Details for gene set HALLMARK_XENOBIOTIC_METABOLISM[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Phenotype	Phenotype.FSHD2.ARH.cls#FSHD2_versus_ARH
Upregulated in class	FSHD2
GeneSet	HALLMARK_XENOBIOTIC_METABOLISM
Enrichment Score (ES)	0.27362055
Normalized Enrichment Score (NES)	1.3296587
Nominal p-value	0.038406827
FDR q-value	0.11556337
FWER p-Value	0.836

Fig 1: Enrichment plot: HALLMARK_XENOBIOTIC_METABOLISM   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	TGFB2	ENSG00000092969.12			152	1.317	0.0165	Yes
2	CYP2E1	ENSG00000130649.10			315	1.122	0.0297	Yes
3	GNMT	ENSG00000124713.6			333	1.100	0.0462	Yes
4	ABCC3	ENSG00000108846.16			520	1.008	0.0571	Yes
5	EPHX1	ENSG00000143819.12			570	0.990	0.0710	Yes
6	FBLN1	ENSG00000077942.19			705	0.938	0.0821	Yes
7	KYNU	ENSG00000115919.15			734	0.930	0.0957	Yes
8	SLC22A1	ENSG00000175003.15			991	0.860	0.1026	Yes
9	DHPS	ENSG00000095059.16			1100	0.838	0.1128	Yes
10	JUP	ENSG00000173801.17			1285	0.804	0.1207	Yes
11	CYP1A1	ENSG00000140465.14			1309	0.801	0.1324	Yes
12	IL1R1	ENSG00000115594.12			1321	0.799	0.1443	Yes
13	SMOX	ENSG00000088826.18			1712	0.745	0.1462	Yes
14	CYP2S1	ENSG00000167600.14			2047	0.699	0.1488	Yes
15	ALDH3A1	ENSG00000108602.18			2386	0.664	0.1507	Yes
16	SLC6A6	ENSG00000131389.17			2725	0.630	0.1521	Yes
17	SLC46A3	ENSG00000139508.14			2778	0.625	0.1604	Yes
18	IGFBP4	ENSG00000141753.7			3723	0.556	0.1459	Yes
19	GCKR	ENSG00000084734.9			3734	0.555	0.1542	Yes
20	PLG	ENSG00000122194.18			3746	0.554	0.1624	Yes
21	CYP27A1	ENSG00000135929.9			3774	0.552	0.1702	Yes
22	MT2A	ENSG00000125148.7			3939	0.543	0.1745	Yes
23	CYP2C18	ENSG00000108242.13			4489	0.518	0.1691	Yes
24	GSTM4	ENSG00000168765.17			4534	0.517	0.1759	Yes
25	LEAP2	ENSG00000164406.8			4589	0.514	0.1825	Yes
26	HGFAC	ENSG00000109758.8			4599	0.514	0.1901	Yes
27	PROS1	ENSG00000184500.15			4767	0.507	0.1938	Yes
28	CFB	ENSG00000243649.8			4800	0.504	0.2008	Yes
29	UPB1	ENSG00000100024.15			4894	0.498	0.2061	Yes
30	HSD11B1	ENSG00000117594.10			4922	0.496	0.2131	Yes
31	SLC6A12	ENSG00000111181.12			4987	0.492	0.2190	Yes
32	FBP1	ENSG00000165140.10			5107	0.483	0.2235	Yes
33	CYP2J2	ENSG00000134716.11			5250	0.474	0.2273	Yes
34	TTPA	ENSG00000137561.5			5884	0.439	0.2186	Yes
35	ESR1	ENSG00000091831.23			5971	0.435	0.2232	Yes
36	PPARD	ENSG00000112033.14			6007	0.433	0.2290	Yes
37	NQO1	ENSG00000181019.13			6107	0.428	0.2331	Yes
38	GCH1	ENSG00000131979.19			6236	0.421	0.2364	Yes
39	RBP4	ENSG00000138207.14			6241	0.421	0.2428	Yes
40	FAH	ENSG00000103876.12			6411	0.412	0.2450	Yes
41	UPP1	ENSG00000183696.14			6504	0.408	0.2490	Yes
42	CSAD	ENSG00000139631.18			6661	0.401	0.2513	Yes
43	CCL25	ENSG00000131142.13			6786	0.397	0.2544	Yes
44	POR	ENSG00000127948.16			6799	0.396	0.2601	Yes
