Details for gene set HALLMARK_KRAS_SIGNALING_UP[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Phenotype	Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Upregulated in class	FSHD2
GeneSet	HALLMARK_KRAS_SIGNALING_UP
Enrichment Score (ES)	0.33839008
Normalized Enrichment Score (NES)	1.6401646
Nominal p-value	0.0014164306
FDR q-value	0.062324457
FWER p-Value	0.101

Fig 1: Enrichment plot: HALLMARK_KRAS_SIGNALING_UP   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	SOX9	ENSG00000125398.8			43	1.704	0.0233	Yes
2	ETV1	ENSG00000006468.14			305	1.126	0.0330	Yes
3	VWA5A	ENSG00000110002.16			433	1.042	0.0448	Yes
4	ALDH1A2	ENSG00000128918.15			554	0.995	0.0561	Yes
5	PEG3	ENSG00000198300.14			620	0.969	0.0684	Yes
6	LCP1	ENSG00000136167.14			660	0.955	0.0811	Yes
7	BMP2	ENSG00000125845.7			710	0.936	0.0933	Yes
8	CD37	ENSG00000104894.12			1006	0.858	0.0983	Yes
9	MALL	ENSG00000144063.3			1084	0.841	0.1085	Yes
10	PTGS2	ENSG00000073756.12			1105	0.837	0.1199	Yes
11	JUP	ENSG00000173801.17			1285	0.804	0.1271	Yes
12	RELN	ENSG00000189056.14			1303	0.802	0.1381	Yes
13	IL33	ENSG00000137033.11			1451	0.780	0.1457	Yes
14	LIF	ENSG00000128342.5			1603	0.758	0.1528	Yes
15	ATG10	ENSG00000152348.16			1701	0.747	0.1611	Yes
16	FCER1G	ENSG00000158869.11			1708	0.746	0.1716	Yes
17	LAT2	ENSG00000086730.17			1932	0.713	0.1764	Yes
18	CFH	ENSG00000000971.15			2168	0.686	0.1805	Yes
19	IGFBP3	ENSG00000146674.15			2420	0.661	0.1838	Yes
20	GALNT3	ENSG00000115339.14			2460	0.658	0.1922	Yes
21	TRIB2	ENSG00000071575.11			2614	0.642	0.1977	Yes
22	G0S2	ENSG00000123689.6			2663	0.637	0.2056	Yes
23	SATB1	ENSG00000182568.17			3034	0.604	0.2052	Yes
24	MAP3K1	ENSG00000095015.6			3142	0.596	0.2111	Yes
25	RGS16	ENSG00000143333.7			3170	0.593	0.2189	Yes
26	IL1B	ENSG00000125538.12			3430	0.572	0.2208	Yes
27	SPON1	ENSG00000262655.4			3535	0.565	0.2263	Yes
28	SLPI	ENSG00000124107.5			3694	0.557	0.2304	Yes
29	MMP10	ENSG00000166670.10			3778	0.552	0.2363	Yes
30	TRIB1	ENSG00000173334.4			3784	0.551	0.2440	Yes
31	CXCR4	ENSG00000121966.6			3819	0.548	0.2510	Yes
32	IL1RL2	ENSG00000115598.10			3937	0.543	0.2559	Yes
33	FUCA1	ENSG00000179163.11			4024	0.539	0.2616	Yes
34	CFB	ENSG00000243649.8			4800	0.504	0.2498	Yes
35	CCND2	ENSG00000118971.8			4862	0.500	0.2555	Yes
36	GADD45G	ENSG00000130222.11			4871	0.500	0.2625	Yes
37	HSD11B1	ENSG00000117594.10			4922	0.496	0.2683	Yes
38	CPE	ENSG00000109472.14			4995	0.492	0.2736	Yes
39	CBX8	ENSG00000141570.11			5149	0.481	0.2767	Yes
40	PCSK1N	ENSG00000102109.9			5202	0.477	0.2823	Yes
41	GYPC	ENSG00000136732.16			5219	0.476	0.2887	Yes
42	PRKG2	ENSG00000138669.9			5365	0.467	0.2918	Yes
43	SEMA3B	ENSG00000012171.20			5425	0.463	0.2970	Yes
44	MMP11	ENSG00000099953.10			5438	0.463	0.3033	Yes
45	LAPTM5	ENSG00000162511.8			5486	0.460	0.3088	Yes
