Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Phenotype | Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Upregulated in class | FSHD2M |
| GeneSet | HALLMARK_E2F_TARGETS |
| Enrichment Score (ES) | -0.5170629 |
| Normalized Enrichment Score (NES) | -2.073709 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | HMGA1 | ENSG00000137309.19 | 1346 | 1.908 | -0.0202 | No | ||
| 2 | CIT | ENSG00000122966.16 | 1667 | 1.767 | -0.0174 | No | ||
| 3 | PRDX4 | ENSG00000123131.13 | 2016 | 1.623 | -0.0160 | No | ||
| 4 | TFRC | ENSG00000072274.13 | 2501 | 1.475 | -0.0187 | No | ||
| 5 | RAD1 | ENSG00000113456.19 | 3183 | 1.292 | -0.0271 | No | ||
| 6 | WEE1 | ENSG00000166483.11 | 3367 | 1.252 | -0.0240 | No | ||
| 7 | STAG1 | ENSG00000118007.13 | 3483 | 1.228 | -0.0195 | No | ||
| 8 | WDR90 | ENSG00000161996.19 | 3874 | 1.151 | -0.0219 | No | ||
| 9 | CDK4 | ENSG00000135446.17 | 4137 | 1.105 | -0.0216 | No | ||
| 10 | DUT | ENSG00000128951.14 | 4996 | 0.969 | -0.0359 | No | ||
| 11 | CHEK2 | ENSG00000183765.22 | 5677 | 0.879 | -0.0466 | No | ||
| 12 | CDKN1B | ENSG00000111276.11 | 6128 | 0.825 | -0.0523 | No | ||
| 13 | CHEK1 | ENSG00000149554.13 | 6143 | 0.823 | -0.0478 | No | ||
| 14 | SHMT1 | ENSG00000176974.20 | 6798 | 0.757 | -0.0587 | No | ||
| 15 | NUDT21 | ENSG00000167005.14 | 6924 | 0.744 | -0.0572 | No | ||
| 16 | SLBP | ENSG00000163950.13 | 7725 | 0.670 | -0.0720 | No | ||
| 17 | PPM1D | ENSG00000170836.11 | 7867 | 0.658 | -0.0714 | No | ||
| 18 | LBR | ENSG00000143815.15 | 8417 | 0.611 | -0.0806 | No | ||
| 19 | PSIP1 | ENSG00000164985.15 | 8464 | 0.608 | -0.0782 | No | ||
| 20 | CKS1B | ENSG00000173207.13 | 8704 | 0.590 | -0.0803 | No | ||
| 21 | PCNA | ENSG00000132646.11 | 8869 | 0.578 | -0.0807 | No | ||
| 22 | CDKN2C | ENSG00000123080.12 | 10414 | 0.484 | -0.1139 | No | ||
| 23 | TP53 | ENSG00000141510.17 | 10940 | 0.449 | -0.1235 | No | ||
| 24 | PRIM2 | ENSG00000146143.19 | 11511 | 0.413 | -0.1344 | No | ||
| 25 | PHF5A | ENSG00000100410.8 | 11542 | 0.411 | -0.1327 | No | ||
| 26 | MMS22L | ENSG00000146263.11 | 13242 | 0.343 | -0.1703 | No | ||
| 27 | PDS5B | ENSG00000083642.19 | 14594 | 0.304 | -0.2000 | No | ||
| 28 | POLD3 | ENSG00000077514.9 | 14781 | 0.293 | -0.2026 | No | ||
| 29 | POLE | ENSG00000177084.17 | 16492 | 0.220 | -0.2412 | No | ||
| 30 | SMC4 | ENSG00000113810.16 | 17164 | 0.189 | -0.2557 | No | ||
| 31 | ING3 | ENSG00000071243.16 | 19663 | 0.063 | -0.3135 | No | ||
