Details for gene set HALLMARK_TNFA_SIGNALING_VIA_NFKB[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Phenotype	Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Upregulated in class	ARH
GeneSet	HALLMARK_TNFA_SIGNALING_VIA_NFKB
Enrichment Score (ES)	-0.24736075
Normalized Enrichment Score (NES)	-1.3142079
Nominal p-value	0.029411765
FDR q-value	0.07888254
FWER p-Value	0.546

Fig 1: Enrichment plot: HALLMARK_TNFA_SIGNALING_VIA_NFKB   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	CCRL2	ENSG00000121797.10			4	2.444	0.0316	No
2	EFNA1	ENSG00000169242.12			382	1.073	0.0363	No
3	NR4A1	ENSG00000123358.20			437	1.041	0.0485	No
4	NR4A2	ENSG00000153234.14			519	1.008	0.0596	No
5	BMP2	ENSG00000125845.7			710	0.936	0.0671	No
6	KYNU	ENSG00000115919.15			734	0.930	0.0787	No
7	PTGS2	ENSG00000073756.12			1105	0.837	0.0805	No
8	IER3	ENSG00000137331.12			1454	0.779	0.0821	No
9	NR4A3	ENSG00000119508.18			1487	0.776	0.0914	No
10	TLR2	ENSG00000137462.8			1599	0.759	0.0985	No
11	LIF	ENSG00000128342.5			1603	0.758	0.1083	No
12	EGR3	ENSG00000179388.9			1788	0.735	0.1133	No
13	ZC3H12A	ENSG00000163874.11			1812	0.731	0.1222	No
14	SLC16A6	ENSG00000108932.12			2187	0.685	0.1220	No
15	G0S2	ENSG00000123689.6			2663	0.637	0.1187	No
16	PHLDA1	ENSG00000139289.13			2729	0.630	0.1253	No
17	PTGER4	ENSG00000171522.6			2872	0.616	0.1298	No
18	CXCL6	ENSG00000124875.10			2918	0.612	0.1366	No
19	TNFAIP2	ENSG00000185215.9			2924	0.612	0.1445	No
20	BTG2	ENSG00000159388.6			2993	0.606	0.1507	No
21	KLF9	ENSG00000119138.4			3180	0.592	0.1538	No
22	CEBPD	ENSG00000221869.5			3377	0.578	0.1565	No
23	HES1	ENSG00000114315.4			3386	0.577	0.1638	No
24	IL1B	ENSG00000125538.12			3430	0.572	0.1702	No
25	DUSP2	ENSG00000158050.5			3532	0.565	0.1750	No
26	CCL4	ENSG00000275302.2			3550	0.564	0.1819	No
27	TRIB1	ENSG00000173334.4			3784	0.551	0.1834	No
28	IFIH1	ENSG00000115267.8			3962	0.542	0.1861	No
29	PDE4B	ENSG00000184588.18			4101	0.537	0.1897	No
30	BCL3	ENSG00000069399.15			4224	0.529	0.1936	No
31	IL1A	ENSG00000115008.5			4274	0.526	0.1992	No
32	ABCA1	ENSG00000165029.16			4697	0.511	0.1955	No
33	NFIL3	ENSG00000165030.4			4763	0.507	0.2005	No
34	CD44	ENSG00000026508.18			4934	0.495	0.2028	No
35	IL12B	ENSG00000113302.4			5068	0.486	0.2059	No
36	KDM6B	ENSG00000132510.10			5274	0.473	0.2070	No
37	NAMPT	ENSG00000105835.12			5278	0.473	0.2131	No
38	ZBTB10	ENSG00000205189.12			5845	0.441	0.2050	No
39	CFLAR	ENSG00000003402.20			5916	0.438	0.2089	No
40	F2RL1	ENSG00000164251.5			6217	0.422	0.2071	No
41	GCH1	ENSG00000131979.19			6236	0.421	0.2121	No
42	PNRC1	ENSG00000146278.11			6605	0.403	0.2084	No
43	LDLR	ENSG00000130164.13			6959	0.391	0.2048	No
44	ACKR3	ENSG00000144476.6			7372	0.373	0.1996	No
45	BTG1	ENSG00000133639.5			7649	0.365	0.1976	No
46	PFKFB3	ENSG00000170525.21			8002	0.361	0.1937	No
