Details for gene set HALLMARK_KRAS_SIGNALING_DN[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Phenotype	Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Upregulated in class	FSHD2
GeneSet	HALLMARK_KRAS_SIGNALING_DN
Enrichment Score (ES)	0.29566613
Normalized Enrichment Score (NES)	1.4179434
Nominal p-value	0.008534851
FDR q-value	0.077876806
FWER p-Value	0.551

Fig 1: Enrichment plot: HALLMARK_KRAS_SIGNALING_DN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	CLSTN3	ENSG00000139182.15			100	1.437	0.0173	Yes
2	TGFB2	ENSG00000092969.12			152	1.317	0.0341	Yes
3	H2AFY2	ENSG00000099284.14			351	1.090	0.0443	Yes
4	CAMK1D	ENSG00000183049.12			357	1.087	0.0591	Yes
5	RGS11	ENSG00000076344.16			362	1.085	0.0739	Yes
6	ZBTB16	ENSG00000109906.14			445	1.038	0.0862	Yes
7	NR4A2	ENSG00000153234.14			519	1.008	0.0982	Yes
8	CPA2	ENSG00000158516.12			610	0.974	0.1094	Yes
9	YBX2	ENSG00000006047.13			836	0.902	0.1163	Yes
10	IL5	ENSG00000113525.10			845	0.900	0.1285	Yes
11	FGF16	ENSG00000196468.8			1014	0.856	0.1362	Yes
12	SLC12A3	ENSG00000070915.9			1040	0.850	0.1472	Yes
13	IFI44L	ENSG00000137959.16			1186	0.820	0.1550	Yes
14	CELSR2	ENSG00000143126.8			1203	0.817	0.1658	Yes
15	DTNB	ENSG00000138101.18			1280	0.805	0.1750	Yes
16	STAG3	ENSG00000066923.17			1839	0.726	0.1714	Yes
17	THNSL2	ENSG00000144115.16			2248	0.678	0.1707	Yes
18	RYR2	ENSG00000198626.17			2415	0.661	0.1758	Yes
19	SLC38A3	ENSG00000188338.15			2560	0.647	0.1811	Yes
20	GPRC5C	ENSG00000170412.18			2586	0.645	0.1894	Yes
21	SPTBN2	ENSG00000173898.13			2627	0.640	0.1972	Yes
22	TEX15	ENSG00000133863.8			2739	0.629	0.2031	Yes
23	MX1	ENSG00000157601.14			2878	0.616	0.2082	Yes
24	BTG2	ENSG00000159388.6			2993	0.606	0.2138	Yes
25	ARHGDIG	ENSG00000242173.10			3062	0.601	0.2204	Yes
26	KLHDC8A	ENSG00000162873.14			3066	0.601	0.2285	Yes
27	NPHS1	ENSG00000161270.19			3552	0.564	0.2245	Yes
28	CD207	ENSG00000116031.9			3562	0.564	0.2320	Yes
29	CD40LG	ENSG00000102245.7			3595	0.563	0.2389	Yes
30	RSAD2	ENSG00000134321.12			3652	0.561	0.2453	Yes
31	DCC	ENSG00000187323.12			3653	0.561	0.2530	Yes
32	MYO15A	ENSG00000091536.19			3744	0.554	0.2584	Yes
33	SLC29A3	ENSG00000198246.9			3791	0.550	0.2648	Yes
34	ABCG4	ENSG00000172350.10			4031	0.539	0.2664	Yes
35	COQ8A	ENSG00000163050.17			4161	0.533	0.2706	Yes
36	CACNA1F	ENSG00000102001.12			4309	0.523	0.2742	Yes
37	PROP1	ENSG00000175325.2			4420	0.519	0.2786	Yes
38	IL12B	ENSG00000113302.4			5068	0.486	0.2695	Yes
39	NRIP2	ENSG00000053702.15			5382	0.466	0.2683	Yes