| 32 | NAA38 | ENSG00000183011.13 | 19813 | 0.055 | -0.3167 | No | ||
| 33 | TCF19 | ENSG00000137310.12 | 19979 | 0.049 | -0.3202 | No | ||
| 34 | UBR7 | ENSG00000012963.15 | 20044 | 0.046 | -0.3215 | No | ||
| 35 | POLE4 | ENSG00000115350.12 | 20281 | 0.033 | -0.3268 | No | ||
| 36 | UNG | ENSG00000076248.10 | 20600 | 0.017 | -0.3341 | No | ||
| 37 | MCM7 | ENSG00000166508.17 | 20623 | 0.016 | -0.3345 | No | ||
| 38 | CDKN2A | ENSG00000147889.17 | 20700 | 0.012 | -0.3362 | No | ||
| 39 | CKS2 | ENSG00000123975.5 | 20736 | 0.010 | -0.3370 | No | ||
| 40 | CDKN3 | ENSG00000100526.20 | 21058 | -0.007 | -0.3444 | No | ||
| 41 | DCLRE1B | ENSG00000118655.7 | 21285 | -0.021 | -0.3495 | No | ||
| 42 | DSCC1 | ENSG00000136982.6 | 21457 | -0.030 | -0.3534 | No | ||
| 43 | DONSON | ENSG00000159147.18 | 21490 | -0.032 | -0.3539 | No | ||
| 44 | NCAPD2 | ENSG00000010292.13 | 21675 | -0.041 | -0.3580 | No | ||
| 45 | H2AFX | ENSG00000188486.3 | 21679 | -0.041 | -0.3578 | No | ||
| 46 | CBX5 | ENSG00000094916.16 | 21958 | -0.054 | -0.3640 | No | ||
| 47 | RAD50 | ENSG00000113522.14 | 21992 | -0.056 | -0.3644 | No | ||
| 48 | ASF1B | ENSG00000105011.9 | 22012 | -0.057 | -0.3645 | No | ||
| 49 | TK1 | ENSG00000167900.12 | 22620 | -0.092 | -0.3781 | No | ||
| 50 | CNOT9 | ENSG00000144580.13 | 22648 | -0.093 | -0.3782 | No | ||
| 51 | EED | ENSG00000074266.21 | 22911 | -0.108 | -0.3837 | No | ||
| 52 | USP1 | ENSG00000162607.13 | 23075 | -0.117 | -0.3868 | No | ||
| 53 | RPA1 | ENSG00000132383.12 | 23094 | -0.118 | -0.3865 | No | ||
| 54 | CENPM | ENSG00000100162.15 | 23379 | -0.134 | -0.3924 | No | ||
| 55 | PPP1R8 | ENSG00000117751.18 | 23812 | -0.159 | -0.4015 | No | ||
| 56 | CTCF | ENSG00000102974.16 | 24088 | -0.177 | -0.4069 | No | ||
| 57 | ATAD2 | ENSG00000156802.13 | 24359 | -0.191 | -0.4120 | No | ||
| 58 | HMGB2 | ENSG00000164104.12 | 25628 | -0.235 | -0.4402 | No | ||
| 59 | HUS1 | ENSG00000136273.13 | 25889 | -0.253 | -0.4448 | No | ||
| 60 | ORC6 | ENSG00000091651.9 | 27104 | -0.281 | -0.4715 | No | ||
| 61 | DDX39A | ENSG00000123136.15 | 27337 | -0.297 | -0.4751 | No | ||
| 62 | LUC7L3 | ENSG00000108848.16 | 27525 | -0.299 | -0.4777 | No | ||
| 63 | SMC3 | ENSG00000108055.9 | 27903 | -0.302 | -0.4848 | No | ||
| 64 | RPA3 | ENSG00000106399.11 | 27907 | -0.302 | -0.4831 | No | ||
| 65 | ORC2 | ENSG00000115942.9 | 28093 | -0.316 | -0.4855 | No | ||