47	CEBPB	ENSG00000172216.6			8012	0.361	0.1982	No
48	IL6ST	ENSG00000134352.20			8019	0.360	0.2027	No
49	JUNB	ENSG00000171223.6			8148	0.355	0.2042	No
50	PMEPA1	ENSG00000124225.16			8181	0.354	0.2080	No
51	STAT5A	ENSG00000126561.16			8732	0.346	0.1990	No
52	TAP1	ENSG00000168394.11			9314	0.323	0.1890	No
53	IRF1	ENSG00000125347.14			9828	0.318	0.1807	No
54	CCL5	ENSG00000271503.6			9843	0.317	0.1844	No
55	ICAM1	ENSG00000090339.9			9924	0.314	0.1866	No
56	ICOSLG	ENSG00000160223.17			10654	0.304	0.1727	No
57	MXD1	ENSG00000059728.11			10676	0.304	0.1761	No
58	NINJ1	ENSG00000131669.10			11926	0.274	0.1492	No
59	GEM	ENSG00000164949.8			11976	0.272	0.1515	No
60	TGIF1	ENSG00000177426.20			12157	0.266	0.1506	No
61	SOCS3	ENSG00000184557.4			12172	0.265	0.1537	No
62	NFE2L2	ENSG00000116044.16			12805	0.244	0.1414	No
63	CXCL1	ENSG00000163739.5			12872	0.242	0.1429	No
64	IL15RA	ENSG00000134470.21			12907	0.241	0.1452	No
65	MAFF	ENSG00000185022.12			13047	0.236	0.1449	No
66	KLF4	ENSG00000136826.15			13176	0.233	0.1448	No
67	MSC	ENSG00000178860.8			13489	0.222	0.1401	No
68	REL	ENSG00000162924.14			13775	0.214	0.1359	No
69	FOSL2	ENSG00000075426.12			13886	0.209	0.1359	No
70	PLEK	ENSG00000115956.10			13995	0.206	0.1360	No
71	TNFAIP6	ENSG00000123610.5			14070	0.204	0.1368	No
72	IRS2	ENSG00000185950.9			14166	0.200	0.1371	No
73	CCL2	ENSG00000108691.9			14738	0.183	0.1255	No
74	VEGFA	ENSG00000112715.22			15227	0.167	0.1158	No
75	SQSTM1	ENSG00000161011.20			15233	0.167	0.1178	No
76	BCL6	ENSG00000113916.18			15472	0.160	0.1141	No
77	LITAF	ENSG00000189067.12			15731	0.152	0.1097	No
78	CD83	ENSG00000112149.10			15825	0.150	0.1094	No
79	EGR1	ENSG00000120738.8			15832	0.149	0.1112	No
80	TRAF1	ENSG00000056558.11			16131	0.142	0.1058	No
81	RHOB	ENSG00000143878.10			16535	0.130	0.0976	No
82	GFPT2	ENSG00000131459.13			16742	0.124	0.0942	No
83	DDX58	ENSG00000107201.10			16873	0.121	0.0926	No
84	IFNGR2	ENSG00000159128.14			16912	0.119	0.0932	No
85	ZFP36	ENSG00000128016.7			17058	0.116	0.0912	No
86	LAMB3	ENSG00000196878.15			17382	0.108	0.0847	No
87	TNIP2	ENSG00000168884.15			17429	0.106	0.0849	No
88	SPSB1	ENSG00000171621.14			17646	0.100	0.0810	No
89	ATP2B1	ENSG00000070961.15			17717	0.099	0.0805	No
90	FOS	ENSG00000170345.10			17933	0.092	0.0765	No
91	CSF1	ENSG00000184371.14			17952	0.092	0.0772	No
92	IFIT2	ENSG00000119922.10			18440	0.081	0.0664	No
93	FUT4	ENSG00000196371.3			18626	0.076	0.0629	No
94	EIF1	ENSG00000173812.11			18733	0.072	0.0612	No
95	AREG	ENSG00000109321.11			18751	0.072	0.0617	No
96	NFKB1	ENSG00000109320.13			19218	0.059	0.0511	No
97	IL23A	ENSG00000110944.9			19286	0.057	0.0502	No
98	SAT1	ENSG00000130066.16			19807	0.043	0.0381	No
99	MAP3K8	ENSG00000107968.10			19857	0.042	0.0374	No
100	RELB	ENSG00000104856.14			19918	0.041	0.0365	No
101	KLF10	ENSG00000155090.15			20051	0.038	0.0338	No
