Details for gene set HALLMARK_COMPLEMENT[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Phenotype	Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Upregulated in class	ARH
GeneSet	HALLMARK_COMPLEMENT
Enrichment Score (ES)	-0.19976564
Normalized Enrichment Score (NES)	-1.0584162
Nominal p-value	0.29520294
FDR q-value	0.39502594
FWER p-Value	0.998

Fig 1: Enrichment plot: HALLMARK_COMPLEMENT   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	TMPRSS6	ENSG00000187045.18			170	1.289	0.0145	No
2	TIMP1	ENSG00000102265.12			352	1.090	0.0259	No
3	PRSS3	ENSG00000010438.16			372	1.078	0.0410	No
4	CP	ENSG00000047457.14			500	1.015	0.0526	No
5	CTSB	ENSG00000164733.21			706	0.938	0.0612	No
6	KYNU	ENSG00000115919.15			734	0.930	0.0740	No
7	IRF7	ENSG00000185507.21			812	0.910	0.0853	No
8	WAS	ENSG00000015285.10			1194	0.819	0.0879	No
9	C1S	ENSG00000182326.15			1233	0.811	0.0987	No
10	PRSS36	ENSG00000178226.11			1409	0.788	0.1058	No
11	CLU	ENSG00000120885.22			1659	0.752	0.1106	No
12	FCER1G	ENSG00000158869.11			1708	0.746	0.1203	No
13	APOBEC3G	ENSG00000239713.9			1720	0.745	0.1308	No
14	NOTCH4	ENSG00000204301.6			2057	0.698	0.1327	No
15	CFH	ENSG00000000971.15			2168	0.686	0.1399	No
16	CASP5	ENSG00000137757.11			2379	0.664	0.1444	No
17	C1R	ENSG00000159403.18			2987	0.607	0.1384	No
18	CR1	ENSG00000203710.11			3191	0.592	0.1420	No
19	PDGFB	ENSG00000100311.17			3269	0.586	0.1486	No
20	LRP1	ENSG00000123384.14			3445	0.571	0.1526	No
21	CD40LG	ENSG00000102245.7			3595	0.563	0.1572	No
22	PLG	ENSG00000122194.18			3746	0.554	0.1615	No
23	LCP2	ENSG00000043462.12			4413	0.519	0.1528	No
24	PLA2G4A	ENSG00000116711.10			4587	0.514	0.1560	No
25	CFB	ENSG00000243649.8			4800	0.504	0.1581	No
26	KCNIP2	ENSG00000120049.19			4817	0.503	0.1650	No
27	AC016586.1	ENSG00000268670.1			5057	0.487	0.1663	No
28	PLA2G7	ENSG00000146070.17			5454	0.462	0.1633	No
29	ANG	ENSG00000214274.9			5563	0.456	0.1673	No
30	PHEX	ENSG00000102174.9			5750	0.445	0.1692	No
31	CTSL	ENSG00000135047.15			6908	0.393	0.1466	No
32	RASGRP1	ENSG00000172575.12			7013	0.389	0.1497	No
33	APOBEC3F	ENSG00000128394.17			7037	0.387	0.1548	No
34	PCSK9	ENSG00000169174.10			7193	0.381	0.1565	No
35	GP1BA	ENSG00000185245.8			7362	0.374	0.1578	No
36	KLKB1	ENSG00000164344.16			7475	0.372	0.1605	No
37	FCN1	ENSG00000085265.11			7665	0.364	0.1611	No
38	CEBPB	ENSG00000172216.6			8012	0.361	0.1579	No
39	HNF4A	ENSG00000101076.16			8585	0.348	0.1490	No
40	GCA	ENSG00000115271.11			8869	0.340	0.1470	No
41	SERPINC1	ENSG00000117601.13			8910	0.339	0.1509	No
42	ITIH1	ENSG00000055957.11			9346	0.321	0.1450	No
43	L3MBTL4	ENSG00000154655.15			9403	0.319	0.1482	No
44	HPCAL4	ENSG00000116983.13			9727	0.319	0.1450	No
45	IRF1	ENSG00000125347.14			9828	0.318	0.1471	No
