 23379 | -0.134 | -0.3889 | No | ||
| 52 | CENPN | ENSG00000166451.13 | 23587 | -0.146 | -0.3928 | No | ||
| 53 | PSMD5 | ENSG00000095261.14 | 23841 | -0.161 | -0.3977 | No | ||
| 54 | DYNLL2 | ENSG00000264364.3 | 23885 | -0.164 | -0.3977 | No | ||
| 55 | RPS27A | ENSG00000143947.13 | 24249 | -0.185 | -0.4050 | No | ||
| 56 | TAOK1 | ENSG00000160551.11 | 24298 | -0.188 | -0.4050 | No | ||
| 57 | RCC2 | ENSG00000179051.14 | 24728 | -0.214 | -0.4137 | No | ||
| 58 | NUP98 | ENSG00000110713.17 | 24843 | -0.220 | -0.4150 | No | ||
| 59 | TUBA3C | ENSG00000198033.12 | 25534 | -0.229 | -0.4297 | No | ||
| 60 | BUB3 | ENSG00000154473.18 | 25548 | -0.230 | -0.4286 | No | ||
| 61 | NSL1 | ENSG00000117697.15 | 25817 | -0.248 | -0.4333 | No | ||
| 62 | PSMA8 | ENSG00000154611.14 | 26134 | -0.263 | -0.4391 | No | ||
| 63 | PSMB11 | ENSG00000222028.5 | 27828 | -0.302 | -0.4767 | No | ||
| 64 | SMC3 | ENSG00000108055.9 | 27903 | -0.302 | -0.4765 | No | ||
| 65 | ANAPC2 | ENSG00000176248.9 | 27964 | -0.306 | -0.4761 | No | ||
| 66 | TUBA8 | ENSG00000183785.15 | 28485 | -0.335 | -0.4861 | No | ||
| 67 | CENPP | ENSG00000188312.14 | 28547 | -0.339 | -0.4855 | No | ||
| 68 | PSMB3 | ENSG00000277791.5 | 29269 | -0.361 | -0.5001 | No | ||
| 69 | SPC24 | ENSG00000161888.11 | 29357 | -0.367 | -0.4998 | No | ||
| 70 | ESPL1 | ENSG00000135476.11 | 29621 | -0.383 | -0.5036 | No | ||
| 71 | TUBB8 | ENSG00000261456.5 | 29700 | -0.387 | -0.5031 | No | ||
| 72 | NDC80 | ENSG00000080986.13 | 29934 | -0.401 | -0.5061 | No | ||
| 73 | CENPA | ENSG00000115163.15 | 30030 | -0.409 | -0.5058 | No | ||
| 74 | TUBB3 | ENSG00000258947.7 | 30130 | -0.416 | -0.5055 | No | ||
| 75 | TUBB4A | ENSG00000104833.12 | 30148 | -0.417 | -0.5034 | No | ||
| 76 | CLIP1 | ENSG00000130779.20 | 30196 | -0.420 | -0.5019 | No | ||
| 77 | BIRC5 | ENSG00000089685.15 | 30216 | -0.422 | -0.4998 | No | ||
| 78 | SPC25 | ENSG00000152253.9 | 30225 | -0.423 | -0.4974 | No | ||
| 79 | CENPK | ENSG00000123219.13 | 30595 | -0.442 | -0.5033 | No | ||
| 80 | PSMA1 | ENSG00000129084.17 | 30662 | -0.448 | -0.5021 | No | ||
| 81 | PSME3 | ENSG00000131467.11 | 30737 | -0.449 | -0.5010 | No | ||
| 82 | CENPQ | ENSG00000031691.7 | 31169 | -0.473 | -0.5082 | No | ||
| 83 | CDCA5 | ENSG00000146670.10 | 31708 | -0.498 | -0.5177 | No | ||
| 84 | PPP2R1B | ENSG00000137713.16 | 31743 | -0.499 | -0.5154 | No | ||
| 85 | NUP37 | ENSG00000075188.9 | 31852 | -0.505 | -0.5148 | No | ||
| 86 | PSMA3 | ENSG00000100567.13 | 31911 | -0.509 | -0.5131 | No | ||
| 87 | CENPE | ENSG00000138778.12 | 32083 | -0.520 | -0.5139 | No | ||
| 88 | NUF2 | ENSG00000143228.13 | 32394 | -0.538 | -0.5178 | Yes | ||
| 89 | MAD2L1 | ENSG00000164109.14 | 32397 | -0.539 | -0.5146 | Yes | ||