102	CCL20	ENSG00000115009.13			20079	0.037	0.0336	No
103	CLCF1	ENSG00000175505.11			20491	0.025	0.0239	No
104	TNIP1	ENSG00000145901.15			20716	0.019	0.0187	No
105	CXCL11	ENSG00000169248.13			20828	0.017	0.0162	No
106	JAG1	ENSG00000101384.12			21019	0.012	0.0117	No
107	TIPARP	ENSG00000163659.13			21091	0.009	0.0101	No
108	RIPK2	ENSG00000104312.8			21192	0.007	0.0077	No
109	CCNL1	ENSG00000163660.11			21288	0.004	0.0055	No
110	CDKN1A	ENSG00000124762.13			21297	0.004	0.0053	No
111	TNF	ENSG00000232810.4			21705	-0.006	-0.0045	No
112	NFKBIE	ENSG00000146232.16			21730	-0.007	-0.0050	No
113	SOD2	ENSG00000112096.18			21731	-0.007	-0.0050	No
114	SDC4	ENSG00000124145.6			21749	-0.008	-0.0053	No
115	CXCL3	ENSG00000163734.4			21826	-0.010	-0.0070	No
116	SLC2A6	ENSG00000160326.14			22176	-0.017	-0.0153	No
117	ETS2	ENSG00000157557.13			22722	-0.031	-0.0282	No
118	NFKBIA	ENSG00000100906.10			22848	-0.035	-0.0308	No
119	RELA	ENSG00000173039.19			23632	-0.056	-0.0492	No
120	NFKB2	ENSG00000077150.20			23693	-0.058	-0.0499	No
121	SNN	ENSG00000184602.6			23898	-0.063	-0.0541	No
122	GADD45A	ENSG00000116717.13			23989	-0.064	-0.0554	No
123	SMAD3	ENSG00000166949.16			24321	-0.074	-0.0625	No
124	PLK2	ENSG00000145632.15			24475	-0.076	-0.0653	No
125	FOSB	ENSG00000125740.14			24969	-0.091	-0.0761	No
126	BIRC2	ENSG00000110330.8			25185	-0.096	-0.0802	No
127	MCL1	ENSG00000143384.13			25273	-0.098	-0.0810	No
128	BHLHE40	ENSG00000134107.5			25483	-0.105	-0.0847	No
129	CXCL2	ENSG00000081041.9			25575	-0.107	-0.0856	No
130	GPR183	ENSG00000169508.7			25743	-0.112	-0.0882	No
131	IL18	ENSG00000150782.12			26822	-0.144	-0.1126	No
132	IER2	ENSG00000160888.7			26999	-0.149	-0.1150	No
133	PPP1R15A	ENSG00000087074.8			27000	-0.149	-0.1131	No
134	TNFAIP3	ENSG00000118503.15			27043	-0.151	-0.1121	No
135	ATF3	ENSG00000162772.17			27076	-0.151	-0.1110	No
136	IER5	ENSG00000162783.11			27633	-0.169	-0.1223	No
137	B4GALT5	ENSG00000158470.5			28090	-0.184	-0.1311	No
138	TRIP10	ENSG00000125733.18			28717	-0.203	-0.1438	No
139	MARCKS	ENSG00000277443.3			28843	-0.207	-0.1441	No
140	PTPRE	ENSG00000132334.16			28934	-0.210	-0.1436	No
141	IL6	ENSG00000136244.12			29624	-0.231	-0.1574	No
142	TANK	ENSG00000136560.14			29913	-0.241	-0.1613	No
143	BCL2A1	ENSG00000140379.8			29964	-0.243	-0.1594	No
144	CCN1	ENSG00000142871.17			30290	-0.253	-0.1640	No
145	PHLDA2	ENSG00000181649.8			30736	-0.267	-0.1714	No
146	DUSP4	ENSG00000120875.9			31857	-0.292	-0.1950	No
147	CD80	ENSG00000121594.12			32342	-0.311	-0.2028	No
148	CXCL10	ENSG00000169245.6			32700	-0.324	-0.2073	No
149	PLAU	ENSG00000122861.16			32703	-0.324	-0.2031	No
150	NFAT5	ENSG00000102908.22			33535	-0.337	-0.2190	No
151	SERPINB8	ENSG00000166401.15			34138	-0.347	-0.2292	No
152	EHD1	ENSG00000110047.18			34703	-0.356	-0.2384	No