45	TNFRSF1A	ENSG00000067182.7			7098	0.385	0.2588	Yes
46	NPC1	ENSG00000141458.13			7120	0.384	0.2641	Yes
47	FMO1	ENSG00000010932.17			7182	0.381	0.2685	Yes
48	CYP1A2	ENSG00000140505.7			7424	0.372	0.2683	Yes
49	LCAT	ENSG00000213398.8			7482	0.372	0.2726	Yes
50	GCLC	ENSG00000001084.13			7671	0.364	0.2736	Yes
51	ACSM1	ENSG00000166743.9			8145	0.355	0.2675	No
52	HNF4A	ENSG00000101076.16			8585	0.348	0.2621	No
53	PEMT	ENSG00000133027.18			8729	0.346	0.2640	No
54	CAT	ENSG00000121691.7			8736	0.346	0.2691	No
55	CDO1	ENSG00000129596.5			8894	0.340	0.2705	No
56	HMOX1	ENSG00000100292.17			9075	0.332	0.2712	No
57	ITIH1	ENSG00000055957.11			9346	0.321	0.2695	No
58	MBL2	ENSG00000165471.6			9409	0.319	0.2729	No
59	TMEM97	ENSG00000109084.14			9826	0.318	0.2676	No
60	CRP	ENSG00000132693.12			10259	0.305	0.2617	No
61	PTGDS	ENSG00000107317.13			10645	0.305	0.2570	No
62	AKR1C2	ENSG00000151632.17			10705	0.302	0.2602	No
63	APOE	ENSG00000130203.10			10826	0.298	0.2618	No
64	PTGES	ENSG00000148344.11			10848	0.297	0.2659	No
65	ACOX2	ENSG00000168306.13			11842	0.277	0.2459	No
66	NINJ1	ENSG00000131669.10			11926	0.274	0.2480	No
67	SLC35D1	ENSG00000116704.8			12017	0.270	0.2500	No
68	MARCH6	ENSG00000145495.16			12033	0.270	0.2538	No
69	PDK4	ENSG00000004799.8			12277	0.262	0.2518	No
70	GABARAPL1	ENSG00000139112.11			12462	0.255	0.2513	No
71	CA2	ENSG00000104267.10			12533	0.253	0.2534	No
72	MPP2	ENSG00000108852.14			12762	0.246	0.2516	No
73	SERTAD1	ENSG00000197019.5			12988	0.238	0.2498	No
74	VTN	ENSG00000109072.14			13279	0.229	0.2462	No
75	IGF1	ENSG00000017427.16			13404	0.225	0.2466	No
76	ACP2	ENSG00000134575.12			13600	0.219	0.2452	No
77	HSD17B2	ENSG00000086696.11			13673	0.217	0.2468	No
78	NDRG2	ENSG00000165795.23			13680	0.216	0.2500	No
79	GSTT2	ENSG00000099984.11			14325	0.197	0.2373	No
80	SHMT2	ENSG00000182199.11			14562	0.188	0.2344	No
81	ABCD2	ENSG00000173208.4			14695	0.184	0.2340	No
82	CYFIP2	ENSG00000055163.20			14875	0.178	0.2323	No
83	TKFC	ENSG00000149476.15			14982	0.174	0.2324	No
84	ANGPTL3	ENSG00000132855.5			15223	0.167	0.2291	No
85	CBR1	ENSG00000159228.13			15279	0.165	0.2303	No
86	ALDH2	ENSG00000111275.13			15545	0.158	0.2263	No
87	HRG	ENSG00000113905.4			15955	0.146	0.2185	No
88	DHRS7	ENSG00000100612.14			16041	0.144	0.2187	No
89	GAD1	ENSG00000128683.14			16125	0.142	0.2188	No
90	CNDP2	ENSG00000133313.15			17103	0.115	0.1967	No
91	MAOA	ENSG00000189221.9			17441	0.106	0.1901	No
92	AKR1C3	ENSG00000196139.14			18197	0.085	0.1730	No
93	SLC12A4	ENSG00000124067.17			18300	0.084	0.1718	No
94	HES6	ENSG00000144485.11			18342	0.083	0.1720	No
95	ACOX1	ENSG00000161533.12			18471	0.080	0.1701	No
96	PGD	ENSG00000142657.21			18499	0.079	0.1707	No
97	DHRS1	ENSG00000157379.14			18520	0.078	0.1714	No
98	ELOVL5	ENSG00000012660.14			18561	0.077	0.1716	No