| 90 | KNTC1 | ENSG00000184445.12 | 32401 | -0.539 | -0.5113 | Yes | ||
| 91 | NUP133 | ENSG00000069248.12 | 32517 | -0.544 | -0.5107 | Yes | ||
| 92 | PPP2R5B | ENSG00000068971.14 | 32568 | -0.549 | -0.5085 | Yes | ||
| 93 | CDC27 | ENSG00000004897.12 | 32830 | -0.571 | -0.5111 | Yes | ||
| 94 | PSMB1 | ENSG00000008018.9 | 33034 | -0.586 | -0.5122 | Yes | ||
| 95 | CENPU | ENSG00000151725.12 | 33091 | -0.590 | -0.5099 | Yes | ||
| 96 | NUP85 | ENSG00000125450.11 | 33137 | -0.593 | -0.5074 | Yes | ||
| 97 | ERCC6L | ENSG00000186871.7 | 33144 | -0.594 | -0.5039 | Yes | ||
| 98 | CENPF | ENSG00000117724.13 | 33145 | -0.594 | -0.5002 | Yes | ||
| 99 | SKA1 | ENSG00000154839.10 | 33189 | -0.597 | -0.4976 | Yes | ||
| 100 | RANGAP1 | ENSG00000100401.19 | 33269 | -0.602 | -0.4958 | Yes | ||
| 101 | KIF2C | ENSG00000142945.13 | 33404 | -0.613 | -0.4951 | Yes | ||
| 102 | AHCTF1 | ENSG00000153207.15 | 33411 | -0.614 | -0.4915 | Yes | ||
| 103 | PSMD13 | ENSG00000185627.18 | 33437 | -0.616 | -0.4883 | Yes | ||
| 104 | PSMB4 | ENSG00000159377.11 | 33581 | -0.627 | -0.4878 | Yes | ||
| 105 | PSME2 | ENSG00000100911.16 | 33632 | -0.632 | -0.4851 | Yes | ||
| 106 | BUB1B | ENSG00000156970.12 | 33679 | -0.637 | -0.4823 | Yes | ||
| 107 | SEH1L | ENSG00000085415.16 | 33694 | -0.638 | -0.4787 | Yes | ||
| 108 | ZW10 | ENSG00000086827.9 | 33786 | -0.643 | -0.4769 | Yes | ||
| 109 | PSMD10 | ENSG00000101843.19 | 33841 | -0.648 | -0.4742 | Yes | ||
| 110 | TMPO | ENSG00000120802.13 | 33875 | -0.652 | -0.4710 | Yes | ||
| 111 | CENPH | ENSG00000153044.10 | 33904 | -0.654 | -0.4677 | Yes | ||
| 112 | CDCA8 | ENSG00000134690.11 | 33985 | -0.661 | -0.4655 | Yes | ||
| 113 | SGO1 | ENSG00000129810.15 | 34521 | -0.704 | -0.4736 | Yes | ||
| 114 | PPP2CB | ENSG00000104695.13 | 34925 | -0.735 | -0.4785 | Yes | ||
| 115 | PPP2R5D | ENSG00000112640.15 | 34930 | -0.736 | -0.4741 | Yes | ||
| 116 | ZWINT | ENSG00000122952.17 | 34958 | -0.738 | -0.4702 | Yes | ||
| 117 | UBE2C | ENSG00000175063.17 | 34985 | -0.740 | -0.4663 | Yes | ||
| 118 | PLK1 | ENSG00000166851.15 | 35046 | -0.745 | -0.4632 | Yes | ||
| 119 | WAPL | ENSG00000062650.19 | 35121 | -0.752 | -0.4603 | Yes | ||
| 120 | BUB1 | ENSG00000169679.15 | 35145 | -0.755 | -0.4562 | Yes | ||
| 121 | HDAC8 | ENSG00000147099.21 | 35271 | -0.765 | -0.4544 | Yes | ||
| 122 | ZWILCH | ENSG00000174442.12 | 35328 | -0.771 | -0.4510 | Yes | ||
| 123 | ANKLE2 | ENSG00000176915.15 | 35421 | -0.780 | -0.4484 | Yes | ||
| 124 | PSMC5 | ENSG00000087191.13 | 35455 | -0.783 | -0.4444 | Yes | ||
| 125 | AURKB | ENSG00000178999.13 | 35505 | -0.787 | -0.4407 | Yes | ||