153	BIRC3	ENSG00000023445.14			35047	-0.367	-0.2420	No
154	SIK1	ENSG00000142178.9			35268	-0.376	-0.2425	Yes
155	EGR2	ENSG00000122877.16			35295	-0.378	-0.2382	Yes
156	PLAUR	ENSG00000011422.12			35312	-0.379	-0.2337	Yes
157	PLPP3	ENSG00000162407.9			35490	-0.388	-0.2330	Yes
158	RNF19B	ENSG00000116514.16			35671	-0.396	-0.2322	Yes
159	SPHK1	ENSG00000176170.13			35713	-0.398	-0.2280	Yes
160	ID2	ENSG00000115738.10			36059	-0.406	-0.2312	Yes
161	BTG3	ENSG00000154640.14			36289	-0.416	-0.2314	Yes
162	TNC	ENSG00000041982.16			36501	-0.427	-0.2310	Yes
163	INHBA	ENSG00000122641.11			36833	-0.442	-0.2334	Yes
164	SGK1	ENSG00000118515.11			37317	-0.472	-0.2390	Yes
165	SERPINE1	ENSG00000106366.8			37533	-0.487	-0.2379	Yes
166	PANX1	ENSG00000110218.9			37632	-0.496	-0.2339	Yes
167	YRDC	ENSG00000196449.4			37693	-0.502	-0.2289	Yes
168	TNFSF9	ENSG00000125657.5			37744	-0.507	-0.2235	Yes
169	KLF2	ENSG00000127528.5			37803	-0.512	-0.2183	Yes
170	B4GALT1	ENSG00000086062.12			38033	-0.530	-0.2170	Yes
171	CSF2	ENSG00000164400.6			38203	-0.543	-0.2141	Yes
172	CCND1	ENSG00000110092.3			38307	-0.552	-0.2094	Yes
173	HBEGF	ENSG00000113070.8			38438	-0.558	-0.2054	Yes
174	IL7R	ENSG00000168685.15			38829	-0.583	-0.2073	Yes
175	MAP2K3	ENSG00000034152.19			38842	-0.584	-0.2000	Yes
176	MYC	ENSG00000136997.19			39003	-0.602	-0.1961	Yes
177	TNFAIP8	ENSG00000145779.8			39080	-0.611	-0.1901	Yes
178	DENND5A	ENSG00000184014.8			39087	-0.611	-0.1823	Yes
179	OLR1	ENSG00000173391.9			39260	-0.619	-0.1784	Yes
180	DUSP5	ENSG00000138166.6			39412	-0.627	-0.1740	Yes
181	FJX1	ENSG00000179431.7			39554	-0.642	-0.1691	Yes
182	DNAJB4	ENSG00000162616.9			39607	-0.647	-0.1620	Yes
183	DUSP1	ENSG00000120129.6			39618	-0.648	-0.1538	Yes
184	EDN1	ENSG00000078401.7			39866	-0.688	-0.1509	Yes
185	F3	ENSG00000117525.14			40005	-0.714	-0.1450	Yes
186	GADD45B	ENSG00000099860.9			40019	-0.716	-0.1360	Yes
187	KLF6	ENSG00000067082.15			40162	-0.745	-0.1298	Yes
188	PDLIM5	ENSG00000163110.15			40169	-0.746	-0.1203	Yes
189	DRAM1	ENSG00000136048.14			40240	-0.762	-0.1121	Yes
190	TUBB2A	ENSG00000137267.6			40266	-0.768	-0.1028	Yes
191	PTX3	ENSG00000163661.4			40279	-0.771	-0.0931	Yes
192	JUN	ENSG00000177606.7			40305	-0.779	-0.0836	Yes
193	SLC2A3	ENSG00000059804.16			40569	-0.866	-0.0788	Yes
194	FOSL1	ENSG00000175592.9			40633	-0.890	-0.0687	Yes
195	TSC22D1	ENSG00000102804.15			40879	-1.021	-0.0615	Yes
196	SERPINB2	ENSG00000197632.9			40988	-1.121	-0.0496	Yes
197	RCAN1	ENSG00000159200.18			41022	-1.179	-0.0351	Yes
198	CD69	ENSG00000110848.8			41040	-1.206	-0.0198	Yes
199	TNFRSF9	ENSG00000049249.8			41133	-1.755	0.0007	Yes

Fig 2: HALLMARK_TNFA_SIGNALING_VIA_NFKB   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_TNFA_SIGNALING_VIA_NFKB: Random ES distribution   
Gene set null distribution of ES for HALLMARK_TNFA_SIGNALING_VIA_NFKB