Details for gene set HALLMARK_APOPTOSIS[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Phenotype	Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Upregulated in class	FSHD2
GeneSet	HALLMARK_APOPTOSIS
Enrichment Score (ES)	0.1745431
Normalized Enrichment Score (NES)	0.8181992
Nominal p-value	0.86151606
FDR q-value	0.8427977
FWER p-Value	1.0

Fig 1: Enrichment plot: HALLMARK_APOPTOSIS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	TGFB2	ENSG00000092969.12			152	1.317	0.0211	Yes
2	TIMP1	ENSG00000102265.12			352	1.090	0.0368	Yes
3	BMP2	ENSG00000125845.7			710	0.936	0.0457	Yes
4	IER3	ENSG00000137331.12			1454	0.779	0.0422	Yes
5	CLU	ENSG00000120885.22			1659	0.752	0.0514	Yes
6	EGR3	ENSG00000179388.9			1788	0.735	0.0621	Yes
7	BMF	ENSG00000104081.14			1991	0.707	0.0705	Yes
8	KRT18	ENSG00000111057.11			2128	0.690	0.0802	Yes
9	HGF	ENSG00000019991.18			2292	0.673	0.0889	Yes
10	IFNGR1	ENSG00000027697.14			2329	0.669	0.1006	Yes
11	BCL2L11	ENSG00000153094.23			2637	0.640	0.1052	Yes
12	BTG2	ENSG00000159388.6			2993	0.606	0.1079	Yes
13	SATB1	ENSG00000182568.17			3034	0.604	0.1183	Yes
14	LUM	ENSG00000139329.5			3247	0.588	0.1242	Yes
15	PRF1	ENSG00000180644.8			3351	0.580	0.1326	Yes
16	IL1B	ENSG00000125538.12			3430	0.572	0.1415	Yes
17	IL1A	ENSG00000115008.5			4274	0.526	0.1309	Yes
18	CDKN1B	ENSG00000111276.11			4380	0.521	0.1381	Yes
19	CD38	ENSG00000004468.13			4696	0.511	0.1400	Yes
20	CCND2	ENSG00000118971.8			4862	0.500	0.1454	Yes
21	CD44	ENSG00000026508.18			4934	0.495	0.1530	Yes
22	BCL2L10	ENSG00000137875.4			5825	0.442	0.1397	Yes
23	CFLAR	ENSG00000003402.20			5916	0.438	0.1457	Yes
24	GCH1	ENSG00000131979.19			6236	0.421	0.1459	Yes
25	TNFSF10	ENSG00000121858.11			6380	0.413	0.1502	Yes
26	PDGFRB	ENSG00000113721.14			6580	0.405	0.1529	Yes
27	ISG20	ENSG00000172183.15			6772	0.397	0.1557	Yes
28	EBP	ENSG00000147155.11			6973	0.391	0.1582	Yes
29	PSEN2	ENSG00000143801.17			7101	0.385	0.1624	Yes
30	SC5D	ENSG00000109929.10			7132	0.384	0.1689	Yes
31	LEF1	ENSG00000138795.10			7194	0.381	0.1745	Yes
32	RARA	ENSG00000131759.18			8101	0.358	0.1592	No
33	BGN	ENSG00000182492.16			8477	0.352	0.1567	No
34	HMOX1	ENSG00000100292.17			9075	0.332	0.1484	No
35	DIABLO	ENSG00000184047.19			9135	0.329	0.1531	No
36	TAP1	ENSG00000168394.11			9314	0.323	0.1549	No
37	RHOT2	ENSG00000140983.14			9334	0.322	0.1605	No
38	CD2	ENSG00000116824.5			9412	0.319	0.1646	No
39	IRF1	ENSG00000125347.14			9828	0.318	0.1605	No
40	ANKH	ENSG00000154122.14			10019	0.311	0.1617	No
41	F2R	ENSG00000181104.7			10089	0.309	0.1658	No
42	CASP2	ENSG00000106144.20			11060	0.289	0.1476	No
43	LGALS3	ENSG00000131981.16			11103	0.287	0.1520	No
44	F2	ENSG00000180210.14			12841	0.243	0.1142	No
45	CREBBP	ENSG00000005339.14			13694	0.216	0.0975	No
46	DAP	ENSG00000112977.15			13727	0.215	0.1007	No
47	CASP4	ENSG00000196954.14			13818	0.213	0.1025	No
48	MMP2	ENSG00000087245.13			14001	0.206	0.1020	No
49	MADD	ENSG00000110514.19			14013	0.205	0.1056	No
50	BIK	ENSG00000100290.3			14260	0.198	0.1033	No
