Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Phenotype | Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Upregulated in class | FSHD2M |
| GeneSet | REACTOME_ORC1_REMOVAL_FROM_CHROMATIN |
| Enrichment Score (ES) | -0.5774984 |
| Normalized Enrichment Score (NES) | -2.0393755 |
| Nominal p-value | 0.0 |
| FDR q-value | 6.7942106E-4 |
| FWER p-Value | 0.019 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | PSMB9 | ENSG00000240065.8 | 653 | 2.409 | 0.0222 | No | ||
| 2 | PSMB8 | ENSG00000204264.11 | 1023 | 2.095 | 0.0460 | No | ||
| 3 | PSMB10 | ENSG00000205220.12 | 3086 | 1.313 | 0.0185 | No | ||
| 4 | UBA52 | ENSG00000221983.8 | 9987 | 0.512 | -0.1339 | No | ||
| 5 | PSMA2 | ENSG00000106588.11 | 16418 | 0.224 | -0.2798 | No | ||
| 6 | UBB | ENSG00000170315.14 | 17176 | 0.189 | -0.2944 | No | ||
| 7 | PSME1 | ENSG00000092010.15 | 17744 | 0.161 | -0.3051 | No | ||
| 8 | PSMF1 | ENSG00000125818.18 | 20560 | 0.019 | -0.3702 | No | ||
| 9 | MCM7 | ENSG00000166508.17 | 20623 | 0.016 | -0.3714 | No | ||
| 10 | SEM1 | ENSG00000127922.9 | 21274 | -0.020 | -0.3862 | No | ||
| 11 | UBC | ENSG00000150991.15 | 21944 | -0.054 | -0.4009 | No | ||
| 12 | CDT1 | ENSG00000167513.9 | 22064 | -0.060 | -0.4027 | No | ||
| 13 | PSMD9 | ENSG00000110801.14 | 23060 | -0.115 | -0.4240 | No | ||
| 14 | PSMD5 | ENSG00000095261.14 | 23841 | -0.161 | -0.4397 | No | ||
| 15 | RPS27A | ENSG00000143947.13 | 24249 | -0.185 | -0.4463 | No | ||
| 16 | ORC5 | ENSG00000164815.11 | 24869 | -0.222 | -0.4572 | No | ||
| 17 | PSMA8 | ENSG00000154611.14 | 26134 | -0.263 | -0.4825 | No | ||
| 18 | CUL1 | ENSG00000055130.17 | 26496 | -0.266 | -0.4868 | No | ||
| 19 | ORC6 | ENSG00000091651.9 | 27104 | -0.281 | -0.4965 | No | ||
| 20 | PSMB11 | ENSG00000222028.5 | 27828 | -0.302 | -0.5086 | No | ||
| 21 | ORC2 | ENSG00000115942.9 | 28093 | -0.316 | -0.5099 | No | ||
| 22 | MCM6 | ENSG00000076003.5 | 28225 | -0.325 | -0.5079 | No | ||
| 23 | PSMB3 | ENSG00000277791.5 | 29269 | -0.361 | -0.5265 | No | ||
| 24 | ORC3 | ENSG00000135336.14 | 29356 | -0.366 | -0.5228 | No | ||
| 25 | MCM3 | ENSG00000112118.20 | 29614 | -0.382 | -0.5229 | No | ||
| 26 | PSMA1 | ENSG00000129084.17 | 30662 | -0.448 | -0.5403 | No | ||
| 27 | PSME3 | ENSG00000131467.11 | 30737 | -0.449 | -0.5350 | No | ||
| 28 | PSMA3 | ENSG00000100567.13 | 31911 | -0.509 | -0.5544 | No | ||
| 29 | MCM5 | ENSG00000100297.16 | 32907 | -0.577 | -0.5686 | Yes | ||
| 30 | PSMB1 | ENSG00000008018.9 | 33034 | -0.586 | -0.5624 | Yes | ||
| 31 | RBX1 | ENSG00000100387.9 | 33259 | -0.602 | -0.5583 | Yes | ||
| 32 | ORC4 | ENSG00000115947.13 | 33408 | -0.613 | -0.5522 | Yes | ||
| 33 | PSMD13 | ENSG00000185627.18 | 33437 | -0.616 | -0.5433 | Yes | ||