| 126 | PAFAH1B1 | ENSG00000007168.13 | 35553 | -0.792 | -0.4370 | Yes | ||
| 127 | ANAPC1 | ENSG00000153107.13 | 35605 | -0.799 | -0.4333 | Yes | ||
| 128 | NUP43 | ENSG00000120253.14 | 35668 | -0.806 | -0.4298 | Yes | ||
| 129 | KNL1 | ENSG00000137812.19 | 35694 | -0.808 | -0.4254 | Yes | ||
| 130 | PSMA7 | ENSG00000101182.15 | 35709 | -0.810 | -0.4208 | Yes | ||
| 131 | PSMB2 | ENSG00000126067.12 | 35837 | -0.822 | -0.4188 | Yes | ||
| 132 | CDC20 | ENSG00000117399.14 | 35877 | -0.828 | -0.4146 | Yes | ||
| 133 | NUP160 | ENSG00000030066.13 | 35953 | -0.838 | -0.4112 | Yes | ||
| 134 | DYNC1I1 | ENSG00000158560.14 | 35990 | -0.843 | -0.4069 | Yes | ||
| 135 | BANF1 | ENSG00000175334.8 | 36126 | -0.859 | -0.4048 | Yes | ||
| 136 | PSMA5 | ENSG00000143106.13 | 36170 | -0.865 | -0.4005 | Yes | ||
| 137 | DYNC1LI2 | ENSG00000135720.13 | 36194 | -0.867 | -0.3957 | Yes | ||
| 138 | CKAP5 | ENSG00000175216.15 | 36214 | -0.869 | -0.3909 | Yes | ||
| 139 | LMNB1 | ENSG00000113368.12 | 36411 | -0.890 | -0.3900 | Yes | ||
| 140 | UBE2E1 | ENSG00000170142.12 | 36422 | -0.891 | -0.3848 | Yes | ||
| 141 | PSMC2 | ENSG00000161057.12 | 36487 | -0.899 | -0.3808 | Yes | ||
| 142 | NUDC | ENSG00000090273.14 | 36798 | -0.941 | -0.3822 | Yes | ||
| 143 | PSMB7 | ENSG00000136930.13 | 36803 | -0.941 | -0.3766 | Yes | ||
| 144 | CDC23 | ENSG00000094880.11 | 36926 | -0.956 | -0.3736 | Yes | ||
| 145 | PSMB6 | ENSG00000142507.10 | 37064 | -0.976 | -0.3708 | Yes | ||
| 146 | INCENP | ENSG00000149503.13 | 37272 | -1.002 | -0.3695 | Yes | ||
| 147 | SGO2 | ENSG00000163535.18 | 37344 | -1.013 | -0.3650 | Yes | ||
| 148 | TUBA4A | ENSG00000127824.14 | 37405 | -1.021 | -0.3601 | Yes | ||
| 149 | CENPI | ENSG00000102384.13 | 37415 | -1.022 | -0.3541 | Yes | ||
| 150 | VRK1 | ENSG00000100749.8 | 37642 | -1.058 | -0.3529 | Yes | ||
| 151 | NUP107 | ENSG00000111581.10 | 37710 | -1.069 | -0.3479 | Yes | ||
| 152 | XPO1 | ENSG00000082898.17 | 37727 | -1.072 | -0.3417 | Yes | ||
| 153 | SKA2 | ENSG00000182628.13 | 37753 | -1.077 | -0.3357 | Yes | ||
| 154 | TUBA1B | ENSG00000123416.15 | 37968 | -1.112 | -0.3339 | Yes | ||
| 155 | PPP2R1A | ENSG00000105568.18 | 38173 | -1.148 | -0.3316 | Yes | ||
| 156 | PPP2R2A | ENSG00000221914.11 | 38312 | -1.174 | -0.3277 | Yes | ||
| 157 | PSMA4 | ENSG00000041357.16 | 38333 | -1.177 | -0.3209 | Yes | ||
| 158 | DYNC1I2 | ENSG00000077380.15 | 38350 | -1.179 | -0.3141 | Yes | ||
| 159 | MIS12 | ENSG00000167842.15 | 38476 | -1.201 | -0.3097 | Yes | ||
| 160 | TUBB2A | ENSG00000137267.6 | 38477 | -1.201 | -0.3023 | Yes | ||
| 161 | PSMB5 | ENSG00000100804.19 | 38565 | -1.217 | -0.2969 | Yes | ||
| 162 | DYNC1LI1 | ENSG00000144635.9 | 38679 | -1.239 | -0.2920 | Yes | ||
