Details for gene set REACTOME_SPHINGOLIPID_METABOLISM[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Phenotype	Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Upregulated in class	FSHD2
GeneSet	REACTOME_SPHINGOLIPID_METABOLISM
Enrichment Score (ES)	0.44926846
Normalized Enrichment Score (NES)	1.8154521
Nominal p-value	0.0
FDR q-value	0.03100423
FWER p-Value	0.671

Fig 1: Enrichment plot: REACTOME_SPHINGOLIPID_METABOLISM   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	PLPP3	ENSG00000162407.9			18	4.425	0.0477	Yes
2	HEXB	ENSG00000049860.14			415	2.734	0.0682	Yes
3	B3GALNT1	ENSG00000169255.15			507	2.592	0.0943	Yes
4	ALDH3A2	ENSG00000072210.19			840	2.223	0.1108	Yes
5	KDSR	ENSG00000119537.18			853	2.214	0.1346	Yes
6	GBA	ENSG00000177628.16			1072	2.067	0.1520	Yes
7	PLPP2	ENSG00000141934.10			1096	2.052	0.1738	Yes
8	ARSG	ENSG00000141337.12			1326	1.924	0.1894	Yes
9	SUMF1	ENSG00000144455.14			1354	1.904	0.2095	Yes
10	STS	ENSG00000101846.7			1712	1.750	0.2202	Yes
11	PRKD2	ENSG00000105287.12			1835	1.698	0.2359	Yes
12	GLB1	ENSG00000170266.16			1972	1.642	0.2505	Yes
13	PRKD3	ENSG00000115825.10			2052	1.612	0.2662	Yes
14	GM2A	ENSG00000196743.9			2138	1.587	0.2815	Yes
15	SPHK2	ENSG00000063176.16			2570	1.450	0.2873	Yes
16	HEXA	ENSG00000213614.9			2587	1.446	0.3026	Yes
17	CERS2	ENSG00000143418.19			2714	1.404	0.3150	Yes
18	DEGS1	ENSG00000143753.13			3004	1.332	0.3228	Yes
19	ARSA	ENSG00000100299.18			3068	1.317	0.3356	Yes
20	SMPD1	ENSG00000166311.10			3178	1.292	0.3471	Yes
21	ACER3	ENSG00000078124.12			3389	1.247	0.3558	Yes
22	CTSA	ENSG00000064601.18			3731	1.177	0.3607	Yes
23	PPM1L	ENSG00000163590.14			3743	1.176	0.3732	Yes
24	CERS4	ENSG00000090661.12			4025	1.122	0.3789	Yes
25	SMPD3	ENSG00000103056.12			4087	1.114	0.3896	Yes
26	PLPP1	ENSG00000067113.17			4224	1.088	0.3983	Yes
27	SUMF2	ENSG00000129103.18			4226	1.088	0.4101	Yes
28	SMPD2	ENSG00000135587.9			4336	1.071	0.4192	Yes
29	GLTP	ENSG00000139433.10			4348	1.069	0.4306	Yes
30	SPTLC1	ENSG00000090054.15			5014	0.966	0.4256	Yes
31	GLB1L	ENSG00000163521.16			5059	0.960	0.4350	Yes
32	GLA	ENSG00000102393.10			5414	0.912	0.4367	Yes
33	CPTP	ENSG00000224051.7			5532	0.896	0.4438	Yes
34	ORMDL3	ENSG00000172057.10			5953	0.847	0.4432	Yes
35	CSNK1G2	ENSG00000133275.16			6082	0.831	0.4493	Yes
36	CERK	ENSG00000100422.14			6861	0.751	0.4394	No
37	PSAP	ENSG00000197746.14			7009	0.737	0.4440	No
38	ACER2	ENSG00000177076.6			7345	0.706	0.4439	No
39	SPTSSA	ENSG00000165389.7			7716	0.671	0.4426	No
40	SPTSSB	ENSG00000196542.8			7880	0.657	0.4459	No
41	ACER1	ENSG00000167769.5			8360	0.615	0.4415	No
42	SPHK1	ENSG00000176170.13			8512	0.605	0.4445	No