46	CCL5	ENSG00000271503.6			9843	0.317	0.1514	No
47	CTSH	ENSG00000103811.16			9963	0.313	0.1530	No
48	C4BPB	ENSG00000123843.13			10036	0.310	0.1558	No
49	GZMK	ENSG00000113088.6			10210	0.305	0.1560	No
50	LGALS3	ENSG00000131981.16			11103	0.287	0.1383	No
51	LCK	ENSG00000182866.17			11848	0.276	0.1242	No
52	PLSCR1	ENSG00000188313.13			12014	0.270	0.1241	No
53	GATA3	ENSG00000107485.18			12041	0.269	0.1273	No
54	BRPF3	ENSG00000096070.19			12101	0.267	0.1298	No
55	CA2	ENSG00000104267.10			12533	0.253	0.1229	No
56	APOC1	ENSG00000130208.9			12577	0.252	0.1255	No
57	MMP14	ENSG00000157227.13			12590	0.252	0.1289	No
58	CTSS	ENSG00000163131.11			12694	0.248	0.1299	No
59	F2	ENSG00000180210.14			12841	0.243	0.1299	No
60	CXCL1	ENSG00000163739.5			12872	0.242	0.1327	No
61	MAFF	ENSG00000185022.12			13047	0.236	0.1319	No
62	C3	ENSG00000125730.17			13115	0.235	0.1336	No
63	CASP4	ENSG00000196954.14			13818	0.213	0.1196	No
64	CPM	ENSG00000135678.12			13833	0.212	0.1223	No
65	PLEK	ENSG00000115956.10			13995	0.206	0.1213	No
66	F7	ENSG00000057593.13			14587	0.187	0.1096	No
67	CASP1	ENSG00000137752.24			15477	0.160	0.0902	No
68	PRCP	ENSG00000137509.11			15766	0.151	0.0854	No
69	DUSP6	ENSG00000139318.8			16150	0.141	0.0781	No
70	CTSC	ENSG00000109861.16			16154	0.141	0.0801	No
71	C2	ENSG00000166278.15			16704	0.125	0.0685	No
72	ME1	ENSG00000065833.9			17317	0.109	0.0551	No
73	RCE1	ENSG00000173653.8			17617	0.101	0.0493	No
74	SERPING1	ENSG00000149131.15			17821	0.096	0.0457	No
75	SPOCK2	ENSG00000107742.13			17942	0.092	0.0441	No
76	LYN	ENSG00000254087.8			18130	0.087	0.0408	No
77	PIM1	ENSG00000137193.14			18349	0.082	0.0367	No
78	KLK1	ENSG00000167748.11			18428	0.081	0.0360	No
79	RBSN	ENSG00000131381.12			18624	0.076	0.0323	No
80	ITGAM	ENSG00000169896.18			18894	0.068	0.0267	No
81	DGKH	ENSG00000102780.16			18983	0.065	0.0255	No
82	MMP8	ENSG00000118113.12			18994	0.065	0.0262	No
83	ZFPM2	ENSG00000169946.14			19179	0.060	0.0226	No
84	JAK2	ENSG00000096968.13			19235	0.058	0.0221	No
85	TFPI2	ENSG00000105825.14			19794	0.044	0.0091	No
86	IRF2	ENSG00000168310.11			20158	0.035	0.0008	No
87	S100A13	ENSG00000189171.14			20350	0.029	-0.0035	No
88	DOCK9	ENSG00000088387.19			20497	0.025	-0.0067	No
89	CD46	ENSG00000117335.19			20971	0.013	-0.0180	No
90	CBLB	ENSG00000114423.22			21237	0.006	-0.0244	No
91	LIPA	ENSG00000107798.18			21596	-0.004	-0.0331	No
92	CD55	ENSG00000196352.15			21778	-0.009	-0.0374	No
93	CD59	ENSG00000085063.16			22198	-0.018	-0.0474	No
94	CASP10	ENSG00000003400.14			22206	-0.018	-0.0473	No
95	DPP4	ENSG00000197635.10			22241	-0.019	-0.0478	No
96	LGMN	ENSG00000100600.15			22291	-0.020	-0.0487	No
97	CTSV	ENSG00000136943.11			22972	-0.039	-0.0648	No