| 163 | PTTG1 | ENSG00000164611.13 | 38713 | -1.246 | -0.2851 | Yes | ||
| 164 | DYNLL1 | ENSG00000088986.11 | 38766 | -1.258 | -0.2786 | Yes | ||
| 165 | PSMD7 | ENSG00000103035.11 | 38868 | -1.282 | -0.2731 | Yes | ||
| 166 | PPP2CA | ENSG00000113575.10 | 38889 | -1.286 | -0.2657 | Yes | ||
| 167 | ANAPC7 | ENSG00000196510.12 | 38905 | -1.290 | -0.2582 | Yes | ||
| 168 | TUBB2B | ENSG00000137285.10 | 38935 | -1.296 | -0.2510 | Yes | ||
| 169 | CLASP1 | ENSG00000074054.18 | 39163 | -1.344 | -0.2480 | Yes | ||
| 170 | ANAPC11 | ENSG00000141552.17 | 39180 | -1.349 | -0.2402 | Yes | ||
| 171 | CENPT | ENSG00000102901.13 | 39263 | -1.367 | -0.2337 | Yes | ||
| 172 | PSMD6 | ENSG00000163636.10 | 39440 | -1.407 | -0.2292 | Yes | ||
| 173 | DYNC1H1 | ENSG00000197102.12 | 39457 | -1.412 | -0.2209 | Yes | ||
| 174 | PSMA6 | ENSG00000100902.11 | 39610 | -1.444 | -0.2157 | Yes | ||
| 175 | PSMD3 | ENSG00000108344.15 | 39660 | -1.456 | -0.2079 | Yes | ||
| 176 | PSMD4 | ENSG00000159352.15 | 39708 | -1.468 | -0.2000 | Yes | ||
| 177 | ANAPC15 | ENSG00000110200.8 | 39750 | -1.479 | -0.1919 | Yes | ||
| 178 | PSMC1 | ENSG00000100764.14 | 39751 | -1.479 | -0.1829 | Yes | ||
| 179 | RANBP2 | ENSG00000153201.16 | 39878 | -1.517 | -0.1765 | Yes | ||
| 180 | KIF18A | ENSG00000121621.7 | 39980 | -1.543 | -0.1695 | Yes | ||
| 181 | PSMD12 | ENSG00000197170.10 | 40160 | -1.590 | -0.1639 | Yes | ||
| 182 | CLASP2 | ENSG00000163539.17 | 40223 | -1.605 | -0.1555 | Yes | ||
| 183 | TUBB4B | ENSG00000188229.6 | 40254 | -1.615 | -0.1464 | Yes | ||
| 184 | PSMD8 | ENSG00000099341.11 | 40314 | -1.631 | -0.1378 | Yes | ||
| 185 | PSMC4 | ENSG00000013275.8 | 40405 | -1.659 | -0.1297 | Yes | ||
| 186 | KIF2A | ENSG00000068796.16 | 40453 | -1.672 | -0.1206 | Yes | ||
| 187 | PSMD11 | ENSG00000108671.11 | 40619 | -1.724 | -0.1139 | Yes | ||
| 188 | PSMD14 | ENSG00000115233.12 | 40751 | -1.767 | -0.1061 | Yes | ||
| 189 | PSMC6 | ENSG00000100519.12 | 40791 | -1.783 | -0.0961 | Yes | ||
| 190 | SMC1A | ENSG00000072501.17 | 40902 | -1.825 | -0.0875 | Yes | ||
| 191 | PSMD1 | ENSG00000173692.13 | 41284 | -1.994 | -0.0842 | Yes | ||
| 192 | MAPRE1 | ENSG00000101367.9 | 41383 | -2.053 | -0.0740 | Yes | ||
| 193 | PSMC3 | ENSG00000165916.8 | 41467 | -2.112 | -0.0630 | Yes | ||
| 194 | RAD21 | ENSG00000164754.14 | 41762 | -2.297 | -0.0558 | Yes | ||
| 195 | PSME4 | ENSG00000068878.15 | 41799 | -2.328 | -0.0424 | Yes | ||
| 196 | PSMD2 | ENSG00000175166.17 | 41820 | -2.343 | -0.0285 | Yes | ||
| 197 | TUBA1C | ENSG00000167553.15 | 41915 | -2.420 | -0.0159 | Yes | ||
| 198 | TUBA1A | ENSG00000167552.14 | 42574 | -3.253 | -0.0113 | Yes | ||
| 199 | TUBB6 | ENSG00000176014.13 | 42804 | -3.928 | 0.0073 | Yes |
