Details for gene set HALLMARK_APICAL_JUNCTION[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Phenotype	Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Upregulated in class	ARH
GeneSet	HALLMARK_APICAL_JUNCTION
Enrichment Score (ES)	-0.29505527
Normalized Enrichment Score (NES)	-1.5694858
Nominal p-value	0.0
FDR q-value	0.014778253
FWER p-Value	0.082

Fig 1: Enrichment plot: HALLMARK_APICAL_JUNCTION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	AMIGO1	ENSG00000181754.7			13	2.016	0.0285	No
2	GRB7	ENSG00000141738.14			51	1.629	0.0508	No
3	RHOF	ENSG00000139725.8			871	0.891	0.0436	No
4	JUP	ENSG00000173801.17			1285	0.804	0.0450	No
5	CLDN4	ENSG00000189143.9			1492	0.775	0.0510	No
6	TRO	ENSG00000067445.21			1540	0.768	0.0608	No
7	CLDN15	ENSG00000106404.13			1707	0.746	0.0674	No
8	ACTN3	ENSG00000248746.6			1745	0.740	0.0771	No
9	CX3CL1	ENSG00000006210.7			1988	0.707	0.0813	No
10	CD34	ENSG00000174059.17			2020	0.702	0.0905	No
11	CLDN9	ENSG00000213937.4			2107	0.691	0.0983	No
12	CDH6	ENSG00000113361.13			2559	0.647	0.0965	No
13	CDH4	ENSG00000179242.16			2657	0.637	0.1033	No
14	PDZD3	ENSG00000172367.16			3060	0.601	0.1020	No
15	ADAM15	ENSG00000143537.13			3095	0.599	0.1098	No
16	AMH	ENSG00000104899.8			3357	0.580	0.1117	No
17	MDK	ENSG00000110492.15			3765	0.553	0.1096	No
18	MAPK13	ENSG00000156711.17			3833	0.547	0.1158	No
19	NLGN3	ENSG00000196338.12			3869	0.547	0.1228	No
20	CLDN18	ENSG00000066405.13			4231	0.528	0.1215	No
21	MVD	ENSG00000167508.12			4547	0.516	0.1212	No
22	CDH3	ENSG00000062038.14			4791	0.505	0.1224	No
23	LAMA3	ENSG00000053747.16			5156	0.480	0.1204	No
24	VWF	ENSG00000110799.13			5222	0.476	0.1256	No
25	EVL	ENSG00000196405.13			5263	0.474	0.1314	No
26	MADCAM1	ENSG00000099866.15			5780	0.444	0.1252	No
27	CD99	ENSG00000002586.20			5908	0.438	0.1283	No
28	NRTN	ENSG00000171119.2			6204	0.422	0.1271	No
29	COL16A1	ENSG00000084636.18			6521	0.407	0.1252	No
30	ITGA2	ENSG00000164171.11			7028	0.388	0.1184	No
31	PIK3R3	ENSG00000117461.15			7066	0.387	0.1230	No
32	NECTIN1	ENSG00000110400.11			7078	0.386	0.1283	No
33	COL9A1	ENSG00000112280.16			8277	0.352	0.1041	No
34	INSIG1	ENSG00000186480.13			8475	0.352	0.1043	No
35	PKD1	ENSG00000008710.19			8998	0.336	0.0963	No
36	ICAM1	ENSG00000090339.9			9924	0.314	0.0783	No
37	VCAM1	ENSG00000162692.12			9928	0.314	0.0827	No
38	ATP1A3	ENSG00000105409.19			9984	0.312	0.0858	No
39	PLCG1	ENSG00000124181.14			10758	0.300	0.0712	No
40	CADM2	ENSG00000175161.13			10782	0.299	0.0749	No
41	NLGN2	ENSG00000169992.10			11877	0.275	0.0521	No
42	SLC30A3	ENSG00000115194.11			12102	0.267	0.0505	No
43	TNFRSF11B	ENSG00000164761.9			12330	0.259	0.0487	No
44	MYH10	ENSG00000133026.12			12352	0.259	0.0518	No
45	PBX2	ENSG00000204304.12			13023	0.237	0.0389	No
46	FSCN1	ENSG00000075618.18			13471	0.223	0.0311	No