40	PRKN	ENSG00000185345.21			5406	0.465	0.2741	Yes
41	MTHFR	ENSG00000177000.12			5726	0.446	0.2724	Yes
42	YPEL1	ENSG00000100027.16			5745	0.445	0.2781	Yes
43	TG	ENSG00000042832.12			5770	0.444	0.2836	Yes
44	KCNE2	ENSG00000159197.3			5890	0.439	0.2868	Yes
45	PCDHB1	ENSG00000171815.5			5901	0.438	0.2926	Yes
46	ATP4A	ENSG00000105675.9			6154	0.426	0.2922	Yes
47	COL2A1	ENSG00000139219.19			6306	0.417	0.2943	Yes
48	SELENOP	ENSG00000250722.6			6481	0.409	0.2957	Yes
49	MAGIX	ENSG00000269313.5			7230	0.379	0.2826	No
50	GP1BA	ENSG00000185245.8			7362	0.374	0.2846	No
51	IDUA	ENSG00000127415.13			7505	0.371	0.2862	No
52	TAS2R4	ENSG00000127364.3			7536	0.369	0.2905	No
53	PAX4	ENSG00000106331.17			7730	0.363	0.2908	No
54	SIDT1	ENSG00000072858.10			8057	0.359	0.2878	No
55	TSHB	ENSG00000134200.3			8624	0.348	0.2787	No
56	SLC6A3	ENSG00000142319.18			9024	0.334	0.2736	No
57	TENT5C	ENSG00000183508.5			9043	0.333	0.2777	No
58	INSL5	ENSG00000172410.4			9079	0.332	0.2815	No
59	UPK3B	ENSG00000243566.6			9254	0.325	0.2817	No
60	KRT5	ENSG00000186081.12			9854	0.317	0.2714	No
61	HTR1B	ENSG00000135312.6			9893	0.316	0.2748	No
62	EFHD1	ENSG00000115468.12			9965	0.313	0.2774	No
63	SYNPO	ENSG00000171992.13			10048	0.310	0.2796	No
64	IRS4	ENSG00000133124.11			10801	0.299	0.2654	No
65	SLC5A5	ENSG00000105641.4			11017	0.290	0.2641	No
66	KLK7	ENSG00000169035.12			11270	0.285	0.2619	No
67	KCNN1	ENSG00000105642.15			11673	0.283	0.2560	No
68	SLC25A23	ENSG00000125648.15			11796	0.278	0.2568	No
69	SLC30A3	ENSG00000115194.11			12102	0.267	0.2531	No
70	OXT	ENSG00000101405.3			12270	0.262	0.2526	No
71	ZC2HC1C	ENSG00000119703.14			12497	0.255	0.2506	No
72	HSD11B2	ENSG00000176387.7			12625	0.251	0.2509	No
73	ZNF112	ENSG00000062370.16			12751	0.246	0.2512	No
74	DLK2	ENSG00000171462.15			13210	0.232	0.2433	No
75	MAST3	ENSG00000099308.10			13219	0.231	0.2462	No
76	MSH5	ENSG00000204410.15			13375	0.226	0.2456	No
77	MEFV	ENSG00000103313.12			13403	0.225	0.2480	No
78	IGFBP2	ENSG00000115457.10			13426	0.224	0.2505	No
79	GPR19	ENSG00000183150.8			13607	0.219	0.2491	No
80	NPY4R	ENSG00000204174.8			13796	0.213	0.2475	No
81	KMT2D	ENSG00000167548.15			13999	0.206	0.2454	No
82	TGM1	ENSG00000092295.12			14202	0.199	0.2432	No
83	EDN2	ENSG00000127129.10			14507	0.190	0.2384	No
84	TCF7L1	ENSG00000152284.5			14910	0.177	0.2310	No
85	LYPD3	ENSG00000124466.9			15009	0.173	0.2310	No
86	HTR1D	ENSG00000179546.4			15284	0.165	0.2266	No
87	FGF22	ENSG00000070388.11			16087	0.143	0.2090	No
88	GTF3C5	ENSG00000148308.17			16214	0.139	0.2078	No
