Details for gene set HALLMARK_APICAL_JUNCTION[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Phenotype	Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Upregulated in class	FSHD2M
GeneSet	HALLMARK_APICAL_JUNCTION
Enrichment Score (ES)	-0.38823855
Normalized Enrichment Score (NES)	-1.5465555
Nominal p-value	0.0012970169
FDR q-value	0.010822162
FWER p-Value	0.149

Fig 1: Enrichment plot: HALLMARK_APICAL_JUNCTION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	ITGA2	ENSG00000164171.11			327	2.899	0.0038	No
2	SGCE	ENSG00000127990.19			345	2.869	0.0147	No
3	RAC2	ENSG00000128340.15			379	2.785	0.0249	No
4	AMIGO1	ENSG00000181754.7			449	2.680	0.0338	No
5	SLIT2	ENSG00000145147.20			459	2.664	0.0441	No
6	EGFR	ENSG00000146648.18			529	2.570	0.0526	No
7	COL16A1	ENSG00000084636.18			589	2.483	0.0610	No
8	FYB1	ENSG00000082074.18			857	2.213	0.0635	No
9	SORBS3	ENSG00000120896.13			884	2.183	0.0715	No
10	CERCAM	ENSG00000167123.19			910	2.164	0.0794	No
11	CLDN11	ENSG00000013297.11			969	2.122	0.0864	No
12	FSCN1	ENSG00000075618.18			1089	2.055	0.0917	No
13	SRC	ENSG00000197122.11			1168	2.008	0.0978	No
14	SDC3	ENSG00000162512.16			1208	1.985	0.1047	No
15	MAPK13	ENSG00000156711.17			1253	1.961	0.1114	No
16	INSIG1	ENSG00000186480.13			1265	1.957	0.1189	No
17	EPB41L2	ENSG00000079819.19			1286	1.948	0.1261	No
18	RRAS	ENSG00000126458.4			1335	1.916	0.1325	No
19	TSPAN4	ENSG00000214063.11			1342	1.912	0.1399	No
20	TNFRSF11B	ENSG00000164761.9			1360	1.901	0.1470	No
21	MADCAM1	ENSG00000099866.15			1423	1.877	0.1529	No
22	MAP4K2	ENSG00000168067.12			1501	1.844	0.1584	No
23	CRAT	ENSG00000095321.17			1730	1.743	0.1599	No
24	NLGN2	ENSG00000169992.10			1752	1.735	0.1662	No
25	MPZL1	ENSG00000197965.12			2024	1.621	0.1663	No
26	MYH10	ENSG00000133026.12			2114	1.594	0.1705	No
27	MAPK11	ENSG00000185386.15			2130	1.590	0.1764	No
28	THY1	ENSG00000154096.13			2244	1.552	0.1799	No
29	LAYN	ENSG00000204381.11			2467	1.482	0.1806	No
30	CLDN7	ENSG00000181885.18			2537	1.461	0.1847	No
31	MMP2	ENSG00000087245.13			2616	1.437	0.1885	No
32	CDH11	ENSG00000140937.14			2757	1.391	0.1908	No
33	CLDN15	ENSG00000106404.13			2934	1.348	0.1920	No
34	TMEM8B	ENSG00000137103.20			3195	1.290	0.1910	No
35	MVD	ENSG00000167508.12			3276	1.273	0.1941	No
36	LDLRAP1	ENSG00000157978.11			3364	1.252	0.1970	No
37	VWF	ENSG00000110799.13			3693	1.186	0.1941	No
38	WASL	ENSG00000106299.8			3858	1.154	0.1948	No
39	PBX2	ENSG00000204304.12			3959	1.135	0.1969	No
40	ADAM15	ENSG00000143537.13			4091	1.114	0.1982	No
41	ICAM1	ENSG00000090339.9			4204	1.093	0.1999	No
42	RSU1	ENSG00000148484.18			4475	1.048	0.1978	No
43	CLDN18	ENSG00000066405.13			4688	1.016	0.1968	No
44	AKT2	ENSG00000105221.18			4775	1.001	0.1988	No
45	CX3CL1	ENSG00000006210.7			4796	0.999	0.2022	No
46	NECTIN3	ENSG00000177707.11			4974	0.972	0.2019	No
