Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH |
| Phenotype | Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH |
| Upregulated in class | ARH |
| GeneSet | HALLMARK_E2F_TARGETS |
| Enrichment Score (ES) | -0.59961104 |
| Normalized Enrichment Score (NES) | -3.217025 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | WDR90 | ENSG00000161996.19 | 2633 | 0.640 | -0.0553 | No | ||
| 2 | CDKN1B | ENSG00000111276.11 | 4380 | 0.521 | -0.0907 | No | ||
| 3 | LBR | ENSG00000143815.15 | 7515 | 0.370 | -0.1620 | No | ||
| 4 | PAN2 | ENSG00000135473.15 | 8925 | 0.339 | -0.1917 | No | ||
| 5 | SHMT1 | ENSG00000176974.20 | 8977 | 0.337 | -0.1882 | No | ||
| 6 | EXOSC8 | ENSG00000120699.13 | 9375 | 0.320 | -0.1935 | No | ||
| 7 | LUC7L3 | ENSG00000108848.16 | 12342 | 0.259 | -0.2622 | No | ||
| 8 | NASP | ENSG00000132780.17 | 13329 | 0.227 | -0.2831 | No | ||
| 9 | CHEK2 | ENSG00000183765.22 | 14522 | 0.190 | -0.3096 | No | ||
| 10 | PNN | ENSG00000100941.9 | 14966 | 0.175 | -0.3180 | No | ||
| 11 | POLE4 | ENSG00000115350.12 | 15368 | 0.163 | -0.3255 | No | ||
| 12 | CDC25B | ENSG00000101224.17 | 15629 | 0.156 | -0.3297 | No | ||
| 13 | PDS5B | ENSG00000083642.19 | 16191 | 0.140 | -0.3414 | No | ||
| 14 | RPA2 | ENSG00000117748.10 | 16945 | 0.118 | -0.3581 | No | ||
| 15 | RAD1 | ENSG00000113456.19 | 17050 | 0.116 | -0.3590 | No | ||
| 16 | MCM7 | ENSG00000166508.17 | 17495 | 0.104 | -0.3684 | No | ||
| 17 | ASF1A | ENSG00000111875.8 | 17873 | 0.094 | -0.3763 | No | ||
| 18 | EED | ENSG00000074266.21 | 18011 | 0.090 | -0.3784 | No | ||
| 19 | HMGA1 | ENSG00000137309.19 | 18018 | 0.090 | -0.3773 | No | ||
| 20 | SSRP1 | ENSG00000149136.9 | 18191 | 0.086 | -0.3803 | No | ||
| 21 | PHF5A | ENSG00000100410.8 | 18618 | 0.076 | -0.3896 | No | ||
| 22 | RAD21 | ENSG00000164754.14 | 18730 | 0.073 | -0.3913 | No | ||
| 23 | POLE | ENSG00000177084.17 | 19403 | 0.054 | -0.4070 | No | ||
| 24 | ORC2 | ENSG00000115942.9 | 19607 | 0.048 | -0.4113 | No | ||
| 25 | MRE11 | ENSG00000020922.12 | 19896 | 0.041 | -0.4177 | No | ||
| 26 | SNRPB | ENSG00000125835.18 | 20050 | 0.038 | -0.4209 | No | ||
| 27 | NOLC1 | ENSG00000166197.16 | 20493 | 0.025 | -0.4314 | No | ||
| 28 | CDKN1A | ENSG00000124762.13 | 21297 | 0.004 | -0.4509 | No | ||
| 29 | SMC4 | ENSG00000113810.16 | 21685 | -0.006 | -0.4603 | No | ||
| 30 | NBN | ENSG00000104320.13 | 21733 | -0.007 | -0.4613 | No | ||
| 31 | TBRG4 | ENSG00000136270.14 | 21759 | -0.008 | -0.4618 | No | ||