46	PTBP2	ENSG00000117569.18			5584	0.454	0.3129	Yes
47	MAFB	ENSG00000204103.4			5655	0.450	0.3176	Yes
48	SERPINA3	ENSG00000196136.17			5867	0.440	0.3188	Yes
49	TSPAN1	ENSG00000117472.10			6102	0.428	0.3192	Yes
50	SPARCL1	ENSG00000152583.12			6166	0.425	0.3237	Yes
51	F2RL1	ENSG00000164251.5			6217	0.422	0.3285	Yes
52	RBP4	ENSG00000138207.14			6241	0.421	0.3340	Yes
53	KIF5C	ENSG00000168280.17			6305	0.417	0.3384	Yes
54	HOXD11	ENSG00000128713.14			6956	0.392	0.3281	No
55	ITGA2	ENSG00000164171.11			7028	0.388	0.3319	No
56	PRDM1	ENSG00000057657.17			7107	0.385	0.3355	No
57	CMKLR1	ENSG00000174600.14			7266	0.377	0.3371	No
58	ST6GAL1	ENSG00000073849.15			7610	0.366	0.3339	No
59	NAP1L2	ENSG00000186462.9			9027	0.334	0.3041	No
60	TLR8	ENSG00000101916.11			9327	0.322	0.3014	No
61	ANKH	ENSG00000154122.14			10019	0.311	0.2890	No
62	PPBP	ENSG00000163736.4			10187	0.305	0.2893	No
63	GABRA3	ENSG00000011677.13			10870	0.296	0.2769	No
64	ETV4	ENSG00000175832.13			11684	0.283	0.2611	No
65	ADAMDEC1	ENSG00000134028.14			12304	0.261	0.2497	No
66	CA2	ENSG00000104267.10			12533	0.253	0.2478	No
67	GPNMB	ENSG00000136235.16			12650	0.250	0.2485	No
68	CTSS	ENSG00000163131.11			12694	0.248	0.2510	No
69	KLF4	ENSG00000136826.15			13176	0.233	0.2426	No
70	ANO1	ENSG00000131620.17			13204	0.232	0.2452	No
71	CIDEA	ENSG00000176194.18			13297	0.229	0.2462	No
72	APOD	ENSG00000189058.9			13505	0.221	0.2444	No
73	MAP4K1	ENSG00000104814.13			13908	0.209	0.2375	No
74	PSMB8	ENSG00000204264.11			14058	0.204	0.2368	No
75	ABCB1	ENSG00000085563.14			14109	0.202	0.2385	No
76	EPHB2	ENSG00000133216.16			14152	0.201	0.2403	No
77	IGF2	ENSG00000167244.21			14882	0.177	0.2251	No
78	ANXA10	ENSG00000109511.12			14912	0.177	0.2269	No
79	TMEM100	ENSG00000166292.12			15315	0.164	0.2194	No
80	PRRX1	ENSG00000116132.12			15553	0.158	0.2159	No
81	CDADC1	ENSG00000102543.14			16066	0.143	0.2054	No
82	TRAF1	ENSG00000056558.11			16131	0.142	0.2059	No
83	DUSP6	ENSG00000139318.8			16150	0.141	0.2075	No
84	ACE	ENSG00000159640.16			16370	0.135	0.2041	No
85	RBM4	ENSG00000173933.20			16388	0.134	0.2056	No
86	GFPT2	ENSG00000131459.13			16742	0.124	0.1987	No
87	IKZF1	ENSG00000185811.19			17387	0.107	0.1845	No
88	TSPAN13	ENSG00000106537.8			18017	0.090	0.1705	No
89	AKT2	ENSG00000105221.18			18110	0.088	0.1695	No
90	ADAM17	ENSG00000151694.14			18419	0.082	0.1631	No
91	WNT7A	ENSG00000154764.6			18492	0.079	0.1625	No
92	FGF9	ENSG00000102678.7			18537	0.078	0.1625	No
93	ADGRA2	ENSG00000020181.18			19096	0.063	0.1498	No
94	MMD	ENSG00000108960.9			19552	0.050	0.1394	No
95	CROT	ENSG00000005469.11			19961	0.039	0.1300	No
96	CCL20	ENSG00000115009.13			20079	0.037	0.1277	No
97	TFPI	ENSG00000003436.16			20290	0.032	0.1230	No
98	DNMBP	ENSG00000107554.17			20411	0.028	0.1205	No
