Details for gene set HALLMARK_P53_PATHWAY[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Phenotype	Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Upregulated in class	ARH
GeneSet	HALLMARK_P53_PATHWAY
Enrichment Score (ES)	-0.18776575
Normalized Enrichment Score (NES)	-1.0167292
Nominal p-value	0.41509435
FDR q-value	0.4405988
FWER p-Value	0.998

Fig 1: Enrichment plot: HALLMARK_P53_PATHWAY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	VWA5A	ENSG00000110002.16			433	1.042	0.0069	No
2	ZBTB16	ENSG00000109906.14			445	1.038	0.0241	No
3	EPHX1	ENSG00000143819.12			570	0.990	0.0377	No
4	BMP2	ENSG00000125845.7			710	0.936	0.0500	No
5	TSPYL2	ENSG00000184205.14			988	0.860	0.0577	No
6	IER3	ENSG00000137331.12			1454	0.779	0.0594	No
7	LIF	ENSG00000128342.5			1603	0.758	0.0685	No
8	PERP	ENSG00000112378.12			1793	0.734	0.0763	No
9	CTSF	ENSG00000174080.11			2136	0.689	0.0795	No
10	TCHH	ENSG00000159450.12			2593	0.644	0.0792	No
11	CDKN2B	ENSG00000147883.12			2601	0.644	0.0898	No
12	TCN2	ENSG00000185339.9			2658	0.637	0.0991	No
13	BTG2	ENSG00000159388.6			2993	0.606	0.1012	No
14	RGS16	ENSG00000143333.7			3170	0.593	0.1068	No
15	CEBPA	ENSG00000245848.3			3673	0.559	0.1039	No
16	GLS2	ENSG00000135423.13			3943	0.543	0.1065	No
17	FUCA1	ENSG00000179163.11			4024	0.539	0.1136	No
18	JAG2	ENSG00000184916.9			4118	0.536	0.1203	No
19	COQ8A	ENSG00000163050.17			4161	0.533	0.1283	No
20	DDIT4	ENSG00000168209.5			4218	0.529	0.1358	No
21	HIST3H2A	ENSG00000181218.5			4265	0.526	0.1435	No
22	IL1A	ENSG00000115008.5			4274	0.526	0.1521	No
23	CCND2	ENSG00000118971.8			4862	0.500	0.1462	No
24	VDR	ENSG00000111424.11			5518	0.458	0.1379	No
25	SLC7A11	ENSG00000151012.13			5674	0.449	0.1416	No
26	ST14	ENSG00000149418.11			5900	0.438	0.1435	No
27	INHBB	ENSG00000163083.6			5957	0.435	0.1495	No
28	UPP1	ENSG00000183696.14			6504	0.408	0.1430	No
29	PIDD1	ENSG00000177595.18			6852	0.394	0.1411	No
30	NHLH2	ENSG00000177551.5			6970	0.391	0.1448	No
31	BTG1	ENSG00000133639.5			7649	0.365	0.1344	No
32	STEAP3	ENSG00000115107.20			8227	0.352	0.1262	No
33	HMOX1	ENSG00000100292.17			9075	0.332	0.1111	No
34	GPX2	ENSG00000176153.12			9299	0.323	0.1111	No
35	TAP1	ENSG00000168394.11			9314	0.323	0.1162	No
36	F2R	ENSG00000181104.7			10089	0.309	0.1025	No
37	RRP8	ENSG00000132275.11			10103	0.308	0.1073	No
38	MXD1	ENSG00000059728.11			10676	0.304	0.0985	No
39	SLC3A2	ENSG00000168003.16			10832	0.297	0.0997	No
40	CD82	ENSG00000085117.12			11688	0.283	0.0835	No
41	NINJ1	ENSG00000131669.10			11926	0.274	0.0824	No
42	WRAP73	ENSG00000116213.16			11947	0.273	0.0865	No
43	HIST1H1C	ENSG00000187837.3			11997	0.271	0.0898	No
44	SLC35D1	ENSG00000116704.8			12017	0.270	0.0939	No
45	RAD9A	ENSG00000172613.8			12032	0.270	0.0981	No
46	IP6K2	ENSG00000068745.15			12561	0.253	0.0894	No
47	DDB2	ENSG00000134574.11			12599	0.251	0.0927	No
