Details for gene set HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Phenotype	Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Upregulated in class	FSHD2
GeneSet	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
Enrichment Score (ES)	0.4048666
Normalized Enrichment Score (NES)	1.8267726
Nominal p-value	0.0
FDR q-value	5.192308E-4
FWER p-Value	0.002

Fig 1: Enrichment plot: HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	SLIT3	ENSG00000184347.14			0	4.923	0.0165	Yes
2	DCN	ENSG00000011465.17			6	4.734	0.0322	Yes
3	FBLN5	ENSG00000140092.14			11	4.579	0.0475	Yes
4	PCOLCE	ENSG00000106333.13			33	4.267	0.0613	Yes
5	FBLN1	ENSG00000077942.19			63	3.993	0.0740	Yes
6	PDGFRB	ENSG00000113721.14			106	3.655	0.0853	Yes
7	CTHRC1	ENSG00000164932.13			123	3.593	0.0970	Yes
8	IGFBP4	ENSG00000141753.7			151	3.478	0.1080	Yes
9	CD44	ENSG00000026508.18			157	3.446	0.1194	Yes
10	FMOD	ENSG00000122176.12			215	3.256	0.1290	Yes
11	ANPEP	ENSG00000166825.14			265	3.089	0.1382	Yes
12	PCOLCE2	ENSG00000163710.9			294	3.004	0.1476	Yes
13	PMP22	ENSG00000109099.15			310	2.946	0.1571	Yes
14	ITGA2	ENSG00000164171.11			327	2.899	0.1665	Yes
15	COL6A3	ENSG00000163359.15			371	2.812	0.1749	Yes
16	SLIT2	ENSG00000145147.20			459	2.664	0.1818	Yes
17	TGFBR3	ENSG00000069702.11			474	2.641	0.1903	Yes
18	SERPINE2	ENSG00000135919.13			544	2.548	0.1973	Yes
19	MATN2	ENSG00000132561.14			579	2.497	0.2048	Yes
20	TIMP1	ENSG00000102265.12			582	2.491	0.2131	Yes
21	COL16A1	ENSG00000084636.18			589	2.483	0.2213	Yes
22	WIPF1	ENSG00000115935.17			654	2.409	0.2279	Yes
23	COL6A2	ENSG00000142173.15			816	2.246	0.2317	Yes
24	VIM	ENSG00000026025.16			852	2.214	0.2383	Yes
25	SDC4	ENSG00000124145.6			886	2.182	0.2448	Yes
26	TIMP3	ENSG00000100234.11			892	2.178	0.2520	Yes
27	FAS	ENSG00000026103.22			911	2.164	0.2588	Yes
28	MSX1	ENSG00000163132.8			976	2.117	0.2644	Yes
29	FBLN2	ENSG00000163520.14			977	2.116	0.2715	Yes
30	CAPG	ENSG00000042493.16			994	2.108	0.2782	Yes
31	ECM1	ENSG00000143369.15			1104	2.046	0.2825	Yes
32	PRRX1	ENSG00000116132.12			1144	2.020	0.2884	Yes
33	DKK1	ENSG00000107984.10			1299	1.941	0.2913	Yes
34	TNFRSF11B	ENSG00000164761.9			1360	1.901	0.2963	Yes
35	LUM	ENSG00000139329.5			1391	1.886	0.3019	Yes
36	THBS2	ENSG00000186340.15			1447	1.867	0.3069	Yes
37	LOX	ENSG00000113083.14			1511	1.838	0.3116	Yes
38	CD59	ENSG00000085063.16			1662	1.770	0.3140	Yes
39	PPIB	ENSG00000166794.4			1719	1.748	0.3186	Yes
40	GEM	ENSG00000164949.8			1767	1.729	0.3233	Yes
41	CXCL12	ENSG00000107562.16			1796	1.720	0.3284	Yes
42	IGFBP3	ENSG00000146674.15			1828	1.702	0.3334	Yes
43	NT5E	ENSG00000135318.12			2035	1.617	0.3340	Yes
44	LAMA1	ENSG00000101680.15			2061	1.609	0.3388	Yes
45	SFRP1	ENSG00000104332.12			2175	1.573	0.3414	Yes
46	THY1	ENSG00000154096.13			2244	1.552	0.3450	Yes