| 32 | NAP1L1 | ENSG00000187109.14 | 22158 | -0.017 | -0.4713 | No | ||
| 33 | CTCF | ENSG00000102974.16 | 22185 | -0.018 | -0.4717 | No | ||
| 34 | RAD50 | ENSG00000113522.14 | 22224 | -0.019 | -0.4724 | No | ||
| 35 | HNRNPD | ENSG00000138668.19 | 22348 | -0.022 | -0.4751 | No | ||
| 36 | TRA2B | ENSG00000136527.18 | 22499 | -0.027 | -0.4784 | No | ||
| 37 | POP7 | ENSG00000172336.5 | 22583 | -0.028 | -0.4800 | No | ||
| 38 | MSH2 | ENSG00000095002.14 | 22645 | -0.030 | -0.4811 | No | ||
| 39 | AK2 | ENSG00000004455.17 | 22999 | -0.039 | -0.4891 | No | ||
| 40 | PPM1D | ENSG00000170836.11 | 23026 | -0.040 | -0.4892 | No | ||
| 41 | CIT | ENSG00000122966.16 | 23230 | -0.045 | -0.4935 | No | ||
| 42 | NAA38 | ENSG00000183011.13 | 23374 | -0.049 | -0.4963 | No | ||
| 43 | HMGB2 | ENSG00000164104.12 | 23415 | -0.050 | -0.4966 | No | ||
| 44 | DSCC1 | ENSG00000136982.6 | 23467 | -0.051 | -0.4971 | No | ||
| 45 | NUDT21 | ENSG00000167005.14 | 24528 | -0.078 | -0.5219 | No | ||
| 46 | NCAPD2 | ENSG00000010292.13 | 24848 | -0.087 | -0.5285 | No | ||
| 47 | POLA2 | ENSG00000014138.9 | 24862 | -0.087 | -0.5276 | No | ||
| 48 | MTHFD2 | ENSG00000065911.12 | 25466 | -0.104 | -0.5409 | No | ||
| 49 | RBBP7 | ENSG00000102054.17 | 25519 | -0.106 | -0.5406 | No | ||
| 50 | DDX39A | ENSG00000123136.15 | 25570 | -0.107 | -0.5404 | No | ||
| 51 | POLD1 | ENSG00000062822.14 | 25827 | -0.115 | -0.5450 | No | ||
| 52 | PPP1R8 | ENSG00000117751.18 | 25945 | -0.119 | -0.5462 | No | ||
| 53 | ILF3 | ENSG00000129351.17 | 26047 | -0.122 | -0.5470 | No | ||
| 54 | PSIP1 | ENSG00000164985.15 | 26088 | -0.123 | -0.5462 | No | ||
| 55 | RFC1 | ENSG00000035928.16 | 26169 | -0.125 | -0.5464 | No | ||
| 56 | POLD3 | ENSG00000077514.9 | 26261 | -0.128 | -0.5469 | No | ||
| 57 | CDK4 | ENSG00000135446.17 | 26296 | -0.129 | -0.5459 | No | ||
| 58 | UBR7 | ENSG00000012963.15 | 26398 | -0.132 | -0.5465 | No | ||
| 59 | XRCC6 | ENSG00000196419.12 | 26529 | -0.136 | -0.5478 | No | ||
| 60 | SMC6 | ENSG00000163029.16 | 26572 | -0.137 | -0.5469 | No | ||
| 61 | H2AFX | ENSG00000188486.3 | 26590 | -0.138 | -0.5454 | No | ||
| 62 | RFC2 | ENSG00000049541.11 | 26606 | -0.138 | -0.5438 | No | ||
| 63 | UNG | ENSG00000076248.10 | 26682 | -0.140 | -0.5437 | No | ||
| 64 | NUP107 | ENSG00000111581.10 | 26867 | -0.145 | -0.5462 | No | ||
| 65 | DCTPP1 | ENSG00000179958.9 | 26881 | -0.146 | -0.5445 | No | ||