51	IGF2R	ENSG00000197081.14			14615	0.187	0.0982	No
52	GUCY2D	ENSG00000132518.6			15106	0.171	0.0895	No
53	GPX4	ENSG00000167468.17			15215	0.168	0.0900	No
54	SQSTM1	ENSG00000161011.20			15233	0.167	0.0927	No
55	H1F0	ENSG00000189060.5			15408	0.161	0.0915	No
56	CASP1	ENSG00000137752.24			15477	0.160	0.0929	No
57	CDC25B	ENSG00000101224.17			15629	0.156	0.0921	No
58	BCAP31	ENSG00000185825.17			16103	0.142	0.0832	No
59	RHOB	ENSG00000143878.10			16535	0.130	0.0752	No
60	PLPPR4	ENSG00000117600.12			16593	0.128	0.0762	No
61	AIFM3	ENSG00000183773.15			16607	0.128	0.0783	No
62	DPYD	ENSG00000188641.13			17096	0.115	0.0686	No
63	CTH	ENSG00000116761.12			17265	0.110	0.0665	No
64	IFITM3	ENSG00000142089.16			17463	0.105	0.0637	No
65	CCNA1	ENSG00000133101.10			17734	0.098	0.0590	No
66	FDXR	ENSG00000161513.12			18088	0.088	0.0520	No
67	GPX3	ENSG00000211445.12			18462	0.080	0.0444	No
68	SAT1	ENSG00000130066.16			19807	0.043	0.0125	No
69	GNA15	ENSG00000060558.4			20226	0.033	0.0029	No
70	DCN	ENSG00000011465.17			20288	0.032	0.0020	No
71	EREG	ENSG00000124882.4			20508	0.024	-0.0029	No
72	CDKN1A	ENSG00000124762.13			21297	0.004	-0.0220	No
73	DDIT3	ENSG00000175197.12			21390	0.001	-0.0242	No
74	TNF	ENSG00000232810.4			21705	-0.006	-0.0318	No
75	SOD2	ENSG00000112096.18			21731	-0.007	-0.0322	No
76	SMAD7	ENSG00000101665.9			22592	-0.028	-0.0527	No
77	ERBB3	ENSG00000065361.15			22995	-0.039	-0.0617	No
78	HMGB2	ENSG00000164104.12			23415	-0.050	-0.0710	No
79	RELA	ENSG00000173039.19			23632	-0.056	-0.0752	No
80	CASP9	ENSG00000132906.18			23652	-0.057	-0.0746	No
81	PTK2	ENSG00000169398.19			23810	-0.061	-0.0773	No
82	GADD45A	ENSG00000116717.13			23989	-0.064	-0.0804	No
83	CTNNB1	ENSG00000168036.18			24288	-0.073	-0.0863	No
84	PSEN1	ENSG00000080815.19			24443	-0.076	-0.0887	No
85	GPX1	ENSG00000233276.5			24689	-0.082	-0.0931	No
86	CASP7	ENSG00000165806.20			24757	-0.084	-0.0932	No
87	SLC20A1	ENSG00000144136.11			24853	-0.087	-0.0938	No
88	TSPO	ENSG00000100300.18			24994	-0.091	-0.0955	No
89	MCL1	ENSG00000143384.13			25273	-0.098	-0.1005	No
90	AVPR1A	ENSG00000166148.3			25596	-0.108	-0.1063	No
91	FEZ1	ENSG00000149557.14			25646	-0.110	-0.1054	No
92	RETSAT	ENSG00000042445.14			25766	-0.113	-0.1062	No
93	PMAIP1	ENSG00000141682.11			25799	-0.113	-0.1048	No
94	RNASEL	ENSG00000135828.11			26645	-0.139	-0.1228	No
95	TIMP3	ENSG00000100234.11			26802	-0.144	-0.1239	No
96	IL18	ENSG00000150782.12			26822	-0.144	-0.1217	No
97	BCL2L2	ENSG00000129473.9			27071	-0.151	-0.1249	No
98	ATF3	ENSG00000162772.17			27076	-0.151	-0.1221	No
99	BNIP3L	ENSG00000104765.16			27191	-0.155	-0.1220	No
100	CASP6	ENSG00000138794.10			27327	-0.159	-0.1223	No
101	MGMT	ENSG00000170430.10			27385	-0.160	-0.1206	No
102	GSTM1	ENSG00000134184.13			27430	-0.162	-0.1187	No
103	GSR	ENSG00000104687.14			28212	-0.187	-0.1342	No
104	PPT1	ENSG00000131238.17			28310	-0.190	-0.1330	No
105	GSN	ENSG00000148180.19			28530	-0.197	-0.1346	No
106	BAX	ENSG00000087088.20			28685	-0.202	-0.1346	No
107	APP	ENSG00000142192.21			29094	-0.215	-0.1405	No