47	DPYSL3	ENSG00000113657.13			2327	1.526	0.3483	Yes
48	GJA1	ENSG00000152661.9			2383	1.509	0.3520	Yes
49	MXRA5	ENSG00000101825.8			2436	1.494	0.3558	Yes
50	MMP1	ENSG00000196611.5			2473	1.481	0.3600	Yes
51	MMP3	ENSG00000149968.12			2562	1.453	0.3628	Yes
52	FUCA1	ENSG00000179163.11			2594	1.443	0.3669	Yes
53	MMP2	ENSG00000087245.13			2616	1.437	0.3712	Yes
54	PTHLH	ENSG00000087494.16			2751	1.393	0.3728	Yes
55	CDH11	ENSG00000140937.14			2757	1.391	0.3773	Yes
56	IGFBP2	ENSG00000115457.10			2774	1.385	0.3816	Yes
57	PTX3	ENSG00000163661.4			2789	1.381	0.3859	Yes
58	EMP3	ENSG00000142227.11			2904	1.355	0.3878	Yes
59	EFEMP2	ENSG00000172638.13			2973	1.339	0.3907	Yes
60	LRP1	ENSG00000123384.14			3000	1.333	0.3945	Yes
61	GAS1	ENSG00000180447.7			3007	1.331	0.3988	Yes
62	ECM2	ENSG00000106823.12			3170	1.296	0.3994	Yes
63	FAP	ENSG00000078098.14			3443	1.238	0.3972	Yes
64	MGP	ENSG00000111341.10			3725	1.178	0.3946	Yes
65	VEGFC	ENSG00000150630.4			3931	1.140	0.3937	Yes
66	DAB2	ENSG00000153071.15			4095	1.112	0.3936	Yes
67	THBS1	ENSG00000137801.11			4127	1.107	0.3966	Yes
68	GREM1	ENSG00000166923.12			4206	1.092	0.3984	Yes
69	LGALS1	ENSG00000100097.12			4241	1.085	0.4013	Yes
70	ITGB5	ENSG00000082781.12			4315	1.074	0.4032	Yes
71	TNC	ENSG00000041982.16			4396	1.062	0.4049	Yes
72	FGF2	ENSG00000138685.15			4734	1.009	0.4004	No
73	SNAI2	ENSG00000019549.13			4808	0.996	0.4020	No
74	CXCL6	ENSG00000124875.10			5459	0.905	0.3899	No
75	FBN1	ENSG00000166147.13			5850	0.858	0.3837	No
76	IL15	ENSG00000164136.17			6136	0.824	0.3798	No
77	COMP	ENSG00000105664.11			6225	0.814	0.3805	No
78	CADM1	ENSG00000182985.17			6243	0.812	0.3828	No
79	COL1A2	ENSG00000164692.17			6324	0.804	0.3837	No
80	COL12A1	ENSG00000111799.21			6723	0.765	0.3770	No
81	P3H1	ENSG00000117385.15			7005	0.738	0.3729	No
82	BGN	ENSG00000182492.16			7136	0.724	0.3723	No
83	TFPI2	ENSG00000105825.14			7157	0.723	0.3742	No
84	SPOCK1	ENSG00000152377.14			7208	0.718	0.3755	No
85	COL3A1	ENSG00000168542.14			7229	0.715	0.3774	No
86	LRRC15	ENSG00000172061.8			7351	0.706	0.3770	No
87	QSOX1	ENSG00000116260.17			8176	0.631	0.3599	No
88	LOXL1	ENSG00000129038.16			9240	0.552	0.3370	No
89	MMP14	ENSG00000157227.13			9489	0.539	0.3330	No
90	FN1	ENSG00000115414.19			9913	0.516	0.3249	No
91	PLOD3	ENSG00000106397.12			10261	0.493	0.3184	No
92	TPM4	ENSG00000167460.17			11125	0.437	0.2998	No
93	FBN2	ENSG00000138829.12			11219	0.432	0.2991	No
94	COPA	ENSG00000122218.16			11223	0.431	0.3004	No
95	GLIPR1	ENSG00000139278.10			11320	0.426	0.2996	No
96	FSTL1	ENSG00000163430.12			11613	0.407	0.2942	No
97	SDC1	ENSG00000115884.11			13286	0.340	0.2564	No
98	BDNF	ENSG00000176697.19			13340	0.337	0.2563	No
99	BASP1	ENSG00000176788.9			13365	0.335	0.2568	No
100	PRSS2	ENSG00000275896.5			13875	0.322	0.2461	No
101	TGM2	ENSG00000198959.12			14132	0.309	0.2411	No
