Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Phenotype | Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Upregulated in class | FSHD2M |
| GeneSet | REACTOME_TRNA_PROCESSING |
| Enrichment Score (ES) | -0.54756683 |
| Normalized Enrichment Score (NES) | -2.0421884 |
| Nominal p-value | 0.0 |
| FDR q-value | 7.036861E-4 |
| FWER p-Value | 0.019 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | TRMT9B | ENSG00000250305.9 | 531 | 2.569 | 0.0163 | No | ||
| 2 | RPP25 | ENSG00000178718.6 | 3706 | 1.182 | -0.0442 | No | ||
| 3 | NUP50 | ENSG00000093000.19 | 4550 | 1.036 | -0.0523 | No | ||
| 4 | NUP54 | ENSG00000138750.15 | 6566 | 0.781 | -0.0904 | No | ||
| 5 | TYW3 | ENSG00000162623.16 | 6776 | 0.760 | -0.0868 | No | ||
| 6 | CPSF1 | ENSG00000071894.17 | 8058 | 0.642 | -0.1094 | No | ||
| 7 | TRMT11 | ENSG00000066651.20 | 10231 | 0.495 | -0.1544 | No | ||
| 8 | RPP21 | ENSG00000241370.5 | 10608 | 0.471 | -0.1579 | No | ||
| 9 | TSEN34 | ENSG00000170892.12 | 11192 | 0.433 | -0.1666 | No | ||
| 10 | TRMT61A | ENSG00000166166.13 | 12151 | 0.379 | -0.1846 | No | ||
| 11 | C2orf49 | ENSG00000135974.10 | 12334 | 0.373 | -0.1847 | No | ||
| 12 | MT-RNR1 | ENSG00000211459.2 | 14093 | 0.311 | -0.2221 | No | ||
| 13 | CLP1 | ENSG00000172409.6 | 15441 | 0.279 | -0.2503 | No | ||
| 14 | THG1L | ENSG00000113272.14 | 16448 | 0.222 | -0.2712 | No | ||
| 15 | XPOT | ENSG00000184575.12 | 17845 | 0.155 | -0.3019 | No | ||
| 16 | TRDMT1 | ENSG00000107614.22 | 18139 | 0.139 | -0.3072 | No | ||
| 17 | ADAT1 | ENSG00000065457.10 | 19199 | 0.088 | -0.3308 | No | ||
| 18 | RPP38 | ENSG00000152464.15 | 19275 | 0.085 | -0.3316 | No | ||
| 19 | MTO1 | ENSG00000135297.15 | 19762 | 0.058 | -0.3423 | No | ||
| 20 | URM1 | ENSG00000167118.10 | 20162 | 0.040 | -0.3511 | No | ||
| 21 | OSGEP | ENSG00000092094.11 | 20211 | 0.037 | -0.3518 | No | ||
| 22 | SEC13 | ENSG00000157020.18 | 21577 | -0.036 | -0.3831 | No | ||
| 23 | TSEN2 | ENSG00000154743.18 | 22436 | -0.081 | -0.4022 | No | ||
| 24 | RPP14 | ENSG00000163684.11 | 22726 | -0.098 | -0.4078 | No | ||
| 25 | TP53RK | ENSG00000172315.6 | 23551 | -0.144 | -0.4254 | No | ||
| 26 | ALKBH8 | ENSG00000137760.14 | 23627 | -0.148 | -0.4254 | No | ||
| 27 | CTU1 | ENSG00000142544.7 | 23778 | -0.155 | -0.4272 | No | ||
| 28 | NSUN6 | ENSG00000241058.4 | 23932 | -0.167 | -0.4289 | No | ||
| 29 | NUP98 | ENSG00000110713.17 | 24843 | -0.220 | -0.4476 | No | ||
| 30 | QTRT2 | ENSG00000151576.10 | 25552 | -0.230 | -0.4615 | No | ||
| 31 | AAAS | ENSG00000094914.14 | 26543 | -0.269 | -0.4815 | No | ||
| 32 | TRMT112 | ENSG00000173113.6 | 27220 | -0.289 | -0.4940 | No | ||
| 33 | PUS3 | ENSG00000110060.9 | 27301 | -0.295 | -0.4925 | No | ||
