Details for gene set HALLMARK_ESTROGEN_RESPONSE_EARLY[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Phenotype	Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Upregulated in class	FSHD2
GeneSet	HALLMARK_ESTROGEN_RESPONSE_EARLY
Enrichment Score (ES)	0.25222185
Normalized Enrichment Score (NES)	1.2214786
Nominal p-value	0.09537167
FDR q-value	0.2014021
FWER p-Value	0.99

Fig 1: Enrichment plot: HALLMARK_ESTROGEN_RESPONSE_EARLY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	SLC37A1	ENSG00000160190.14			222	1.206	0.0136	Yes
2	TGM2	ENSG00000198959.12			237	1.183	0.0319	Yes
3	SCNN1A	ENSG00000111319.13			344	1.095	0.0465	Yes
4	SLC7A2	ENSG00000003989.17			597	0.979	0.0558	Yes
5	CISH	ENSG00000114737.15			726	0.933	0.0673	Yes
6	KRT19	ENSG00000171345.13			747	0.927	0.0815	Yes
7	GFRA1	ENSG00000151892.14			803	0.911	0.0945	Yes
8	TJP3	ENSG00000105289.15			1019	0.855	0.1027	Yes
9	PDZK1	ENSG00000174827.13			1022	0.854	0.1161	Yes
10	OLFM1	ENSG00000130558.19			1121	0.833	0.1268	Yes
11	CELSR1	ENSG00000075275.16			1172	0.823	0.1385	Yes
12	CELSR2	ENSG00000143126.8			1203	0.817	0.1507	Yes
13	EGR3	ENSG00000179388.9			1788	0.735	0.1480	Yes
14	SLC22A5	ENSG00000197375.12			1879	0.720	0.1571	Yes
15	KRT18	ENSG00000111057.11			2128	0.690	0.1619	Yes
16	AQP3	ENSG00000165272.16			2318	0.670	0.1679	Yes
17	MUC1	ENSG00000185499.16			2664	0.637	0.1695	Yes
18	GREB1	ENSG00000196208.14			2722	0.630	0.1780	Yes
19	OPN3	ENSG00000054277.14			3184	0.592	0.1761	Yes
20	TPBG	ENSG00000146242.8			3275	0.586	0.1831	Yes
21	MLPH	ENSG00000115648.14			3348	0.580	0.1905	Yes
22	HES1	ENSG00000114315.4			3386	0.577	0.1987	Yes
23	IGFBP4	ENSG00000141753.7			3723	0.556	0.1992	Yes
24	BCL2	ENSG00000171791.13			4386	0.520	0.1912	Yes
25	DHCR7	ENSG00000172893.15			4598	0.514	0.1942	Yes
26	CD44	ENSG00000026508.18			4934	0.495	0.1938	Yes
27	MAPT	ENSG00000186868.15			5172	0.479	0.1956	Yes
28	CCN5	ENSG00000064205.10			5220	0.476	0.2019	Yes
29	KRT8	ENSG00000170421.12			5381	0.466	0.2054	Yes
30	SEMA3B	ENSG00000012171.20			5425	0.463	0.2116	Yes
31	ABLIM1	ENSG00000099204.20			5712	0.447	0.2117	Yes
32	AR	ENSG00000169083.17			5886	0.439	0.2144	Yes
33	INHBB	ENSG00000163083.6			5957	0.435	0.2195	Yes
34	CBFA2T3	ENSG00000129993.15			6284	0.419	0.2181	Yes
35	RPS6KA2	ENSG00000071242.12			6753	0.398	0.2130	Yes
36	MPPED2	ENSG00000066382.16			6923	0.393	0.2150	Yes
37	NPY1R	ENSG00000164128.7			6929	0.393	0.2211	Yes
38	RASGRP1	ENSG00000172575.12			7013	0.389	0.2252	Yes
39	KLK10	ENSG00000129451.12			7356	0.374	0.2227	Yes
40	SLC27A2	ENSG00000140284.11			7378	0.373	0.2281	Yes
41	TGIF2	ENSG00000118707.10			7621	0.366	0.2280	Yes
42	SYT12	ENSG00000173227.14			7802	0.362	0.2293	Yes
43	IL6ST	ENSG00000134352.20			8019	0.360	0.2297	Yes
44	P2RY2	ENSG00000175591.11			8099	0.358	0.2334	Yes