43	B4GALNT1	ENSG00000135454.14			10301	0.491	0.4083	No
44	ARSD	ENSG00000006756.16			10345	0.488	0.4126	No
45	GBA2	ENSG00000070610.14			11319	0.426	0.3947	No
46	SMPD4	ENSG00000136699.19			12070	0.384	0.3814	No
47	ALDH3B2	ENSG00000132746.14			12210	0.377	0.3823	No
48	ENPP7	ENSG00000182156.10			12251	0.375	0.3854	No
49	SGPP1	ENSG00000126821.8			13443	0.331	0.3613	No
50	ALDH3B1	ENSG00000006534.16			14064	0.314	0.3503	No
51	SGMS1	ENSG00000198964.14			15404	0.280	0.3223	No
52	ARSE	ENSG00000157399.15			16268	0.232	0.3047	No
53	SAMD8	ENSG00000156671.15			17804	0.157	0.2708	No
54	ARSB	ENSG00000113273.17			18569	0.120	0.2543	No
55	NEU1	ENSG00000204386.11			20064	0.045	0.2201	No
56	OSBP	ENSG00000110048.12			20544	0.019	0.2092	No
57	ORMDL1	ENSG00000128699.14			20901	0.002	0.2009	No
58	ARSJ	ENSG00000180801.14			22309	-0.075	0.1690	No
59	GALC	ENSG00000054983.17			22503	-0.084	0.1655	No
60	ARSK	ENSG00000164291.17			22655	-0.093	0.1630	No
61	DEGS2	ENSG00000168350.8			27095	-0.280	0.0629	No
62	ESYT2	ENSG00000117868.17			27175	-0.286	0.0641	No
63	ARSH	ENSG00000205667.2			29627	-0.383	0.0114	No
64	PRKD1	ENSG00000184304.15			29646	-0.384	0.0151	No
65	NEU2	ENSG00000115488.3			29819	-0.394	0.0154	No
66	SGMS2	ENSG00000164023.14			29947	-0.403	0.0168	No
67	ORMDL2	ENSG00000123353.10			30197	-0.421	0.0156	No
68	VAPA	ENSG00000101558.13			31618	-0.495	-0.0120	No
69	SPTLC3	ENSG00000172296.13			31841	-0.504	-0.0117	No
70	ARSF	ENSG00000062096.15			32737	-0.564	-0.0263	No
71	NEU4	ENSG00000204099.11			34590	-0.709	-0.0617	No
72	FA2H	ENSG00000103089.9			35352	-0.773	-0.0709	No
73	UGT8	ENSG00000174607.11			35823	-0.820	-0.0729	No
74	CERS3	ENSG00000154227.13			35840	-0.823	-0.0644	No
75	ASAH2	ENSG00000188611.15			36136	-0.860	-0.0619	No
76	CERS1	ENSG00000223802.7			36629	-0.919	-0.0633	No
77	NEU3	ENSG00000162139.10			36743	-0.935	-0.0558	No
78	CERS5	ENSG00000139624.13			37273	-1.002	-0.0572	No
79	UGCG	ENSG00000148154.10			37430	-1.024	-0.0496	No
80	ESYT3	ENSG00000158220.14			38196	-1.153	-0.0549	No
81	ASAH1	ENSG00000104763.19			38422	-1.192	-0.0472	No
82	VAPB	ENSG00000124164.15			39198	-1.352	-0.0505	No
83	SPTLC2	ENSG00000100596.6			40030	-1.556	-0.0528	No
84	SGPP2	ENSG00000163082.10			40840	-1.798	-0.0521	No
85	CERS6	ENSG00000172292.14			41144	-1.929	-0.0382	No
86	SGPL1	ENSG00000166224.17			41263	-1.982	-0.0193	No
87	ESYT1	ENSG00000139641.12			41393	-2.061	0.0001	No
88	ARSI	ENSG00000183876.9			42731	-3.679	0.0090	No

Fig 2: REACTOME_SPHINGOLIPID_METABOLISM   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: REACTOME_SPHINGOLIPID_METABOLISM: Random ES distribution   
Gene set null distribution of ES for REACTOME_SPHINGOLIPID_METABOLISM