102	PLOD1	ENSG00000083444.17			15475	0.276	0.2108	No
103	SAT1	ENSG00000130066.16			15520	0.274	0.2107	No
104	MAGEE1	ENSG00000198934.5			16225	0.235	0.1951	No
105	APLP1	ENSG00000105290.12			16304	0.230	0.1940	No
106	CDH6	ENSG00000113361.13			16393	0.226	0.1927	No
107	CXCL1	ENSG00000163739.5			17045	0.196	0.1782	No
108	WNT5A	ENSG00000114251.14			17212	0.187	0.1750	No
109	RGS4	ENSG00000117152.13			18763	0.109	0.1392	No
110	MYLK	ENSG00000065534.18			19434	0.074	0.1239	No
111	ID2	ENSG00000115738.10			19442	0.074	0.1239	No
112	COL8A2	ENSG00000171812.13			20347	0.029	0.1030	No
113	SPP1	ENSG00000118785.14			20575	0.018	0.0977	No
114	MCM7	ENSG00000166508.17			20623	0.016	0.0967	No
115	CCN1	ENSG00000142871.17			22390	-0.079	0.0558	No
116	LAMC1	ENSG00000135862.6			22432	-0.081	0.0551	No
117	LAMA2	ENSG00000196569.12			22603	-0.091	0.0515	No
118	GPX7	ENSG00000116157.6			23167	-0.122	0.0388	No
119	COLGALT1	ENSG00000130309.11			23871	-0.162	0.0229	No
120	NOTCH2	ENSG00000134250.20			23887	-0.164	0.0231	No
121	HTRA1	ENSG00000166033.13			24116	-0.177	0.0184	No
122	FZD8	ENSG00000177283.7			27233	-0.290	-0.0532	No
123	COL5A3	ENSG00000080573.7			27521	-0.299	-0.0589	No
124	AREG	ENSG00000109321.11			29159	-0.357	-0.0958	No
125	SERPINH1	ENSG00000149257.14			29331	-0.364	-0.0986	No
126	SCG2	ENSG00000171951.5			30230	-0.423	-0.1181	No
127	ITGB3	ENSG00000259207.7			31330	-0.481	-0.1421	No
128	COL1A1	ENSG00000108821.13			32343	-0.536	-0.1639	No
129	CCN2	ENSG00000118523.6			32823	-0.570	-0.1731	No
130	MEST	ENSG00000106484.16			32879	-0.574	-0.1725	No
131	ADAM12	ENSG00000148848.14			32976	-0.582	-0.1728	No
132	LAMA3	ENSG00000053747.16			32988	-0.582	-0.1711	No
133	OXTR	ENSG00000180914.10			33167	-0.595	-0.1732	No
134	POSTN	ENSG00000133110.15			33395	-0.612	-0.1765	No
135	EDIL3	ENSG00000164176.13			33729	-0.640	-0.1821	No
136	CALD1	ENSG00000122786.20			33950	-0.658	-0.1850	No
137	ABI3BP	ENSG00000154175.17			35307	-0.769	-0.2140	No
138	VCAN	ENSG00000038427.16			36187	-0.866	-0.2316	No
139	ITGB1	ENSG00000150093.19			36454	-0.895	-0.2348	No
140	FLNA	ENSG00000196924.17			36458	-0.895	-0.2319	No
141	COL5A2	ENSG00000204262.14			36764	-0.936	-0.2358	No
142	CALU	ENSG00000128595.17			36775	-0.937	-0.2329	No
143	ELN	ENSG00000049540.17			37004	-0.966	-0.2350	No
144	SPARC	ENSG00000113140.11			37052	-0.974	-0.2328	No
145	NID2	ENSG00000087303.18			37054	-0.975	-0.2296	No
146	COL5A1	ENSG00000130635.15			37069	-0.977	-0.2266	No
147	JUN	ENSG00000177606.7			37141	-0.985	-0.2250	No
148	IL6	ENSG00000136244.12			37366	-1.015	-0.2268	No
149	LAMC2	ENSG00000058085.15			37414	-1.022	-0.2245	No
150	CXCL8	ENSG00000169429.11			37884	-1.098	-0.2317	No
151	SGCB	ENSG00000163069.12			38176	-1.149	-0.2347	No
152	FOXC2	ENSG00000176692.8			38284	-1.169	-0.2332	No
153	SERPINE1	ENSG00000106366.8			38403	-1.189	-0.2320	No
