Details for gene set HALLMARK_HEME_METABOLISM[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Phenotype	Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Upregulated in class	ARH
GeneSet	HALLMARK_HEME_METABOLISM
Enrichment Score (ES)	-0.14680187
Normalized Enrichment Score (NES)	-0.78116244
Nominal p-value	0.98188406
FDR q-value	0.9575866
FWER p-Value	1.0

Fig 1: Enrichment plot: HALLMARK_HEME_METABOLISM   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	CROCCP2	ENSG00000215908.10			212	1.224	0.0163	No
2	ACSL6	ENSG00000164398.14			549	0.996	0.0256	No
3	CTSB	ENSG00000164733.21			706	0.938	0.0382	No
4	EPB41	ENSG00000159023.21			916	0.879	0.0485	No
5	LMO2	ENSG00000135363.12			1320	0.799	0.0527	No
6	SMOX	ENSG00000088826.18			1712	0.745	0.0563	No
7	CLIC2	ENSG00000155962.13			1866	0.722	0.0652	No
8	ABCB6	ENSG00000115657.14			2070	0.696	0.0725	No
9	KDM7A	ENSG00000006459.11			2156	0.688	0.0825	No
10	SLC30A10	ENSG00000196660.10			2256	0.677	0.0919	No
11	AQP3	ENSG00000165272.16			2318	0.670	0.1022	No
12	PRDX2	ENSG00000167815.12			2763	0.627	0.1024	No
13	AC010618.1	ENSG00000243771.1			2962	0.609	0.1082	No
14	TRIM58	ENSG00000162722.9			2979	0.608	0.1185	No
15	BTG2	ENSG00000159388.6			2993	0.606	0.1288	No
16	FTCD	ENSG00000160282.14			4777	0.506	0.0942	No
17	RBM38	ENSG00000132819.17			5108	0.483	0.0946	No
18	GYPC	ENSG00000136732.16			5219	0.476	0.1003	No
19	SLC7A11	ENSG00000151012.13			5674	0.449	0.0971	No
20	ELL2	ENSG00000118985.16			5952	0.436	0.0980	No
21	RANBP10	ENSG00000141084.11			6061	0.430	0.1029	No
22	PPOX	ENSG00000143224.18			6215	0.422	0.1065	No
23	TSPO2	ENSG00000112212.12			6307	0.417	0.1116	No
24	ALAS2	ENSG00000158578.21			6312	0.416	0.1188	No
25	KEL	ENSG00000197993.9			6573	0.405	0.1196	No
26	BCAM	ENSG00000187244.11			6634	0.402	0.1252	No
27	ABCG2	ENSG00000118777.12			6779	0.397	0.1286	No
28	CCDC28A	ENSG00000024862.17			6999	0.389	0.1301	No
29	FN3K	ENSG00000167363.14			7217	0.380	0.1315	No
30	ASNS	ENSG00000070669.17			7241	0.378	0.1376	No
31	IGSF3	ENSG00000143061.17			7661	0.364	0.1337	No
32	GCLC	ENSG00000001084.13			7671	0.364	0.1399	No
33	AHSP	ENSG00000169877.10			8384	0.352	0.1287	No
34	GYPA	ENSG00000170180.22			8640	0.348	0.1286	No
35	CAT	ENSG00000121691.7			8736	0.346	0.1323	No
36	TENT5C	ENSG00000183508.5			9043	0.333	0.1307	No
37	XK	ENSG00000047597.7			9044	0.333	0.1366	No
38	RHCE	ENSG00000188672.18			9917	0.315	0.1208	No
39	SLC6A8	ENSG00000130821.16			9951	0.313	0.1255	No
40	KLF1	ENSG00000105610.5			11268	0.285	0.0984	No
41	SLC4A1	ENSG00000004939.15			12372	0.258	0.0760	No
42	RBM5	ENSG00000003756.17			12448	0.256	0.0787	No
43	CA2	ENSG00000104267.10			12533	0.253	0.0811	No
44	AC092338.1	ENSG00000260635.1			12578	0.252	0.0844	No