| 66 | MCM6 | ENSG00000076003.5 | 28225 | -0.325 | -0.4867 | No | ||
| 67 | EXOSC8 | ENSG00000120699.13 | 28676 | -0.343 | -0.4952 | No | ||
| 68 | MELK | ENSG00000165304.8 | 28762 | -0.349 | -0.4951 | No | ||
| 69 | MXD3 | ENSG00000213347.10 | 28768 | -0.350 | -0.4932 | No | ||
| 70 | LIG1 | ENSG00000105486.14 | 29118 | -0.354 | -0.4993 | No | ||
| 71 | SPC24 | ENSG00000161888.11 | 29357 | -0.367 | -0.5027 | No | ||
| 72 | HELLS | ENSG00000119969.15 | 29449 | -0.371 | -0.5026 | No | ||
| 73 | AURKA | ENSG00000087586.17 | 29575 | -0.379 | -0.5033 | No | ||
| 74 | MCM3 | ENSG00000112118.20 | 29614 | -0.382 | -0.5020 | No | ||
| 75 | ESPL1 | ENSG00000135476.11 | 29621 | -0.383 | -0.4999 | No | ||
| 76 | CDCA3 | ENSG00000111665.11 | 29727 | -0.389 | -0.5001 | No | ||
| 77 | CCNB2 | ENSG00000157456.8 | 30092 | -0.412 | -0.5062 | No | ||
| 78 | RBBP7 | ENSG00000102054.17 | 30110 | -0.414 | -0.5041 | No | ||
| 79 | BIRC5 | ENSG00000089685.15 | 30216 | -0.422 | -0.5041 | No | ||
| 80 | SPC25 | ENSG00000152253.9 | 30225 | -0.423 | -0.5018 | No | ||
| 81 | H2AFZ | ENSG00000164032.12 | 30267 | -0.427 | -0.5003 | No | ||
| 82 | CDC25B | ENSG00000101224.17 | 30297 | -0.429 | -0.4985 | No | ||
| 83 | TRIP13 | ENSG00000071539.14 | 30440 | -0.434 | -0.4993 | No | ||
| 84 | RAD51AP1 | ENSG00000111247.14 | 30553 | -0.438 | -0.4993 | No | ||
| 85 | SUV39H1 | ENSG00000101945.16 | 30758 | -0.451 | -0.5014 | No | ||
| 86 | ASF1A | ENSG00000111875.8 | 30896 | -0.457 | -0.5020 | No | ||
| 87 | RRM2 | ENSG00000171848.15 | 31059 | -0.464 | -0.5030 | No | ||
| 88 | CDK1 | ENSG00000170312.16 | 31062 | -0.464 | -0.5004 | No | ||
| 89 | RFC3 | ENSG00000133119.13 | 31151 | -0.472 | -0.4997 | No | ||
| 90 | MTHFD2 | ENSG00000065911.12 | 31162 | -0.472 | -0.4972 | No | ||
| 91 | PSMC3IP | ENSG00000131470.14 | 32017 | -0.514 | -0.5141 | Yes | ||
| 92 | CENPE | ENSG00000138778.12 | 32083 | -0.520 | -0.5125 | Yes | ||
| 93 | PAN2 | ENSG00000135473.15 | 32257 | -0.531 | -0.5135 | Yes | ||
| 94 | MAD2L1 | ENSG00000164109.14 | 32397 | -0.539 | -0.5136 | Yes | ||
| 95 | NUP205 | ENSG00000155561.15 | 32543 | -0.546 | -0.5138 | Yes | ||
| 96 | TACC3 | ENSG00000013810.19 | 32622 | -0.553 | -0.5124 | Yes | ||
| 97 | RANBP1 | ENSG00000099901.17 | 32652 | -0.556 | -0.5098 | Yes | ||
| 98 | RACGAP1 | ENSG00000161800.13 | 32756 | -0.565 | -0.5089 | Yes | ||
| 99 | MCM5 | ENSG00000100297.16 | 32907 | -0.577 | -0.5090 | Yes | ||
| 100 | HMMR | ENSG00000072571.20 | 33009 | -0.584 | -0.5080 | Yes | ||