| 66 | CNOT9 | ENSG00000144580.13 | 27082 | -0.152 | -0.5472 | No | ||
| 67 | TFRC | ENSG00000072274.13 | 27176 | -0.154 | -0.5473 | No | ||
| 68 | USP1 | ENSG00000162607.13 | 27180 | -0.154 | -0.5452 | No | ||
| 69 | TP53 | ENSG00000141510.17 | 27245 | -0.156 | -0.5446 | No | ||
| 70 | CBX5 | ENSG00000094916.16 | 27290 | -0.158 | -0.5435 | No | ||
| 71 | DUT | ENSG00000128951.14 | 27355 | -0.160 | -0.5428 | No | ||
| 72 | MXD3 | ENSG00000213347.10 | 27476 | -0.163 | -0.5435 | No | ||
| 73 | NOP56 | ENSG00000101361.17 | 27506 | -0.165 | -0.5419 | No | ||
| 74 | SUV39H1 | ENSG00000101945.16 | 27901 | -0.176 | -0.5490 | No | ||
| 75 | STAG1 | ENSG00000118007.13 | 28245 | -0.188 | -0.5548 | No | ||
| 76 | ING3 | ENSG00000071243.16 | 28287 | -0.189 | -0.5531 | No | ||
| 77 | LIG1 | ENSG00000105486.14 | 28401 | -0.193 | -0.5532 | No | ||
| 78 | MCM3 | ENSG00000112118.20 | 29007 | -0.212 | -0.5650 | No | ||
| 79 | SRSF2 | ENSG00000161547.16 | 29115 | -0.215 | -0.5646 | No | ||
| 80 | DONSON | ENSG00000159147.18 | 29209 | -0.218 | -0.5639 | No | ||
| 81 | NUP153 | ENSG00000124789.11 | 29336 | -0.222 | -0.5638 | No | ||
| 82 | EZH2 | ENSG00000106462.10 | 29613 | -0.231 | -0.5673 | No | ||
| 83 | POLD2 | ENSG00000106628.10 | 29968 | -0.243 | -0.5726 | No | ||
| 84 | CKS2 | ENSG00000123975.5 | 30183 | -0.250 | -0.5743 | No | ||
| 85 | CKS1B | ENSG00000173207.13 | 30473 | -0.259 | -0.5777 | No | ||
| 86 | CDKN3 | ENSG00000100526.20 | 30484 | -0.259 | -0.5744 | No | ||
| 87 | RANBP1 | ENSG00000099901.17 | 30689 | -0.265 | -0.5756 | No | ||
| 88 | CDKN2C | ENSG00000123080.12 | 30743 | -0.267 | -0.5732 | No | ||
| 89 | PRKDC | ENSG00000253729.7 | 30793 | -0.269 | -0.5706 | No | ||
| 90 | CDCA3 | ENSG00000111665.11 | 30816 | -0.270 | -0.5674 | No | ||
| 91 | ZW10 | ENSG00000086827.9 | 30856 | -0.271 | -0.5646 | No | ||
| 92 | KIF22 | ENSG00000079616.12 | 30925 | -0.274 | -0.5624 | No | ||
| 93 | TIMELESS | ENSG00000111602.12 | 31041 | -0.279 | -0.5613 | No | ||
| 94 | RPA1 | ENSG00000132383.12 | 31119 | -0.282 | -0.5592 | No | ||
| 95 | PA2G4 | ENSG00000170515.14 | 31890 | -0.293 | -0.5739 | No | ||
| 96 | SYNCRIP | ENSG00000135316.18 | 31926 | -0.294 | -0.5707 | No | ||
| 97 | PTTG1 | ENSG00000164611.13 | 31965 | -0.295 | -0.5675 | No | ||
| 98 | MLH1 | ENSG00000076242.14 | 32002 | -0.296 | -0.5642 | No | ||
| 99 | CCNE1 | ENSG00000105173.14 | 32197 | -0.305 | -0.5647 | No | ||