48	RALGDS	ENSG00000160271.16			12605	0.251	0.0968	No
49	CD81	ENSG00000110651.11			12744	0.247	0.0976	No
50	KLF4	ENSG00000136826.15			13176	0.233	0.0910	No
51	FAM162A	ENSG00000114023.15			13232	0.231	0.0935	No
52	PITPNC1	ENSG00000154217.15			13272	0.229	0.0964	No
53	RPL36	ENSG00000130255.13			13451	0.223	0.0958	No
54	ABCC5	ENSG00000114770.17			13504	0.221	0.0983	No
55	ACVR1B	ENSG00000135503.13			13757	0.214	0.0957	No
56	PLXNB2	ENSG00000196576.15			14211	0.199	0.0880	No
57	TM4SF1	ENSG00000169908.12			14394	0.194	0.0868	No
58	DEF6	ENSG00000023892.11			14502	0.190	0.0874	No
59	MXD4	ENSG00000123933.17			14617	0.187	0.0878	No
60	CYFIP2	ENSG00000055163.20			14875	0.178	0.0845	No
61	CDKN2AIP	ENSG00000168564.6			14878	0.178	0.0874	No
62	CASP1	ENSG00000137752.24			15477	0.160	0.0755	No
63	ITGB4	ENSG00000132470.14			15750	0.152	0.0714	No
64	IRAK1	ENSG00000184216.14			16673	0.126	0.0510	No
65	SEC61A1	ENSG00000058262.10			16746	0.124	0.0513	No
66	FOXO3	ENSG00000118689.15			17017	0.117	0.0467	No
67	POM121	ENSG00000196313.11			17139	0.114	0.0457	No
68	HEXIM1	ENSG00000186834.3			17236	0.111	0.0452	No
69	RPL18	ENSG00000063177.13			17257	0.110	0.0465	No
70	FOS	ENSG00000170345.10			17933	0.092	0.0316	No
71	ERCC5	ENSG00000134899.21			17990	0.091	0.0318	No
72	FDXR	ENSG00000161513.12			18088	0.088	0.0309	No
73	ANKRA2	ENSG00000164331.10			18111	0.088	0.0318	No
74	PRKAB1	ENSG00000111725.11			18449	0.081	0.0249	No
75	MKNK2	ENSG00000099875.14			18659	0.075	0.0211	No
76	ISCU	ENSG00000136003.15			18869	0.069	0.0172	No
77	RAB40C	ENSG00000197562.10			19002	0.065	0.0150	No
78	NDRG1	ENSG00000104419.14			19578	0.049	0.0018	No
79	SAT1	ENSG00000130066.16			19807	0.043	-0.0030	No
80	SLC19A2	ENSG00000117479.15			19866	0.042	-0.0037	No
81	TP63	ENSG00000073282.13			20240	0.033	-0.0123	No
82	RXRA	ENSG00000186350.12			20264	0.032	-0.0123	No
83	RAP2B	ENSG00000181467.5			20319	0.030	-0.0131	No
84	HDAC3	ENSG00000171720.10			20512	0.024	-0.0174	No
85	KRT17	ENSG00000128422.17			20691	0.020	-0.0214	No
86	PROCR	ENSG00000101000.6			20786	0.018	-0.0234	No
87	SP1	ENSG00000185591.10			20970	0.013	-0.0277	No
88	CDKN1A	ENSG00000124762.13			21297	0.004	-0.0356	No
89	SFN	ENSG00000175793.12			21306	0.004	-0.0357	No
90	DDIT3	ENSG00000175197.12			21390	0.001	-0.0377	No
91	PHLDA3	ENSG00000174307.7			21565	-0.003	-0.0419	No
92	ZFP36L1	ENSG00000185650.9			22042	-0.015	-0.0532	No
93	XPC	ENSG00000154767.14			22181	-0.018	-0.0563	No
94	NUPR1	ENSG00000176046.8			22289	-0.020	-0.0586	No
95	CSRNP2	ENSG00000110925.7			22397	-0.023	-0.0608	No
96	RACK1	ENSG00000204628.12			22465	-0.026	-0.0620	No
97	TRIB3	ENSG00000101255.11			22498	-0.027	-0.0624	No
98	ALOX15B	ENSG00000179593.16			22718	-0.031	-0.0672	No
99	NOTCH1	ENSG00000148400.12			22768	-0.032	-0.0678	No
100	RPS12	ENSG00000112306.8			22791	-0.033	-0.0678	No
