Details for gene set HALLMARK_ESTROGEN_RESPONSE_EARLY[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Phenotype	Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Upregulated in class	FSHD2M
GeneSet	HALLMARK_ESTROGEN_RESPONSE_EARLY
Enrichment Score (ES)	-0.31527123
Normalized Enrichment Score (NES)	-1.2627671
Nominal p-value	0.0585034
FDR q-value	0.119230986
FWER p-Value	0.952

Fig 1: Enrichment plot: HALLMARK_ESTROGEN_RESPONSE_EARLY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	NBL1	ENSG00000158747.14			142	3.516	0.0102	No
2	IGFBP4	ENSG00000141753.7			151	3.478	0.0234	No
3	CD44	ENSG00000026508.18			157	3.446	0.0365	No
4	SCNN1A	ENSG00000111319.13			172	3.375	0.0492	No
5	SH3BP5	ENSG00000131370.16			212	3.263	0.0608	No
6	FAM102A	ENSG00000167106.12			222	3.245	0.0731	No
7	PGR	ENSG00000082175.15			256	3.111	0.0843	No
8	IL6ST	ENSG00000134352.20			282	3.044	0.0954	No
9	TPBG	ENSG00000146242.8			331	2.893	0.1054	No
10	BCL2	ENSG00000171791.13			349	2.862	0.1160	No
11	KLF4	ENSG00000136826.15			421	2.729	0.1249	No
12	ADD3	ENSG00000148700.15			598	2.472	0.1303	No
13	CYP26B1	ENSG00000003137.8			683	2.377	0.1375	No
14	MICB	ENSG00000204516.10			794	2.266	0.1436	No
15	OLFM1	ENSG00000130558.19			825	2.239	0.1515	No
16	RHOD	ENSG00000173156.7			954	2.131	0.1567	No
17	ASB13	ENSG00000196372.13			1041	2.086	0.1628	No
18	CISH	ENSG00000114737.15			1052	2.083	0.1705	No
19	RPS6KA2	ENSG00000071242.12			1099	2.049	0.1774	No
20	MREG	ENSG00000118242.16			1365	1.899	0.1785	No
21	KCNK15	ENSG00000124249.7			1548	1.821	0.1812	No
22	EGR3	ENSG00000179388.9			1551	1.818	0.1882	No
23	BLVRB	ENSG00000090013.11			1648	1.782	0.1928	No
24	PAPSS2	ENSG00000198682.13			1705	1.753	0.1982	No
25	CXCL12	ENSG00000107562.16			1796	1.720	0.2028	No
26	KRT19	ENSG00000171345.13			1802	1.716	0.2092	No
27	TSKU	ENSG00000182704.8			1939	1.654	0.2124	No
28	TJP3	ENSG00000105289.15			1957	1.648	0.2184	No
29	MAPT	ENSG00000186868.15			2157	1.580	0.2198	No
30	CCN5	ENSG00000064205.10			2260	1.545	0.2234	No
31	ELF1	ENSG00000120690.16			2323	1.527	0.2278	No
32	PPIF	ENSG00000108179.14			2376	1.511	0.2324	No
33	GJA1	ENSG00000152661.9			2383	1.509	0.2381	No
34	CLDN7	ENSG00000181885.18			2537	1.461	0.2401	No
35	IL17RB	ENSG00000056736.10			2614	1.438	0.2439	No
36	AFF1	ENSG00000172493.20			2700	1.409	0.2473	No
37	BCL11B	ENSG00000127152.18			2754	1.392	0.2515	No
38	MUC1	ENSG00000185499.16			2826	1.372	0.2551	No
39	MPPED2	ENSG00000066382.16			2858	1.365	0.2596	No
40	FASN	ENSG00000169710.9			3072	1.316	0.2597	No
41	CA12	ENSG00000074410.14			3104	1.310	0.2640	No
42	IGF1R	ENSG00000140443.15			3111	1.309	0.2689	No
43	RASGRP1	ENSG00000172575.12			3180	1.292	0.2723	No
44	INHBB	ENSG00000163083.6			3525	1.221	0.2690	No
45	SLC37A1	ENSG00000160190.14			3579	1.211	0.2724	No
46	SCARB1	ENSG00000073060.16			3609	1.204	0.2764	No