47	KCNH2	ENSG00000055118.15			13802	0.213	0.0261	No
48	MMP2	ENSG00000087245.13			14001	0.206	0.0242	No
49	GTF2F1	ENSG00000125651.14			14092	0.203	0.0249	No
50	BMP1	ENSG00000168487.19			14194	0.200	0.0253	No
51	CD209	ENSG00000090659.18			14711	0.183	0.0153	No
52	PARD6G	ENSG00000178184.16			15040	0.172	0.0098	No
53	SYMPK	ENSG00000125755.19			15281	0.165	0.0063	No
54	MPZL1	ENSG00000197965.12			15577	0.157	0.0013	No
55	ITGB4	ENSG00000132470.14			15750	0.152	-0.0007	No
56	TRAF1	ENSG00000056558.11			16131	0.142	-0.0080	No
57	IRS1	ENSG00000169047.5			16185	0.140	-0.0073	No
58	INPPL1	ENSG00000165458.14			16199	0.140	-0.0056	No
59	ICAM5	ENSG00000105376.5			16597	0.128	-0.0134	No
60	CDH8	ENSG00000150394.14			17329	0.109	-0.0297	No
61	LAMB3	ENSG00000196878.15			17382	0.108	-0.0295	No
62	THY1	ENSG00000154096.13			17556	0.102	-0.0322	No
63	TAOK2	ENSG00000149930.18			17725	0.098	-0.0349	No
64	AKT2	ENSG00000105221.18			18110	0.088	-0.0430	No
65	ADAM23	ENSG00000114948.13			18128	0.087	-0.0422	No
66	FBN1	ENSG00000166147.13			18163	0.087	-0.0418	No
67	CD276	ENSG00000103855.18			18467	0.080	-0.0481	No
68	DSC3	ENSG00000134762.17			18539	0.078	-0.0487	No
69	SHC1	ENSG00000160691.18			18728	0.073	-0.0522	No
70	SORBS3	ENSG00000120896.13			18804	0.070	-0.0531	No
71	AMIGO2	ENSG00000139211.6			18930	0.067	-0.0551	No
72	CLDN19	ENSG00000164007.11			18953	0.066	-0.0547	No
73	TSC1	ENSG00000165699.14			19580	0.049	-0.0693	No
74	MAPK11	ENSG00000185386.15			19782	0.044	-0.0736	No
75	PTEN	ENSG00000171862.11			19922	0.040	-0.0764	No
76	MAP4K2	ENSG00000168067.12			19948	0.040	-0.0765	No
77	CDH11	ENSG00000140937.14			20042	0.039	-0.0782	No
78	DHX16	ENSG00000204560.10			20188	0.034	-0.0812	No
79	CADM3	ENSG00000162706.13			20336	0.030	-0.0844	No
80	ITGA9	ENSG00000144668.12			20650	0.021	-0.0917	No
81	PECAM1	ENSG00000261371.6			20696	0.020	-0.0925	No
82	IKBKG	ENSG00000269335.5			20921	0.014	-0.0978	No
83	VCAN	ENSG00000038427.16			20990	0.012	-0.0993	No
84	CLDN6	ENSG00000184697.7			21062	0.010	-0.1009	No
85	TIAL1	ENSG00000151923.17			21262	0.005	-0.1057	No
86	TMEM8B	ENSG00000137103.20			21354	0.002	-0.1079	No
87	ADRA1B	ENSG00000170214.5			21501	-0.001	-0.1114	No
88	CLDN7	ENSG00000181885.18			22614	-0.029	-0.1381	No
89	CDK8	ENSG00000132964.12			22656	-0.030	-0.1387	No
90	ALOX15B	ENSG00000179593.16			22718	-0.031	-0.1398	No
91	SGCE	ENSG00000127990.19			22774	-0.033	-0.1406	No
92	PCDH1	ENSG00000156453.13			22966	-0.038	-0.1448	No
93	TJP1	ENSG00000104067.16			23008	-0.040	-0.1452	No
94	PTK2	ENSG00000169398.19			23810	-0.061	-0.1639	No
95	CDSN	ENSG00000204539.4			23849	-0.062	-0.1639	No
96	NEGR1	ENSG00000172260.15			24004	-0.064	-0.1668	No
97	HADH	ENSG00000138796.16			24127	-0.067	-0.1688	No
98	CDH15	ENSG00000129910.8			24335	-0.074	-0.1728	No
99	SPEG	ENSG00000072195.15			24357	-0.075	-0.1722	No