| 101 | SSRP1 | ENSG00000149136.9 | 33026 | -0.585 | -0.5049 | Yes | ||
| 102 | KIF2C | ENSG00000142945.13 | 33404 | -0.613 | -0.5102 | Yes | ||
| 103 | PLK4 | ENSG00000142731.11 | 33445 | -0.616 | -0.5075 | Yes | ||
| 104 | TOP2A | ENSG00000131747.15 | 33556 | -0.624 | -0.5064 | Yes | ||
| 105 | TRA2B | ENSG00000136527.18 | 33612 | -0.630 | -0.5040 | Yes | ||
| 106 | BUB1B | ENSG00000156970.12 | 33679 | -0.637 | -0.5018 | Yes | ||
| 107 | PMS2 | ENSG00000122512.16 | 33753 | -0.641 | -0.4998 | Yes | ||
| 108 | ZW10 | ENSG00000086827.9 | 33786 | -0.643 | -0.4968 | Yes | ||
| 109 | DLGAP5 | ENSG00000126787.13 | 33812 | -0.646 | -0.4936 | Yes | ||
| 110 | KIF18B | ENSG00000186185.14 | 33854 | -0.650 | -0.4908 | Yes | ||
| 111 | TMPO | ENSG00000120802.13 | 33875 | -0.652 | -0.4875 | Yes | ||
| 112 | CDCA8 | ENSG00000134690.11 | 33985 | -0.661 | -0.4861 | Yes | ||
| 113 | KIF22 | ENSG00000079616.12 | 34367 | -0.690 | -0.4910 | Yes | ||
| 114 | KIF4A | ENSG00000090889.12 | 34413 | -0.694 | -0.4880 | Yes | ||
| 115 | PLK1 | ENSG00000166851.15 | 35046 | -0.745 | -0.4984 | Yes | ||
| 116 | DEPDC1 | ENSG00000024526.17 | 35083 | -0.749 | -0.4949 | Yes | ||
| 117 | MKI67 | ENSG00000148773.14 | 35148 | -0.755 | -0.4919 | Yes | ||
| 118 | MYC | ENSG00000136997.19 | 35251 | -0.763 | -0.4899 | Yes | ||
| 119 | BRCA2 | ENSG00000139618.15 | 35470 | -0.784 | -0.4904 | Yes | ||
| 120 | SPAG5 | ENSG00000076382.17 | 35485 | -0.786 | -0.4861 | Yes | ||
| 121 | SMC6 | ENSG00000163029.16 | 35497 | -0.787 | -0.4818 | Yes | ||
| 122 | AURKB | ENSG00000178999.13 | 35505 | -0.787 | -0.4774 | Yes | ||
| 123 | MLH1 | ENSG00000076242.14 | 35519 | -0.789 | -0.4731 | Yes | ||
| 124 | HNRNPD | ENSG00000138668.19 | 35597 | -0.797 | -0.4702 | Yes | ||
| 125 | SYNCRIP | ENSG00000135316.18 | 35659 | -0.804 | -0.4670 | Yes | ||
| 126 | POP7 | ENSG00000172336.5 | 35707 | -0.809 | -0.4633 | Yes | ||
| 127 | SNRPB | ENSG00000125835.18 | 35755 | -0.814 | -0.4597 | Yes | ||
| 128 | CDC20 | ENSG00000117399.14 | 35877 | -0.828 | -0.4577 | Yes | ||
| 129 | MCM4 | ENSG00000104738.18 | 35969 | -0.840 | -0.4549 | Yes | ||
| 130 | MSH2 | ENSG00000095002.14 | 36064 | -0.851 | -0.4521 | Yes | ||
| 131 | RFC1 | ENSG00000035928.16 | 36076 | -0.852 | -0.4474 | Yes | ||
| 132 | RFC2 | ENSG00000049541.11 | 36206 | -0.868 | -0.4454 | Yes | ||
| 133 | GINS1 | ENSG00000101003.10 | 36223 | -0.870 | -0.4407 | Yes | ||