47	DHCR7	ENSG00000172893.15			3663	1.193	0.2797	No
48	FDFT1	ENSG00000079459.13			3715	1.180	0.2831	No
49	ADCY1	ENSG00000164742.16			3895	1.146	0.2833	No
50	ELOVL5	ENSG00000012660.14			3930	1.140	0.2869	No
51	OLFML3	ENSG00000116774.12			4161	1.102	0.2858	No
52	ZNF185	ENSG00000147394.18			4364	1.066	0.2852	No
53	PTGES	ENSG00000148344.11			4412	1.060	0.2881	No
54	SLC1A1	ENSG00000106688.12			4645	1.023	0.2867	No
55	CCND1	ENSG00000110092.3			4717	1.011	0.2889	No
56	SEMA3B	ENSG00000012171.20			4765	1.004	0.2917	No
57	FOXC1	ENSG00000054598.9			5058	0.960	0.2886	No
58	SYNGR1	ENSG00000100321.15			5063	0.959	0.2922	No
59	ELOVL2	ENSG00000197977.4			5404	0.914	0.2878	No
60	GLA	ENSG00000102393.10			5414	0.912	0.2911	No
61	NADSYN1	ENSG00000172890.13			5558	0.893	0.2912	No
62	ABAT	ENSG00000183044.12			5596	0.888	0.2937	No
63	RAB31	ENSG00000168461.13			6077	0.831	0.2857	No
64	TFAP2C	ENSG00000087510.7			6149	0.822	0.2872	No
65	PMAIP1	ENSG00000141682.11			6227	0.814	0.2886	No
66	ITPK1	ENSG00000100605.17			6290	0.807	0.2902	No
67	THSD4	ENSG00000187720.14			6296	0.807	0.2932	No
68	DLC1	ENSG00000164741.15			6359	0.801	0.2949	No
69	MED13L	ENSG00000123066.8			7300	0.709	0.2757	No
70	KRT8	ENSG00000170421.12			7314	0.708	0.2781	No
71	LRIG1	ENSG00000144749.13			7468	0.693	0.2772	No
72	GREB1	ENSG00000196208.14			7500	0.690	0.2791	No
73	UNC119	ENSG00000109103.11			7826	0.662	0.2741	No
74	FARP1	ENSG00000152767.17			7828	0.661	0.2766	No
75	KAZN	ENSG00000189337.17			8222	0.627	0.2699	No
76	CALB2	ENSG00000172137.19			8638	0.596	0.2625	No
77	PRSS23	ENSG00000150687.12			8732	0.588	0.2626	No
78	SULT2B1	ENSG00000088002.11			8911	0.575	0.2607	No
79	KRT15	ENSG00000171346.16			9499	0.538	0.2491	No
80	FOS	ENSG00000170345.10			9664	0.525	0.2473	No
81	DEPTOR	ENSG00000155792.10			10451	0.481	0.2308	No
82	RET	ENSG00000165731.20			12408	0.369	0.1866	No
83	FCMR	ENSG00000162894.12			12710	0.361	0.1810	No
84	CALCR	ENSG00000004948.15			13124	0.350	0.1727	No
85	RETREG1	ENSG00000154153.13			13990	0.317	0.1538	No
86	ALDH3B1	ENSG00000006534.16			14064	0.314	0.1533	No
87	TGM2	ENSG00000198959.12			14132	0.309	0.1529	No
88	SYBU	ENSG00000147642.17			14570	0.306	0.1439	No
89	CANT1	ENSG00000171302.17			14775	0.293	0.1403	No
90	NPY1R	ENSG00000164128.7			16610	0.214	0.0984	No
91	HR	ENSG00000168453.15			17070	0.194	0.0885	No
92	KLK10	ENSG00000129451.12			17579	0.170	0.0773	No
93	CHPT1	ENSG00000111666.11			17710	0.162	0.0749	No
94	SLC39A6	ENSG00000141424.13			17863	0.153	0.0719	No
95	TTC39A	ENSG00000085831.15			18523	0.123	0.0570	No
96	PEX11A	ENSG00000166821.9			18829	0.105	0.0503	No
97	ANXA9	ENSG00000143412.10			19674	0.062	0.0309	No
98	ISG20L2	ENSG00000143319.16			20550	0.019	0.0106	No
99	MYOF	ENSG00000138119.17			20576	0.018	0.0101	No
100	MINDY1	ENSG00000143409.15			21655	-0.040	-0.0149	No