45	RARA	ENSG00000131759.18			8101	0.358	0.2390	Yes
46	FASN	ENSG00000169710.9			8136	0.356	0.2437	Yes
47	TTC39A	ENSG00000085831.15			8494	0.351	0.2406	Yes
48	CXCL12	ENSG00000107562.16			8504	0.351	0.2459	Yes
49	CALCR	ENSG00000004948.15			8664	0.348	0.2475	Yes
50	FKBP5	ENSG00000096060.14			8892	0.340	0.2473	Yes
51	PRSS23	ENSG00000150687.12			9200	0.327	0.2449	Yes
52	KAZN	ENSG00000189337.17			9213	0.326	0.2498	Yes
53	IGF1R	ENSG00000140443.15			9322	0.322	0.2522	Yes
54	RET	ENSG00000165731.20			9916	0.315	0.2427	No
55	MED24	ENSG00000008838.20			10756	0.300	0.2270	No
56	PTGES	ENSG00000148344.11			10848	0.297	0.2294	No
57	MINDY1	ENSG00000143409.15			12128	0.266	0.2024	No
58	SEC14L2	ENSG00000100003.18			12136	0.266	0.2064	No
59	FDFT1	ENSG00000079459.13			12228	0.263	0.2083	No
60	UNC119	ENSG00000109103.11			12229	0.263	0.2125	No
61	GLA	ENSG00000102393.10			12631	0.250	0.2066	No
62	ANXA9	ENSG00000143412.10			12653	0.250	0.2100	No
63	RAPGEFL1	ENSG00000108352.12			13083	0.235	0.2033	No
64	CLIC3	ENSG00000169583.13			13128	0.234	0.2059	No
65	KLF4	ENSG00000136826.15			13176	0.233	0.2084	No
66	FOXC1	ENSG00000054598.9			13199	0.232	0.2115	No
67	FCMR	ENSG00000162894.12			13474	0.223	0.2083	No
68	RHOD	ENSG00000173156.7			13948	0.208	0.2001	No
69	SYNGR1	ENSG00000100321.15			14277	0.198	0.1952	No
70	WFS1	ENSG00000109501.13			14511	0.190	0.1925	No
71	SCARB1	ENSG00000073060.16			15471	0.160	0.1716	No
72	ASB13	ENSG00000196372.13			15797	0.150	0.1660	No
73	NADSYN1	ENSG00000172890.13			16155	0.141	0.1595	No
74	TMEM164	ENSG00000157600.12			16476	0.131	0.1538	No
75	PEX11A	ENSG00000166821.9			17086	0.115	0.1407	No
76	ITPK1	ENSG00000100605.17			17546	0.103	0.1311	No
77	HR	ENSG00000168453.15			17623	0.100	0.1309	No
78	TBC1D30	ENSG00000111490.14			17668	0.099	0.1313	No
79	SIAH2	ENSG00000181788.4			17816	0.096	0.1293	No
80	NAV2	ENSG00000166833.21			17879	0.094	0.1292	No
81	FAM102A	ENSG00000167106.12			17926	0.093	0.1296	No
82	FOS	ENSG00000170345.10			17933	0.092	0.1309	No
83	CA12	ENSG00000074410.14			17955	0.092	0.1318	No
84	KCNK15	ENSG00000124249.7			18268	0.085	0.1255	No
85	HSPB8	ENSG00000152137.6			18377	0.082	0.1242	No
86	ELOVL5	ENSG00000012660.14			18561	0.077	0.1209	No
87	AREG	ENSG00000109321.11			18751	0.072	0.1174	No
88	GAB2	ENSG00000033327.13			18963	0.066	0.1133	No
89	AKAP1	ENSG00000121057.13			19217	0.059	0.1081	No
90	JAK2	ENSG00000096968.13			19235	0.058	0.1086	No
91	AMFR	ENSG00000159461.15			19429	0.053	0.1047	No
92	MICB	ENSG00000204516.10			19593	0.049	0.1015	No
93	STC2	ENSG00000113739.10			19602	0.048	0.1021	No
94	SLC1A1	ENSG00000106688.12			19730	0.045	0.0997	No
95	AFF1	ENSG00000172493.20			19768	0.044	0.0995	No
96	SLC2A1	ENSG00000117394.23			19798	0.043	0.0995	No
97	SLC19A2	ENSG00000117479.15			19866	0.042	0.0985	No
98	ELOVL2	ENSG00000197977.4			19890	0.041	0.0986	No