| 34 | TPR | ENSG00000047410.14 | 27549 | -0.301 | -0.4949 | No | ||
| 35 | TYW5 | ENSG00000162971.11 | 27923 | -0.303 | -0.5002 | No | ||
| 36 | THADA | ENSG00000115970.18 | 28653 | -0.341 | -0.5133 | No | ||
| 37 | ADAT3 | ENSG00000213638.6 | 28734 | -0.347 | -0.5113 | No | ||
| 38 | CDKAL1 | ENSG00000145996.11 | 28787 | -0.351 | -0.5086 | No | ||
| 39 | POP4 | ENSG00000105171.10 | 29564 | -0.379 | -0.5224 | No | ||
| 40 | POM121C | ENSG00000272391.6 | 30109 | -0.414 | -0.5304 | No | ||
| 41 | TRMT1 | ENSG00000104907.12 | 30641 | -0.446 | -0.5378 | No | ||
| 42 | TRMT61B | ENSG00000171103.11 | 30795 | -0.454 | -0.5363 | No | ||
| 43 | RAE1 | ENSG00000101146.13 | 30841 | -0.456 | -0.5323 | No | ||
| 44 | LAGE3 | ENSG00000196976.7 | 30893 | -0.457 | -0.5283 | No | ||
| 45 | POM121 | ENSG00000196313.11 | 31048 | -0.463 | -0.5268 | No | ||
| 46 | NUP37 | ENSG00000075188.9 | 31852 | -0.505 | -0.5398 | No | ||
| 47 | TRMT12 | ENSG00000183665.5 | 32188 | -0.526 | -0.5417 | Yes | ||
| 48 | TRNT1 | ENSG00000072756.17 | 32285 | -0.533 | -0.5380 | Yes | ||
| 49 | NUP133 | ENSG00000069248.12 | 32517 | -0.544 | -0.5373 | Yes | ||
| 50 | NUP205 | ENSG00000155561.15 | 32543 | -0.546 | -0.5318 | Yes | ||
| 51 | ADAT2 | ENSG00000189007.16 | 32903 | -0.577 | -0.5337 | Yes | ||
| 52 | QTRT1 | ENSG00000213339.9 | 33028 | -0.585 | -0.5300 | Yes | ||
| 53 | NUP85 | ENSG00000125450.11 | 33137 | -0.593 | -0.5259 | Yes | ||
| 54 | GTPBP3 | ENSG00000130299.17 | 33549 | -0.624 | -0.5285 | Yes | ||
| 55 | TRMU | ENSG00000100416.15 | 33592 | -0.628 | -0.5224 | Yes | ||
| 56 | CTU2 | ENSG00000174177.13 | 33619 | -0.631 | -0.5160 | Yes | ||
| 57 | SEH1L | ENSG00000085415.16 | 33694 | -0.638 | -0.5106 | Yes | ||
| 58 | RTCB | ENSG00000100220.12 | 33804 | -0.645 | -0.5059 | Yes | ||
| 59 | CPSF4 | ENSG00000160917.15 | 34399 | -0.692 | -0.5120 | Yes | ||
| 60 | NUP35 | ENSG00000163002.13 | 34581 | -0.709 | -0.5083 | Yes | ||
| 61 | NUP62 | ENSG00000213024.11 | 35039 | -0.744 | -0.5106 | Yes | ||
| 62 | EPRS | ENSG00000136628.18 | 35243 | -0.763 | -0.5068 | Yes | ||
| 63 | LCMT2 | ENSG00000168806.8 | 35287 | -0.767 | -0.4993 | Yes | ||
| 64 | NUP43 | ENSG00000120253.14 | 35668 | -0.806 | -0.4991 | Yes | ||
| 65 | PUS1 | ENSG00000177192.14 | 35670 | -0.806 | -0.4901 | Yes | ||
| 66 | POP7 | ENSG00000172336.5 | 35707 | -0.809 | -0.4819 | Yes | ||
| 67 | RPP40 | ENSG00000124787.14 | 35895 | -0.830 | -0.4770 | Yes | ||
| 68 | NUP214 | ENSG00000126883.17 | 35916 | -0.833 | -0.4682 | Yes | ||
| 69 | TSEN54 | ENSG00000182173.13 | 35918 | -0.833 | -0.4589 | Yes | ||
| 70 | NUP160 | ENSG00000030066.13 | 35953 | -0.838 | -0.4503 | Yes | ||
| 71 | TRMT10A | ENSG00000145331.14 | 36446 | -0.894 | -0.4518 | Yes | ||