| 134 | LMNB1 | ENSG00000113368.12 | 36411 | -0.890 | -0.4398 | Yes | ||
| 135 | MYBL2 | ENSG00000101057.16 | 36500 | -0.900 | -0.4366 | Yes | ||
| 136 | NUP153 | ENSG00000124789.11 | 36546 | -0.906 | -0.4324 | Yes | ||
| 137 | NBN | ENSG00000104320.13 | 36600 | -0.915 | -0.4283 | Yes | ||
| 138 | XRCC6 | ENSG00000196419.12 | 36832 | -0.946 | -0.4282 | Yes | ||
| 139 | GINS3 | ENSG00000181938.13 | 36855 | -0.948 | -0.4231 | Yes | ||
| 140 | PNN | ENSG00000100941.9 | 36905 | -0.953 | -0.4187 | Yes | ||
| 141 | MCM2 | ENSG00000073111.14 | 36965 | -0.962 | -0.4145 | Yes | ||
| 142 | TUBG1 | ENSG00000131462.8 | 36973 | -0.963 | -0.4090 | Yes | ||
| 143 | DNMT1 | ENSG00000130816.16 | 37194 | -0.992 | -0.4084 | Yes | ||
| 144 | GINS4 | ENSG00000147536.12 | 37217 | -0.994 | -0.4031 | Yes | ||
| 145 | SRSF1 | ENSG00000136450.13 | 37367 | -1.015 | -0.4007 | Yes | ||
| 146 | DCTPP1 | ENSG00000179958.9 | 37380 | -1.017 | -0.3950 | Yes | ||
| 147 | CDKN1A | ENSG00000124762.13 | 37465 | -1.029 | -0.3910 | Yes | ||
| 148 | DEK | ENSG00000124795.17 | 37596 | -1.050 | -0.3879 | Yes | ||
| 149 | ANP32E | ENSG00000143401.15 | 37604 | -1.051 | -0.3819 | Yes | ||
| 150 | RPA2 | ENSG00000117748.10 | 37640 | -1.058 | -0.3766 | Yes | ||
| 151 | SRSF2 | ENSG00000161547.16 | 37659 | -1.061 | -0.3708 | Yes | ||
| 152 | NUP107 | ENSG00000111581.10 | 37710 | -1.069 | -0.3657 | Yes | ||
| 153 | XPO1 | ENSG00000082898.17 | 37727 | -1.072 | -0.3599 | Yes | ||
| 154 | PAICS | ENSG00000128050.8 | 37849 | -1.091 | -0.3563 | Yes | ||
| 155 | BRMS1L | ENSG00000100916.14 | 37935 | -1.106 | -0.3518 | Yes | ||
| 156 | CCP110 | ENSG00000103540.16 | 38174 | -1.148 | -0.3507 | Yes | ||
| 157 | BARD1 | ENSG00000138376.11 | 38347 | -1.179 | -0.3478 | Yes | ||
| 158 | BRCA1 | ENSG00000012048.22 | 38494 | -1.205 | -0.3442 | Yes | ||
| 159 | PRKDC | ENSG00000253729.7 | 38692 | -1.242 | -0.3416 | Yes | ||
| 160 | PTTG1 | ENSG00000164611.13 | 38713 | -1.246 | -0.3348 | Yes | ||
| 161 | CDC25A | ENSG00000164045.12 | 38736 | -1.251 | -0.3280 | Yes | ||
| 162 | GSPT1 | ENSG00000103342.13 | 38876 | -1.284 | -0.3237 | Yes | ||
| 163 | ILF3 | ENSG00000129351.17 | 38976 | -1.304 | -0.3184 | Yes | ||
| 164 | NAP1L1 | ENSG00000187109.14 | 39234 | -1.361 | -0.3165 | Yes | ||
| 165 | TUBB | ENSG00000196230.13 | 39313 | -1.380 | -0.3103 | Yes | ||
| 166 | CSE1L | ENSG00000124207.17 | 39389 | -1.397 | -0.3039 | Yes | ||
| 167 | IPO7 | ENSG00000205339.10 | 39485 | -1.420 | -0.2978 | Yes | ||