99	NXT1	ENSG00000132661.4			19931	0.040	0.0982	No
100	TFAP2C	ENSG00000087510.7			19936	0.040	0.0987	No
101	KLF10	ENSG00000155090.15			20051	0.038	0.0966	No
102	TIAM1	ENSG00000156299.13			20475	0.025	0.0866	No
103	BCL11B	ENSG00000127152.18			20587	0.023	0.0843	No
104	ISG20L2	ENSG00000143319.16			20880	0.015	0.0774	No
105	TIPARP	ENSG00000163659.13			21091	0.009	0.0724	No
106	SFN	ENSG00000175793.12			21306	0.004	0.0672	No
107	CANT1	ENSG00000171302.17			21563	-0.003	0.0610	No
108	TSKU	ENSG00000182704.8			22329	-0.022	0.0427	No
109	ADCY1	ENSG00000164742.16			22353	-0.022	0.0425	No
110	SOX3	ENSG00000134595.8			22396	-0.023	0.0418	No
111	CLDN7	ENSG00000181885.18			22614	-0.029	0.0370	No
112	ADCY9	ENSG00000162104.10			22658	-0.030	0.0364	No
113	KRT15	ENSG00000171346.16			22685	-0.030	0.0363	No
114	XBP1	ENSG00000100219.16			22900	-0.036	0.0316	No
115	RAB31	ENSG00000168461.13			23170	-0.044	0.0257	No
116	ABHD2	ENSG00000140526.18			23280	-0.046	0.0238	No
117	RAB17	ENSG00000124839.13			23772	-0.059	0.0127	No
118	ADD3	ENSG00000148700.15			24136	-0.068	0.0050	No
119	BAG1	ENSG00000107262.23			24279	-0.073	0.0026	No
120	DHRS3	ENSG00000162496.9			24804	-0.086	-0.0088	No
121	MYBBP1A	ENSG00000132382.14			24980	-0.091	-0.0117	No
122	KDM4B	ENSG00000127663.15			25153	-0.095	-0.0144	No
123	NBL1	ENSG00000158747.14			25372	-0.101	-0.0181	No
124	BHLHE40	ENSG00000134107.5			25483	-0.105	-0.0191	No
125	NRIP1	ENSG00000180530.11			25533	-0.106	-0.0186	No
126	SLC7A5	ENSG00000103257.9			25788	-0.113	-0.0231	No
127	PMAIP1	ENSG00000141682.11			25799	-0.113	-0.0215	No
128	SH3BP5	ENSG00000131370.16			25855	-0.116	-0.0210	No
129	SULT2B1	ENSG00000088002.11			25907	-0.117	-0.0204	No
130	DEPTOR	ENSG00000155792.10			25924	-0.118	-0.0190	No
131	PLAAT3	ENSG00000176485.11			26163	-0.125	-0.0228	No
132	RHOBTB3	ENSG00000164292.13			26209	-0.126	-0.0219	No
133	ESRP2	ENSG00000103067.14			26252	-0.127	-0.0210	No
134	SLC24A3	ENSG00000185052.12			26442	-0.133	-0.0235	No
135	RETREG1	ENSG00000154153.13			26504	-0.135	-0.0228	No
136	SYBU	ENSG00000147642.17			26621	-0.138	-0.0235	No
137	FRK	ENSG00000111816.8			26728	-0.142	-0.0238	No
138	FARP1	ENSG00000152767.17			26841	-0.145	-0.0243	No
139	TPD52L1	ENSG00000111907.21			26861	-0.145	-0.0225	No
140	SLC1A4	ENSG00000115902.11			26994	-0.149	-0.0234	No
141	PAPSS2	ENSG00000198682.13			27309	-0.158	-0.0285	No
142	BLVRB	ENSG00000090013.11			27336	-0.159	-0.0267	No
143	MYB	ENSG00000118513.19			27404	-0.161	-0.0258	No
144	SLC9A3R1	ENSG00000109062.12			27565	-0.167	-0.0270	No
145	PGR	ENSG00000082175.15			27674	-0.170	-0.0270	No
146	SLC16A1	ENSG00000155380.11			27778	-0.173	-0.0268	No
147	ELF1	ENSG00000120690.16			27897	-0.176	-0.0269	No
148	DHRS2	ENSG00000100867.14			27922	-0.177	-0.0247	No
149	NCOR2	ENSG00000196498.13			28339	-0.191	-0.0318	No