47	MDK	ENSG00000110492.15			5041	0.962	0.2042	No
48	GNAI2	ENSG00000114353.17			5091	0.956	0.2068	No
49	CNN2	ENSG00000064666.15			5294	0.928	0.2058	No
50	FBN1	ENSG00000166147.13			5850	0.858	0.1962	No
51	GNAI1	ENSG00000127955.17			5889	0.854	0.1987	No
52	THBS3	ENSG00000169231.13			6284	0.808	0.1927	No
53	NLGN3	ENSG00000196338.12			6377	0.800	0.1937	No
54	MAP3K20	ENSG00000091436.17			6549	0.783	0.1928	No
55	TRAF1	ENSG00000056558.11			6707	0.767	0.1921	No
56	SKAP2	ENSG00000005020.13			6720	0.765	0.1949	No
57	CD99	ENSG00000002586.20			6907	0.746	0.1935	No
58	CLDN4	ENSG00000189143.9			8062	0.642	0.1691	No
59	RHOF	ENSG00000139725.8			8475	0.608	0.1619	No
60	CALB2	ENSG00000172137.19			8638	0.596	0.1605	No
61	NFASC	ENSG00000163531.15			8774	0.585	0.1596	No
62	PDZD3	ENSG00000172367.16			9232	0.553	0.1512	No
63	NEGR1	ENSG00000172260.15			9390	0.544	0.1497	No
64	ICAM5	ENSG00000105376.5			10136	0.501	0.1343	No
65	MAPK14	ENSG00000112062.10			10900	0.451	0.1183	No
66	PIK3R3	ENSG00000117461.15			11004	0.444	0.1176	No
67	EVL	ENSG00000196405.13			11210	0.432	0.1145	No
68	SIRPA	ENSG00000198053.11			11216	0.432	0.1161	No
69	NRTN	ENSG00000171119.2			11280	0.428	0.1163	No
70	BAIAP2	ENSG00000175866.15			11334	0.425	0.1168	No
71	IKBKG	ENSG00000269335.5			11365	0.423	0.1178	No
72	TIAL1	ENSG00000151923.17			12072	0.384	0.1028	No
73	DMP1	ENSG00000152592.14			14902	0.287	0.0380	No
74	ADAM9	ENSG00000168615.12			15364	0.282	0.0284	No
75	TSC1	ENSG00000165699.14			15451	0.278	0.0275	No
76	SHC1	ENSG00000160691.18			15852	0.257	0.0192	No
77	CD209	ENSG00000090659.18			16218	0.235	0.0116	No
78	PARD6G	ENSG00000178184.16			16320	0.229	0.0102	No
79	CDH6	ENSG00000113361.13			16393	0.226	0.0094	No
80	DSC3	ENSG00000134762.17			16817	0.206	0.0003	No
81	ITGB4	ENSG00000132470.14			16947	0.199	-0.0019	No
82	PARVA	ENSG00000197702.14			17194	0.188	-0.0069	No
83	ICAM2	ENSG00000108622.11			17387	0.179	-0.0107	No
84	NF1	ENSG00000196712.17			18068	0.143	-0.0259	No
85	PPP2R2C	ENSG00000074211.14			19540	0.069	-0.0599	No
86	ATP1A3	ENSG00000105409.19			20648	0.014	-0.0857	No
87	CNTN1	ENSG00000018236.15			22301	-0.074	-0.1239	No
88	PTEN	ENSG00000171862.11			22605	-0.091	-0.1306	No
89	CAP1	ENSG00000131236.17			22692	-0.096	-0.1322	No
90	COL9A1	ENSG00000112280.16			23057	-0.115	-0.1402	No
91	STX4	ENSG00000103496.15			23081	-0.117	-0.1403	No
92	ZYX	ENSG00000159840.16			23404	-0.135	-0.1473	No
93	PECAM1	ENSG00000261371.6			23502	-0.141	-0.1490	No
94	CDH3	ENSG00000062038.14			23825	-0.160	-0.1558	No
95	ARPC2	ENSG00000163466.16			24381	-0.192	-0.1680	No
96	PKD1	ENSG00000008710.19			24395	-0.193	-0.1676	No
97	TAOK2	ENSG00000149930.18			24538	-0.201	-0.1701	No
98	YWHAH	ENSG00000128245.15			25599	-0.233	-0.1939	No
99	CDSN	ENSG00000204539.4			25960	-0.258	-0.2012	No
100	MPZL2	ENSG00000149573.9			26944	-0.275	-0.2230	No