108	DNAJC3	ENSG00000102580.15			29103	-0.215	-0.1366	No
109	ETF1	ENSG00000120705.13			29337	-0.222	-0.1381	No
110	BID	ENSG00000015475.18			29396	-0.225	-0.1353	No
111	HSPB1	ENSG00000106211.9			29472	-0.226	-0.1329	No
112	IL6	ENSG00000136244.12			29624	-0.231	-0.1322	No
113	SPTAN1	ENSG00000197694.16			29628	-0.232	-0.1279	No
114	ADD1	ENSG00000087274.17			29654	-0.233	-0.1241	No
115	PPP3R1	ENSG00000221823.11			29805	-0.238	-0.1233	No
116	ERBB2	ENSG00000141736.13			30053	-0.246	-0.1247	No
117	CASP8	ENSG00000064012.21			30481	-0.259	-0.1302	No
118	TIMP2	ENSG00000035862.12			30859	-0.272	-0.1343	No
119	VDAC2	ENSG00000165637.13			31005	-0.277	-0.1326	No
120	PPP2R5B	ENSG00000068971.14			31101	-0.281	-0.1297	No
121	DFFA	ENSG00000160049.12			31733	-0.287	-0.1396	No
122	DNAJA1	ENSG00000086061.16			32115	-0.301	-0.1433	No
123	CDK2	ENSG00000123374.11			32246	-0.307	-0.1407	No
124	SOD1	ENSG00000142168.14			32307	-0.310	-0.1363	No
125	DAP3	ENSG00000132676.16			32312	-0.310	-0.1306	No
126	CYLD	ENSG00000083799.17			32578	-0.319	-0.1310	No
127	NEDD9	ENSG00000111859.17			33548	-0.338	-0.1483	No
128	FAS	ENSG00000026103.22			34075	-0.344	-0.1546	No
129	CD14	ENSG00000170458.14			34097	-0.345	-0.1487	No
130	LMNA	ENSG00000160789.20			34605	-0.352	-0.1544	No
131	TNFRSF12A	ENSG00000006327.13			34756	-0.359	-0.1513	No
132	BIRC3	ENSG00000023445.14			35047	-0.367	-0.1515	No
133	DNM1L	ENSG00000087470.18			35155	-0.372	-0.1471	No
134	NEFH	ENSG00000100285.10			35194	-0.374	-0.1410	No
135	CASP3	ENSG00000164305.19			35329	-0.380	-0.1371	No
136	PLAT	ENSG00000104368.18			35576	-0.392	-0.1357	No
137	XIAP	ENSG00000101966.12			35786	-0.401	-0.1332	No
138	BTG3	ENSG00000154640.14			36289	-0.416	-0.1376	No
139	ANXA1	ENSG00000135046.14			36480	-0.425	-0.1343	No
140	PAK1	ENSG00000149269.9			36549	-0.430	-0.1278	No
141	ENO2	ENSG00000111674.9			36606	-0.431	-0.1211	No
142	EMP1	ENSG00000134531.10			36872	-0.444	-0.1192	No
143	TGFBR3	ENSG00000069702.11			37426	-0.479	-0.1236	No
144	PDCD4	ENSG00000150593.18			38083	-0.533	-0.1296	No
145	CCND1	ENSG00000110092.3			38307	-0.552	-0.1246	No
146	PLCB2	ENSG00000137841.12			38462	-0.558	-0.1179	No
147	BCL2L1	ENSG00000171552.13			38679	-0.568	-0.1124	No
148	ROCK1	ENSG00000067900.8			39050	-0.606	-0.1101	No
149	BCL10	ENSG00000142867.14			39261	-0.619	-0.1035	No
150	TOP2A	ENSG00000131747.15			39313	-0.624	-0.0930	No
151	IGFBP6	ENSG00000167779.9			39424	-0.628	-0.0839	No
152	TXNIP	ENSG00000265972.6			39777	-0.670	-0.0798	No
153	BRCA1	ENSG00000012048.22			39857	-0.687	-0.0688	No
154	WEE1	ENSG00000166483.11			40002	-0.714	-0.0589	No
155	GADD45B	ENSG00000099860.9			40019	-0.716	-0.0458	No
156	PEA15	ENSG00000162734.12			40282	-0.772	-0.0376	No
157	JUN	ENSG00000177606.7			40305	-0.779	-0.0235	No
158	CAV1	ENSG00000105974.12			41003	-1.149	-0.0189	No
159	CD69	ENSG00000110848.8			41040	-1.206	0.0030	No

Fig 2: HALLMARK_APOPTOSIS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_APOPTOSIS: Random ES distribution   
Gene set null distribution of ES for HALLMARK_APOPTOSIS