89	EGF	ENSG00000138798.13			16379	0.135	0.2057	No
90	CNTFR	ENSG00000122756.15			16694	0.125	0.1997	No
91	PRODH	ENSG00000100033.16			17502	0.104	0.1815	No
92	SLC6A14	ENSG00000268104.3			17694	0.099	0.1782	No
93	CCNA1	ENSG00000133101.10			17734	0.098	0.1786	No
94	PDK2	ENSG00000005882.12			17895	0.093	0.1759	No
95	CCDC106	ENSG00000173581.7			17914	0.093	0.1768	No
96	PTGFR	ENSG00000122420.10			18031	0.090	0.1752	No
97	PLAG1	ENSG00000181690.8			18114	0.088	0.1744	No
98	C5	ENSG00000106804.7			18173	0.086	0.1741	No
99	ABCB11	ENSG00000073734.10			18254	0.085	0.1734	No
100	SLC16A7	ENSG00000118596.12			18670	0.074	0.1643	No
101	AKR1B10	ENSG00000198074.10			18726	0.073	0.1639	No
102	P2RX6	ENSG00000099957.16			19616	0.048	0.1429	No
103	KCNQ2	ENSG00000075043.18			19999	0.039	0.1341	No
104	MFSD6	ENSG00000151690.15			20609	0.022	0.1195	No
105	NR6A1	ENSG00000148200.17			21014	0.012	0.1099	No
106	ASB7	ENSG00000183475.12			21398	0.001	0.1005	No
107	CDKAL1	ENSG00000145996.11			21729	-0.007	0.0926	No
108	ATP6V1B1	ENSG00000116039.13			22021	-0.015	0.0857	No
109	CCR8	ENSG00000179934.7			22100	-0.016	0.0840	No
110	P2RY4	ENSG00000186912.6			22362	-0.022	0.0779	No
111	KRT4	ENSG00000170477.13			22635	-0.029	0.0717	No
112	KRT15	ENSG00000171346.16			22685	-0.030	0.0709	No
113	NUDT11	ENSG00000196368.5			22898	-0.036	0.0662	No
114	SPHK2	ENSG00000063176.16			22980	-0.039	0.0648	No
115	WNT16	ENSG00000002745.13			23154	-0.044	0.0612	No
116	PKP1	ENSG00000081277.12			23458	-0.051	0.0545	No
117	CPEB3	ENSG00000107864.15			23535	-0.053	0.0534	No
118	GRID2	ENSG00000152208.13			23651	-0.057	0.0513	No
119	CHRNG	ENSG00000196811.13			23760	-0.059	0.0495	No
120	SNN	ENSG00000184602.6			23898	-0.063	0.0470	No
121	FGFR3	ENSG00000068078.18			24034	-0.065	0.0446	No
122	SOX10	ENSG00000100146.17			24061	-0.066	0.0449	No
123	SERPINA10	ENSG00000140093.10			24245	-0.071	0.0414	No
124	NTF3	ENSG00000185652.12			24986	-0.091	0.0246	No
125	RYR1	ENSG00000196218.12			25194	-0.096	0.0209	No
126	GAMT	ENSG00000130005.13			25302	-0.099	0.0196	No
127	CYP39A1	ENSG00000146233.8			26087	-0.123	0.0022	No
128	CKM	ENSG00000104879.5			26984	-0.149	-0.0176	No
129	NOS1	ENSG00000089250.19			27089	-0.152	-0.0181	No
130	CHST2	ENSG00000175040.6			27669	-0.170	-0.0299	No
131	CAPN9	ENSG00000135773.13			27872	-0.175	-0.0324	No
132	CACNG1	ENSG00000108878.5			27982	-0.180	-0.0326	No
133	CALCB	ENSG00000175868.14			28459	-0.195	-0.0415	No
134	SNCB	ENSG00000074317.11			28564	-0.198	-0.0413	No
135	MYH7	ENSG00000092054.13			29177	-0.217	-0.0533	No
136	NGB	ENSG00000165553.4			29450	-0.226	-0.0568	No