99	RAP1GAP	ENSG00000076864.19			18890	0.068	0.1647	No
100	GCNT2	ENSG00000111846.17			18915	0.068	0.1651	No
101	ECH1	ENSG00000104823.9			19400	0.054	0.1541	No
102	PSMB10	ENSG00000205220.12			19937	0.040	0.1416	No
103	CROT	ENSG00000005469.11			19961	0.039	0.1417	No
104	PGRMC1	ENSG00000101856.10			21489	-0.001	0.1044	No
105	ACO2	ENSG00000100412.16			21529	-0.002	0.1035	No
106	BPHL	ENSG00000137274.13			21993	-0.014	0.0924	No
107	PYCR1	ENSG00000183010.17			22333	-0.022	0.0845	No
108	AOX1	ENSG00000138356.14			22339	-0.022	0.0847	No
109	DDAH2	ENSG00000213722.9			22360	-0.022	0.0845	No
110	ATP2A2	ENSG00000174437.17			22480	-0.026	0.0820	No
111	ETS2	ENSG00000157557.13			22722	-0.031	0.0766	No
112	AP4B1	ENSG00000134262.13			22742	-0.032	0.0766	No
113	IDH1	ENSG00000138413.13			22996	-0.039	0.0711	No
114	ALAS1	ENSG00000023330.15			23130	-0.043	0.0685	No
115	ITIH4	ENSG00000055955.17			23165	-0.044	0.0683	No
116	ABCC2	ENSG00000023839.12			23803	-0.060	0.0537	No
117	TPST1	ENSG00000169902.15			24255	-0.072	0.0438	No
118	ARG1	ENSG00000118520.15			24273	-0.072	0.0445	No
119	SLC35B1	ENSG00000121073.15			24312	-0.073	0.0447	No
120	ACP1	ENSG00000143727.16			24324	-0.074	0.0456	No
121	DCXR	ENSG00000169738.8			24886	-0.088	0.0332	No
122	TMEM176B	ENSG00000106565.18			25133	-0.094	0.0286	No
123	F10	ENSG00000126218.12			25229	-0.097	0.0278	No
124	CYB5A	ENSG00000166347.19			25515	-0.106	0.0225	No
125	PMM1	ENSG00000100417.12			25550	-0.107	0.0233	No
126	KARS	ENSG00000065427.14			25576	-0.107	0.0243	No
127	RETSAT	ENSG00000042445.14			25766	-0.113	0.0214	No
128	LONP1	ENSG00000196365.12			26016	-0.121	0.0172	No
129	COMT	ENSG00000093010.13			26064	-0.123	0.0179	No
130	ALDH9A1	ENSG00000143149.12			26176	-0.125	0.0171	No
131	PINK1	ENSG00000158828.8			26178	-0.125	0.0190	No
132	AQP9	ENSG00000103569.10			26201	-0.126	0.0204	No
133	NFS1	ENSG00000244005.13			26256	-0.127	0.0211	No
134	BCAT1	ENSG00000060982.15			26443	-0.133	0.0186	No
135	TDO2	ENSG00000151790.9			26514	-0.136	0.0189	No
136	ATOH8	ENSG00000168874.13			27038	-0.151	0.0085	No
137	TMBIM6	ENSG00000139644.13			27100	-0.152	0.0093	No
138	PTS	ENSG00000150787.8			27261	-0.157	0.0078	No
139	PAPSS2	ENSG00000198682.13			27309	-0.158	0.0091	No
140	CASP6	ENSG00000138794.10			27327	-0.159	0.0111	No
141	BLVRB	ENSG00000090013.11			27336	-0.159	0.0133	No
142	BCAR1	ENSG00000050820.17			27576	-0.167	0.0101	No
143	UGDH	ENSG00000109814.12			27716	-0.171	0.0093	No
144	ENPEP	ENSG00000138792.10			27731	-0.171	0.0116	No
145	SLC1A5	ENSG00000105281.12			28017	-0.181	0.0074	No
146	SAR1B	ENSG00000152700.14			28046	-0.182	0.0095	No
147	CES1	ENSG00000198848.12			28060	-0.183	0.0120	No
148	GSR	ENSG00000104687.14			28212	-0.187	0.0112	No
149	IGFBP1	ENSG00000146678.10			28557	-0.198	0.0058	No