| 100 | MCM2 | ENSG00000073111.14 | 32546 | -0.318 | -0.5688 | No | ||
| 101 | HMGB3 | ENSG00000029993.15 | 32666 | -0.323 | -0.5672 | No | ||
| 102 | TMPO | ENSG00000120802.13 | 32905 | -0.332 | -0.5683 | No | ||
| 103 | CDC20 | ENSG00000117399.14 | 34187 | -0.349 | -0.5947 | Yes | ||
| 104 | PSMC3IP | ENSG00000131470.14 | 34196 | -0.349 | -0.5901 | Yes | ||
| 105 | SRSF1 | ENSG00000136450.13 | 34211 | -0.350 | -0.5855 | Yes | ||
| 106 | HUS1 | ENSG00000136273.13 | 34665 | -0.355 | -0.5916 | Yes | ||
| 107 | MCM6 | ENSG00000076003.5 | 34728 | -0.357 | -0.5881 | Yes | ||
| 108 | MMS22L | ENSG00000146263.11 | 34820 | -0.362 | -0.5853 | Yes | ||
| 109 | H2AFZ | ENSG00000164032.12 | 35129 | -0.370 | -0.5876 | Yes | ||
| 110 | CDKN2A | ENSG00000147889.17 | 35138 | -0.371 | -0.5827 | Yes | ||
| 111 | TACC3 | ENSG00000013810.19 | 35296 | -0.378 | -0.5812 | Yes | ||
| 112 | E2F8 | ENSG00000129173.13 | 35405 | -0.384 | -0.5785 | Yes | ||
| 113 | BRMS1L | ENSG00000100916.14 | 35432 | -0.385 | -0.5737 | Yes | ||
| 114 | CCP110 | ENSG00000103540.16 | 35632 | -0.395 | -0.5731 | Yes | ||
| 115 | MCM5 | ENSG00000100297.16 | 35805 | -0.402 | -0.5717 | Yes | ||
| 116 | DNMT1 | ENSG00000130816.16 | 36095 | -0.409 | -0.5730 | Yes | ||
| 117 | CTPS1 | ENSG00000171793.16 | 36239 | -0.413 | -0.5707 | Yes | ||
| 118 | BIRC5 | ENSG00000089685.15 | 36279 | -0.415 | -0.5659 | Yes | ||
| 119 | ESPL1 | ENSG00000135476.11 | 36287 | -0.415 | -0.5602 | Yes | ||
| 120 | LYAR | ENSG00000145220.14 | 36304 | -0.416 | -0.5548 | Yes | ||
| 121 | ANP32E | ENSG00000143401.15 | 36344 | -0.418 | -0.5499 | Yes | ||
| 122 | NUP205 | ENSG00000155561.15 | 36490 | -0.426 | -0.5475 | Yes | ||
| 123 | TK1 | ENSG00000167900.12 | 36493 | -0.426 | -0.5416 | Yes | ||
| 124 | RAN | ENSG00000132341.12 | 36507 | -0.427 | -0.5360 | Yes | ||
| 125 | PMS2 | ENSG00000122512.16 | 36521 | -0.428 | -0.5303 | Yes | ||
| 126 | CCNB2 | ENSG00000157456.8 | 36613 | -0.432 | -0.5265 | Yes | ||
| 127 | RPA3 | ENSG00000106399.11 | 36661 | -0.434 | -0.5216 | Yes | ||
| 128 | SPC24 | ENSG00000161888.11 | 36669 | -0.434 | -0.5157 | Yes | ||
| 129 | GINS3 | ENSG00000181938.13 | 36693 | -0.435 | -0.5102 | Yes | ||
| 130 | PLK1 | ENSG00000166851.15 | 36707 | -0.436 | -0.5044 | Yes | ||
| 131 | UBE2S | ENSG00000108106.14 | 36803 | -0.440 | -0.5005 | Yes | ||
| 132 | DCLRE1B | ENSG00000118655.7 | 36838 | -0.442 | -0.4952 | Yes | ||
| 133 | KIF2C | ENSG00000142945.13 | 36852 | -0.443 | -0.4893 | Yes | ||