101	AKT3	ENSG00000117020.18			27205	-0.288	-0.2280	No
102	CLDN19	ENSG00000164007.11			27939	-0.305	-0.2438	No
103	CLDN6	ENSG00000184697.7			28170	-0.321	-0.2479	No
104	CD276	ENSG00000103855.18			28292	-0.329	-0.2495	No
105	CRB3	ENSG00000130545.16			28656	-0.341	-0.2566	No
106	WNK4	ENSG00000126562.17			29085	-0.353	-0.2652	No
107	CD86	ENSG00000114013.16			29238	-0.360	-0.2673	No
108	PLCG1	ENSG00000124181.14			29500	-0.374	-0.2719	No
109	NECTIN1	ENSG00000110400.11			29652	-0.385	-0.2739	No
110	PIK3CB	ENSG00000051382.8			30141	-0.417	-0.2836	No
111	ACTG1	ENSG00000184009.12			30626	-0.445	-0.2932	No
112	GTF2F1	ENSG00000125651.14			30762	-0.451	-0.2945	No
113	MMP9	ENSG00000100985.7			31139	-0.471	-0.3014	No
114	CDK8	ENSG00000132964.12			31354	-0.482	-0.3045	No
115	JUP	ENSG00000173801.17			31855	-0.505	-0.3142	No
116	EXOC4	ENSG00000131558.15			32395	-0.538	-0.3246	No
117	LAMA3	ENSG00000053747.16			32988	-0.582	-0.3361	No
118	ADAMTS5	ENSG00000154736.6			33077	-0.588	-0.3359	No
119	ITGA9	ENSG00000144668.12			33291	-0.604	-0.3384	No
120	ADAM23	ENSG00000114948.13			33607	-0.630	-0.3433	No
121	SYMPK	ENSG00000125755.19			33623	-0.631	-0.3412	No
122	COL17A1	ENSG00000065618.21			33743	-0.641	-0.3414	No
123	DHX16	ENSG00000204560.10			33810	-0.646	-0.3404	No
124	GRB7	ENSG00000141738.14			33880	-0.652	-0.3394	No
125	PTK2	ENSG00000169398.19			34139	-0.671	-0.3428	No
126	LIMA1	ENSG00000050405.13			34334	-0.686	-0.3446	No
127	SHROOM2	ENSG00000146950.13			35559	-0.793	-0.3700	No
128	IRS1	ENSG00000169047.5			35781	-0.816	-0.3720	No
129	VCAN	ENSG00000038427.16			36187	-0.866	-0.3780	No
130	ITGB1	ENSG00000150093.19			36454	-0.895	-0.3807	No
131	CADM3	ENSG00000162706.13			36703	-0.930	-0.3828	No
132	ADRA1B	ENSG00000170214.5			36938	-0.957	-0.3845	Yes
133	TUBG1	ENSG00000131462.8			36973	-0.963	-0.3815	Yes
134	CDH1	ENSG00000039068.19			37235	-0.997	-0.3836	Yes
135	LAMC2	ENSG00000058085.15			37414	-1.022	-0.3838	Yes
136	PCDH1	ENSG00000156453.13			37463	-1.029	-0.3808	Yes
137	VCL	ENSG00000035403.17			37662	-1.061	-0.3813	Yes
138	VAV2	ENSG00000160293.17			37686	-1.065	-0.3776	Yes
139	MYL12B	ENSG00000118680.13			37797	-1.083	-0.3759	Yes
140	TJP1	ENSG00000104067.16			37865	-1.093	-0.3732	Yes
141	VASP	ENSG00000125753.14			37949	-1.108	-0.3707	Yes
142	CLDN9	ENSG00000213937.4			37970	-1.113	-0.3668	Yes
143	SYK	ENSG00000165025.15			38062	-1.127	-0.3645	Yes
144	SPEG	ENSG00000072195.15			38065	-1.128	-0.3601	Yes
145	CD34	ENSG00000174059.17			38113	-1.137	-0.3567	Yes
146	NF2	ENSG00000186575.18			38185	-1.151	-0.3539	Yes
147	HRAS	ENSG00000174775.17			38198	-1.153	-0.3496	Yes
148	GAMT	ENSG00000130005.13			38317	-1.174	-0.3477	Yes
149	ACTB	ENSG00000075624.16			38506	-1.208	-0.3474	Yes
150	CADM2	ENSG00000175161.13			38535	-1.213	-0.3432	Yes