101	BAG1	ENSG00000107262.23			21672	-0.041	-0.0151	No
102	ADCY9	ENSG00000162104.10			22643	-0.093	-0.0373	No
103	WWC1	ENSG00000113645.14			22682	-0.095	-0.0378	No
104	NXT1	ENSG00000132661.4			22966	-0.111	-0.0440	No
105	SIAH2	ENSG00000181788.4			23013	-0.113	-0.0447	No
106	FHL2	ENSG00000115641.19			23221	-0.125	-0.0490	No
107	WFS1	ENSG00000109501.13			23770	-0.155	-0.0612	No
108	SFN	ENSG00000175793.12			23845	-0.161	-0.0623	No
109	STC2	ENSG00000113739.10			24147	-0.179	-0.0686	No
110	SOX3	ENSG00000134595.8			24382	-0.192	-0.0733	No
111	TIPARP	ENSG00000163659.13			24403	-0.193	-0.0730	No
112	AMFR	ENSG00000159461.15			24485	-0.198	-0.0742	No
113	ARL3	ENSG00000138175.9			25638	-0.236	-0.1001	No
114	MLPH	ENSG00000115648.14			25801	-0.247	-0.1029	No
115	INPP5F	ENSG00000198825.15			25943	-0.257	-0.1052	No
116	RBBP8	ENSG00000101773.19			26021	-0.261	-0.1060	No
117	OVOL2	ENSG00000125850.11			26280	-0.263	-0.1110	No
118	AREG	ENSG00000109321.11			29159	-0.357	-0.1767	No
119	SLC26A2	ENSG00000155850.7			29548	-0.377	-0.1843	No
120	CELSR1	ENSG00000075275.16			29683	-0.386	-0.1859	No
121	KRT18	ENSG00000111057.11			30409	-0.432	-0.2011	No
122	SLC27A2	ENSG00000140284.11			30591	-0.441	-0.2036	No
123	JAK2	ENSG00000096968.13			31758	-0.501	-0.2289	No
124	XBP1	ENSG00000100219.16			32221	-0.529	-0.2376	No
125	SNX24	ENSG00000064652.11			32525	-0.545	-0.2426	No
126	DHRS3	ENSG00000162496.9			32706	-0.560	-0.2446	No
127	FLNB	ENSG00000136068.14			32870	-0.574	-0.2462	No
128	ESRP2	ENSG00000103067.14			33361	-0.610	-0.2553	No
129	KRT13	ENSG00000171401.15			34387	-0.691	-0.2765	No
130	KCNK5	ENSG00000164626.9			34538	-0.705	-0.2773	No
131	ENDOD1	ENSG00000149218.5			34830	-0.728	-0.2813	No
132	GFRA1	ENSG00000151892.14			34887	-0.732	-0.2798	No
133	MAST4	ENSG00000069020.18			35062	-0.747	-0.2809	No
134	MYC	ENSG00000136997.19			35251	-0.763	-0.2824	No
135	CLIC3	ENSG00000169583.13			35360	-0.774	-0.2819	No
136	ELF3	ENSG00000163435.16			35419	-0.779	-0.2803	No
137	NAV2	ENSG00000166833.21			35863	-0.826	-0.2874	No
138	RAPGEFL1	ENSG00000108352.12			36612	-0.917	-0.3013	No
139	RARA	ENSG00000131759.18			37114	-0.982	-0.3092	No
140	DHRS2	ENSG00000100867.14			37225	-0.995	-0.3079	No
141	TOB1	ENSG00000141232.5			37303	-1.007	-0.3059	No
142	CBFA2T3	ENSG00000129993.15			37395	-1.019	-0.3041	No
143	UGCG	ENSG00000148154.10			37430	-1.024	-0.3009	No
144	MYBL1	ENSG00000185697.16			37607	-1.052	-0.3010	No
145	AR	ENSG00000169083.17			38078	-1.131	-0.3076	No
146	DYNLT3	ENSG00000165169.11			38084	-1.132	-0.3033	No
147	KLF10	ENSG00000155090.15			38597	-1.222	-0.3106	Yes
148	PDZK1	ENSG00000174827.13			38667	-1.237	-0.3074	Yes
149	SYT12	ENSG00000173227.14			38927	-1.294	-0.3085	Yes
150	KDM4B	ENSG00000127663.15			38932	-1.295	-0.3036	Yes
151	TUBB2B	ENSG00000137285.10			38935	-1.296	-0.2987	Yes