154	TGFB1	ENSG00000105329.10			38478	-1.201	-0.2297	No
155	RHOB	ENSG00000143878.10			38518	-1.210	-0.2265	No
156	MFAP5	ENSG00000197614.11			38668	-1.237	-0.2259	No
157	SLC6A8	ENSG00000130821.16			38709	-1.245	-0.2226	No
158	PFN2	ENSG00000070087.14			38838	-1.276	-0.2213	No
159	LOXL2	ENSG00000134013.16			38961	-1.300	-0.2198	No
160	COL4A1	ENSG00000187498.16			39310	-1.380	-0.2233	No
161	TNFAIP3	ENSG00000118503.15			39359	-1.390	-0.2198	No
162	COL7A1	ENSG00000114270.17			39421	-1.404	-0.2165	No
163	COL4A2	ENSG00000134871.19			39460	-1.413	-0.2126	No
164	BMP1	ENSG00000168487.19			39505	-1.423	-0.2089	No
165	ENO2	ENSG00000111674.9			39689	-1.464	-0.2083	No
166	CRLF1	ENSG00000006016.11			39981	-1.543	-0.2099	No
167	MATN3	ENSG00000132031.13			40083	-1.566	-0.2070	No
168	MYL9	ENSG00000101335.10			40187	-1.596	-0.2040	No
169	COL11A1	ENSG00000060718.22			40275	-1.618	-0.2006	No
170	ITGA5	ENSG00000161638.11			40419	-1.662	-0.1984	No
171	DST	ENSG00000151914.20			40581	-1.710	-0.1964	No
172	TGFBI	ENSG00000120708.17			40715	-1.752	-0.1936	No
173	VEGFA	ENSG00000112715.22			40824	-1.792	-0.1901	No
174	PMEPA1	ENSG00000124225.16			40906	-1.826	-0.1859	No
175	NNMT	ENSG00000166741.7			40927	-1.833	-0.1802	No
176	GADD45B	ENSG00000099860.9			40977	-1.852	-0.1752	No
177	SGCD	ENSG00000170624.13			41042	-1.886	-0.1703	No
178	ITGAV	ENSG00000138448.12			41100	-1.907	-0.1653	No
179	PLAUR	ENSG00000011422.12			41170	-1.945	-0.1604	No
180	TNFRSF12A	ENSG00000006327.13			41188	-1.954	-0.1542	No
181	GADD45A	ENSG00000116717.13			41218	-1.966	-0.1483	No
182	VCAM1	ENSG00000162692.12			41228	-1.969	-0.1419	No
183	INHBA	ENSG00000122641.11			41421	-2.082	-0.1394	No
184	FERMT2	ENSG00000073712.15			41491	-2.127	-0.1339	No
185	CDH2	ENSG00000170558.9			41908	-2.414	-0.1355	No
186	TAGLN	ENSG00000149591.17			41950	-2.456	-0.1282	No
187	NTM	ENSG00000182667.14			42122	-2.597	-0.1235	No
188	ACTA2	ENSG00000107796.13			42259	-2.777	-0.1174	No
189	SGCG	ENSG00000102683.7			42272	-2.813	-0.1082	No
190	PVR	ENSG00000073008.15			42407	-2.989	-0.1013	No
191	IL32	ENSG00000008517.16			42438	-3.039	-0.0918	No
192	PDLIM4	ENSG00000131435.13			42504	-3.130	-0.0829	No
193	PLOD2	ENSG00000152952.12			42521	-3.156	-0.0727	No
194	GPC1	ENSG00000063660.9			42528	-3.165	-0.0622	No
195	SNTB1	ENSG00000172164.15			42613	-3.372	-0.0528	No
196	FSTL3	ENSG00000070404.10			42644	-3.449	-0.0420	No
197	SFRP4	ENSG00000106483.12			42775	-3.803	-0.0323	No
198	TPM1	ENSG00000140416.21			42794	-3.877	-0.0197	No
199	CAP2	ENSG00000112186.12			42820	-3.986	-0.0069	No
200	TPM2	ENSG00000198467.15			42854	-4.136	0.0062	No

Fig 2: HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION: Random ES distribution   
Gene set null distribution of ES for HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION