Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Phenotype | Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Upregulated in class | FSHD2 |
| GeneSet | HALLMARK_APOPTOSIS |
| Enrichment Score (ES) | 0.36363396 |
| Normalized Enrichment Score (NES) | 1.6139448 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.006198044 |
| FWER p-Value | 0.038 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | DCN | ENSG00000011465.17 | 6 | 4.734 | 0.0260 | Yes | ||
| 2 | PDGFRB | ENSG00000113721.14 | 106 | 3.655 | 0.0438 | Yes | ||
| 3 | LGALS3 | ENSG00000131981.16 | 150 | 3.486 | 0.0621 | Yes | ||
| 4 | CD44 | ENSG00000026508.18 | 157 | 3.446 | 0.0809 | Yes | ||
| 5 | FEZ1 | ENSG00000149557.14 | 366 | 2.821 | 0.0917 | Yes | ||
| 6 | TIMP2 | ENSG00000035862.12 | 402 | 2.753 | 0.1060 | Yes | ||
| 7 | DPYD | ENSG00000188641.13 | 405 | 2.750 | 0.1212 | Yes | ||
| 8 | TGFBR3 | ENSG00000069702.11 | 474 | 2.641 | 0.1342 | Yes | ||
| 9 | TIMP1 | ENSG00000102265.12 | 582 | 2.491 | 0.1454 | Yes | ||
| 10 | DAP | ENSG00000112977.15 | 634 | 2.424 | 0.1576 | Yes | ||
| 11 | EMP1 | ENSG00000134531.10 | 648 | 2.414 | 0.1706 | Yes | ||
| 12 | GPX4 | ENSG00000167468.17 | 652 | 2.411 | 0.1838 | Yes | ||
| 13 | IFITM3 | ENSG00000142089.16 | 861 | 2.207 | 0.1912 | Yes | ||
| 14 | TIMP3 | ENSG00000100234.11 | 892 | 2.178 | 0.2025 | Yes | ||
| 15 | FAS | ENSG00000026103.22 | 911 | 2.164 | 0.2140 | Yes | ||
| 16 | SATB1 | ENSG00000182568.17 | 963 | 2.125 | 0.2246 | Yes | ||
| 17 | HGF | ENSG00000019991.18 | 1039 | 2.087 | 0.2343 | Yes | ||
| 18 | IGFBP6 | ENSG00000167779.9 | 1241 | 1.971 | 0.2405 | Yes | ||
| 19 | LUM | ENSG00000139329.5 | 1391 | 1.886 | 0.2475 | Yes | ||
| 20 | PDCD4 | ENSG00000150593.18 | 1417 | 1.879 | 0.2572 | Yes | ||
| 21 | EGR3 | ENSG00000179388.9 | 1551 | 1.818 | 0.2642 | Yes | ||
| 22 | SQSTM1 | ENSG00000161011.20 | 1557 | 1.815 | 0.2741 | Yes | ||
| 23 | CD14 | ENSG00000170458.14 | 1584 | 1.809 | 0.2835 | Yes | ||
| 24 | GPX1 | ENSG00000233276.5 | 1675 | 1.764 | 0.2911 | Yes | ||
| 25 | FDXR | ENSG00000161513.12 | 1927 | 1.658 | 0.2944 | Yes | ||
| 26 | BCL10 | ENSG00000142867.14 | 1956 | 1.649 | 0.3028 | Yes | ||
| 27 | CASP4 | ENSG00000196954.14 | 2254 | 1.548 | 0.3045 | Yes | ||
| 28 | CLU | ENSG00000120885.22 | 2415 | 1.500 | 0.3090 | Yes | ||
| 29 | TSPO | ENSG00000100300.18 | 2475 | 1.481 | 0.3158 | Yes | ||
| 30 | MMP2 | ENSG00000087245.13 | 2616 | 1.437 | 0.3205 | Yes | ||
| 31 | CAV1 | ENSG00000105974.12 | 2696 | 1.410 | 0.3264 | Yes | ||
| 32 | CASP1 | ENSG00000137752.24 | 2840 | 1.369 | 0.3307 | Yes | ||
| 33 | ISG20 | ENSG00000172183.15 | 3169 | 1.296 | 0.3302 | Yes | ||
| 34 | BMP2 | ENSG00000125845.7 | 3203 | 1.288 | 0.3365 | Yes | ||
| 35 | WEE1 | ENSG00000166483.11 | 3367 | 1.252 | 0.3396 | Yes | ||
| 36 | BNIP3L | ENSG00000104765.16 | 3379 | 1.249 | 0.3463 | Yes | ||
| 37 | IRF1 | ENSG00000125347.14 | 3458 | 1.235 | 0.3513 | Yes | ||