45	NARF	ENSG00000141562.18			12947	0.239	0.0796	No
46	C3	ENSG00000125730.17			13115	0.235	0.0797	No
47	SLC6A9	ENSG00000196517.11			13688	0.216	0.0695	No
48	GATA1	ENSG00000102145.14			13724	0.215	0.0724	No
49	EPOR	ENSG00000187266.14			13834	0.212	0.0735	No
50	SPTA1	ENSG00000163554.15			14127	0.202	0.0699	No
51	PIGQ	ENSG00000007541.16			14132	0.201	0.0733	No
52	SLC25A37	ENSG00000147454.14			14353	0.196	0.0714	No
53	CA1	ENSG00000133742.13			14680	0.184	0.0667	No
54	TSPAN5	ENSG00000168785.8			15164	0.169	0.0578	No
55	ISCA1	ENSG00000135070.15			15172	0.169	0.0606	No
56	H1F0	ENSG00000189060.5			15408	0.161	0.0577	No
57	DMTN	ENSG00000158856.18			15550	0.158	0.0571	No
58	TFDP2	ENSG00000114126.17			15564	0.157	0.0595	No
59	SIDT2	ENSG00000149577.16			15595	0.156	0.0615	No
60	SELENBP1	ENSG00000143416.21			15624	0.156	0.0636	No
61	TNRC6B	ENSG00000100354.21			15844	0.149	0.0608	No
62	NUDT4	ENSG00000173598.14			16293	0.137	0.0523	No
63	OSBP2	ENSG00000184792.16			16386	0.134	0.0524	No
64	DCAF11	ENSG00000100897.17			16402	0.134	0.0544	No
65	KHNYN	ENSG00000100441.10			16407	0.134	0.0566	No
66	BSG	ENSG00000172270.19			16494	0.131	0.0568	No
67	SLC30A1	ENSG00000170385.10			16879	0.121	0.0496	No
68	GLRX5	ENSG00000182512.5			16896	0.120	0.0513	No
69	FOXO3	ENSG00000118689.15			17017	0.117	0.0504	No
70	RNF123	ENSG00000164068.16			17171	0.113	0.0487	No
71	CPOX	ENSG00000080819.9			17654	0.100	0.0387	No
72	ACKR1	ENSG00000213088.12			17692	0.099	0.0395	No
73	ERMAP	ENSG00000164010.15			17738	0.098	0.0401	No
74	FBXO9	ENSG00000112146.16			17966	0.091	0.0362	No
75	ANK1	ENSG00000029534.20			17982	0.091	0.0374	No
76	MKRN1	ENSG00000133606.11			18049	0.089	0.0374	No
77	NFE2	ENSG00000123405.14			18321	0.083	0.0322	No
78	SLC22A4	ENSG00000197208.6			18487	0.079	0.0296	No
79	TMEM9B	ENSG00000175348.11			18640	0.075	0.0272	No
80	CIR1	ENSG00000138433.16			18761	0.072	0.0255	No
81	SLC10A3	ENSG00000126903.16			18782	0.071	0.0263	No
82	RAP1GAP	ENSG00000076864.19			18890	0.068	0.0249	No
83	VEZF1	ENSG00000136451.9			19236	0.058	0.0175	No
84	FOXJ2	ENSG00000065970.9			19375	0.054	0.0150	No
85	AGPAT4	ENSG00000026652.15			19410	0.053	0.0152	No
86	SLC2A1	ENSG00000117394.23			19798	0.043	0.0065	No
87	CTNS	ENSG00000040531.14			20289	0.032	-0.0049	No
88	UROD	ENSG00000126088.14			20903	0.015	-0.0196	No
89	UBAC1	ENSG00000130560.9			21201	0.007	-0.0268	No
90	PDZK1IP1	ENSG00000162366.8			21342	0.003	-0.0301	No
91	BACH1	ENSG00000156273.16			21508	-0.001	-0.0341	No
92	MOSPD1	ENSG00000101928.13			21746	-0.008	-0.0398	No
93	EZH1	ENSG00000108799.13			21747	-0.008	-0.0397	No
94	SNCA	ENSG00000145335.15			21777	-0.009	-0.0402	No
95	XPO7	ENSG00000130227.17			21979	-0.014	-0.0449	No
96	ALAD	ENSG00000148218.16			22286	-0.020	-0.0520	No