150	NMT1	ENSG00000136448.12			28656	-0.201	0.0065	No
151	ARG2	ENSG00000081181.8			29501	-0.227	-0.0106	No
152	GSS	ENSG00000100983.12			29622	-0.231	-0.0100	No
153	CYP17A1	ENSG00000148795.7			29819	-0.239	-0.0111	No
154	CDA	ENSG00000158825.6			29864	-0.240	-0.0085	No
155	PC	ENSG00000173599.15			30008	-0.244	-0.0083	No
156	GART	ENSG00000159131.17			30040	-0.245	-0.0053	No
157	PTGES3	ENSG00000110958.16			30197	-0.250	-0.0053	No
158	SPINT2	ENSG00000167642.13			30256	-0.252	-0.0028	No
159	ETFDH	ENSG00000171503.12			30873	-0.272	-0.0137	No
160	F11	ENSG00000088926.13			31232	-0.285	-0.0180	No
161	ADH1C	ENSG00000248144.6			31787	-0.289	-0.0271	No
162	ABHD6	ENSG00000163686.15			32914	-0.332	-0.0495	No
163	ENTPD5	ENSG00000187097.12			32955	-0.334	-0.0454	No
164	PTGR1	ENSG00000106853.20			32967	-0.335	-0.0405	No
165	CD36	ENSG00000135218.19			32994	-0.336	-0.0360	No
166	G6PC	ENSG00000131482.10			33064	-0.336	-0.0325	No
167	MAN1A1	ENSG00000111885.7			33550	-0.338	-0.0392	No
168	DDT	ENSG00000099977.14			33641	-0.342	-0.0362	No
169	TYR	ENSG00000077498.9			33753	-0.342	-0.0336	No
170	FAS	ENSG00000026103.22			34075	-0.344	-0.0362	No
171	MCCC2	ENSG00000131844.16			34708	-0.356	-0.0462	No
172	CYP26A1	ENSG00000095596.12			34937	-0.363	-0.0462	No
173	AHCY	ENSG00000101444.13			35184	-0.373	-0.0464	No
174	GSTO1	ENSG00000148834.13			35765	-0.400	-0.0545	No
175	ID2	ENSG00000115738.10			36059	-0.406	-0.0554	No
176	HACL1	ENSG00000131373.15			36411	-0.421	-0.0575	No
177	VNN1	ENSG00000112299.8			36430	-0.423	-0.0515	No
178	HPRT1	ENSG00000165704.15			36862	-0.444	-0.0552	No
179	SERPINA6	ENSG00000170099.6			37032	-0.454	-0.0524	No
180	DDC	ENSG00000132437.18			37176	-0.462	-0.0488	No
181	SSR3	ENSG00000114850.6			37238	-0.466	-0.0431	No
182	FMO3	ENSG00000007933.13			37515	-0.486	-0.0424	No
183	SERPINE1	ENSG00000106366.8			37533	-0.487	-0.0353	No
184	ASL	ENSG00000126522.17			37561	-0.490	-0.0285	No
185	ADH5	ENSG00000197894.11			37712	-0.503	-0.0245	No
186	LPIN2	ENSG00000101577.9			37920	-0.522	-0.0215	No
187	ADH7	ENSG00000196344.11			37933	-0.523	-0.0138	No
188	TAT	ENSG00000198650.11			38222	-0.544	-0.0125	No
189	CYP4F2	ENSG00000186115.13			38494	-0.558	-0.0105	No
190	EPHA2	ENSG00000142627.13			38526	-0.559	-0.0027	No
191	XDH	ENSG00000158125.10			38767	-0.577	0.0003	No
192	ARPP19	ENSG00000128989.10			38877	-0.588	0.0066	No
193	ACOX3	ENSG00000087008.16			39414	-0.628	0.0031	No
194	PDLIM5	ENSG00000163110.15			40169	-0.746	-0.0038	No
195	MTHFD1	ENSG00000100714.17			40252	-0.766	0.0059	No
196	FETUB	ENSG00000090512.12			40944	-1.061	0.0053	No

Fig 2: HALLMARK_XENOBIOTIC_METABOLISM   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_XENOBIOTIC_METABOLISM: Random ES distribution   
Gene set null distribution of ES for HALLMARK_XENOBIOTIC_METABOLISM