| 134 | KIF18B | ENSG00000186185.14 | 36892 | -0.446 | -0.4841 | Yes | ||
| 135 | SMC3 | ENSG00000108055.9 | 36921 | -0.447 | -0.4785 | Yes | ||
| 136 | SPC25 | ENSG00000152253.9 | 37054 | -0.455 | -0.4753 | Yes | ||
| 137 | PCNA | ENSG00000132646.11 | 37166 | -0.461 | -0.4716 | Yes | ||
| 138 | XPO1 | ENSG00000082898.17 | 37227 | -0.465 | -0.4666 | Yes | ||
| 139 | HMMR | ENSG00000072571.20 | 37412 | -0.479 | -0.4644 | Yes | ||
| 140 | AURKB | ENSG00000178999.13 | 37485 | -0.484 | -0.4594 | Yes | ||
| 141 | RFC3 | ENSG00000133119.13 | 37532 | -0.487 | -0.4537 | Yes | ||
| 142 | PRDX4 | ENSG00000123131.13 | 37599 | -0.493 | -0.4484 | Yes | ||
| 143 | KIF4A | ENSG00000090889.12 | 37615 | -0.495 | -0.4419 | Yes | ||
| 144 | DLGAP5 | ENSG00000126787.13 | 37762 | -0.508 | -0.4383 | Yes | ||
| 145 | MAD2L1 | ENSG00000164109.14 | 37893 | -0.520 | -0.4342 | Yes | ||
| 146 | DEK | ENSG00000124795.17 | 37896 | -0.520 | -0.4270 | Yes | ||
| 147 | SMC1A | ENSG00000072501.17 | 37922 | -0.522 | -0.4203 | Yes | ||
| 148 | TCF19 | ENSG00000137310.12 | 37952 | -0.524 | -0.4137 | Yes | ||
| 149 | NME1 | ENSG00000239672.7 | 38038 | -0.530 | -0.4084 | Yes | ||
| 150 | BUB1B | ENSG00000156970.12 | 38129 | -0.537 | -0.4031 | Yes | ||
| 151 | TIPIN | ENSG00000075131.10 | 38235 | -0.545 | -0.3980 | Yes | ||
| 152 | IPO7 | ENSG00000205339.10 | 38268 | -0.547 | -0.3912 | Yes | ||
| 153 | CHEK1 | ENSG00000149554.13 | 38279 | -0.549 | -0.3837 | Yes | ||
| 154 | TUBG1 | ENSG00000131462.8 | 38291 | -0.550 | -0.3763 | Yes | ||
| 155 | SLBP | ENSG00000163950.13 | 38304 | -0.552 | -0.3689 | Yes | ||
| 156 | SPAG5 | ENSG00000076382.17 | 38312 | -0.553 | -0.3614 | Yes | ||
| 157 | CDCA8 | ENSG00000134690.11 | 38629 | -0.564 | -0.3612 | Yes | ||
| 158 | AURKA | ENSG00000087586.17 | 38638 | -0.565 | -0.3535 | Yes | ||
| 159 | EIF2S1 | ENSG00000134001.13 | 38693 | -0.570 | -0.3468 | Yes | ||
| 160 | CENPM | ENSG00000100162.15 | 38711 | -0.572 | -0.3393 | Yes | ||
| 161 | RAD51C | ENSG00000108384.15 | 38848 | -0.585 | -0.3344 | Yes | ||
| 162 | ORC6 | ENSG00000091651.9 | 38888 | -0.589 | -0.3271 | Yes | ||
| 163 | STMN1 | ENSG00000117632.23 | 38971 | -0.598 | -0.3208 | Yes | ||
| 164 | MYC | ENSG00000136997.19 | 39003 | -0.602 | -0.3131 | Yes | ||
| 165 | DEPDC1 | ENSG00000024526.17 | 39009 | -0.602 | -0.3048 | Yes | ||
| 166 | TUBB | ENSG00000196230.13 | 39081 | -0.611 | -0.2980 | Yes | ||
| 167 | PLK4 | ENSG00000142731.11 | 39267 | -0.620 | -0.2939 | Yes | ||