97	RNF19A	ENSG00000034677.13			22337	-0.022	-0.0528	No
98	DAAM1	ENSG00000100592.15			22886	-0.036	-0.0656	No
99	SDCBP	ENSG00000137575.12			23102	-0.042	-0.0701	No
100	LRP10	ENSG00000197324.9			23418	-0.050	-0.0769	No
101	ALDH1L1	ENSG00000144908.13			23457	-0.051	-0.0769	No
102	ACP5	ENSG00000102575.13			23612	-0.056	-0.0797	No
103	TMCC2	ENSG00000133069.17			23690	-0.057	-0.0806	No
104	BLVRA	ENSG00000106605.11			24009	-0.065	-0.0872	No
105	SLC25A38	ENSG00000144659.13			24506	-0.077	-0.0980	No
106	YPEL5	ENSG00000119801.13			24509	-0.077	-0.0967	No
107	HBZ	ENSG00000130656.6			24610	-0.080	-0.0977	No
108	TNS1	ENSG00000079308.19			24766	-0.084	-0.1000	No
109	MARK3	ENSG00000075413.18			24889	-0.088	-0.1014	No
110	EIF2AK1	ENSG00000086232.13			25616	-0.109	-0.1172	No
111	FECH	ENSG00000066926.11			25804	-0.114	-0.1198	No
112	TOP1	ENSG00000198900.6			25928	-0.118	-0.1207	No
113	BTRC	ENSG00000166167.18			25965	-0.119	-0.1195	No
114	TRIM10	ENSG00000204613.11			26044	-0.122	-0.1193	No
115	PSMD9	ENSG00000110801.14			26323	-0.129	-0.1238	No
116	ALDH6A1	ENSG00000119711.13			26620	-0.138	-0.1286	No
117	GMPS	ENSG00000163655.16			26897	-0.146	-0.1328	No
118	LAMP2	ENSG00000005893.15			26933	-0.147	-0.1310	No
119	ADD2	ENSG00000075340.23			27158	-0.154	-0.1338	No
120	TFRC	ENSG00000072274.13			27176	-0.154	-0.1315	No
121	BNIP3L	ENSG00000104765.16			27191	-0.155	-0.1291	No
122	BLVRB	ENSG00000090013.11			27336	-0.159	-0.1299	No
123	FBXO7	ENSG00000100225.18			27424	-0.162	-0.1291	No
124	RHD	ENSG00000187010.21			27546	-0.166	-0.1292	No
125	HDGF	ENSG00000143321.19			27609	-0.168	-0.1278	No
126	MFHAS1	ENSG00000147324.11			27768	-0.173	-0.1286	No
127	SEC14L1	ENSG00000129657.16			27889	-0.176	-0.1284	No
128	MXI1	ENSG00000119950.21			28064	-0.183	-0.1295	No
129	HTRA2	ENSG00000115317.11			28297	-0.189	-0.1318	No
130	DCAF10	ENSG00000122741.16			28565	-0.198	-0.1348	No
131	MINPP1	ENSG00000107789.16			28780	-0.204	-0.1365	No
132	ADIPOR1	ENSG00000159346.13			28914	-0.209	-0.1361	No
133	BPGM	ENSG00000172331.12			29104	-0.215	-0.1369	No
134	NFE2L1	ENSG00000082641.16			29511	-0.228	-0.1428	Yes
135	MYL4	ENSG00000198336.9			29531	-0.228	-0.1393	Yes
136	ADD1	ENSG00000087274.17			29654	-0.233	-0.1382	Yes
137	HTATIP2	ENSG00000109854.13			29670	-0.233	-0.1344	Yes
138	CDC27	ENSG00000004897.12			29738	-0.236	-0.1319	Yes
139	KAT2B	ENSG00000114166.8			29916	-0.241	-0.1320	Yes
140	MOCOS	ENSG00000075643.6			29924	-0.242	-0.1280	Yes
141	GCLM	ENSG00000023909.10			29935	-0.242	-0.1240	Yes
142	PC	ENSG00000173599.15			30008	-0.244	-0.1214	Yes
143	E2F2	ENSG00000007968.7			30138	-0.249	-0.1202	Yes
144	HBD	ENSG00000223609.11			30411	-0.257	-0.1223	Yes
145	SLC11A2	ENSG00000110911.16			30597	-0.262	-0.1223	Yes
146	GDE1	ENSG00000006007.12			30616	-0.263	-0.1181	Yes