| 38 | BAX | ENSG00000087088.20 | 3520 | 1.222 | 0.3566 | Yes | ||
| 39 | TNFSF10 | ENSG00000121858.11 | 3755 | 1.173 | 0.3576 | Yes | ||
| 40 | AIFM3 | ENSG00000183773.15 | 3774 | 1.169 | 0.3636 | Yes | ||
| 41 | DDIT3 | ENSG00000175197.12 | 4354 | 1.068 | 0.3561 | No | ||
| 42 | IFNGR1 | ENSG00000027697.14 | 4559 | 1.035 | 0.3570 | No | ||
| 43 | CCND1 | ENSG00000110092.3 | 4717 | 1.011 | 0.3589 | No | ||
| 44 | EREG | ENSG00000124882.4 | 4928 | 0.979 | 0.3594 | No | ||
| 45 | PLPPR4 | ENSG00000117600.12 | 4997 | 0.969 | 0.3632 | No | ||
| 46 | GNA15 | ENSG00000060558.4 | 5581 | 0.890 | 0.3546 | No | ||
| 47 | MGMT | ENSG00000170430.10 | 5829 | 0.861 | 0.3536 | No | ||
| 48 | CDKN1B | ENSG00000111276.11 | 6128 | 0.825 | 0.3512 | No | ||
| 49 | PMAIP1 | ENSG00000141682.11 | 6227 | 0.814 | 0.3534 | No | ||
| 50 | IL18 | ENSG00000150782.12 | 6797 | 0.757 | 0.3443 | No | ||
| 51 | BGN | ENSG00000182492.16 | 7136 | 0.724 | 0.3404 | No | ||
| 52 | GCH1 | ENSG00000131979.19 | 7161 | 0.723 | 0.3439 | No | ||
| 53 | F2R | ENSG00000181104.7 | 7392 | 0.701 | 0.3424 | No | ||
| 54 | DIABLO | ENSG00000184047.19 | 7529 | 0.687 | 0.3430 | No | ||
| 55 | CREBBP | ENSG00000005339.14 | 7714 | 0.671 | 0.3424 | No | ||
| 56 | CASP8 | ENSG00000064012.21 | 7888 | 0.656 | 0.3420 | No | ||
| 57 | GPX3 | ENSG00000211445.12 | 7962 | 0.650 | 0.3439 | No | ||
| 58 | CD38 | ENSG00000004468.13 | 8415 | 0.611 | 0.3368 | No | ||
| 59 | AVPR1A | ENSG00000166148.3 | 8467 | 0.608 | 0.3389 | No | ||
| 60 | CASP2 | ENSG00000106144.20 | 9203 | 0.555 | 0.3249 | No | ||
| 61 | EBP | ENSG00000147155.11 | 9521 | 0.536 | 0.3205 | No | ||
| 62 | HMOX1 | ENSG00000100292.17 | 9579 | 0.532 | 0.3221 | No | ||
| 63 | ADD1 | ENSG00000087274.17 | 9672 | 0.524 | 0.3228 | No | ||
| 64 | BCL2L10 | ENSG00000137875.4 | 9775 | 0.522 | 0.3233 | No | ||
| 65 | IL1A | ENSG00000115008.5 | 10008 | 0.511 | 0.3207 | No | ||
| 66 | CFLAR | ENSG00000003402.20 | 10310 | 0.491 | 0.3164 | No | ||
| 67 | RETSAT | ENSG00000042445.14 | 11072 | 0.439 | 0.3011 | No | ||
| 68 | DFFA | ENSG00000160049.12 | 11412 | 0.419 | 0.2956 | No | ||
| 69 | LEF1 | ENSG00000138795.10 | 12321 | 0.374 | 0.2765 | No | ||
| 70 | ANXA1 | ENSG00000135046.14 | 12384 | 0.370 | 0.2771 | No | ||
| 71 | BIRC3 | ENSG00000023445.14 | 12432 | 0.366 | 0.2780 | No | ||
| 72 | GSTM1 | ENSG00000134184.13 | 12663 | 0.363 | 0.2747 | No | ||
| 73 | TAP1 | ENSG00000168394.11 | 14010 | 0.316 | 0.2451 | No | ||
| 74 | APP | ENSG00000142192.21 | 14143 | 0.308 | 0.2437 | No | ||
| 75 | LMNA | ENSG00000160789.20 | 15491 | 0.275 | 0.2139 | No | ||
| 76 | SAT1 | ENSG00000130066.16 | 15520 | 0.274 | 0.2147 | No | ||
| 77 | MADD | ENSG00000110514.19 | 16477 | 0.221 | 0.1937 | No | ||
| 78 | ANKH | ENSG00000154122.14 | 16879 | 0.203 | 0.1855 | No | ||
| 79 | H1F0 | ENSG00000189060.5 | 16934 | 0.200 | 0.1853 | No | ||