98	PSMB9	ENSG00000240065.8			23347	-0.048	-0.0732	No
99	MMP15	ENSG00000102996.5			23626	-0.056	-0.0792	No
100	CASP9	ENSG00000132906.18			23652	-0.057	-0.0790	No
101	MMP13	ENSG00000137745.12			23862	-0.062	-0.0832	No
102	PSEN1	ENSG00000080815.19			24443	-0.076	-0.0962	No
103	CTSO	ENSG00000256043.3			24619	-0.080	-0.0993	No
104	LTA4H	ENSG00000111144.10			24714	-0.083	-0.1004	No
105	CASP7	ENSG00000165806.20			24757	-0.084	-0.1002	No
106	SERPINA1	ENSG00000197249.13			25161	-0.095	-0.1087	No
107	F10	ENSG00000126218.12			25229	-0.097	-0.1089	No
108	SCG3	ENSG00000104112.9			25353	-0.101	-0.1105	No
109	MSRB1	ENSG00000198736.11			25505	-0.105	-0.1126	No
110	PPP4C	ENSG00000149923.14			25689	-0.111	-0.1155	No
111	PREP	ENSG00000085377.14			25883	-0.116	-0.1185	No
112	CTSD	ENSG00000117984.14			25979	-0.120	-0.1191	No
113	COL4A2	ENSG00000134871.19			26354	-0.131	-0.1263	No
114	CPQ	ENSG00000104324.16			26491	-0.135	-0.1277	No
115	AKAP10	ENSG00000108599.15			26550	-0.137	-0.1271	No
116	RHOG	ENSG00000177105.10			26871	-0.145	-0.1329	No
117	LAMP2	ENSG00000005893.15			26933	-0.147	-0.1322	No
118	TNFAIP3	ENSG00000118503.15			27043	-0.151	-0.1327	No
119	PRDM4	ENSG00000110851.12			27070	-0.151	-0.1311	No
120	USP8	ENSG00000138592.14			27099	-0.152	-0.1296	No
121	RABIF	ENSG00000183155.5			27378	-0.160	-0.1341	No
122	SH2B3	ENSG00000111252.10			27552	-0.166	-0.1359	No
123	STX4	ENSG00000103496.15			27714	-0.171	-0.1373	No
124	DYRK2	ENSG00000127334.10			27876	-0.176	-0.1387	No
125	SRC	ENSG00000197122.11			28621	-0.200	-0.1540	No
126	GNB2	ENSG00000172354.10			28962	-0.211	-0.1592	No
127	PCLO	ENSG00000186472.20			28966	-0.211	-0.1563	No
128	FDX1	ENSG00000137714.3			29012	-0.212	-0.1543	No
129	PIK3CA	ENSG00000121879.5			29125	-0.216	-0.1539	No
130	RNF4	ENSG00000063978.16			29506	-0.227	-0.1599	No
131	IL6	ENSG00000136244.12			29624	-0.231	-0.1594	No
132	ACTN2	ENSG00000077522.13			29748	-0.236	-0.1590	No
133	CDA	ENSG00000158825.6			29864	-0.240	-0.1583	No
134	PDP1	ENSG00000164951.16			30013	-0.244	-0.1584	No
135	F8	ENSG00000185010.15			30159	-0.249	-0.1583	No
136	GNAI2	ENSG00000114353.17			30306	-0.254	-0.1582	No
137	KCNIP3	ENSG00000115041.13			30395	-0.256	-0.1566	No
138	LAP3	ENSG00000002549.12			30778	-0.269	-0.1621	No
139	RAF1	ENSG00000132155.11			30802	-0.270	-0.1587	No
140	XPNPEP1	ENSG00000108039.18			30817	-0.270	-0.1551	No
141	TIMP2	ENSG00000035862.12			30859	-0.272	-0.1522	No
142	LTF	ENSG00000012223.13			31945	-0.294	-0.1744	No
143	VCPIP1	ENSG00000175073.8			31949	-0.295	-0.1702	No
144	ERAP2	ENSG00000164308.16			32046	-0.298	-0.1683	No
145	CDK5R1	ENSG00000176749.9			32195	-0.304	-0.1675	No
146	HSPA5	ENSG00000044574.8			32282	-0.308	-0.1651	No
147	GNAI3	ENSG00000065135.11			32448	-0.315	-0.1646	No
