Details for gene set HALLMARK_IL6_JAK_STAT3_SIGNALING[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Phenotype	Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Upregulated in class	FSHD2
GeneSet	HALLMARK_IL6_JAK_STAT3_SIGNALING
Enrichment Score (ES)	0.26760516
Normalized Enrichment Score (NES)	1.1359929
Nominal p-value	0.22983257
FDR q-value	0.2607797
FWER p-Value	0.999

Fig 1: Enrichment plot: HALLMARK_IL6_JAK_STAT3_SIGNALING   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	IL1R2	ENSG00000115590.14			280	1.147	0.0389	Yes
2	IL1R1	ENSG00000115594.12			1321	0.799	0.0454	Yes
3	TLR2	ENSG00000137462.8			1599	0.759	0.0689	Yes
4	CCL7	ENSG00000108688.11			1881	0.720	0.0907	Yes
5	IFNGR1	ENSG00000027697.14			2329	0.669	0.1064	Yes
6	PLA2G2A	ENSG00000188257.11			3165	0.594	0.1098	Yes
7	STAT3	ENSG00000168610.14			3305	0.583	0.1296	Yes
8	LTB	ENSG00000227507.2			3397	0.576	0.1503	Yes
9	IL1B	ENSG00000125538.12			3430	0.572	0.1724	Yes
10	CD38	ENSG00000004468.13			4696	0.511	0.1619	Yes
11	CD44	ENSG00000026508.18			4934	0.495	0.1759	Yes
12	IRF9	ENSG00000213928.9			5089	0.484	0.1914	Yes
13	CD9	ENSG00000010278.14			5422	0.464	0.2018	Yes
14	ACVRL1	ENSG00000139567.12			5427	0.463	0.2202	Yes
15	A2M	ENSG00000175899.14			5880	0.440	0.2267	Yes
16	TYK2	ENSG00000105397.14			6410	0.412	0.2302	Yes
17	TNFRSF1A	ENSG00000067182.7			7098	0.385	0.2288	Yes
18	IL18R1	ENSG00000115604.10			7316	0.376	0.2385	Yes
19	IL6ST	ENSG00000134352.20			8019	0.360	0.2358	Yes
20	CSF3R	ENSG00000119535.17			8224	0.352	0.2448	Yes
21	CCR1	ENSG00000163823.4			8802	0.344	0.2445	Yes
22	IL4R	ENSG00000077238.14			8901	0.339	0.2556	Yes
23	HMOX1	ENSG00000100292.17			9075	0.332	0.2646	Yes
24	IRF1	ENSG00000125347.14			9828	0.318	0.2590	Yes
25	MYD88	ENSG00000172936.14			10743	0.301	0.2487	Yes
26	DNTT	ENSG00000107447.8			11198	0.285	0.2490	Yes
27	SOCS3	ENSG00000184557.4			12172	0.265	0.2359	Yes
28	CSF2RB	ENSG00000100368.14			12216	0.264	0.2453	Yes
29	TNFRSF21	ENSG00000146072.6			12662	0.249	0.2444	Yes
30	PF4	ENSG00000163737.4			12734	0.247	0.2525	Yes
31	CXCL1	ENSG00000163739.5			12872	0.242	0.2588	Yes
32	IL15RA	ENSG00000134470.21			12907	0.241	0.2676	Yes
33	STAT2	ENSG00000170581.14			13299	0.229	0.2672	No
34	ACVR1B	ENSG00000135503.13			13757	0.214	0.2646	No
35	EBI3	ENSG00000105246.6			14531	0.189	0.2533	No
36	PTPN2	ENSG00000175354.20			15648	0.155	0.2323	No
37	IL2RA	ENSG00000134460.17			15953	0.146	0.2308	No
38	CXCL9	ENSG00000138755.6			16417	0.133	0.2248	No
39	CNTFR	ENSG00000122756.15			16694	0.125	0.2231	No