| 72 | NUP153 | ENSG00000124789.11 | 36546 | -0.906 | -0.4440 | Yes | ||
| 73 | DDX1 | ENSG00000079785.15 | 36736 | -0.934 | -0.4379 | Yes | ||
| 74 | NUP188 | ENSG00000095319.14 | 36744 | -0.935 | -0.4277 | Yes | ||
| 75 | ZBTB8OS | ENSG00000176261.15 | 36766 | -0.936 | -0.4177 | Yes | ||
| 76 | TRMT44 | ENSG00000155275.19 | 36785 | -0.939 | -0.4076 | Yes | ||
| 77 | TPRKB | ENSG00000144034.15 | 36819 | -0.944 | -0.3979 | Yes | ||
| 78 | POP5 | ENSG00000167272.11 | 36991 | -0.965 | -0.3911 | Yes | ||
| 79 | TRMT13 | ENSG00000122435.10 | 37012 | -0.967 | -0.3807 | Yes | ||
| 80 | FAM98B | ENSG00000171262.11 | 37457 | -1.027 | -0.3796 | Yes | ||
| 81 | POP1 | ENSG00000104356.11 | 37645 | -1.058 | -0.3721 | Yes | ||
| 82 | TRIT1 | ENSG00000043514.17 | 37696 | -1.066 | -0.3614 | Yes | ||
| 83 | NUP107 | ENSG00000111581.10 | 37710 | -1.069 | -0.3497 | Yes | ||
| 84 | RPP30 | ENSG00000148688.13 | 38544 | -1.214 | -0.3556 | Yes | ||
| 85 | TYW1 | ENSG00000198874.13 | 38650 | -1.233 | -0.3442 | Yes | ||
| 86 | METTL1 | ENSG00000037897.17 | 38991 | -1.306 | -0.3375 | Yes | ||
| 87 | MT-RNR2 | ENSG00000210082.2 | 39074 | -1.325 | -0.3247 | Yes | ||
| 88 | RTRAF | ENSG00000087302.9 | 39081 | -1.326 | -0.3100 | Yes | ||
| 89 | TRMT5 | ENSG00000126814.7 | 39199 | -1.353 | -0.2976 | Yes | ||
| 90 | ELAC2 | ENSG00000006744.19 | 39233 | -1.361 | -0.2832 | Yes | ||
| 91 | NUP88 | ENSG00000108559.12 | 39539 | -1.429 | -0.2743 | Yes | ||
| 92 | WDR4 | ENSG00000160193.12 | 39557 | -1.433 | -0.2587 | Yes | ||
| 93 | NDC1 | ENSG00000058804.12 | 39702 | -1.467 | -0.2457 | Yes | ||
| 94 | RANBP2 | ENSG00000153201.16 | 39878 | -1.517 | -0.2328 | Yes | ||
| 95 | RAN | ENSG00000132341.12 | 39982 | -1.544 | -0.2180 | Yes | ||
| 96 | NSUN2 | ENSG00000037474.15 | 40094 | -1.570 | -0.2030 | Yes | ||
| 97 | NUP210 | ENSG00000132182.12 | 40138 | -1.584 | -0.1863 | Yes | ||
| 98 | NUP155 | ENSG00000113569.16 | 40500 | -1.687 | -0.1759 | Yes | ||
| 99 | TRMT10C | ENSG00000174173.7 | 40553 | -1.702 | -0.1581 | Yes | ||
| 100 | TSEN15 | ENSG00000198860.12 | 40830 | -1.793 | -0.1445 | Yes | ||
| 101 | TRMT6 | ENSG00000089195.15 | 40871 | -1.811 | -0.1252 | Yes | ||
| 102 | CSTF2 | ENSG00000101811.13 | 40885 | -1.816 | -0.1052 | Yes | ||
| 103 | DUS2 | ENSG00000167264.18 | 41020 | -1.876 | -0.0874 | Yes | ||
| 104 | HSD17B10 | ENSG00000072506.12 | 41554 | -2.165 | -0.0756 | Yes | ||
| 105 | FTSJ1 | ENSG00000068438.15 | 41577 | -2.179 | -0.0518 | Yes | ||
| 106 | NUP58 | ENSG00000139496.16 | 41803 | -2.330 | -0.0310 | Yes | ||
| 107 | PUS7 | ENSG00000091127.14 | 41886 | -2.389 | -0.0062 | Yes | ||
| 108 | NUP93 | ENSG00000102900.13 | 42500 | -3.124 | 0.0144 | Yes |