100	NECTIN2	ENSG00000130202.10			24951	-0.090	-0.1854	No
101	MMP9	ENSG00000100985.7			25181	-0.096	-0.1896	No
102	GAMT	ENSG00000130005.13			25302	-0.099	-0.1911	No
103	ZYX	ENSG00000159840.16			25419	-0.103	-0.1925	No
104	CD274	ENSG00000120217.14			25534	-0.106	-0.1938	No
105	CNTN1	ENSG00000018236.15			25551	-0.107	-0.1926	No
106	CLDN5	ENSG00000184113.9			25663	-0.110	-0.1938	No
107	DMP1	ENSG00000152592.14			26068	-0.123	-0.2019	No
108	NRAP	ENSG00000197893.13			26101	-0.124	-0.2009	No
109	KRT31	ENSG00000094796.5			26198	-0.126	-0.2014	No
110	JAM3	ENSG00000166086.13			26245	-0.127	-0.2007	No
111	MAPK14	ENSG00000112062.10			26416	-0.133	-0.2030	No
112	BAIAP2	ENSG00000175866.15			26425	-0.133	-0.2013	No
113	VAV2	ENSG00000160293.17			26522	-0.136	-0.2017	No
114	TSPAN4	ENSG00000214063.11			26951	-0.148	-0.2100	No
115	THBS3	ENSG00000169231.13			27375	-0.160	-0.2181	No
116	ADAMTS5	ENSG00000154736.6			27545	-0.166	-0.2198	No
117	STX4	ENSG00000103496.15			27714	-0.171	-0.2215	No
118	CLDN11	ENSG00000013297.11			27771	-0.173	-0.2204	No
119	WASL	ENSG00000106299.8			27968	-0.179	-0.2226	No
120	NFASC	ENSG00000163531.15			28013	-0.181	-0.2211	No
121	SIRPA	ENSG00000198053.11			28040	-0.182	-0.2191	No
122	ACTN1	ENSG00000072110.13			28265	-0.188	-0.2219	No
123	SRC	ENSG00000197122.11			28621	-0.200	-0.2277	No
124	ACTA1	ENSG00000143632.14			28635	-0.200	-0.2252	No
125	PIK3CB	ENSG00000051382.8			28950	-0.210	-0.2298	No
126	CRAT	ENSG00000095321.17			29033	-0.213	-0.2288	No
127	CRB3	ENSG00000130545.16			29605	-0.231	-0.2395	No
128	ACTN2	ENSG00000077522.13			29748	-0.236	-0.2396	No
129	EXOC4	ENSG00000131558.15			29794	-0.238	-0.2373	No
130	NF1	ENSG00000196712.17			29983	-0.243	-0.2384	No
131	GNAI1	ENSG00000127955.17			30005	-0.244	-0.2354	No
132	SHROOM2	ENSG00000146950.13			30092	-0.247	-0.2340	No
133	ICAM2	ENSG00000108622.11			30148	-0.249	-0.2318	No
134	GNAI2	ENSG00000114353.17			30306	-0.254	-0.2320	No
135	CTNNA1	ENSG00000044115.21			30649	-0.264	-0.2366	No
136	ARHGEF6	ENSG00000129675.16			30786	-0.269	-0.2360	No
137	HRAS	ENSG00000174775.17			30941	-0.275	-0.2359	No
138	NECTIN4	ENSG00000143217.9			31067	-0.279	-0.2349	No
139	MAP3K20	ENSG00000091436.17			31138	-0.282	-0.2326	No
140	LAMC2	ENSG00000058085.15			31167	-0.284	-0.2292	No
141	NRXN2	ENSG00000110076.18			32739	-0.325	-0.2629	No
142	EGFR	ENSG00000146648.18			32910	-0.332	-0.2623	No
143	MSN	ENSG00000147065.17			34050	-0.343	-0.2853	No
144	CTNND1	ENSG00000198561.13			34100	-0.345	-0.2815	No
145	RASA1	ENSG00000145715.15			34655	-0.354	-0.2900	Yes
146	CERCAM	ENSG00000167123.19			34718	-0.357	-0.2864	Yes
147	SKAP2	ENSG00000005020.13			34726	-0.357	-0.2815	Yes
148	AKT3	ENSG00000117020.18			35028	-0.366	-0.2836	Yes
149	DLG1	ENSG00000075711.21			35280	-0.377	-0.2843	Yes