148	MT3	ENSG00000087250.8			32970	-0.335	-0.1724	No
149	CD36	ENSG00000135218.19			32994	-0.336	-0.1681	No
150	CALM3	ENSG00000160014.17			33609	-0.341	-0.1782	No
151	PIK3R5	ENSG00000141506.13			34205	-0.350	-0.1876	No
152	EHD1	ENSG00000110047.18			34703	-0.356	-0.1946	Yes
153	PRKCD	ENSG00000163932.15			34711	-0.356	-0.1896	Yes
154	USP16	ENSG00000156256.15			34755	-0.359	-0.1855	Yes
155	DGKG	ENSG00000058866.15			35021	-0.366	-0.1866	Yes
156	GRB2	ENSG00000177885.15			35242	-0.375	-0.1866	Yes
157	PLAUR	ENSG00000011422.12			35312	-0.379	-0.1828	Yes
158	CASP3	ENSG00000164305.19			35329	-0.380	-0.1776	Yes
159	DOCK4	ENSG00000128512.22			35473	-0.387	-0.1755	Yes
160	USP15	ENSG00000135655.16			35549	-0.391	-0.1717	Yes
161	PLAT	ENSG00000104368.18			35576	-0.392	-0.1667	Yes
162	HSPA1A	ENSG00000204389.10			35629	-0.395	-0.1622	Yes
163	C1QA	ENSG00000173372.17			35837	-0.402	-0.1614	Yes
164	F5	ENSG00000198734.11			35972	-0.404	-0.1588	Yes
165	PIK3CG	ENSG00000105851.11			36210	-0.412	-0.1587	Yes
166	GPD2	ENSG00000115159.16			36374	-0.420	-0.1566	Yes
167	ADRA2B	ENSG00000274286.2			36632	-0.433	-0.1566	Yes
168	KIF2A	ENSG00000068796.16			36994	-0.452	-0.1588	Yes
169	ZEB1	ENSG00000148516.21			37086	-0.457	-0.1544	Yes
170	CSRP1	ENSG00000159176.14			37484	-0.484	-0.1571	Yes
171	SERPINE1	ENSG00000106366.8			37533	-0.487	-0.1512	Yes
172	FYN	ENSG00000010810.17			37878	-0.518	-0.1521	Yes
173	ADAM9	ENSG00000168615.12			37925	-0.522	-0.1457	Yes
174	USP14	ENSG00000101557.15			38195	-0.542	-0.1444	Yes
175	ATOX1	ENSG00000177556.12			38206	-0.543	-0.1368	Yes
176	CALM1	ENSG00000198668.12			38464	-0.558	-0.1350	Yes
177	GZMB	ENSG00000100453.13			38501	-0.558	-0.1278	Yes
178	PFN1	ENSG00000108518.7			38610	-0.563	-0.1222	Yes
179	PPP2CB	ENSG00000104695.13			38708	-0.572	-0.1163	Yes
180	OLR1	ENSG00000173391.9			39260	-0.619	-0.1208	Yes
181	DUSP5	ENSG00000138166.6			39412	-0.627	-0.1154	Yes
182	CDH13	ENSG00000140945.17			39497	-0.634	-0.1083	Yes
183	GMFB	ENSG00000197045.13			39786	-0.671	-0.1056	Yes
184	GNB4	ENSG00000114450.10			39856	-0.687	-0.0973	Yes
185	F3	ENSG00000117525.14			40005	-0.714	-0.0906	Yes
186	GNG2	ENSG00000186469.8			40450	-0.824	-0.0895	Yes
187	GNGT2	ENSG00000167083.7			40499	-0.839	-0.0785	Yes
188	FN1	ENSG00000115414.19			40842	-0.991	-0.0725	Yes
189	DOCK10	ENSG00000135905.19			40890	-1.024	-0.0588	Yes
190	ANXA5	ENSG00000164111.15			40922	-1.038	-0.0445	Yes
191	C9	ENSG00000113600.11			40949	-1.072	-0.0297	Yes
192	SERPINB2	ENSG00000197632.9			40988	-1.121	-0.0143	Yes
193	MMP12	ENSG00000262406.3			41064	-1.280	0.0024	Yes

Fig 2: HALLMARK_COMPLEMENT   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_COMPLEMENT: Random ES distribution   
Gene set null distribution of ES for HALLMARK_COMPLEMENT