40	IL7	ENSG00000104432.14			16729	0.124	0.2272	No
41	IFNGR2	ENSG00000159128.14			16912	0.119	0.2275	No
42	CSF1	ENSG00000184371.14			17952	0.092	0.2059	No
43	OSMR	ENSG00000145623.13			18084	0.088	0.2062	No
44	IL13RA1	ENSG00000131724.11			18289	0.084	0.2046	No
45	PIM1	ENSG00000137193.14			18349	0.082	0.2064	No
46	INHBE	ENSG00000139269.3			18378	0.082	0.2090	No
47	ITGB3	ENSG00000259207.7			19335	0.055	0.1879	No
48	MAP3K8	ENSG00000107968.10			19857	0.042	0.1769	No
49	CXCL11	ENSG00000169248.13			20828	0.017	0.1540	No
50	ITGA4	ENSG00000115232.14			20855	0.016	0.1540	No
51	TNF	ENSG00000232810.4			21705	-0.006	0.1336	No
52	CXCL3	ENSG00000163734.4			21826	-0.010	0.1311	No
53	IL17RA	ENSG00000177663.13			21939	-0.012	0.1288	No
54	IL12RB1	ENSG00000096996.16			22290	-0.020	0.1211	No
55	CXCL13	ENSG00000156234.7			22603	-0.029	0.1147	No
56	IFNAR1	ENSG00000142166.13			24251	-0.072	0.0774	No
57	CBL	ENSG00000110395.6			25021	-0.092	0.0624	No
58	IL10RB	ENSG00000243646.10			25335	-0.100	0.0587	No
59	PTPN1	ENSG00000196396.10			25434	-0.103	0.0605	No
60	PDGFC	ENSG00000145431.11			25767	-0.113	0.0569	No
61	SOCS1	ENSG00000185338.5			26705	-0.141	0.0397	No
62	TGFB1	ENSG00000105329.10			26855	-0.145	0.0418	No
63	BAK1	ENSG00000030110.13			27307	-0.158	0.0371	No
64	TNFRSF1B	ENSG00000028137.19			28280	-0.189	0.0210	No
65	IL6	ENSG00000136244.12			29624	-0.231	-0.0025	No
66	HAX1	ENSG00000143575.14			29941	-0.242	-0.0005	No
67	STAT1	ENSG00000115415.18			30631	-0.263	-0.0068	No
68	CXCL10	ENSG00000169245.6			32700	-0.324	-0.0442	No
69	PTPN11	ENSG00000179295.17			32726	-0.325	-0.0319	No
70	CD36	ENSG00000135218.19			32994	-0.336	-0.0250	No
71	FAS	ENSG00000026103.22			34075	-0.344	-0.0376	No
72	CD14	ENSG00000170458.14			34097	-0.345	-0.0244	No
73	PIK3R5	ENSG00000141506.13			34205	-0.350	-0.0131	No
74	STAM2	ENSG00000115145.10			34753	-0.359	-0.0121	No
75	TNFRSF12A	ENSG00000006327.13			34756	-0.359	0.0021	No
76	GRB2	ENSG00000177885.15			35242	-0.375	0.0053	No
77	IL2RG	ENSG00000147168.12			36157	-0.412	-0.0006	No
78	IL17RB	ENSG00000056736.10			37655	-0.498	-0.0172	No
79	CSF2	ENSG00000164400.6			38203	-0.543	-0.0089	No
80	AC005840.1	ENSG00000213942.3			38965	-0.597	-0.0036	No
81	LEPR	ENSG00000116678.19			39644	-0.653	0.0059	No
82	JUN	ENSG00000177606.7			40305	-0.779	0.0208	No

Fig 2: HALLMARK_IL6_JAK_STAT3_SIGNALING   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_IL6_JAK_STAT3_SIGNALING: Random ES distribution   
Gene set null distribution of ES for HALLMARK_IL6_JAK_STAT3_SIGNALING