| 168 | LYAR | ENSG00000145220.14 | 39563 | -1.434 | -0.2912 | Yes | ||
| 169 | POLD1 | ENSG00000062822.14 | 39718 | -1.471 | -0.2862 | Yes | ||
| 170 | TBRG4 | ENSG00000136270.14 | 39777 | -1.485 | -0.2789 | Yes | ||
| 171 | NASP | ENSG00000132780.17 | 39879 | -1.517 | -0.2725 | Yes | ||
| 172 | AK2 | ENSG00000004455.17 | 39939 | -1.532 | -0.2649 | Yes | ||
| 173 | RAN | ENSG00000132341.12 | 39982 | -1.544 | -0.2569 | Yes | ||
| 174 | RNASEH2A | ENSG00000104889.6 | 40034 | -1.556 | -0.2490 | Yes | ||
| 175 | POLD2 | ENSG00000106628.10 | 40288 | -1.623 | -0.2454 | Yes | ||
| 176 | DCK | ENSG00000156136.10 | 40305 | -1.629 | -0.2363 | Yes | ||
| 177 | NOP56 | ENSG00000101361.17 | 40492 | -1.685 | -0.2308 | Yes | ||
| 178 | TIMELESS | ENSG00000111602.12 | 40507 | -1.690 | -0.2213 | Yes | ||
| 179 | RAD51C | ENSG00000108384.15 | 40548 | -1.701 | -0.2123 | Yes | ||
| 180 | MRE11 | ENSG00000020922.12 | 40549 | -1.702 | -0.2024 | Yes | ||
| 181 | EIF2S1 | ENSG00000134001.13 | 40613 | -1.722 | -0.1938 | Yes | ||
| 182 | TIPIN | ENSG00000075131.10 | 40899 | -1.823 | -0.1898 | Yes | ||
| 183 | SMC1A | ENSG00000072501.17 | 40902 | -1.825 | -0.1792 | Yes | ||
| 184 | NME1 | ENSG00000239672.7 | 41010 | -1.873 | -0.1708 | Yes | ||
| 185 | POLA2 | ENSG00000014138.9 | 41096 | -1.906 | -0.1617 | Yes | ||
| 186 | PA2G4 | ENSG00000170515.14 | 41191 | -1.955 | -0.1525 | Yes | ||
| 187 | CCNE1 | ENSG00000105173.14 | 41239 | -1.974 | -0.1420 | Yes | ||
| 188 | NOLC1 | ENSG00000166197.16 | 41247 | -1.977 | -0.1307 | Yes | ||
| 189 | KPNA2 | ENSG00000182481.9 | 41262 | -1.982 | -0.1195 | Yes | ||
| 190 | CTPS1 | ENSG00000171793.16 | 41388 | -2.056 | -0.1104 | Yes | ||
| 191 | UBE2S | ENSG00000108106.14 | 41441 | -2.097 | -0.0994 | Yes | ||
| 192 | STMN1 | ENSG00000117632.23 | 41736 | -2.282 | -0.0929 | Yes | ||
| 193 | RAD21 | ENSG00000164754.14 | 41762 | -2.297 | -0.0801 | Yes | ||
| 194 | HMGB3 | ENSG00000029993.15 | 41778 | -2.309 | -0.0670 | Yes | ||
| 195 | DIAPH3 | ENSG00000139734.19 | 41827 | -2.348 | -0.0544 | Yes | ||
| 196 | E2F8 | ENSG00000129173.13 | 41830 | -2.351 | -0.0408 | Yes | ||
| 197 | EZH2 | ENSG00000106462.10 | 41901 | -2.405 | -0.0284 | Yes | ||
| 198 | UBE2T | ENSG00000077152.11 | 42007 | -2.495 | -0.0163 | Yes | ||
| 199 | PRPS1 | ENSG00000147224.11 | 42335 | -2.892 | -0.0070 | Yes | ||
| 200 | JPT1 | ENSG00000189159.16 | 42914 | -4.335 | 0.0048 | Yes |