151	ACTN3	ENSG00000248746.6			39105	-1.332	-0.3512	Yes
152	TRO	ENSG00000067445.21			39139	-1.338	-0.3467	Yes
153	BMP1	ENSG00000168487.19			39505	-1.423	-0.3497	Yes
154	ITGA10	ENSG00000143127.13			39526	-1.426	-0.3445	Yes
155	B4GALT1	ENSG00000086062.12			39786	-1.489	-0.3447	Yes
156	ALOX15B	ENSG00000179593.16			39887	-1.519	-0.3410	Yes
157	PFN1	ENSG00000108518.7			40055	-1.560	-0.3388	Yes
158	LAMB3	ENSG00000196878.15			40157	-1.589	-0.3349	Yes
159	NRAP	ENSG00000197893.13			40158	-1.589	-0.3286	Yes
160	MYL9	ENSG00000101335.10			40187	-1.596	-0.3230	Yes
161	JAM3	ENSG00000166086.13			40198	-1.599	-0.3169	Yes
162	DLG1	ENSG00000075711.21			40257	-1.615	-0.3119	Yes
163	CLDN14	ENSG00000159261.12			40281	-1.620	-0.3061	Yes
164	HADH	ENSG00000138796.16			40435	-1.667	-0.3031	Yes
165	MSN	ENSG00000147065.17			40565	-1.706	-0.2994	Yes
166	TGFBI	ENSG00000120708.17			40715	-1.752	-0.2960	Yes
167	ACTN1	ENSG00000072110.13			40848	-1.801	-0.2919	Yes
168	CDH4	ENSG00000179242.16			40997	-1.866	-0.2881	Yes
169	CD274	ENSG00000120217.14			40999	-1.867	-0.2807	Yes
170	CTNND1	ENSG00000198561.13			41012	-1.873	-0.2736	Yes
171	VCAM1	ENSG00000162692.12			41228	-1.969	-0.2709	Yes
172	MPP5	ENSG00000072415.9			41456	-2.104	-0.2679	Yes
173	CTNNA1	ENSG00000044115.21			41488	-2.125	-0.2603	Yes
174	NRXN2	ENSG00000110076.18			41510	-2.135	-0.2523	Yes
175	MYH9	ENSG00000100345.21			41599	-2.193	-0.2458	Yes
176	ACTG2	ENSG00000163017.14			41741	-2.285	-0.2401	Yes
177	RASA1	ENSG00000145715.15			41787	-2.315	-0.2320	Yes
178	ACTN4	ENSG00000130402.12			41788	-2.315	-0.2229	Yes
179	SLC30A3	ENSG00000115194.11			41805	-2.332	-0.2141	Yes
180	NECTIN2	ENSG00000130202.10			41868	-2.379	-0.2062	Yes
181	NECTIN4	ENSG00000143217.9			41869	-2.381	-0.1968	Yes
182	KCNH2	ENSG00000055118.15			41985	-2.477	-0.1897	Yes
183	PTPRC	ENSG00000081237.20			42203	-2.706	-0.1841	Yes
184	AMIGO2	ENSG00000139211.6			42276	-2.821	-0.1747	Yes
185	AMH	ENSG00000104899.8			42282	-2.829	-0.1637	Yes
186	INPPL1	ENSG00000165458.14			42351	-2.918	-0.1538	Yes
187	ARHGEF6	ENSG00000129675.16			42382	-2.958	-0.1428	Yes
188	ITGA3	ENSG00000005884.18			42556	-3.222	-0.1342	Yes
189	CDH8	ENSG00000150394.14			42668	-3.494	-0.1230	Yes
190	KRT31	ENSG00000094796.5			42678	-3.521	-0.1094	Yes
191	ACTA1	ENSG00000143632.14			42721	-3.653	-0.0960	Yes
192	CLDN5	ENSG00000184113.9			42752	-3.728	-0.0820	Yes
193	FLNC	ENSG00000128591.15			42852	-4.113	-0.0681	Yes
194	ACTN2	ENSG00000077522.13			42966	-4.553	-0.0528	Yes
195	NEXN	ENSG00000162614.18			42973	-4.596	-0.0349	Yes
196	CDH15	ENSG00000129910.8			43003	-4.739	-0.0169	Yes
197	ACTC1	ENSG00000159251.8			43108	-4.973	0.0003	Yes

Fig 2: HALLMARK_APICAL_JUNCTION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_APICAL_JUNCTION: Random ES distribution   
Gene set null distribution of ES for HALLMARK_APICAL_JUNCTION