150	REEP1	ENSG00000068615.18			28658	-0.201	-0.0364	No
151	PPIF	ENSG00000108179.14			29206	-0.218	-0.0464	No
152	SLC26A2	ENSG00000155850.7			29218	-0.218	-0.0432	No
153	ELF3	ENSG00000163435.16			29394	-0.224	-0.0439	No
154	OLFML3	ENSG00000116774.12			29989	-0.243	-0.0546	No
155	MREG	ENSG00000118242.16			30010	-0.244	-0.0513	No
156	KRT13	ENSG00000171401.15			30497	-0.260	-0.0590	No
157	KCNK5	ENSG00000164626.9			30697	-0.266	-0.0597	No
158	INPP5F	ENSG00000198825.15			30750	-0.268	-0.0567	No
159	FKBP4	ENSG00000004478.8			30809	-0.270	-0.0539	No
160	MAST4	ENSG00000069020.18			31007	-0.277	-0.0544	No
161	THSD4	ENSG00000187720.14			31761	-0.288	-0.0682	No
162	MED13L	ENSG00000123066.8			31833	-0.291	-0.0654	No
163	RRP12	ENSG00000052749.13			31997	-0.296	-0.0647	No
164	SLC39A6	ENSG00000141424.13			32428	-0.314	-0.0702	No
165	DYNLT3	ENSG00000165169.11			32854	-0.330	-0.0754	No
166	RBBP8	ENSG00000101773.19			32876	-0.331	-0.0707	No
167	MSMB	ENSG00000263639.7			34308	-0.350	-0.1001	No
168	CYP26B1	ENSG00000003137.8			34633	-0.353	-0.1025	No
169	ABAT	ENSG00000183044.12			35658	-0.396	-0.1212	No
170	DLC1	ENSG00000164741.15			35687	-0.397	-0.1157	No
171	LAD1	ENSG00000159166.15			36370	-0.420	-0.1257	No
172	ZNF185	ENSG00000147394.18			36460	-0.424	-0.1212	No
173	FHL2	ENSG00000115641.19			36508	-0.427	-0.1156	No
174	UGCG	ENSG00000148154.10			37047	-0.455	-0.1216	No
175	PDLIM3	ENSG00000154553.15			37084	-0.457	-0.1153	No
176	LRIG1	ENSG00000144749.13			37286	-0.470	-0.1128	No
177	PODXL	ENSG00000128567.17			37451	-0.481	-0.1092	No
178	SVIL	ENSG00000197321.14			37602	-0.494	-0.1051	No
179	ENDOD1	ENSG00000149218.5			37641	-0.497	-0.0982	No
180	IL17RB	ENSG00000056736.10			37655	-0.498	-0.0907	No
181	TOB1	ENSG00000141232.5			37842	-0.516	-0.0871	No
182	GJA1	ENSG00000152661.9			37853	-0.517	-0.0792	No
183	B4GALT1	ENSG00000086062.12			38033	-0.530	-0.0752	No
184	ALDH3B1	ENSG00000006534.16			38133	-0.537	-0.0692	No
185	CCND1	ENSG00000110092.3			38307	-0.552	-0.0647	No
186	CHPT1	ENSG00000111666.11			38727	-0.573	-0.0659	No
187	MYC	ENSG00000136997.19			39003	-0.602	-0.0632	No
188	ARL3	ENSG00000138175.9			39355	-0.624	-0.0619	No
189	ABCA3	ENSG00000167972.14			39450	-0.631	-0.0542	No
190	SNX24	ENSG00000064652.11			39549	-0.641	-0.0465	No
191	TUBB2B	ENSG00000137285.10			40109	-0.733	-0.0486	No
192	WWC1	ENSG00000113645.14			40173	-0.747	-0.0384	No
193	MYOF	ENSG00000138119.17			40236	-0.761	-0.0280	No
194	CALB2	ENSG00000172137.19			40844	-0.993	-0.0271	No
195	MYBL1	ENSG00000185697.16			40976	-1.105	-0.0129	No
196	FLNB	ENSG00000136068.14			40977	-1.106	0.0045	No

Fig 2: HALLMARK_ESTROGEN_RESPONSE_EARLY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_ESTROGEN_RESPONSE_EARLY: Random ES distribution   
Gene set null distribution of ES for HALLMARK_ESTROGEN_RESPONSE_EARLY