| 34 | PSMB4 | ENSG00000159377.11 | 33581 | -0.627 | -0.5369 | Yes | ||
| 35 | PSME2 | ENSG00000100911.16 | 33632 | -0.632 | -0.5283 | Yes | ||
| 36 | PSMD10 | ENSG00000101843.19 | 33841 | -0.648 | -0.5231 | Yes | ||
| 37 | CCNA1 | ENSG00000133101.10 | 34815 | -0.726 | -0.5345 | Yes | ||
| 38 | CCNA2 | ENSG00000145386.10 | 35426 | -0.780 | -0.5365 | Yes | ||
| 39 | PSMC5 | ENSG00000087191.13 | 35455 | -0.783 | -0.5251 | Yes | ||
| 40 | PSMA7 | ENSG00000101182.15 | 35709 | -0.810 | -0.5184 | Yes | ||
| 41 | PSMB2 | ENSG00000126067.12 | 35837 | -0.822 | -0.5086 | Yes | ||
| 42 | MCM4 | ENSG00000104738.18 | 35969 | -0.840 | -0.4986 | Yes | ||
| 43 | PSMA5 | ENSG00000143106.13 | 36170 | -0.865 | -0.4899 | Yes | ||
| 44 | PSMC2 | ENSG00000161057.12 | 36487 | -0.899 | -0.4833 | Yes | ||
| 45 | ORC1 | ENSG00000085840.13 | 36693 | -0.928 | -0.4737 | Yes | ||
| 46 | PSMB7 | ENSG00000136930.13 | 36803 | -0.941 | -0.4616 | Yes | ||
| 47 | SKP1 | ENSG00000113558.18 | 36892 | -0.952 | -0.4489 | Yes | ||
| 48 | MCM2 | ENSG00000073111.14 | 36965 | -0.962 | -0.4357 | Yes | ||
| 49 | CDK2 | ENSG00000123374.11 | 37047 | -0.974 | -0.4225 | Yes | ||
| 50 | PSMB6 | ENSG00000142507.10 | 37064 | -0.976 | -0.4077 | Yes | ||
| 51 | MCM8 | ENSG00000125885.13 | 37350 | -1.014 | -0.3986 | Yes | ||
| 52 | PSMA4 | ENSG00000041357.16 | 38333 | -1.177 | -0.4032 | Yes | ||
| 53 | PSMB5 | ENSG00000100804.19 | 38565 | -1.217 | -0.3897 | Yes | ||
| 54 | PSMD7 | ENSG00000103035.11 | 38868 | -1.282 | -0.3769 | Yes | ||
| 55 | PSMD6 | ENSG00000163636.10 | 39440 | -1.407 | -0.3683 | Yes | ||
| 56 | PSMA6 | ENSG00000100902.11 | 39610 | -1.444 | -0.3499 | Yes | ||
| 57 | PSMD3 | ENSG00000108344.15 | 39660 | -1.456 | -0.3285 | Yes | ||
| 58 | PSMD4 | ENSG00000159352.15 | 39708 | -1.468 | -0.3068 | Yes | ||
| 59 | PSMC1 | ENSG00000100764.14 | 39751 | -1.479 | -0.2849 | Yes | ||
| 60 | PSMD12 | ENSG00000197170.10 | 40160 | -1.590 | -0.2697 | Yes | ||
| 61 | PSMD8 | ENSG00000099341.11 | 40314 | -1.631 | -0.2480 | Yes | ||
| 62 | PSMC4 | ENSG00000013275.8 | 40405 | -1.659 | -0.2244 | Yes | ||
| 63 | PSMD11 | ENSG00000108671.11 | 40619 | -1.724 | -0.2026 | Yes | ||
| 64 | PSMD14 | ENSG00000115233.12 | 40751 | -1.767 | -0.1783 | Yes | ||
| 65 | PSMC6 | ENSG00000100519.12 | 40791 | -1.783 | -0.1516 | Yes | ||
| 66 | PSMD1 | ENSG00000173692.13 | 41284 | -1.994 | -0.1321 | Yes | ||
| 67 | PSMC3 | ENSG00000165916.8 | 41467 | -2.112 | -0.1036 | Yes | ||
| 68 | CDC6 | ENSG00000094804.12 | 41614 | -2.200 | -0.0729 | Yes | ||
| 69 | SKP2 | ENSG00000145604.16 | 41748 | -2.288 | -0.0406 | Yes | ||
| 70 | PSME4 | ENSG00000068878.15 | 41799 | -2.328 | -0.0057 | Yes | ||
| 71 | PSMD2 | ENSG00000175166.17 | 41820 | -2.343 | 0.0302 | Yes |