| 168 | TOP2A | ENSG00000131747.15 | 39313 | -0.624 | -0.2863 | Yes | ||
| 169 | ASF1B | ENSG00000105011.9 | 39398 | -0.626 | -0.2796 | Yes | ||
| 170 | CDK1 | ENSG00000170312.16 | 39453 | -0.632 | -0.2721 | Yes | ||
| 171 | TRIP13 | ENSG00000071539.14 | 39454 | -0.632 | -0.2632 | Yes | ||
| 172 | RACGAP1 | ENSG00000161800.13 | 39469 | -0.633 | -0.2547 | Yes | ||
| 173 | CSE1L | ENSG00000124207.17 | 39486 | -0.633 | -0.2463 | Yes | ||
| 174 | RNASEH2A | ENSG00000104889.6 | 39511 | -0.636 | -0.2380 | Yes | ||
| 175 | PAICS | ENSG00000128050.8 | 39603 | -0.646 | -0.2312 | Yes | ||
| 176 | GSPT1 | ENSG00000103342.13 | 39655 | -0.655 | -0.2233 | Yes | ||
| 177 | BARD1 | ENSG00000138376.11 | 39685 | -0.660 | -0.2148 | Yes | ||
| 178 | LMNB1 | ENSG00000113368.12 | 39725 | -0.665 | -0.2064 | Yes | ||
| 179 | MYBL2 | ENSG00000101057.16 | 39815 | -0.677 | -0.1991 | Yes | ||
| 180 | GINS4 | ENSG00000147536.12 | 39830 | -0.681 | -0.1900 | Yes | ||
| 181 | BRCA1 | ENSG00000012048.22 | 39857 | -0.687 | -0.1810 | Yes | ||
| 182 | BRCA2 | ENSG00000139618.15 | 39873 | -0.690 | -0.1717 | Yes | ||
| 183 | PRIM2 | ENSG00000146143.19 | 39937 | -0.702 | -0.1635 | Yes | ||
| 184 | RAD51AP1 | ENSG00000111247.14 | 39953 | -0.704 | -0.1540 | Yes | ||
| 185 | JPT1 | ENSG00000189159.16 | 39972 | -0.708 | -0.1445 | Yes | ||
| 186 | RRM2 | ENSG00000171848.15 | 39983 | -0.710 | -0.1349 | Yes | ||
| 187 | WEE1 | ENSG00000166483.11 | 40002 | -0.714 | -0.1253 | Yes | ||
| 188 | HELLS | ENSG00000119969.15 | 40020 | -0.717 | -0.1157 | Yes | ||
| 189 | CENPE | ENSG00000138778.12 | 40145 | -0.740 | -0.1084 | Yes | ||
| 190 | GINS1 | ENSG00000101003.10 | 40151 | -0.741 | -0.0982 | Yes | ||
| 191 | MKI67 | ENSG00000148773.14 | 40220 | -0.757 | -0.0893 | Yes | ||
| 192 | CDC25A | ENSG00000164045.12 | 40263 | -0.768 | -0.0796 | Yes | ||
| 193 | ATAD2 | ENSG00000156802.13 | 40289 | -0.773 | -0.0694 | Yes | ||
| 194 | DCK | ENSG00000156136.10 | 40438 | -0.820 | -0.0615 | Yes | ||
| 195 | MELK | ENSG00000165304.8 | 40497 | -0.839 | -0.0512 | Yes | ||
| 196 | MCM4 | ENSG00000104738.18 | 40591 | -0.872 | -0.0413 | Yes | ||
| 197 | KPNA2 | ENSG00000182481.9 | 40625 | -0.887 | -0.0297 | Yes | ||
| 198 | UBE2T | ENSG00000077152.11 | 40631 | -0.889 | -0.0174 | Yes | ||
| 199 | DIAPH3 | ENSG00000139734.19 | 40924 | -1.041 | -0.0100 | Yes | ||
| 200 | PRPS1 | ENSG00000147224.11 | 40992 | -1.129 | 0.0041 | Yes |