101	GM2A	ENSG00000196743.9			22925	-0.037	-0.0704	No
102	PPM1D	ENSG00000170836.11			23026	-0.040	-0.0722	No
103	HSPA4L	ENSG00000164070.12			23282	-0.046	-0.0776	No
104	NOL8	ENSG00000198000.12			23289	-0.047	-0.0770	No
105	TPRKB	ENSG00000144034.15			23384	-0.049	-0.0785	No
106	ADA	ENSG00000196839.13			23425	-0.051	-0.0786	No
107	GADD45A	ENSG00000116717.13			23989	-0.064	-0.0913	No
108	LRMP	ENSG00000118308.15			24243	-0.071	-0.0963	No
109	PLK2	ENSG00000145632.15			24475	-0.076	-0.1006	No
110	MDM2	ENSG00000135679.25			24559	-0.079	-0.1013	No
111	EPS8L2	ENSG00000177106.16			24818	-0.086	-0.1062	No
112	DCXR	ENSG00000169738.8			24886	-0.088	-0.1063	No
113	EI24	ENSG00000149547.15			25020	-0.092	-0.1080	No
114	CLCA2	ENSG00000137975.8			25214	-0.096	-0.1111	No
115	PMM1	ENSG00000100417.12			25550	-0.107	-0.1175	No
116	PVT1	ENSG00000249859.11			25625	-0.109	-0.1175	No
117	CGRRF1	ENSG00000100532.12			25704	-0.111	-0.1175	No
118	RETSAT	ENSG00000042445.14			25766	-0.113	-0.1171	No
119	ABHD4	ENSG00000100439.10			25801	-0.113	-0.1160	No
120	MAPKAPK3	ENSG00000114738.11			25884	-0.116	-0.1161	No
121	AEN	ENSG00000181026.15			25941	-0.118	-0.1155	No
122	CTSD	ENSG00000117984.14			25979	-0.120	-0.1144	No
123	RHBDF2	ENSG00000129667.12			26056	-0.122	-0.1142	No
124	PRMT2	ENSG00000160310.18			26381	-0.132	-0.1199	No
125	APAF1	ENSG00000120868.13			26387	-0.132	-0.1178	No
126	BAIAP2	ENSG00000175866.15			26425	-0.133	-0.1164	No
127	SOCS1	ENSG00000185338.5			26705	-0.141	-0.1209	No
128	LDHB	ENSG00000111716.13			26739	-0.142	-0.1193	No
129	TGFB1	ENSG00000105329.10			26855	-0.145	-0.1197	No
130	TPD52L1	ENSG00000111907.21			26861	-0.145	-0.1174	No
131	PPP1R15A	ENSG00000087074.8			27000	-0.149	-0.1182	No
132	ATF3	ENSG00000162772.17			27076	-0.151	-0.1175	No
133	TRAF4	ENSG00000076604.15			27124	-0.153	-0.1161	No
134	TP53	ENSG00000141510.17			27245	-0.156	-0.1164	No
135	BAK1	ENSG00000030110.13			27307	-0.158	-0.1152	No
136	ZNF365	ENSG00000138311.17			27331	-0.159	-0.1131	No
137	IER5	ENSG00000162783.11			27633	-0.169	-0.1176	No
138	PLK3	ENSG00000173846.13			27695	-0.170	-0.1163	No
139	PDGFA	ENSG00000197461.13			27805	-0.174	-0.1160	No
140	TRAFD1	ENSG00000135148.12			28382	-0.192	-0.1268	No
141	BAX	ENSG00000087088.20			28685	-0.202	-0.1308	No
142	AK1	ENSG00000106992.19			28916	-0.209	-0.1329	No
143	PTPRE	ENSG00000132334.16			28934	-0.210	-0.1298	No
144	TNNI1	ENSG00000159173.19			28979	-0.211	-0.1274	No
145	APP	ENSG00000142192.21			29094	-0.215	-0.1265	No
146	ELP1	ENSG00000070061.15			29479	-0.226	-0.1321	No
147	FGF13	ENSG00000129682.16			29879	-0.241	-0.1378	No
148	OSGIN1	ENSG00000140961.14			29978	-0.243	-0.1361	No
149	RPS27L	ENSG00000185088.14			30329	-0.255	-0.1404	No
150	FBXW7	ENSG00000109670.16			30357	-0.255	-0.1368	No
151	STOM	ENSG00000148175.13			30456	-0.259	-0.1348	No
152	HRAS	ENSG00000174775.17			30941	-0.275	-0.1420	No