152	TFF3	ENSG00000160180.15			39084	-1.327	-0.2970	Yes
153	MYBBP1A	ENSG00000132382.14			39171	-1.346	-0.2938	Yes
154	HES1	ENSG00000114315.4			39235	-1.362	-0.2901	Yes
155	SLC9A3R1	ENSG00000109062.12			39524	-1.426	-0.2913	Yes
156	OPN3	ENSG00000054277.14			39590	-1.440	-0.2873	Yes
157	MYB	ENSG00000118513.19			39639	-1.451	-0.2828	Yes
158	B4GALT1	ENSG00000086062.12			39786	-1.489	-0.2805	Yes
159	TBC1D30	ENSG00000111490.14			39801	-1.494	-0.2751	Yes
160	NRIP1	ENSG00000180530.11			39986	-1.544	-0.2734	Yes
161	FKBP5	ENSG00000096060.14			40021	-1.553	-0.2682	Yes
162	BHLHE40	ENSG00000134107.5			40173	-1.593	-0.2656	Yes
163	SLC1A4	ENSG00000115902.11			40339	-1.639	-0.2632	Yes
164	MED24	ENSG00000008838.20			40471	-1.679	-0.2597	Yes
165	P2RY2	ENSG00000175591.11			40519	-1.694	-0.2543	Yes
166	RHOBTB3	ENSG00000164292.13			40540	-1.699	-0.2483	Yes
167	ABHD2	ENSG00000140526.18			40689	-1.746	-0.2450	Yes
168	TGIF2	ENSG00000118707.10			40733	-1.757	-0.2392	Yes
169	FRK	ENSG00000111816.8			40827	-1.793	-0.2345	Yes
170	SLC22A5	ENSG00000197375.12			40836	-1.797	-0.2278	Yes
171	NCOR2	ENSG00000196498.13			40948	-1.842	-0.2233	Yes
172	CELSR2	ENSG00000143126.8			41001	-1.869	-0.2173	Yes
173	TPD52L1	ENSG00000111907.21			41057	-1.891	-0.2113	Yes
174	FKBP4	ENSG00000004478.8			41079	-1.899	-0.2045	Yes
175	SLC24A3	ENSG00000185052.12			41129	-1.924	-0.1982	Yes
176	RAB17	ENSG00000124839.13			41260	-1.981	-0.1937	Yes
177	TMEM164	ENSG00000157600.12			41290	-1.998	-0.1866	Yes
178	SLC19A2	ENSG00000117479.15			41343	-2.029	-0.1801	Yes
179	SVIL	ENSG00000197321.14			41525	-2.146	-0.1760	Yes
180	SLC16A1	ENSG00000155380.11			41724	-2.273	-0.1719	Yes
181	SLC2A1	ENSG00000117394.23			41840	-2.358	-0.1655	Yes
182	RRP12	ENSG00000052749.13			41858	-2.372	-0.1568	Yes
183	SEC14L2	ENSG00000100003.18			41866	-2.378	-0.1478	Yes
184	SLC7A2	ENSG00000003989.17			41914	-2.420	-0.1396	Yes
185	PODXL	ENSG00000128567.17			42100	-2.575	-0.1340	Yes
186	ABCA3	ENSG00000167972.14			42113	-2.590	-0.1243	Yes
187	TIAM1	ENSG00000156299.13			42155	-2.641	-0.1151	Yes
188	PLAAT3	ENSG00000176485.11			42174	-2.666	-0.1053	Yes
189	AKAP1	ENSG00000121057.13			42227	-2.741	-0.0959	Yes
190	LAD1	ENSG00000159166.15			42455	-3.066	-0.0894	Yes
191	GAB2	ENSG00000033327.13			42468	-3.087	-0.0778	Yes
192	ABLIM1	ENSG00000099204.20			42494	-3.116	-0.0664	Yes
193	SLC7A5	ENSG00000103257.9			42645	-3.449	-0.0567	Yes
194	AQP3	ENSG00000165272.16			42764	-3.770	-0.0449	Yes
195	HSPB8	ENSG00000152137.6			42810	-3.949	-0.0308	Yes
196	REEP1	ENSG00000068615.18			43050	-4.889	-0.0176	Yes
197	PDLIM3	ENSG00000154553.15			43113	-4.975	0.0001	Yes

Fig 2: HALLMARK_ESTROGEN_RESPONSE_EARLY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_ESTROGEN_RESPONSE_EARLY: Random ES distribution   
Gene set null distribution of ES for HALLMARK_ESTROGEN_RESPONSE_EARLY