137	SMPX	ENSG00000091482.8			30028	-0.245	-0.0675	No
138	PDCD1	ENSG00000188389.11			30491	-0.260	-0.0752	No
139	KRT13	ENSG00000171401.15			30497	-0.260	-0.0718	No
140	BRDT	ENSG00000137948.18			31330	-0.285	-0.0882	No
141	VPS50	ENSG00000004766.17			32052	-0.298	-0.1017	No
142	EDAR	ENSG00000135960.10			32224	-0.306	-0.1016	No
143	CD80	ENSG00000121594.12			32342	-0.311	-0.1002	No
144	CPB1	ENSG00000153002.12			32619	-0.321	-0.1025	No
145	SCN10A	ENSG00000185313.8			33022	-0.336	-0.1077	No
146	TFCP2L1	ENSG00000115112.8			33677	-0.342	-0.1190	No
147	PDE6B	ENSG00000133256.12			35024	-0.366	-0.1468	No
148	MYOT	ENSG00000120729.9			35120	-0.370	-0.1440	No
149	ARPP21	ENSG00000172995.16			35717	-0.398	-0.1531	No
150	KCNMB1	ENSG00000145936.9			35794	-0.402	-0.1494	No
151	SHOX2	ENSG00000168779.19			36566	-0.430	-0.1623	No
152	LFNG	ENSG00000106003.13			36633	-0.433	-0.1580	No
153	CLDN16	ENSG00000113946.3			37103	-0.458	-0.1632	No
154	SGK1	ENSG00000118515.11			37317	-0.472	-0.1619	No
155	ADRA2C	ENSG00000184160.8			37339	-0.474	-0.1559	No
156	ITGB1BP2	ENSG00000147166.11			37575	-0.491	-0.1549	No
157	PNMT	ENSG00000141744.4			37583	-0.492	-0.1483	No
158	FGGY	ENSG00000172456.17			37777	-0.510	-0.1460	No
159	GPR3	ENSG00000181773.7			38130	-0.537	-0.1472	No
160	ITIH3	ENSG00000162267.12			38305	-0.552	-0.1439	No
161	SKIL	ENSG00000136603.14			39053	-0.607	-0.1537	No
162	COPZ2	ENSG00000005243.10			39066	-0.608	-0.1457	No
163	RIBC2	ENSG00000128408.9			39099	-0.612	-0.1381	No
164	BARD1	ENSG00000138376.11			39685	-0.660	-0.1433	No
165	KCND1	ENSG00000102057.10			39708	-0.662	-0.1347	No
166	ENTPD7	ENSG00000198018.7			39783	-0.671	-0.1273	No
167	EDN1	ENSG00000078401.7			39866	-0.688	-0.1198	No
168	PTPRJ	ENSG00000149177.13			40090	-0.730	-0.1153	No
169	ACTC1	ENSG00000159251.8			40334	-0.785	-0.1104	No
170	THRB	ENSG00000151090.19			40393	-0.803	-0.1008	No
171	EPHA5	ENSG00000145242.13			40516	-0.844	-0.0922	No
172	TENM2	ENSG00000145934.16			40678	-0.913	-0.0835	No
173	BMPR1B	ENSG00000138696.11			40755	-0.937	-0.0725	No
174	HNF1A	ENSG00000135100.17			40909	-1.033	-0.0621	No
175	TNNI3	ENSG00000129991.13			40911	-1.033	-0.0479	No
176	PAX3	ENSG00000135903.19			40958	-1.077	-0.0342	No
177	SERPINB2	ENSG00000197632.9			40988	-1.121	-0.0195	No
178	GDNF	ENSG00000168621.15			41131	-1.727	0.0007	No

Fig 2: HALLMARK_KRAS_SIGNALING_DN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_KRAS_SIGNALING_DN: Random ES distribution   
Gene set null distribution of ES for HALLMARK_KRAS_SIGNALING_DN