150	RAC2	ENSG00000128340.15			35304	-0.379	-0.2795	Yes
151	SDC3	ENSG00000162512.16			35439	-0.385	-0.2773	Yes
152	ITGA10	ENSG00000143127.13			35608	-0.394	-0.2758	Yes
153	CD86	ENSG00000114013.16			35887	-0.402	-0.2768	Yes
154	LAYN	ENSG00000204381.11			36233	-0.412	-0.2793	Yes
155	CNN2	ENSG00000064666.15			36260	-0.414	-0.2741	Yes
156	ACTG1	ENSG00000184009.12			36290	-0.416	-0.2688	Yes
157	ARPC2	ENSG00000163466.16			36320	-0.417	-0.2636	Yes
158	VASP	ENSG00000125753.14			37239	-0.466	-0.2793	Yes
159	CLDN14	ENSG00000159261.12			37432	-0.479	-0.2772	Yes
160	NECTIN3	ENSG00000177707.11			37578	-0.491	-0.2737	Yes
161	ITGB1	ENSG00000150093.19			37687	-0.501	-0.2692	Yes
162	TGFBI	ENSG00000120708.17			37818	-0.514	-0.2650	Yes
163	PARVA	ENSG00000197702.14			37874	-0.518	-0.2590	Yes
164	ADAM9	ENSG00000168615.12			37925	-0.522	-0.2527	Yes
165	VCL	ENSG00000035403.17			37935	-0.523	-0.2455	Yes
166	NF2	ENSG00000186575.18			37996	-0.527	-0.2394	Yes
167	SLIT2	ENSG00000145147.20			38005	-0.528	-0.2321	Yes
168	B4GALT1	ENSG00000086062.12			38033	-0.530	-0.2252	Yes
169	RRAS	ENSG00000126458.4			38269	-0.547	-0.2231	Yes
170	TUBG1	ENSG00000131462.8			38291	-0.550	-0.2157	Yes
171	SYK	ENSG00000165025.15			38609	-0.563	-0.2154	Yes
172	PFN1	ENSG00000108518.7			38610	-0.563	-0.2074	Yes
173	RSU1	ENSG00000148484.18			38618	-0.563	-0.1995	Yes
174	FLNC	ENSG00000128591.15			38901	-0.590	-0.1980	Yes
175	PPP2R2C	ENSG00000074211.14			39060	-0.607	-0.1932	Yes
176	ITGA3	ENSG00000005884.18			39316	-0.624	-0.1905	Yes
177	MYH9	ENSG00000100345.21			39531	-0.641	-0.1866	Yes
178	LDLRAP1	ENSG00000157978.11			39670	-0.656	-0.1806	Yes
179	WNK4	ENSG00000126562.17			39677	-0.658	-0.1713	Yes
180	COL17A1	ENSG00000065618.21			39690	-0.661	-0.1622	Yes
181	ACTG2	ENSG00000163017.14			39698	-0.662	-0.1529	Yes
182	MPP5	ENSG00000072415.9			39799	-0.673	-0.1457	Yes
183	CAP1	ENSG00000131236.17			39910	-0.697	-0.1385	Yes
184	CDH1	ENSG00000039068.19			40053	-0.722	-0.1316	Yes
185	MYL12B	ENSG00000118680.13			40197	-0.752	-0.1244	Yes
186	YWHAH	ENSG00000128245.15			40295	-0.774	-0.1157	Yes
187	EPB41L2	ENSG00000079819.19			40303	-0.778	-0.1048	Yes
188	ACTC1	ENSG00000159251.8			40334	-0.785	-0.0943	Yes
189	NEXN	ENSG00000162614.18			40381	-0.800	-0.0840	Yes
190	ACTB	ENSG00000075624.16			40426	-0.816	-0.0734	Yes
191	MYL9	ENSG00000101335.10			40576	-0.868	-0.0646	Yes
192	ACTN4	ENSG00000130402.12			40593	-0.872	-0.0526	Yes
193	LIMA1	ENSG00000050405.13			40656	-0.901	-0.0412	Yes
194	CALB2	ENSG00000172137.19			40844	-0.993	-0.0316	Yes
195	FYB1	ENSG00000082074.18			41002	-1.149	-0.0190	Yes
196	PTPRC	ENSG00000081237.20			41122	-1.603	0.0010	Yes

Fig 2: HALLMARK_APICAL_JUNCTION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_APICAL_JUNCTION: Random ES distribution   
Gene set null distribution of ES for HALLMARK_APICAL_JUNCTION