153	CCNG1	ENSG00000113328.19			30943	-0.275	-0.1374	No
154	BLCAP	ENSG00000166619.15			31838	-0.291	-0.1544	No
155	SERTAD3	ENSG00000167565.13			31977	-0.295	-0.1528	No
156	CDK5R1	ENSG00000176749.9			32195	-0.304	-0.1530	No
157	CCND3	ENSG00000112576.12			32532	-0.317	-0.1558	No
158	RB1	ENSG00000139687.15			33569	-0.339	-0.1754	No
159	FAS	ENSG00000026103.22			34075	-0.344	-0.1820	Yes
160	H2AFJ	ENSG00000246705.4			34136	-0.347	-0.1776	Yes
161	DGKA	ENSG00000065357.20			34220	-0.350	-0.1738	Yes
162	SESN1	ENSG00000080546.13			34794	-0.360	-0.1817	Yes
163	ZMAT3	ENSG00000172667.11			34962	-0.363	-0.1797	Yes
164	CDKN2A	ENSG00000147889.17			35138	-0.371	-0.1777	Yes
165	DNTTIP2	ENSG00000067334.14			35521	-0.390	-0.1805	Yes
166	SERPINB5	ENSG00000206075.14			35599	-0.393	-0.1758	Yes
167	CCP110	ENSG00000103540.16			35632	-0.395	-0.1699	Yes
168	ABAT	ENSG00000183044.12			35658	-0.396	-0.1639	Yes
169	RNF19B	ENSG00000116514.16			35671	-0.396	-0.1575	Yes
170	CCNK	ENSG00000090061.17			35710	-0.398	-0.1518	Yes
171	SPHK1	ENSG00000176170.13			35713	-0.398	-0.1452	Yes
172	HINT1	ENSG00000169567.12			36111	-0.410	-0.1480	Yes
173	RCHY1	ENSG00000163743.13			36258	-0.414	-0.1446	Yes
174	TAX1BP3	ENSG00000213977.8			36266	-0.414	-0.1378	Yes
175	NUDT15	ENSG00000136159.4			36517	-0.428	-0.1367	Yes
176	VAMP8	ENSG00000118640.11			36910	-0.447	-0.1388	Yes
177	RRAD	ENSG00000166592.12			37027	-0.454	-0.1340	Yes
178	TM7SF3	ENSG00000064115.11			37154	-0.461	-0.1293	Yes
179	PCNA	ENSG00000132646.11			37166	-0.461	-0.1219	Yes
180	KIF13B	ENSG00000197892.13			37199	-0.463	-0.1149	Yes
181	TNFSF9	ENSG00000125657.5			37744	-0.507	-0.1196	Yes
182	WWP1	ENSG00000123124.14			37821	-0.514	-0.1129	Yes
183	TOB1	ENSG00000141232.5			37842	-0.516	-0.1047	Yes
184	TRIAP1	ENSG00000170855.4			38060	-0.532	-0.1011	Yes
185	POLH	ENSG00000170734.11			38286	-0.550	-0.0973	Yes
186	HBEGF	ENSG00000113070.8			38438	-0.558	-0.0916	Yes
187	EPHA2	ENSG00000142627.13			38526	-0.559	-0.0844	Yes
188	S100A10	ENSG00000197747.9			38623	-0.564	-0.0773	Yes
189	RAD51C	ENSG00000108384.15			38848	-0.585	-0.0729	Yes
190	TGFA	ENSG00000163235.16			39092	-0.612	-0.0686	Yes
191	IFI30	ENSG00000216490.4			39276	-0.621	-0.0626	Yes
192	CDH13	ENSG00000140945.17			39497	-0.634	-0.0573	Yes
193	TXNIP	ENSG00000265972.6			39777	-0.670	-0.0529	Yes
194	DRAM1	ENSG00000136048.14			40240	-0.762	-0.0514	Yes
195	SDC1	ENSG00000115884.11			40301	-0.777	-0.0398	Yes
196	JUN	ENSG00000177606.7			40305	-0.779	-0.0268	Yes
197	S100A4	ENSG00000196154.12			40530	-0.850	-0.0180	Yes
198	PTPN14	ENSG00000152104.12			40798	-0.964	-0.0083	Yes
199	TSC22D1	ENSG00000102804.15			40879	-1.021	0.0069	Yes

Fig 2: HALLMARK_P53_PATHWAY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_P53_PATHWAY: Random ES distribution   
Gene set null distribution of ES for HALLMARK_P53_PATHWAY