| 80 | GUCY2D | ENSG00000132518.6 | 17163 | 0.189 | 0.1811 | No | ||
| 81 | IL1B | ENSG00000125538.12 | 17487 | 0.172 | 0.1745 | No | ||
| 82 | NEDD9 | ENSG00000111859.17 | 18126 | 0.140 | 0.1604 | No | ||
| 83 | BCL2L2 | ENSG00000129473.9 | 18748 | 0.109 | 0.1466 | No | ||
| 84 | RELA | ENSG00000173039.19 | 18880 | 0.104 | 0.1441 | No | ||
| 85 | RNASEL | ENSG00000135828.11 | 18968 | 0.100 | 0.1426 | No | ||
| 86 | PSEN1 | ENSG00000080815.19 | 20272 | 0.034 | 0.1125 | No | ||
| 87 | SOD1 | ENSG00000142168.14 | 20939 | -0.001 | 0.0970 | No | ||
| 88 | PLCB2 | ENSG00000137841.12 | 21082 | -0.009 | 0.0937 | No | ||
| 89 | SLC20A1 | ENSG00000144136.11 | 22289 | -0.074 | 0.0661 | No | ||
| 90 | DNAJC3 | ENSG00000102580.15 | 22608 | -0.091 | 0.0592 | No | ||
| 91 | CASP7 | ENSG00000165806.20 | 23029 | -0.113 | 0.0500 | No | ||
| 92 | DNAJA1 | ENSG00000086061.16 | 23161 | -0.122 | 0.0476 | No | ||
| 93 | MCL1 | ENSG00000143384.13 | 23256 | -0.127 | 0.0461 | No | ||
| 94 | PSEN2 | ENSG00000143801.17 | 23491 | -0.140 | 0.0415 | No | ||
| 95 | BIK | ENSG00000100290.3 | 24053 | -0.174 | 0.0294 | No | ||
| 96 | SOD2 | ENSG00000112096.18 | 24563 | -0.202 | 0.0186 | No | ||
| 97 | CD2 | ENSG00000116824.5 | 25496 | -0.227 | -0.0018 | No | ||
| 98 | RHOT2 | ENSG00000140983.14 | 25586 | -0.232 | -0.0026 | No | ||
| 99 | HMGB2 | ENSG00000164104.12 | 25628 | -0.235 | -0.0023 | No | ||
| 100 | ATF3 | ENSG00000162772.17 | 25795 | -0.246 | -0.0048 | No | ||
| 101 | CD69 | ENSG00000110848.8 | 26251 | -0.263 | -0.0139 | No | ||
| 102 | FASLG | ENSG00000117560.8 | 28350 | -0.331 | -0.0609 | No | ||
| 103 | DAP3 | ENSG00000132676.16 | 29977 | -0.405 | -0.0965 | No | ||
| 104 | BCL2L1 | ENSG00000171552.13 | 30289 | -0.428 | -0.1014 | No | ||
| 105 | CDC25B | ENSG00000101224.17 | 30297 | -0.429 | -0.0992 | No | ||
| 106 | KRT18 | ENSG00000111057.11 | 30409 | -0.432 | -0.0994 | No | ||
| 107 | CASP6 | ENSG00000138794.10 | 30445 | -0.435 | -0.0978 | No | ||
| 108 | PAK1 | ENSG00000149269.9 | 30840 | -0.456 | -0.1045 | No | ||
| 109 | CTH | ENSG00000116761.12 | 31007 | -0.460 | -0.1058 | No | ||
| 110 | PRF1 | ENSG00000180644.8 | 31454 | -0.487 | -0.1135 | No | ||
| 111 | PPT1 | ENSG00000131238.17 | 31757 | -0.501 | -0.1178 | No | ||
| 112 | DNM1L | ENSG00000087470.18 | 32060 | -0.519 | -0.1219 | No | ||
| 113 | IFNB1 | ENSG00000171855.7 | 32496 | -0.542 | -0.1291 | No | ||
| 114 | PPP2R5B | ENSG00000068971.14 | 32568 | -0.549 | -0.1277 | No | ||
| 115 | GSN | ENSG00000148180.19 | 32592 | -0.551 | -0.1252 | No | ||
| 116 | IER3 | ENSG00000137331.12 | 33260 | -0.602 | -0.1374 | No | ||
| 117 | TOP2A | ENSG00000131747.15 | 33556 | -0.624 | -0.1408 | No | ||
| 118 | SMAD7 | ENSG00000101665.9 | 33630 | -0.632 | -0.1390 | No | ||
| 119 | PTK2 | ENSG00000169398.19 | 34139 | -0.671 | -0.1472 | No | ||
| 120 | BMF | ENSG00000104081.14 | 34357 | -0.688 | -0.1484 | No | ||