147	RAD23A	ENSG00000179262.10			30726	-0.267	-0.1161	Yes
148	RCL1	ENSG00000120158.12			30807	-0.270	-0.1133	Yes
149	MARCH8	ENSG00000165406.16			30967	-0.276	-0.1123	Yes
150	PPP2R5B	ENSG00000068971.14			31101	-0.281	-0.1106	Yes
151	KLF3	ENSG00000109787.13			31747	-0.287	-0.1213	Yes
152	ARHGEF12	ENSG00000196914.9			31905	-0.293	-0.1200	Yes
153	GYPE	ENSG00000197465.14			31940	-0.294	-0.1157	Yes
154	HBQ1	ENSG00000086506.3			32386	-0.313	-0.1211	Yes
155	NNT	ENSG00000112992.18			32480	-0.316	-0.1178	Yes
156	CCND3	ENSG00000112576.12			32532	-0.317	-0.1135	Yes
157	CLCN3	ENSG00000109572.14			32620	-0.321	-0.1100	Yes
158	DCUN1D1	ENSG00000043093.15			32761	-0.326	-0.1076	Yes
159	TYR	ENSG00000077498.9			33753	-0.342	-0.1258	Yes
160	HEBP1	ENSG00000013583.10			34193	-0.349	-0.1304	Yes
161	TCEA1	ENSG00000187735.14			34643	-0.353	-0.1352	Yes
162	GAPVD1	ENSG00000165219.22			34670	-0.355	-0.1296	Yes
163	SYNJ1	ENSG00000159082.17			34693	-0.356	-0.1239	Yes
164	RIOK3	ENSG00000101782.15			35090	-0.368	-0.1271	Yes
165	CAST	ENSG00000153113.23			35385	-0.383	-0.1275	Yes
166	ARL2BP	ENSG00000102931.8			35491	-0.388	-0.1233	Yes
167	ATG4A	ENSG00000101844.18			35534	-0.390	-0.1175	Yes
168	USP15	ENSG00000135655.16			35549	-0.391	-0.1110	Yes
169	P4HA2	ENSG00000072682.18			35623	-0.395	-0.1058	Yes
170	HMBS	ENSG00000256269.10			35722	-0.399	-0.1012	Yes
171	HIST1H4C	ENSG00000197061.4			36084	-0.408	-0.1029	Yes
172	ATP6V0A1	ENSG00000033627.16			36367	-0.419	-0.1024	Yes
173	NCOA4	ENSG00000266412.5			36372	-0.420	-0.0951	Yes
174	MARCH2	ENSG00000099785.10			37351	-0.475	-0.1107	Yes
175	UCP2	ENSG00000175567.10			37400	-0.478	-0.1034	Yes
176	ENDOD1	ENSG00000149218.5			37641	-0.497	-0.1006	Yes
177	FBXO34	ENSG00000178974.10			37676	-0.500	-0.0926	Yes
178	MPP1	ENSG00000130830.15			37696	-0.502	-0.0843	Yes
179	BMP2K	ENSG00000138756.17			37859	-0.517	-0.0792	Yes
180	UROS	ENSG00000188690.15			37869	-0.518	-0.0703	Yes
181	LPIN2	ENSG00000101577.9			37920	-0.522	-0.0624	Yes
182	TRAK2	ENSG00000115993.13			38082	-0.533	-0.0569	Yes
183	MGST3	ENSG00000143198.13			38656	-0.567	-0.0610	Yes
184	HAGH	ENSG00000063854.13			38799	-0.580	-0.0543	Yes
185	MAP2K3	ENSG00000034152.19			38842	-0.584	-0.0450	Yes
186	PICALM	ENSG00000073921.18			38844	-0.584	-0.0348	Yes
187	OPTN	ENSG00000123240.17			39634	-0.651	-0.0426	Yes
188	NR3C1	ENSG00000113580.15			40550	-0.857	-0.0500	Yes
189	MBOAT2	ENSG00000143797.12			40794	-0.961	-0.0390	Yes
190	SPTB	ENSG00000070182.21			41024	-1.185	-0.0238	Yes
191	NEK7	ENSG00000151414.15			41118	-1.546	0.0010	Yes

Fig 2: HALLMARK_HEME_METABOLISM   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_HEME_METABOLISM: Random ES distribution   
Gene set null distribution of ES for HALLMARK_HEME_METABOLISM