99	EREG	ENSG00000124882.4			20508	0.024	0.1185	No
100	EPB41L3	ENSG00000082397.17			20603	0.022	0.1165	No
101	PECAM1	ENSG00000261371.6			20696	0.020	0.1145	No
102	CLEC4A	ENSG00000111729.14			21391	0.001	0.0976	No
103	MTMR10	ENSG00000166912.17			21776	-0.009	0.0884	No
104	SCN1B	ENSG00000105711.12			22218	-0.018	0.0779	No
105	TPH1	ENSG00000129167.9			22259	-0.020	0.0772	No
106	FLT4	ENSG00000037280.16			22421	-0.024	0.0736	No
107	USH1C	ENSG00000006611.16			22548	-0.027	0.0709	No
108	ADGRL4	ENSG00000162618.15			22853	-0.035	0.0640	No
109	CBR4	ENSG00000145439.12			22970	-0.038	0.0617	No
110	HDAC9	ENSG00000048052.21			23030	-0.040	0.0608	No
111	GPRC5B	ENSG00000167191.12			23172	-0.044	0.0580	No
112	ETV5	ENSG00000244405.8			23177	-0.044	0.0586	No
113	HIST1H2BB	ENSG00000276410.3			23366	-0.049	0.0547	No
114	WDR33	ENSG00000136709.12			23466	-0.051	0.0530	No
115	GLRX	ENSG00000173221.14			23563	-0.054	0.0514	No
116	ENG	ENSG00000106991.13			23886	-0.063	0.0445	No
117	TMEM176A	ENSG00000002933.9			24023	-0.065	0.0421	No
118	ZNF277	ENSG00000198839.10			24048	-0.066	0.0424	No
119	ARG1	ENSG00000118520.15			24273	-0.072	0.0380	No
120	NIN	ENSG00000100503.23			24962	-0.090	0.0225	No
121	CBL	ENSG00000110395.6			25021	-0.092	0.0224	No
122	PLVAP	ENSG00000130300.9			25056	-0.093	0.0229	No
123	TMEM176B	ENSG00000106565.18			25133	-0.094	0.0224	No
124	MMP9	ENSG00000100985.7			25181	-0.096	0.0226	No
125	SCG3	ENSG00000104112.9			25353	-0.101	0.0199	No
126	MAP7	ENSG00000135525.18			25553	-0.107	0.0165	No
127	GNG11	ENSG00000127920.6			25729	-0.112	0.0139	No
128	CFHR2	ENSG00000080910.13			26270	-0.128	0.0025	No
129	PTCD2	ENSG00000049883.15			26339	-0.130	0.0027	No
130	BTC	ENSG00000174808.12			26349	-0.131	0.0043	No
131	NR1H4	ENSG00000012504.15			26772	-0.143	-0.0039	No
132	CAB39L	ENSG00000102547.19			26895	-0.146	-0.0048	No
133	PPP1R15A	ENSG00000087074.8			27000	-0.149	-0.0052	No
134	TNFAIP3	ENSG00000118503.15			27043	-0.151	-0.0041	No
135	PCP4	ENSG00000183036.11			27414	-0.161	-0.0108	No
136	TOR1AIP2	ENSG00000169905.12			27711	-0.171	-0.0156	No
137	ITGB2	ENSG00000160255.18			27949	-0.179	-0.0188	No
138	PIGR	ENSG00000162896.6			28078	-0.183	-0.0193	No
139	TNFRSF1B	ENSG00000028137.19			28280	-0.189	-0.0215	No
140	SNAP25	ENSG00000132639.12			28613	-0.200	-0.0268	No
141	ZNF639	ENSG00000121864.10			28764	-0.204	-0.0275	No
142	SPRY2	ENSG00000136158.12			28819	-0.206	-0.0259	No
143	KCNN4	ENSG00000104783.14			28826	-0.206	-0.0231	No
144	BTBD3	ENSG00000132640.15			28845	-0.207	-0.0206	No
145	ANGPTL4	ENSG00000167772.12			28905	-0.208	-0.0191	No
146	NR0B2	ENSG00000131910.5			29084	-0.215	-0.0203	No
147	BPGM	ENSG00000172331.12			29104	-0.215	-0.0177	No
148	TNNT2	ENSG00000118194.20			29241	-0.219	-0.0179	No