| 121 | SC5D | ENSG00000109929.10 | 34365 | -0.689 | -0.1448 | No | ||
| 122 | ROCK1 | ENSG00000067900.8 | 34657 | -0.715 | -0.1476 | No | ||
| 123 | XIAP | ENSG00000101966.12 | 34810 | -0.725 | -0.1471 | No | ||
| 124 | CCNA1 | ENSG00000133101.10 | 34815 | -0.726 | -0.1432 | No | ||
| 125 | BTG3 | ENSG00000154640.14 | 36393 | -0.887 | -0.1750 | No | ||
| 126 | BCAP31 | ENSG00000185825.17 | 36556 | -0.907 | -0.1738 | No | ||
| 127 | TXNIP | ENSG00000265972.6 | 36595 | -0.913 | -0.1697 | No | ||
| 128 | CDK2 | ENSG00000123374.11 | 37047 | -0.974 | -0.1748 | No | ||
| 129 | RARA | ENSG00000131759.18 | 37114 | -0.982 | -0.1709 | No | ||
| 130 | JUN | ENSG00000177606.7 | 37141 | -0.985 | -0.1661 | No | ||
| 131 | BTG2 | ENSG00000159388.6 | 37157 | -0.987 | -0.1610 | No | ||
| 132 | IL6 | ENSG00000136244.12 | 37366 | -1.015 | -0.1602 | No | ||
| 133 | IGF2R | ENSG00000197081.14 | 37384 | -1.018 | -0.1550 | No | ||
| 134 | CDKN1A | ENSG00000124762.13 | 37465 | -1.029 | -0.1512 | No | ||
| 135 | TNF | ENSG00000232810.4 | 37586 | -1.048 | -0.1482 | No | ||
| 136 | PPP3R1 | ENSG00000221823.11 | 37738 | -1.074 | -0.1458 | No | ||
| 137 | BID | ENSG00000015475.18 | 37741 | -1.075 | -0.1399 | No | ||
| 138 | ERBB2 | ENSG00000141736.13 | 38420 | -1.191 | -0.1491 | No | ||
| 139 | BRCA1 | ENSG00000012048.22 | 38494 | -1.205 | -0.1442 | No | ||
| 140 | RHOB | ENSG00000143878.10 | 38518 | -1.210 | -0.1380 | No | ||
| 141 | ETF1 | ENSG00000120705.13 | 39011 | -1.312 | -0.1422 | No | ||
| 142 | CASP9 | ENSG00000132906.18 | 39565 | -1.434 | -0.1472 | No | ||
| 143 | ENO2 | ENSG00000111674.9 | 39689 | -1.464 | -0.1420 | No | ||
| 144 | GSR | ENSG00000104687.14 | 39972 | -1.542 | -0.1400 | No | ||
| 145 | SPTAN1 | ENSG00000197694.16 | 40071 | -1.565 | -0.1337 | No | ||
| 146 | VDAC2 | ENSG00000165637.13 | 40139 | -1.584 | -0.1265 | No | ||
| 147 | NEFH | ENSG00000100285.10 | 40864 | -1.808 | -0.1334 | No | ||
| 148 | GADD45B | ENSG00000099860.9 | 40977 | -1.852 | -0.1258 | No | ||
| 149 | TNFRSF12A | ENSG00000006327.13 | 41188 | -1.954 | -0.1199 | No | ||
| 150 | GADD45A | ENSG00000116717.13 | 41218 | -1.966 | -0.1097 | No | ||
| 151 | PEA15 | ENSG00000162734.12 | 41225 | -1.969 | -0.0990 | No | ||
| 152 | CTNNB1 | ENSG00000168036.18 | 41475 | -2.117 | -0.0931 | No | ||
| 153 | BCL2L11 | ENSG00000153094.23 | 41506 | -2.133 | -0.0820 | No | ||
| 154 | TGFB2 | ENSG00000092969.12 | 41517 | -2.139 | -0.0705 | No | ||
| 155 | PLAT | ENSG00000104368.18 | 41640 | -2.216 | -0.0611 | No | ||
| 156 | F2 | ENSG00000180210.14 | 41777 | -2.308 | -0.0515 | No | ||
| 157 | CCND2 | ENSG00000118971.8 | 41960 | -2.462 | -0.0422 | No | ||
| 158 | HSPB1 | ENSG00000106211.9 | 42005 | -2.494 | -0.0294 | No | ||
| 159 | CYLD | ENSG00000083799.17 | 42207 | -2.717 | -0.0191 | No | ||
| 160 | CASP3 | ENSG00000164305.19 | 42313 | -2.869 | -0.0057 | No | ||
| 161 | ERBB3 | ENSG00000065361.15 | 42934 | -4.434 | 0.0043 | No |