149	PDCD1LG2	ENSG00000197646.8			29627	-0.232	-0.0240	No
150	STRN	ENSG00000115808.12			29685	-0.234	-0.0220	No
151	SNAP91	ENSG00000065609.14			29977	-0.243	-0.0257	No
152	SDCCAG8	ENSG00000054282.16			30251	-0.252	-0.0287	No
153	GUCY1A1	ENSG00000164116.16			31161	-0.283	-0.0469	No
154	TMEM158	ENSG00000249992.2			31724	-0.286	-0.0565	No
155	HKDC1	ENSG00000156510.13			31806	-0.290	-0.0543	No
156	ETS1	ENSG00000134954.14			31835	-0.291	-0.0509	No
157	ERO1A	ENSG00000197930.13			31946	-0.294	-0.0493	No
158	LY96	ENSG00000154589.7			31980	-0.295	-0.0459	No
159	CXCL10	ENSG00000169245.6			32700	-0.324	-0.0588	No
160	PLAU	ENSG00000122861.16			32703	-0.324	-0.0543	No
161	C3AR1	ENSG00000171860.5			34621	-0.353	-0.0960	No
162	ALDH1A3	ENSG00000184254.17			34635	-0.353	-0.0913	No
163	PTPRR	ENSG00000153233.13			35009	-0.365	-0.0952	No
164	BIRC3	ENSG00000023445.14			35047	-0.367	-0.0908	No
165	SCG5	ENSG00000166922.8			35094	-0.368	-0.0867	No
166	PLAUR	ENSG00000011422.12			35312	-0.379	-0.0866	No
167	PLAT	ENSG00000104368.18			35576	-0.392	-0.0874	No
168	RABGAP1L	ENSG00000152061.23			35578	-0.393	-0.0818	No
169	EVI5	ENSG00000067208.14			35690	-0.397	-0.0788	No
170	AVL9	ENSG00000105778.19			35769	-0.400	-0.0750	No
171	FBXO4	ENSG00000151876.13			35992	-0.405	-0.0746	No
172	F13A1	ENSG00000124491.15			36056	-0.406	-0.0703	No
173	ID2	ENSG00000115738.10			36059	-0.406	-0.0646	No
174	IL2RG	ENSG00000147168.12			36157	-0.412	-0.0611	No
175	INHBA	ENSG00000122641.11			36833	-0.442	-0.0712	No
176	DOCK2	ENSG00000134516.17			36842	-0.442	-0.0651	No
177	EMP1	ENSG00000134531.10			36872	-0.444	-0.0595	No
178	USP12	ENSG00000152484.14			37406	-0.478	-0.0656	No
179	AKAP12	ENSG00000131016.17			37685	-0.501	-0.0653	No
180	YRDC	ENSG00000196449.4			37693	-0.502	-0.0583	No
181	AMMECR1	ENSG00000101935.10			38178	-0.541	-0.0624	No
182	CSF2	ENSG00000164400.6			38203	-0.543	-0.0552	No
183	HBEGF	ENSG00000113070.8			38438	-0.558	-0.0529	No
184	PRELID3B	ENSG00000101166.16			38605	-0.562	-0.0489	No
185	NGF	ENSG00000134259.3			38608	-0.563	-0.0410	No
186	SPP1	ENSG00000118785.14			38686	-0.569	-0.0347	No
187	TSPAN7	ENSG00000156298.12			38729	-0.573	-0.0275	No
188	CCSER2	ENSG00000107771.17			38766	-0.577	-0.0202	No
189	IL7R	ENSG00000168685.15			38829	-0.583	-0.0133	No
190	ITGBL1	ENSG00000198542.14			38854	-0.585	-0.0056	No
191	ADAM8	ENSG00000151651.16			39002	-0.601	-0.0006	No
192	NRP1	ENSG00000099250.18			40541	-0.854	-0.0259	No
193	DCBLD2	ENSG00000057019.16			40653	-0.900	-0.0157	No
194	IL10RA	ENSG00000110324.10			40784	-0.953	-0.0053	No
195	PLEK2	ENSG00000100558.9			40868	-1.012	0.0072	No

Fig 2: HALLMARK_KRAS_SIGNALING_UP   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_KRAS_SIGNALING_UP: Random ES distribution   
Gene set null distribution of ES for HALLMARK_KRAS_SIGNALING_UP